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Article
Diagnosis of Atherosclerosis by using digital image processing

Authors: Dr.Hazeem Baqer --- Abdulkareem. S. Gumar --- Baidaa M.Alsafy
Journal: Univesity of Thi-Qar Journal مجلة جامعة ذي قار العلمية ISSN: 66291818 Year: 2017 Volume: 12 Issue: 3 Pages: 119-126
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

In this paper propose a method for the diagnosis of atherosclerosis as if that was normal or abnormal arteries, it has been the use of neural network technology after making optimizations, filter and remove the impurities of the arteries. Samples were taken from a group of patients in Nasiriyah Heart Center disparate ages and both sexes, which was 110 samples were 60 of them training samples which showed the results of 100% and 50 of these samples were tested results showed 92%


Article
The Effects Of Metformin And Pioglitazone Versus Their Low Dose Combination On Progression Of Atherosclerosis

Authors: Bassim I. Mohammad باسم ارحيم محمد --- Haidar M. Jawad حيدر مهدي جواد
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2009 Volume: 5 Issue: 8 Pages: 108-120
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Results: Metformin and pioglitazone resulted in significant decrease (p<0.01) in AI. Further they caused significant (p<0.01) reduction in serum MDA, hsCRP and plasma fibrinogen.Serum GSH level was significantly (p<0.05) elevated by metformin. Combination treatment decreased AI, serum MDA, plasma fibrinogen and hsCRP, increased GSH and possessed more favorable histological findings better than either drug alone. Conclusion: low doses combination of Met+Pio has more favorable atheroprotective effect than either drug alone possibly due to the combined anti-inflammatory and antioxidant effects. Background: Atherosclerotic diseases remain the leading cause of death in men and women world wide. In addition to lipid lowering, reduction of atherosclerotic disease will require further pharmacological approaches capable of modifying the disease. Materials and methods: 35 rabbits were used in this study. Atherosclerosis was carried out by feeding the rabbits an atherogenic diet (AD). The rabbits were randomly assigned into five groups, 7 rabbits each. Group 1 (normal control) received standard chow diet. In addition to AD, the rabbits in group 2 (atherogenic control), group 3 (Met), group 4 (Pio) and group 5 (Met+Pio) received no treatment, metformin, pioglitazone and combination of low doses of metformin and pioglitazone respectively for 10 weeks. At the end of 10th week, all rabbits were sacrificed; serum lipids, MDA, GSH, hsCRP, plasma fibrinogen and aortic histological examination were determined.

أجريت هذه الدراسة لتقييم تأثير عقاري المتفورمين والبايوكليتازون على تصلب الشرايين.وأن خمسة وثلاثونٍ ذكرا من الأرانب البيض (نيوزيلند) استخدمت في هذه الدراسة. هذه الحيوانات قسمت بشكل عشوائي إلى خمسة مجاميع . المجموعة الاولى أعطيت غداء طبيعي قياسي طوال التجربة لمدة 10 أسابيع، واعتبرت مجموعة سيطرة (الغذاء الطبيعي). أن تصلب الشرايين في باقي ألمجاميع تم بواسطة أعطائها غداء عالي الدهون. إعطيت الحيوانات في المجموعة الثانية غداء عالي الدهون فقط واعتبرت بمثابة مجموعة سيطرة (عالي الدهون). بالإضافة إلى الغذاء عالي الدهون ، كل من المجموعات الثلاث الأخرى أعطيت واحدا من العقاقير التالية: متفورمين (المجموعة الثالثه) أو بايوكليتازون (المجموعة الرابعة) أو متفورمين و بايوكليتازون (المجموعة الخامسة) . قتلت الرانب في النهاية وتم قياس صورة الدهن ، مؤشرات التخثر ، و مؤشرات الاكسدة, الفحص النسيجي للأبهر الرأسي . وتم التوصل إلى النتائج التالية. مجموعة متفورمين و بايوكليتازون تسببت في انخفاض كبير في مؤشر التصلب و التخثر ، و الاكسدة عن باقي المجاميع


