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Article
Association of some Viral infectionsand asthma: serological evidence

Authors: Tara shaker Al-charmwindi --- Nidal Albdul-Muhaimen --- Shehab Ahmed lafi
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2008 Volume: 4 Issue: 2 Pages: 5-12
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: It is well known that mycotic antigens have an important role in atopy and the induction of asthma. Now one of the important subjects is the relation between respiratory bacterial and viral infections in the inflammatory reactions accompanied with bronchial asthma viruses Bacteria or their metabolites act as trigger for asthma or increase it's intensity .
Objectives: To show the relation between asthma and some viral infections serologically.
Methods: Direct ELISA test was employed to detect lgG specific for Respiratory Syncytial virus (Rsv) parainfluenza virus type (p13) and influenza virus in sera of (100) asthmatic patients of two age groups. (10-17) and(18-50) years old. Serum samples from(32) intact control individuals of the same age groups were also investigated.
Results: significant mean values of lgG specific for parainfluenza type-3 and Respiratory Syncytial viruse were found incontrast to normal control individuals. Non significant values of lgG specific for influenza virus were detected in asthmatics in contrast to control normal individuals.
Conclusion: Respiratory Syncytial virus appears to be a prominent cause of concomitant infections in asthmatic children and some adults as well as parainfluenza virus type-3 within age group ( 10-17) years old asthmatics so RSV and p1-3 viruses may be contributers to asthma severity in asthmatic patients.
Keywords: Asthma, Infection and asthma, Virus and asthma.


Article
Mothers Information Regarding Asthmatic Child Care in Kirkuk City
معلومات الامهات حول العناية بالطفل المصاب بالربو في مدينة كركوك

Author: Blend B. Ameen بليند ايمن
Journal: nursing national Iraqi specility المجلة العراقية الوطنية للعلوم التمريضية ISSN: 18122388 Year: 2015 Volume: 28 Issue: 2 Pages: 83-92
Publisher: Baghdad University جامعة بغداد

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Objectives: To assess the information of mothers regarding asthmatic child care, and to find out the relationship between information of mothers and some of demographic characteristic such as age of mothers, Level of education, and away of child feeding. Methodology: Quantitative design (a descriptive study) was conducted in pediatric hospital in Kirkuk city from the period of first of July 2011 to the end of March 2012. To achieve the objectives of the study, non probability sample of (50) mothers having asthmatic children who attend to the pediatric hospital.The data are collected through utilization of constructed questionnaire. It consists of two parts: part one include (8) items, about demographic characteristics of mothers and her children and part two include (26) items, which includes (3) sections, section (1) consist of (7) items, about aggravating factors of asthma, section (2) consist of (6) items, about symptom of sever attack of asthma, and section (3) consist of (13) items, about asthmatic child care. To content validity of instrument was established through penal of (5) expert. Data I collected by interview technique using the questionnaire, data I gathered and analyzed by the application of descriptive and inferential statistics methods.Results: The study indicated that the majority of children are aged between (1-3) years old, and highest percentage of children are male (62%). Regarding to the child feeding, the majority of children are food feeding and represent (48%). Regarding age of mother the study finding that the highest percentage (38 (% of the mothers their age group between (23-27) years, and concerning mothers’ educational level, the majority of them graduated from primary school (40%). The study also approves that there was a statistical significant association between mother's information and some of demographic characteristic such as (Age, and level education of mothers and way of child feeding).Recommendation: Education program should be provided to the mothers who have children with asthma and course training program should be developed and implemented.

