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Article
Transurethral Microwave Thermotherapy (TUMT) For Benign Prostatic Hyperplasia

Author: Firas Shakir Attar
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 1 Pages: 24-26
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Benign prostatic hyperplasia (BPH) is one of the most common diseases of the aging male. Minimally invasive therapies for treatment of BPH compete with the gold standard transurethral resection of the prostate (TURP). The aim of this study is to assess the efficacy of transurethral microwave therapy (TUMT) in patients with otherwise poor general health.METHODS:Thirty (30) patients with associated chronic medical diseases and lower urinary tract symptoms due to BPH were subjected for TUMT as an outpatient single session procedure, from June 2001 to August 2005. Follow up was performed 2 weeks, and then one month following treatment clinically and by assessing residual urine volume, maximal flow rate and prostate size.RESULTS:Out of (28) treated patients, (21) were labeled as non – responders as they were unable to pass urine freely 2-weeks after a trial of decatheterisation. In contrast (7) patients passed urine freely after decatheterisation. In the latter group, it was found that there was no statistical significance of the values of maximum flow rate, residual urine volume or prostate size between pre- and one month post TUMT.CONCLUSION:TUMT is a possible option for the treatment of BPH in poor general health patients or those refusing other surgical modalities. However, it did not prove to be effective for those patients with chronic urinary retention and BPH


Article
THE EFFECT OF FINASTERIDE ON BLEEDING DURING TRANSURETHRAL RESECTION OF THE PROSTATE

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Background:Finasteride is a selective 5- reductase enzyme inhibitor that blocks the conversion of testosterone to dihydrotestosterone, down regulates prostatic angiogenesis and blood flow and promotes apoptosis of prostatic cells. It significantly decreases suburethral prostatic microvessel density in patients with benign prostatic hyperplasia, which may explain its efficacy for decreasing benign prostatic hyperplasia -associated bleeding. Transurtheral resection of the prostate is considered the gold standard operation for symptomatic benign prostatic hyperplasia. It is characterized by immediate treatment success with long-lasting improvement of symptoms.Objective:To study the effect of finasteride on bleeding during transurethral resection of the prostate.Methods:Thirty eight patients with benign prostatic hyperplasia underwent transurethral resection of the prostate. Patients were randomly assigned into two groups, the finasteride group (18 patients) and the control group (20 patients). The intra-operative bleeding was measured.Results:Statistically less significant bleeding during transurethral resection of the prostate in patients who were placed on 10 mg finasteride for 6 weeks prior to the surgery. Conclusion:Finasteride given daily for 6 weeks prior to transurethral resection of the prostate reduces time of surgery, bleeding, and irrigation fluid requirements.Keywords:Hematuria, Finasteride, Benign prostatic hyperalgesia.


Article
The Role of Celecoxib for Treatment of Refractory Nocturia Caused by Benign Prostatic Hyperplasia

Authors: Mohammed Bassil Ismail --- Adil Hefdhi Al.soufi --- Hasanin Farhan Hasan
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2014 Volume: 11 Issue: 2 Pages: 428-436
Publisher: Babylon University جامعة بابل

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Abstract

Objective: Nocturia is a well-recognized symptom in patient with benign prostatic hyperplasia ( BPH), which is commonly treated by alpha- blocker and/ or 5 alpha - reductase inhibitors. However, the effectiveness of these drugs for nocturia has been reported to be only 25%- 39%. The aim of this study was to investigate the efficacy of celecoxib, a cyclooxygenase -2 inhibitor, in the treatment of patient with BPH complaing of nocturia.Patients and methods: A prospective study of 50 men with signs tract symptoms and BPH of refractory nocturia to alpha- blocker and/ or 5 alpha reductase inhibitor more than two episodes of nocturia per night were involved for nocturia. Although these patients had received standard drug therapy for more than one month , they had still three or more episodes of nocturia. The patients took a single dose of 100 mg of celecoxib at night prior to sleep. and 2 week after the initiation of this therapy, the effects of this treatment were assessed by frequency chart and a questionnaire.Results: In the questionnaire ,32 of 50 patients (64%) had an excellent response with celecoxib treatment than previous treatments, 14 of 50 patients (24%) had an improvement with celecoxib treatment than previous treatments, 4 of 50 patients (8%) had no response with celecoxib treatment, Nocturnal frequency showed a statistically significant reduction from, baseline after two weeks treatment with celecoxib (P < 0.01), International Prostate Symptom Score( IPSS) showed a statistically significant reduction from baseline after two weeks treatment with celecoxib (P < 0.01), peak flow rate showed a statistically no response from baseline after two weeks treatment with celecoxib (P < 0.05).Conclusion: Celecoxib is effective in the treatment of patients with BPH complaining of refractory nocturia. The results suggest a novel treatment option for this common condition.