Article
EFFECT OF CHICORIUM INTYBUS EXTRACT ON HISTOLOGICAL CHANGES IN LIVER AND KIDNEY OF HYPERCHOLESTEROLEMIC RABBITS
تأثير نبات الطرخشقون على التغيرات النسيجية لكبد وكلى أرانب فرط الكوليسترول

Author: Nawras A. Alwan نورس عبدالاله علوان
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2009 Volume: 8 Issue: 1 Pages: 98-107
Publisher: Basrah University جامعة البصرة

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Abstract

In this study, the experiment was designed to investigate the effect of daily oral administration of (0.5gm/kg. B.W) of chicory (Chicorium intybus) for one month on weight and histology of kidney and liver of hypercholesterolemic rabbits (induced by oral administration of 0.5 gm/kg of cholesterol dissolved in 3ml Soya bean oil) and compared this effect with medicial therapy used for atherosclerosis treatment . The results revealed a significant increase (P <0.05) the weights of livers and kidneys in hypercholesterolemic group when compared with other groups ,while the histopathological results showed histological changes in the livers and kidneys of hypercholesterolemic rabbits and also in chicory treated group when compared with other groups.

في هذه الدراسة صممت التجربة لملاحظة تأثيرا لتجريع الفموي اليومي لـ(0.5غم/ كغم من وزن الجسم) للمستخلص الكحولي لنبات الطرخشقون (Chicory intybus) لشهر واحد على وزن ونسيج كبد وكلى للاارانب المستحدث فيها فرط الكوليسترول (بواسطة التجريع الفموي لـ0.5 غم/كغم من الكوليسترول مذاب في 3 مل من زيت فول الصويا) ومقارنة هذا التأثير مع الدواء الطبي الاتروفاستاتين المستخدم لعلاج تصلب الشرايين. اظهرت النتائج زيادة معنوية (P<0.5) في وزن كبد وكلى الارانب المستحدث فيها فرط الكوليسترول مقارنةً بالمجاميع الأخرى. بينما اظهرت النتائج المرضية النسيجية تغيرات نسيجية في كبد وكلى أرانب فرط الكوليسترول وكذلك المعالجة بمستخلص الطرخشقون مقارنةً بالمجاميع الأخرى.


Article
Antiatherosclerotic potential of aspirin: Antioxidant and anti-inflammatory approaches

Authors: Najah R Hadi نجاح رايش هادي --- Hussam H Sahib حسام حسن صاحب --- Bassim I Mohammad باسم ارحيم محمد
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2013 Volume: 9 Issue: 16 Pages: 11-21
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Objective: this study was undertaken to evaluate the effect of aspirin on the progression of atherosclerosis. Materials and methods: A total of 28 local domestic rabbits were assigned to four groups: Group I (normal control), Group II (atherogenic control), Group III (vehicle control),Group IV (aspirin 10 mgkg daily). Blood samples were collected at the end of experiment (8 weeks) for measurement of serum triglycerides (TG), total cholesterol (TC), HDL-C, plasma high sensitive C-reactive protein (hsCRP), plasma malondialdehyde (MDA) and plasma reduced glutathione (GSH). Immunohistochemical analysis (VCAM-1, MCP-1, and TNF-α) and histopathologic assessment of aortic atherosclerotic changes were also performed.Results: Compared to NC, levels of lipid profile, atherogenic index, hsCRP, and MDA are increased while GSH were decreased in animals on atherogenic diet (p< 0.05). Immunohistochemical analysis showed that aortic expression of VCAM-1, MCP-1, and TNF-α were significantly increased in AC group compared to NC group (p<0.001). Histopathologic finding showed that animals on atherogenic diet have significant atherosclerotic lesion compared to NC group. Compared to AC group aspirin don’t have significant effect on lipid profile. Aspirin causes statistically significant reduction in hsCRP and MDA (p<0.05). Aspirin treatment causes significantly increase the level of GSH. Aspirin treatment significantly reduced aortic expression of VCAM-1, MCP-1, and TNF-α (p<0.05). Histopathologic examination of aortic arch showed that aspirin significantly reduced atherosclerotic lesion (p<0.05).Conclusions: It thus can conclude that aspirin reduces lipid peroxidation, systemic inflammation and aortic expression of inflammatory markers used in this study and hence reduce the progression of atherosclerosis.