الهدف: تهدف الدراسة الى تقيم معلومات الامهات حول العناية بالطفل المصاب بالربو في مدينة كركوك. وكذلك لايجاد العلاقة بين معارف الامهات و بعض الخصائص الديموغرافية مثل (عمر الامهات، المستوى التعليمي ، و طريقة تغذية الطفل).المنهجيّة: أجريت دراسة وصفية بأتباع أسلوب تقيم طبق على الامهات في مستشفى الاطفال الاتي لديهن أطفال مصابين بالربو للفترة من بداية شهر تموز 2011 لغاية نهاية آذار 2012، ولتحقيق اهداف الدراسة اختيرت عينة غرضية غير احتمالية مكونة من (50) ام لديها أطفل مصاب بالربو في مستشفى الاطفال. صممت استمارة استبيانيه لغرض الدراسة تضمنت جزءان، جزء الاول له علاقة بالصفات الديموغرافية (8) فقرة. والجزء الثاني يتضمن (26) فقرة، مكونة من ثلاثة اقسام،القسم الاول يشمل (7) فقرات، حول عوامل تهيج الربو، القسم الثاني يشمل (6) فقرات، حول اعراض نوبة الربو، القسم الثالث يشمل (13) فقرات حول عناية بالطفل المصاب بالربو. عرضت الاستمارة على (5) خبراْء لتحديد مصداقية محتوى الاستمارة. و بطريقة المقابلة الشخصية مع عينة البحث جمعت المعلومات وقد حللت البيانات باستخدام التحليل الإحصائي الوصفي وكذلك التحليل الأستنتاجي.النتائـج: أشارت نتائج الدراسة إلى أن أغلبيةَ الأطفال يتراوح اعمارهم من (1-3) سنوات واغلبية الاطفال من الذكوروبنسبة (62%) وكذلك اضهرت ان أغلبية الأطفال يعتمدون على الأكل الطعام. و فيما يتعلق بعُمر الأمِّ، وجدت الدراسةِ ان غالبية الأمهات أعمارهم بين (23-27) سنة، وبخصوص المستوى التعليمي ظهر أن أعلى نسبة من الأمهات من خريجي الابتدائية حيث شكلوا (40%). و كذلك أظهرت نتائج الدراسة بان هناك علاقة إحصائية قوية بين معارف الأمهات و المتغيرات التي استخدمت في الدراسة مثل (عمر الام، المستوى التعليمي، و الطريقة التي يعتمدها الطفل في التغذية.التوصيـات: أوصت الدراسة بتواصل التعليم المستمر و تزويد الأمهات بمصادر و مبادئ تربوية للأمهات اللواتي عندهن الأطفالُ المصابات بالربو. وبرنامج التدريبي و تطيبقه

Keywords

Asthma --- Knowledge --- Mother --- Asthma --- Knowledge --- Mother


Article
Assessment of Asthma Severity by History and Lung Function Study in School Age Children

Authors: Zuhair M. Al Musawi --- Akeel Mahdi --- Majeed Matrood --- Haidar A. N. Abood
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2017 Volume: 10 Issue: 1 Pages: 2607-2612
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background: The assessment of childhood asthma severity is important for the diagnosis and determining the initial level or step of the treatment of childhood asthma. It can be performed either by history alone for children less than five years old or by history and pulmonary function test for older children.Objective: to evaluate and compare the utility of history and lung function test in the assessment of asthma severity in childrenPatients and Method: Across-sectional study was conducted in Karbala teaching hospital of pediatrics, during the period from October 1, 2013 - April 30, 2014. The study included 50 children of both genders diagnosed with asthma (diagnosis made by consultant pediatrician). A questionnaire was designed for the assessment of asthma severity by history which included symptoms frequency over the preceding 4 weeks respectively. The lung function test was only done in children 6-year-old and more. All children in our study had performed lung function test.Results: The mean age of studied group was 9.6 ± 2.5. The result of asthma severity assessment based on history was as follow: 14/50 patients (28%) had intermittent asthma, 36/50 (72%) had persistent asthma of different degrees, mild in 11/50 (22%), moderate in 19/50 (38%) and severe persistent asthma in 6/50 (12%). While according to lung function test, 12/50 patients (24%) had intermittent asthma, 15/50 (30%) had mild persistent, 19/50 (38%) had moderate persistent and the remaining 4/50 patients (8%) had severe persistent asthma. There was no significant statistical difference in severity assessment between the two methods (P > 0.05).Conclusions: Our study shows good correlation between history and lung function test regarding classification of childhood asthma severity. History is an excellent tool for the assessment of childhood asthma severity when lung functions test is unavailable or difficult to be done in younger children.


