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Article
A Study Effects of Licorice Plant and Prednisolone on Some Physiological and Immunological Parameters in Experimental Model

Authors: Zaid Al-Nuaimi --- Nasser Almukhtar --- Safaa Alturaihy
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 1 Pages: 113 -125
Publisher: Babylon University جامعة بابل

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Abstract

The present study conducted thirty of adult male white rabbits to uncover the impact of Licorice in minimize the signs associate degreed symptoms after induction of allergic bronchial asthma in rabbits and elucidate what extent it will show an beneficial effects herbs therapy, in state use corticosteroids medical care. The rabbits haphazardly divided into 5 groups and albumen sensitizer was used to stimulate allergic reaction beside to use sensitization boost challenge dose that emphasize by the presence of the clinical symptoms of innate reflex, wheezing, chest tightness and shortness of breath. As well as, to changes within the level of total white blood corpuscle count, Eosinophils measurements, Interleukin-5 estimation and body temperature measurements. Meanwhile, eight days after induction allergic reaction. Extraction of Licorice was given in a variety dose of (160 and 80) mg/kg orally was administrated for eight days. Blood collected samples were done on the day sixteen and thirty, for investigate the above previous parameters through collected blood serum samples. statically analysis fore results were showed that the albumen action considerably (p≤ 0.05) induce allergic response in those of experimental rabbits associate degreed show an elevation with total white blood corpuscle, Eosinophils and Interleukin-5 levels. Whereas orally treating rabbits with root extract observe a big decrease (p≤ 0.05) within the total white blood corpuscle, Eosinophils and with the degree of Interleukin-5. As these effects of (the plant extract) wherever analyzed in comparison with recorded noticeable effects in those of glucocorticoid treated group and those healthy management teams severally.


Article
A Compare Study Effects of Ginkgo biloba Extract and Corticosteroid in Induce Allergic Asthma in Rabbits in Regards to Physiological and Immunological Parameters

Authors: Ali Alwisawi --- Naseer Almukhtar --- Abbas Fadhel Hassoon
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 2 Pages: 341 -352
Publisher: Babylon University جامعة بابل

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Abstract

Thirty adult male of New Zealand Albino white rabbits were used in this article and these rabbits are haphazardly divided into five different experimental groups. Ovalbumin was used in a dose (0.1 mg /kg) to induce allergy and sensitization challenge was confirmed by the presence of the clinical symptoms of wheezing, sneezing, chest tightness, shortness of breath, changes in the level of total white blood cell, neutrophils, eosinophils, Immunoglobulin E and Interleukin-4. Eight days after allergy induction, Ginkgo biloba giving in the dose (25 mg/kg) and in a combination with prednisolone in the half of recommended dose (12.5 + 0.5) mg/kg (Ginkgo biloba + prednisolone) was giving orally for 8 days. The results showed that ovalbumin could induce sensitivity and significantly increased the level of total white blood cell, neutrophils, eosinophils, Immunoglobulin E and Interleukin-4. Oral treatment with Ginkgo biloba in the dose (25 mg/kg) and in a combination with prednisolone as the half of recommended dose (12.5 + 0.5) mg /kg of Ginkgo biloba + prednisolone showed high significant decrease (p≤ 0.01) in the number of total white blood cell, neutrophils and eosinophils and serum levels of Immunoglobulin E and Interleukin-4levels. The effects of this plant extract were comparable with the observed effect of prednisolone-treated group to be present with high efficacy of herbal medical therapy than that of prednisolone treatment a combined with adverse effects when use alone.

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