أجريت هذه الدراسة لتقيم تأثير الاسبرين على تقدم تصلب الشرايين. تم استخدام 42 ذكر من الأرانب في هذه الدراسة.وقسمت هذه الحيوانات بشكل عشوائي إلى 6 مجموعات ( 7 أرانب في كل مجموعة)واعطيت الحيوانات في المجموعة الأولى غذاء طبيعي قياسي واعتبرت مجموعة سيطرة في حين الأرانب في المجموعات الثلاثة الباقية أعطيت غذاء عالي الدهون (2% كوليستيرول) و عولجت كالتالي لمدة 8 أسابيع. 1. مجموعة السيطرة (عالية الدهون) لم تعطى أي علاج 2. مجموعة المذيب (الايثانول) 10% 3 .مجموعة عقار الاسبرين أعطيت اسبرين 10 ملغم لكل كغم يوميا. في نهاية ألثمان أسابيع تم التضحية بكل الحيوانات وتم جمع عينات من الدم لقياس المؤشرات التالية: صورة الدهون, مؤشرات الأكسدة (المدي أي و الجي أس أج ( و مؤشر الالتهاب السي ا ربي عالي التحسس. كما أخذت عينة نسيجية من الشريان الابهر لمعرفة مدى درجة تصلب الشرايين حسب تصنيف الجمعية الأمريكية لأمراض القلب بالإضافة إلى ذلك جرى فحص مؤشرات الالتهاب في النسيج حيث تم فحص مدى ظهور كل من في كام -1, ام سي بي -1, تي ا ناف الفا في طبقات الشريان الابهر.مقارنة بمجموعة السيطرة عالية الدهون,لم يكن للاسبرين تأثير مميز على صورة الدهون في الدم مقارنة بمجموعة السيطرة عالية الدهون, بينما أظهرت التحاليل أن كل من الاسبرين يقللان بصورة واضحة مؤشر الالتهاب في الدم ( السي ا ربي عالي التحسس)كما أظهرت النتائج أن الاسبرين تقلل بصورة واضحة مؤشرات الأكسدة ( ألجي أر أس و والمدي أي), كما أظهرت الدراسة أن كل من الاسبرين والكلوبيدوكريل والخليط من الاسبرين والكلوبيدوكريل يقللان بصورة واضحة علامات الالتهاب في النسيج ( في كام -1, التي ا ناف ألفا, ا مسي بي _1).واخيرا اظهرت الدراسات ان الاسبرين يقلل بصورة واضحة من تقدم تصلب الشرايين .مماسبق يمكن ان نستنتج ان بغض النظر عن عدم تأثير الاسبرين على مستوى الدهون فانه يقلل من تقدم تصلب الشرايين بصورة واضحة.