الهدف: ان هدف الدراسة هو لتحديد فعالية عقار السيليكوكسب في معالجة التبول الليلي عند مرضى تضخم البروستات الحميد.منهج الدراسة: اشتملت الدراسة على 50 مريضا يعانون من التبول الليلي لاكثر من مرتين نتيجة لتضخم البروستات الحميد تتراوح اعمارهم بين (50-75). وقد جمع المرضى من الاستشارية البولية في مدينة الطب في بغداد للفترة من شهر حزيران 2010 الى شهر اب 2011. علما ان هؤلاء المرضى مستمرين على علاج تضخم البروستات الحميد التقليدي لاكثر من شهر وبالرغم من ذلك الا انهم ضلوا يعانون من التبول الليلي لاكثر من مرتين.اعطي هؤلاء عقار السيليكوكسب 100 ملغم مرة واحدة يوميا قبل النوم.وقمنا باحتساب عدد مرات التبول الليلي قبل وبعد اسبوعين اعطاء المرضى عقار السيليكوكسيب اظهرت النتائج بان 32 من المرضى ال50 كانت فعالية العقار عندهم ممتازة.نتائج الدراسة: حسب المقياس الشخصي اظهرت النتائج بان32 (64%) من المرضى كانت فعالية العقار لديهم ممتازة و14 (28%) من المرضى كانت فعالية العقار لديهم مقبولة و 4(8%) ليس لديهم اي استجابة للعقار.الاستنتاج: اثبتت الدراسة فعالية عقار السيليكوكسب في علاج التبول الليلي لدى المرضى الذين يعانون من تضخم البروستات الحميد.


Article
Epidemiological Study of Ocular Manifestation of Molluscum Contagiosum in Al Diwaniyah Governorate: Iraq

Authors: Hassan Raji Jallab --- Saif.Abbas Al-Shamarti
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2014 Volume: 11 Issue: 3 Pages: 574-579
Publisher: Babylon University جامعة بابل

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Abstract

Background:Molluscum contagiosum is skin disease caused by the molluscumcontagiosum virus (MC) usually causing one or multiplesmaller dome shaped umbilicated papules with symptoms that maybe self-resolve. MC virus was once a disease primarily of children, but it has evolved to become a sexually transmitted disease in adults. Objective:To study the epidemiology of ocularMolluscum contagiosum presentation in different age groups of Iraqi patients in Al-Diwaniyah city. Method:This clinical descriptive study was performed in the outpatient department of dermatology and ophthalmologyprivate clinic in Al–Diwaniyah from March 2012 – February 2013. A total of 245 Patients were recruited in this study as they diagnosed as ocular Molluscum contagiosum; both classical and non classical presentation were studied.Results:the results showed that there is high incidence among young patients and this increase was much clear in male than female. The low socioeconomic state has also enhanced the occurrence of this virus .Conclusion: Social risk factor for acquisition of ocular MC, particularly in suburban and low social economic area of Al Diwaniyah cityis significant increased compared to the center of city. Sex and age might also enhance the occurrence of this virus.

تمت هذه الدراسة على وبائية فايروس الفالول اللؤلؤي في العيادة الخارجية لشعبة الامراض الجلدية في م. الديوانية التعليمي وكذلك عيادات العيون في الديوانية للفترة من شهر آذار لعام 2012 الى شهر شباط لعام 2013 على 245 مريض مشمولين بهذه الدراسة حيث كانوا مصابين بفايروس الفالول اللؤلؤي في العين. وكانت النتائج تشير أن هنالك نسبة عالية من المصابين هم من أعمار الشباب وتكون الإصابة بالذكور أكثر من الإناث وتبين في هذه الدراسة ان الحالة المعيشية والاقتصادية لها دور كبير في الإصابات بهذا الفايروس وان النسبة تكون عالية في الطبقات الفقيرة من المجتمع وكذلك تكون الإصابة عالية في المناطق الريفية مقارنة في مركز مدينة الديوانية.


Article
Study the Toxic Effect of Different Doses of Duprost in Liver and Blood of Albino Mice
دراسة التاثير السمي للجرع المختلفة من عقار Duprost في كبد ودم الفئران البيض

Authors: Ban Jasim Mohamad بان جاسم محمد --- Hind Hussein Obaid هند حسين عبيد --- Duha Ibraheem Mohamad ضحى ابراهيم محمد --- Maha Salim Yaseen
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2017 Volume: 58 Issue: 3B Pages: 1381-1392
Publisher: Baghdad University جامعة بغداد

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Abstract

The aim of this study is to investigate the effect of different doses of Duprost in the liver and blood of albino mice. The current study included twenty one albino mice, obtained and grouped into 3 groups: control (3 mice), acute group (12 mice) and chronic group (6 mice). The acute group was subdivided into 4 groups and each group of 3mice, was given a lonely oral dose of (0.25ml, 0.15ml, 0.1 ml and 0.05ml respectively) for 24 hours. Whereas the third group was subdivided into 2 groups and each set was given a daily dose of (0.15ml and 0.05 ml respectively) for 30 days. After the mentioned periods, blood samples from each animal were taken for blood analysis. Then, the mice of all groups were sacrificed and the livers were removed, processed, sectioned and stained for histological analysis. In acute group, all mice that dosed with (0.25 ml) dose, died after 15 minutes of dosing. Blood results showed significant decrease in Hb level, WBC's and platelets' count among acute subgroups in comparison with chronic subgroups which showed significant increase in WBC and platelets' count, but a significant decrease in Hb levels. The histological analysis of liver in acute subgroups showed different forms of liver inflammation among acute subgroups, in comparison with chronic subgroups which showed formation of granulomatous lesions in the liver parenchyma in high dose(0.15ml) but there were inflammatory cells' aggregation in liver parenchyma among lower doses.