Article
Montelukast As An Add On Therapy In Asthma As Compared To Its Use In Asthma Associated With Concomitant Rhinitis Symptoms

Author: kassim M.Sultan قاسم محمد سلطان
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2011 Volume: 53 Issue: 2 Pages: 111-114
Publisher: Baghdad University جامعة بغداد

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Abstract

Back ground: The use of Montelukast in mild and moderate asthma has been studied ,allergic rhinitis or rhinitis and asthma are strongly inter related, Montelukast has been used in both conditions, whether treating rhinitis will improve asthma control ,a point which has been stressed recently.Objectives: To evaluate the effect of Montelukast in mild and moderate asthma according to Global INitiative For Asthma guidelines ( GINA),and to compare its use in asthma alone and in asthma which is associated with persistant rhinitis symptoms.Patients and methods: Seventy patients who fulfill the criteria of mild and moderate asthma according to Global INitiative For Asthma guidelines had been recruited from the consultation clinic of the respiratory diseases in Baghdad Teaching Hospital from the 1st.July 2009 to 31st. December 2010,patients were divided in to 2 groups : Group – 1 patients with asthma only which was subdivided into 2 sub groups: 1-a on salbutamol inhaler on need and 1-b on beclomethasone inhaler 800Mgm/day in addition to salbutamol inhaler on need.Group- 2 patients with asthma and rhinitis which was sub divided in to subgroups: 2-a on salbutamol inhaler on need and 2-b on beclomethasone 800Mgmlday in addition to salbutamol inhaler on need. Evaluation of day and night time symptoms, records of rhinitis symptoms and measurement of FEV1(Forced Expiratory Volume in 1st. second) and FEF 25-75%(Forced Expiratory Flow)were done to all patients .Montelukast 10 mg/ day was given to all patients for 4 weeks,and reevaluation for day , night time symptoms , rhinitis symptoms and measurement of FEV1 and FEF 25-75% were done .Results: There was a significant statiscal improvement in day , night time symptoms , FEV1 , FEF 25-75% and rhinitis symptoms after Montelukast treatment than before treatment ( p value < 0.05), Montelukast use in asthma alone as compared to its use in asthma which was associated with rhinitis did not show a significant statiscal improvement in outcome response in day,night symptoms and in percentage of change in FEV1 and FEF25-75% (p value>0.05) .Conclusion: Montelukast improved day , night time symptoms , FEV1 , FEF 25-75% in mild and moderate asthma ,it also improved rhinitis symptoms but Montelukast use in asthma alone as compared to its use in asthma which was associated with rhinitis did not show a significant statiscal imrovement in asthma control regarding day,night time symptoms,FEV1 and FEF25-75% values.

Keywords

Montelukast --- asthma --- rhinitis


Article
Evaluation of the Relation between Asthma, Obesity and Leptin Level in Iraqi Asthmatic Patients and the Main Risk Factors that are Associated with Leptin Level

Author: Hiba A. Hasan
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2011 Volume: 20 Issue: 2 Pages: 96-101
Publisher: Baghdad University جامعة بغداد

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Abstract

This study tries to clear the correlation and association between asthma, obesity and leptin levels. Also it will work to indicate the main risk factors which play role in the elevation of leptin level within asthmatic patients. This is a case control study conducted on (38) asthmatic patients and (20) healthy control who were closely similar by age, gender and BMI. The main statistical tests used were student t test, linear regression test and correlation test. Significance was set at P < 0.05. Sampling method used for this study was convenience sampling method. The main results of this study show a significant association and positive correlation between age (old age &#8805; 40 years old), female gender, BMI (overweight and obese) and steroid utilization with leptin elevation in Iraqi asthmatic patients since P values < 0.05. This study concludes that there is a correlation between obesity, age, sex and utilization of steroid with leptin level and they were the main risk factors which play role in the mechanism of elevation of leptin in Iraqi asthmatic patients.