Article
Effect of montelukast on progression of atherosclerosis

Authors: Ahmed M Sultan احمد محمود سلطان --- Najah R Hadi نجاح رايش هادي --- Bassim I. Mohammad باسم ارحيم محمد
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2014 Volume: 10 Issue: 17 Pages: 125-133
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Objective: this study was undertaken to evaluate the effect of montelukast on the progression of atherosclerosis. Materials and methods: A total of 28 local domestic rabbits were assigned into four groups: Group I (normal control), Group II (atherogenic control), Group III (vehicle control),Group IV (montelukast 1.5 mgkg daily). Blood samples were collected at the end of experiment (8 weeks) for measurement of serum triglycerides (TG), total cholesterol (TC), HDL-C, plasma high sensitive C-reactive protein (hsCRP), plasma malondialdehyde (MDA) and plasma reduced glutathione (GSH). Immunohistochemical analysis (VCAM-1, MCP-1, and TNF-α) and histopathologic assessment of aortic atherosclerotic changes were also performed.Results: Compared to NC, levels of lipid profile, atherogenic index, hsCRP, and MDA are increased while GSH were decreased in animals on atherogenic diet (p< 0.05). Immunohistochemical analysis showed that aortic expression of VCAM-1, MCP-1, and TNF-α were significantly increased in AC group compared to NC group (p<0.001). Histopathologic finding showed that animals on atherogenic diet have significant atherosclerotic lesion compared to NC group. Compared to AC group montelukast don’t have significant effect on lipid profile. Montelukast causes statistically significant reduction in hsCRP and MDA (p<0.05). Montelukast treatment causes significantly increase the level of GSH. Montelukast treatment significantly reduced aortic expression of VCAM-1, MCP-1, and TNF-α (p<0.005). Histopathologic examination of aortic arch showed that montelukast significantly reduced atherosclerotic lesion (p<0.005).Conclusions: It thus can conclude that montelukast reduces lipid peroxidation, systemic inflammation and aortic expression of inflammatory markers used in this study and hence reduce the progression of atherosclerosis.

أجريت هذه الدراسة لتقيم تأثير المونتيلوكاست على تقدم تصلب الشرايين. واستخدم 28 ذكر من الأرانب في هذه الدراسة. قسمت هذه الحيوانات بشكل عشوائي إلى 4 مجموعات ( 7 أرانب في كل مجموعة), أعطيت الحيوانات في المجموعة الأولى غذاء طبيعي قياسي واعتبرت مجموعة سيطرة في حين أعطيت الأرانب في المجموعات الثلاثة الباقية غذاء عالي الدهون (2% كوليستيرول) و عولجت كالتالي لمدة 8 أسابيع.1.مجموعة السيطرة (عالية الدهون) لم تعطى أي علاج.2.مجموعة المذيب (الايثانول) 10%.3.مجموعة عقار منتيلوكاست أعطيت بجرعة .51 ملغم لكل كغم يوميا.في نهاية ألثمان أسابيع تم التضحية بكل الحيوانات و جمعت عينات من الدم لقياس المؤشرات التالية: صورة الدهون, مؤشرات الأكسدة (الام دي أي و الجي أس أج ( و مؤشر الالتهاب السي اربي عالي التحسس. كما أخذت عينة نسيجية من الشريان الابهر لمعرفة مدى درجة تصلب الشرايين حسب تصنيف الجمعية الأمريكية لأمراض القلب بالإضافة إلى ذلك فحصت مؤشرات الالتهاب في النسيج حيث تم فحص مدى ظهور كل من (في كام -1, ام سي بي -1, و تي ان اف الفا في طبقات الشريان الابهر). مقارنة بمجموعة السيطرة عالية الدهون, لم يكن للمونتيلوكاست تأثير مميز على صورة الدهون في الدم بينما أظهرت التحاليل أن المونتيلوكاست يقلل بصورة واضحة مؤشر الالتهاب في الدم ( السي اربي عالي التحسس)كما أظهرت النتائج أن المونتيلوكاست يقلل بصورة واضحة مؤشرات الأكسدة (الام دي أي و ألجي أر أس), كما أظهرت الدراسة أن المونتيلوكاست يقلل بصورة واضحة علامات الالتهاب في النسيج ( في كام -1, التي ان اف ألفا, و ال ام سي بي -1). وأخيرا أظهرت الدراسة أن المونتيلوكاست يقلل بصورة واضحة من تقدم تصلب الشرايين. مما سبق يمكن أن نستنتج أن بغض النظر عن عدم تأثير المونتيلوكاست على مستوى الدهون فإنه يقلل تقدم تصلب الشرايين بصورة واضحة.


Article
Prevalence of Coronary Atherosclerosis in Babylon Governorate; Histopathological, Postmortem Prospective Study

Authors: Ali Al-Tmeme --- Nemah H. Al-jubori --- Ammar Mohammad Khudeer Al-Aamood
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 2 Pages: 531-535
Publisher: Babylon University جامعة بابل

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Abstract

There is no previous postmortem study about coronary atherosclerosis in the Arab Homeland, including Iraq. Coronary atherosclerosis is the leading cause of death worldwide, and represents a major problem in Iraq causing death to many young people suddenly. The purpose of the present study was to evaluate the prevalence and severity of coronary atherosclerosis among Babylon Governorate resident.This is a prospective randomized cross-sectional study, which included autopsy material from 80 cases collected during the period from 1112013 to 172014, referred to the Office of Forensic Medicine in Babylon. The cases were divided into 7 groups according to age. After extracting the heart, three representative specimens from each main coronary artery were obtained for Histopathological Examination, after staining with hematoxylin and eosin (H & E) stains. The atherosclerotic lesions were classified into fibro-fatty and advanced lesions, thereafter the results were subjected to statistical analysis.The results were as follow: 70% of the cases were males and 30% females, their ages ranged between 13-79 years. More than 60% of cases fallen in the age range 21-40 years. The overall prevalence of coronary atherosclerosis was 91.25% for all age groups; 92.9% of males and 87.5% of females were affected. This prevalence increased with age progression to become almost 100% after age of 40 years old for both (males and females). Moreover the prevalence for advanced lesions only was (61.25%),also it was increasing with age and becoming 100% after age of 50 years old for both (males and females).There is an unexpectedly high prevalence of coronary atherosclerosis in Iraqi people, which is the highest in Asia when compared to results of other similar studies conducted in other countries. Also it was observed that atherosclerosis started as early as 17 years old.An increased prevalence of atherosclerosis was found in the present studied population, specifically the young individuals' accentuate that is necessary to institute the prevention early. It is hoped that the data obtained in this study will be a baseline data for further studies by other investigators throughout all Iraqi Governorates to study atherosclerosis in Iraq overall.


Article
The Role of Plasma Lipoprotein and Carotid Doppler in Detecting Premature Atherosclerosis Among Iraqi Patients with Systemic Lupus Erythematosus

Author: Khudhir Zghayer Mayouf Al-Bidri
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 2 Pages: 147-151
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Cardio vascular involvement is fatal and critical complication of the systemic lupus erythematosus. Serum lipid profile and carotid Doppler studies can be used to evaluate premature atherosclerosis among patients with systemic lupus erythematosus .OBJECTIVE:The purpose of this study was to detect premature atherosclerosis among Iraqi patients with systemic lupus erythematosus by estimation of fasting serum lipid profiles and Doppler Carotid studies.PATIENTS AND METHODS:Fifty Iraqi patients (45 females and 5 males) who fulfilled the American College of Rheumatology (ACR) 1997 revised criteria for classification of SLE were studied . Another 50 healthy (45 females and 5 males) individuals matched for age and sex were collected from relatives and accompanying persons with patients attending the Rheumatology Clinic and studied serving a control group.Full history was taken and complete clinical examination was done for all patients and control group .The levels of serum cholesterol , low and high density lipoprotein and triglycerides were estimated and Doppler studies for common carotid arteries were done for individuals in both groups.The patients were classified according to clinical presentation to four groups:Group 1: Patients with mucocutaneous and musculoskeletal manifestation only.Group 2 : Patients with mucocutanous,musculoskeletal manifestation and serositis.Group 3: Patients with mucocutanous, musculoskeletal, serositis and lupus nephritis without cerebritis.Group 4: Patients with Mucocutanous , musculoskeletal, serositis and lupus cerebritis without nephritis.RESULTS:There were no significant differences in total cholesterol level in group 1 patients compared to control group, but there were significant differences in group 2,3,4 patients compared to control group.There were significant differences in cholesterol, low density lipoproteins (LDL),high density lipoproteins (HDL),and triglyceride (TG) levels between SLE patients compared to control group which is positively correlated with disease duration .There were no significant differences in intimal media thickness(IMT)in group1and2 compared to control group but there were significant differences in IMT in group 3 and 4 compared to control group and the significant differences in IMT were positively correlated with disease duration.CONCLUSION:The results showed that SLE patients mostly have hyperlipidemia as well as ultrasonic markers of atherosclerosis.