تھدف ھذه الدراسة على إیجاد العلاقة بین الربو و السمنة و مستوى اللبتین و تحدید عوامل الخطورة الاساسیھ التي تلعب دوراًفي ارتفاع مستوى اللبتین عند المرضى المصابین بالربو . تشتمل ھذه الدراسة على ( 38 ) مریضاً مصاباً بالربو و ( 20 ) من الأشخاصاختبار الارتداد ,t الأصحاء المتقاربین بكل من العمر و الجنس و كتلھ الجسم. التحلیل الإحصائي المستخدم في ھذه الدراسة ھو اختبارتعتبر الزیادة معنویة. طریقھ جمع العینات كانت بواسطة طریقھ الاختیار المریح. كانت p< الخطي و اختبار العلاقة. إذا كانت 0,05بین العمر (اكبر من او یساوي 40 ), الإناث, كتلھ الجسم (الوزن الزائد و p< النتائج الاساسیھ لھذه الدراسة ھي علاقة معنویة 0,05البدین) و استھلاك الستیروید مع مستوى اللبتین عند المرضى العراقیین المصابین بالربو.تستنتج ھذه الدراسة بان ھناك علاقة بینالسمنة, العمر, الجنس, استھلاك الستیروید و زیادة مستوى اللبتین عند المرضى المصابین بالربو و تعتبر من عوامل الخطورةالاساسیھ التي تلعب دوراً في میكانیكیھ زیادة ھرمون اللبتین عند المرضى العراقیین المصابین بالربو.

Keywords

Leptin --- Asthma --- BMI.


Article
The effect of oral respiration on the dental occlusion in patients with respiratory tract allergies

Author: Sundus M. Bezzo سندس بيزو
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2005 Volume: 17 Issue: 2 Pages: 87-92
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Malocclusion is one of the main problems concerning the oral cavity. This study examined the possible effect of mouth breathing habits in patients with respiratory tract allergies on the dental occlusion.Materials and methods: The study was conducted on 150 patients having allergic rhinitis, asthma or both ranging in age from 5-19 years. A group of 150 healthy individuals matched with gender and age to the study group was used as a control group. The total sample was questioned about their mode of breathing then their occlusion was examined clinically.Results: Significantly higher percentages of mouth breathers were found among the study group (P<0.05). Similarly CLII and CLIII dental occlusion, displaced teeth as well as crowding affected significantly greater percentages of allergic patients in comparison to the control group.Conclusion: Mouth breathing habits in patients with respiratory tract allergies may have an additive role in the development of some undesirable malocclusions


Article
Obesity and Asthma Severity Among Adults Presenting to the Out Patient Clinic

Author: Hashim M. Al-Kadhimi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 2 Pages: 205-210
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Recent studies have suggested a relationship between asthma and obesity. The risk for developing asthma increases with increasing obesity among individuals. Yet little is known about how obesity influences asthma.OBJECTIVE: To determine whether a relation of Obesity to asthma exists among adults presenting to the out patient respiratory clinic , and the correlation between Obesity and spirometric changes in patients with asthma. METHODS: A cross-sectional study was done for one hundred patients aged 17 to 70 years patients with asthma diagnosed by clinical and pulmonary function test , in the respiratory outpatient's clinic in AL Kadhmia Teaching Hospital.Collected from May to December 2010 The following parameters were assessed:Weight, height, body mass index, gender,spirometric parameters which includes of forced expiratory volume in 1 second (FEV1), forced vital capacity(FVC),FEV1FVC ratio, and forced expiratory flow50% (FEF50%)RESULTS:There were 100 asthmatic patients,32 male and 68 female. There age between 17-70 year, classified into four groups according to BMI. There was significant relation between obesity and asthma (p=0.03),this relation was statistically significant in female(p=0.003) but not in male.spirometry in male showed no statistically significant (p-value > 0.05) for FEV1, FVC FEV1FVC ratio, FEF50% in both non obese and obese, but in female statistically significant for FEV1FVC(p 0.05) ,FEF50% (p 0.036) , while no statistically significant for FEV1, FVC in both groups, for both male and female according to BMI there is statistically significant for FEF50% (p 0.015),while no statistically significant for FEV1FVC, FVC, FEV1 in both groups.CONCLUSION:There was a significant relation between asthma and obesity , in female ,but not in male. There is statistically significant difference for FEF50% ,and FEV1FVC in obese female .Also there is statistically significant difference for FEF50% in both male and female according to BMI.