Article
Effect of sitagliptin on lipid profile, Inflammation and Oxidative Stress in high cholesterol –fed male rabbits

Author: Dr Abdul-Hussein A. Faraj MBChB,MSc,PhD
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2011 Volume: 14 Issue: 2 Pages: 187-194
Publisher: University of Kufa جامعة الكوفة

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Abstract

Back ground: Atherosclerosis is the major world wide killing disease. The most common risk factors are hyperlipidemia, diabetes, and ather factors like chronic infection and inflammation.Objective: This study was undertaken to assess the effect of sitagliptin on atherosclerosis via interfering with lipid parameter, inflammatory and oxidative pathwaysMethod: 18 local domestic male rabbits were included in this study. The animals were randomly divided into three groups: Group I rabbits fed normal chow (oxiod) diet for 12 weeks. Group II rabbits fed 1% cholesterol enriched diet. Group III rabbits fed with cholesterol enriched diet for 6 weeks, and then continued on cholesterol enriched diet and treated with Sitaglipin 125mg/kg/day orally for the next 6 weeks. Results: Treatment of rabbits with sitagliptin for 6 weeks results in a significant reduction (P<0.05) in serum level of TC, TG, hsCRP and TNFα and a significant increase (P<0.05) in serum HDL level. There was a significant reduction (P<0.05) in aortic MDA and intima-media thickness, in comparison to the rabbits in the induced untreated control group.sitagliptin treatment cause increment in aortic GSH in comparison to induced untreated group.

يعتبر تصلب الشرايين المرض القاتل الرئيس على مستوى العالم. إن من أهم عوامل الخطورة لهذا المرض هي ارتفاع مستوى الدهون بالدم ومرض السكري وعوامل اخرى مثل الالتهابات المزمنههدف الدراسة: لتقييم تأثير السيتاكلبتين على تقليل مستوى الدهون بالدم والالتهابات وعوامل التاكسد وثأثيرها على سُمْكِ الطبقة الوسطية والداخلية للشريان الأبهر. الطريقة: أدخلت في هذه الدراسة 18 أرنبا محليا تم توزيع هذه الأرانب بصورة عشوائية إلى أربعة مجاميع المجموعة الأولى هي مجموعة السيطرة الطبيعية والمجموعة الثانية أعطيت غذاء عالي الدسم يحتوي1% كولسترول. المجموعة الثالثة أعطيت غذاء عالي الدسم لمدة ستة أسابيع, بعد ذلك أعطيت عقار السيتاكلبتيين 125ملم/ كغم لكل يوم عن طريق الفم.النتائج: سبب تغذية الأرانب بالغذاء عالي الدسم الذي يحتوي1% كولسترول لمدة أثني عشر أسبوعاً في زيادة معنوية (P<0.05) في مستوى الكولسترول الكلي والكلسيريدات الثلاثية ومستوى البروتين المتفاعل نوع C وعامل الالتهاب α-TNF في الدم و ومقياس درجة التصلب وزياده في عامل التاكسد مالونيلداي الديهايد(MDA) وانخفاضا في عامل التاكسد كلوتاثاييون GSH)) في الانسجه. سبب معالجة الارانب بعقار السيتاكلبتيين لمدة ستة أسابيع انخفاضا معنويا (P<0.05) في الكولسترول الكلي ,الكلسيريدات الثلاثية,مستوى البروتين المتفاعل نوع C وعامل الالتهاب α-TNF في الدم ومقياس درجة التصلب. بينما سبب زيادة معنوية (P<0.05) في مستوى الكولسترول عالي الكثافة في الدم وانخفاض في عامل التاكسد (MDA) وزياده في عامل التاكسد GSH))و سبب انخفاضا معنويا (P<0.05) في سمك الطبقه الداخليه والوسطى للشريان الابهر.


Article
Correlation between Visfatin and Creatine Kinase Levels with Periodontal Health Status of Patients with Coronary Atherosclerosis and Chronic Periodontitis

Authors: Basma R. Omer بسمة عمر --- Maha Sh. Mahmood مها محمود
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 3 Pages: 121-125
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Visfatin is a novel adipokine that mainly secreted by visceral adipose tissue, had an important role ininflammation and immune system. Creatine Kinase (CK) which is an enzyme that is involved in energy metabolism,found in large amounts in myocardium, brain and skeletal tissues.This study is carried out To evaluate the periodontal health status of the study groups (chronic periodontitis andchronic periodontitis with coronary atherosclerosis) and control groups, to measure the salivary levels of visfatin andCreatine Kinase in these groups and compare between them, and to determine the correlations between salivaryvisfatin and Creatine Kinase levels with the periodontal parameters in the three groups.Materials and Methods: eighty participants, males and females were recruited in this study with age ranged from (30-60) years, they were divided into three groups: the first study group was the Chronic periodontitis group (n=30), thesecond study group was chronic periodontitis and coronary atherosclerosis (n=30) and the control group(n=20)which was healthy systemically with healthy periodontium. Periodontal health status was determined by measuringplaque index(PLI),gingival index (GI), probing pocket depth(PPD), bleeding on probing (BOP) and clinicalattachment level (CAL),salivary samples were taken from each participants, salivary visfatin levels were determinedby enzyme-linked immune-sorbent assay(ELISA) while the activity of salivary Creatine Kinase was determinedspectrometrically by using the International Federation of the Clinical Chemistry (IFCC) method on Hitachi 911Automatic analyzer.Results: The results of the study showed that the mean values of PLI, GI, visfatin, Creatine Kinase and the percentagesof sites according to PPD scores, CAL scores, BOP were higher in the second study group with chronic periodontitisand coronary atherosclerosis than in the other groups with highly significant differences between the groups at(P≤0.01). Also by using Pearson Correlation Coefficient, salivary visfatin levels were correlated positively with allclinical periodontal parameters with a strong and positive correlation between salivary visfatin levels and CAL scoresand PPD scores. Salivary Creatine Kinase levels were correlated positively with all clinical periodontal parameters witha strong and positive correlation between its levels and mean values of GI and percentages of BOP.Conclusion: The present study showed that salivary visfatin can be used as a marker for the development ofcoronary atherosclerosis and its levels are associated with the degree of periodontal destruction and showed thatCreatine Kinase may be used as a marker for coronary atherosclerosis and chronic periodontitis.


Article
Relationship of some ultra trace elements with atherosclerosis

Author: Shatha Rouf Moustafa
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2019 Volume: 23 Issue: 1 Pages: 66-73
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Trace elements are now measured as possibly having an important role in the pathogenesis of atherosclerosis. This study aimed to investigate the serum rubidium, rhenium, cesium, and boron levels in patients with atherosclerosis as compared with the control group as well as to detect the effect of age and gender and estimate the correlation among the parameters.Methods: This case-control study included 40 patients and 40 apparently healthy adults matched age and gender as a control group. Serum parameter levels were estimated using atomic absorption spectrophotometer.Results: The data of the current study indicated that the levels of rubidium and boron were significantly reduced and there was a significant elevation in the serum level of rhenium while there was no statistical difference in the level of cesium in patients as compared with the control group. In addition, the effect of age and gender did not reveal any significant effect on the serum studied ultra-trace elements levels. There was a negative significant weak correlation between age and Rb (r = -0.38, P = 0.016).Conclusion: Boron and rubidium were significantly reduced; therefore, supplementation could be important for therapy of atherosclerosis.

Keywords

Atherosclerosis --- Boron --- Cesium --- Rhenium --- Rubidium

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