Keywords

asthma --- obesity --- BMI


Article
Childhood Asthma in Relation to Some Predisposing Factors

Author: Masarra Shakir Saeed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 3 Pages: 279-284
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Asthma is the most prevalent chronic condition among children . Both environmental and hereditary factors are important in the pathogenesis of asthma .OBJECTIVE:To determine the severity of asthma among the asthmatic patients and its association with some allergens .METHODS:A cross sectional hospital based study ; involved 120 patients suffering from asthma during the period from Feb.- Aug 2003. A questionnaire was designed for the purpose as well as clinical examination and serological study to asses the level of IgE against selected allergens .RESULTS:The study revealed that 53% of the patients were males . The most age group affected was (2-5) y ; 57(47.5%) of cases . The mild type of asthma is the predominant type; About 39 (32%) of the patients suffering from mild intermittent asthma(MIA) and 53(44%) from mild persistent type . The main age group affected by MIA was (2-5)y ;17(43%) patients. Patients with MIA were more sensitive to H1 allergens 12(40%) and least sensitive to F1 (3%). For moderate persistent asthmatic patients , they were more sensitive to H2 8(34.7%) , then H1 6(26%). Patients from all age groups were sensitive mainly to H1 ; (2-5)y: 18(36%) , for (>5-10)y : 10(38.5%) , for (>10-15)y : 7(33%). There was a significant relation between the mild type of asthma and the family history of asthma , atopy , drug and food allergy . The most important aggravating factor for the age group 2-5y was dust ; 17( 31%), while among the age group (5-10)y was exercise , 10 (31%). Among the age group (10-15) y both dust and exercise were important factors 8 (29.6%) for each . Exposure to dust was a significant aggravating factor for MIA 13(38.2%).CONCLUSION:Since the majority of patients suffering from mild type of asthma we recommend health education to the parents and patients towards home management of asthma and avoidance of the allergens which exacerbate the acute attacks


Article
The Role of Interleukines in Asthmatic Patients
دور الابيضاضيات عند مرضى الربو

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Abstract

Background: Asthma is a chronic inflammatory disease of the airways because body exposure to foreign materials that stimulate immune response characterized by secretion of cytokines from inflammatory cells.Objective: Diagnosis of asthma to detect about IgE,IL 1B,IL 2IL 8,,IL10 ,and IL12 in patients clinically suspected . Patients and Methods:50 blood samples out patients were collected in a labeled 5 ml tubes,aged (26 years to 58 years ) were tested by Enzyme Linkined Immuno Sorbant Assay to detect IgE,IL 1B,IL 2IL 8,,IL10 ,and IL12 were carried in Al-Hussein Hospital in Kerbala ,during the period from May to Augest 2010. Results:50 patients were evaluated for asthma and correlation between IL 1B,IL 2,IL 8,IL 10 ,IL 12 values (20,76,62,44,76)% respectively and IgE value (50)%.Increasing values of IL2,IL 8,IL 10,IL 12 (36,26,24,32)%respectively at ages(37-47)years were led to decreased IgE value(10%),and IL 2,IL 8 values were (24,22)% respectively comparion with IgE(10%). Conclusions: Importance studying factors( IL 1B,IL 2,IL 8,IL 10 ,IL 12) in diagnosis of Asthmatic patients after clinically diagnosis .

الخلفية: الربو مرض التهابي مزمن يصيب المجاري التنفسية نتيجة تعرض المريض للمواد الغريبة المحفزة للاستجابة المناعية يتميز بافراز الابيضاضيات من الخلايا الالتهابية. الهدف :تم تشخيص الربو في المرضى المشكوك بهم سريريا باستخدام الفحوصات المصلية.المرضى وطرائق العمل:تم جمع 50 نموذج دم من المراجعين بعد تشخيصهم من قبل الطبيب المختص وتم وضعها في انابيب اختبار سعة 5 مل باعمار تتراوحت بين (26- 58 )سنة باستخدام اختبار ELISA للكشف عن( (IgE,IL 1B,IL 2,IL 8,IL 10,IL 12 وقد تم انجازها في مستشفى الحسين (ع) التعليمي للفترة من مايس الى آب 2010 .النتائج: تم تقييم 50 مريض بالربو أ ظهرت النتائج قيم المعايير التالية على التوالي:, IL 1B,IL 2,IL 8,IL 10 ,IL 12(20,76,62,44,76) % مقارنة مع قيمة 50%)IgE) ازدياد قيم IL2,IL 8,IL 10,IL 12)) عند الاعمار (37-47) سنة كانت على التوالي (36،26،24،32)% ادت الى انخفاض قيمة IgE(10%) في حين كانت قيم ( IL2،IL 8) عند الاعمار (48-58) سنة كانت على التوالي (24،22)% مقارنة مع قيمة IgE (10%).الاستنتاجات:أهمية دراسة الابيضاضيات ( ( IL 1B,IL 2,IL 8,IL 10 ,IL 12 في تشخيص مرضى الربو بعد تشخيصهم سريريا.


Article
Asthma in Adults; Epidemiology, Risk Factor and Patterns of Presentation: A Cross Sectional, Questionnaire Based Study in Baghdad Teaching

Authors: Shakir M. Muhammed --- Kassim M. Sultan --- Mohammad Y. Abdulrazaq
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2012 Volume: 5 no 1 Issue: 11 Pages: 1255-1261
Publisher: Kerbala University جامعة كربلاء

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Abstract

background :Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role, leading to recurrent episodes of wheezing, breathlessness, chest tightness, and coughing. Although clinicians are satisfied with this definition, epidemiologists are still searching for their own. Studies on asthma used either questionnaire or histopathophysiologic way to define asthma each has its privileges and drawbacks. Asthma has become more common in both children and adults around the world in recent decades. Its prevalence has been dramatically increased during last few years, but still no definite asthma prevalence is specified in Iraq.Aim of the Study : To define the prevalence of some risk factors in Iraqi asthmatics, patterns of presentation, and to find the level of education about asthma among the patients, this study was conducted.Method :Two hundred twenty five asthmatic patients diagnosed by questionnaire, supported by clinical detection of wheeze, were included in a cross sectional study done in outpatients clinic, Baghdad Teaching hospital in Baghdad, collected from December 2007 to March 2008.Results : mean age for the study sample is 38 years, 50 are men and 175 are women. Normal body mass index reported in 86 patients, 78 patients (33.7 %) have positive family history of allergic diseases, 110 patients reported exposure to environment with house dust mite, and 49 patients (21.7%) were passive smoker. Persistent symptoms are commonest pattern of asthma reported in 157 patients. Eighty eight patients use their treatment regularly, and 31 patients used steroid inhalers. Proper usage of inhalers as assessed by demonstration found in only 39 patients. Spirometry or pulmonary function tests are performed only in 11 patients (4.9 %) for diagnosis or asthma follow-up.Conclusions : High body mass index, exposure to an environment in favored for house mite inhabitance, family history of atopy, history of allergic diseases, Gastro-intestinal symptoms suggestive of gastroesophageal reflux disease and Allergic rhinitis and sinusitis are the commonest risk factors reported by asthmatics.Irregular treatment with inhalers especially corticosteroid and their improper usage are still widely spread among our patients, also spirometry and other pulmonary function tests are still rarely used in diagnosis, and management of asthmatic patients.

Keywords

asthma --- allergic diseases --- inhalers

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