تهدف هذه الدراسة الى التحري عن تاثير الجرع المختلفة من عقار Duprost في كبد ودم الفئران البيض. شملت الدراسة 21 فارا تم تقسيمها الى ثلاث مجاميع هي : مجموعة السيطرة (3) فئران, مجموعة الاصابة الحادة (12) فأرا والتي قسمت بدورها الى 4 مجاميع ثانوية اعطيت كل مجموعة منها جرعة فموية واحدة من الحجوم التالية (0.05ml, 0.1 ml ,0.15ml ,0.25mlعلى الترتيبب) لمدة 24 ساعة. اما المجموعة الثالثة مجموعة الاصابة المزمنة ضمت (6) فئران والتي قسمت بدورها الى مجموعتين ثانويتين كل منهما ضمت 3 فئران وتم تجريعها يوميا بجرعة فموية واحدة من الجرع التالية (0.05ml, 0.15ml) لمدة 30 يوم. بعد انقضاء المدة المحددة لكل مجموعة تم سحب عينات الدم من كل فأر لاجراء التحاليل المختلفة وايضا تم تشريح الحيوانات واستخراج الكبد وتقطيعه الى شرائح وتصبيغها لغرض الدراسة النسيجية. اظهرت نتائج مجموعة الاصابة الحادة موت جميع الفئران التي جرعت بجرعة (0.25 ml) من الدواء بعد 15 دقيقة من التجريع. بينما اظهرت نتائج الدم حدوث انخفاض معنوي في مستوى الهيموغلوبين وكذلك تعداد الكريات البيض والصفيحات الدموية في مجموعة الاصابة الحادة مقارنة بمجموعة الاصابة المزمنة التي اظهرت ارتفاعا في مستويات الكريات البيض والصفيحات بينما كان هناك انخفاض في مستوى الهيموغلوبين فيها. اما نتائج الدراسة النسيجية في مجموعة الاصابة الحادة فقد اظهرت وجود اشكال مختلفة من الالتهاب في نسيج الكبد بين مجاميعها الثانوية بمجموعة الاصابة المزمنة التي اظهرت وجود اورام حبيبية في النسيج الحشوي للكبد عند الجرع العالية من الدواء في حين كان هناك تجمع للخلايا الالتهابية عند الجرع الاوطأ.


Article
Prospective analysis of 300 cases of ovarian cysts in Iraqi women

Author: Tlefih A. J. *
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2007 Volume: 1 no.3 Issue: 2 Pages: 203-210
Publisher: Kerbala University جامعة كربلاء

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Abstract

ackground: Most ovarian cysts (O C) are functional, benign, harmless, and may disappear on theirown within a few months. However, they may twist, rupture, bleed, or press on the surroundingorgans. It may be difficult to differentiate malignant O Cs from the benign unless histopathological examis performed. There are many methods for treatment of O Cs.Objectives: The aim of this study is to know the prevalence of O Cs, and to study their types,presentation, and treatment.Methods: Over a 5 year period, from Feb. 2000 to Jan. 2005, a prospective study of 300 women with OCs was carried out in 3 hospitals in Baghdad (Al - Habeabia hospital, Al - Elweya teaching hospital andAl - Kindy teaching hospital).Results: The highest incidence of O C (35%) was among women aged 21 - 30 years. The functional O Cwas the most common type (64.7%), and (31%) of them showed spontaneous resolution. (68.3%) of O Cswere singular.(60%) of O Cs were symptomatic, and lower abdominal pain or discomfort was the most commonsymptom (91.7%). (75%) of cases were treated surgically and cystectomy was the most common surgicalprocedure that was adopted in this study (72.9 %).(2.7%) of women had malignant O Cs. Out of them (75%) were at advanced stage (III or IV), and (87.5%)were postmenopausal.Conclusion: Most of the O Cs were benign or functional, symptomatic and some may disappear withouttreatment, but surgery was the main treatment. The highest incidence of O C was among women aged 21 -30 years. Most malignant O Cs were at advanced stage (III or IV).


Article
Benign Breast Disorders –a Histiopathological Study in Tikrit City
امراض الثدي الحميدة-دراسة نسيجية في مدينة تكريت

Author: Nadia Adnan Ghani نادية عدنان غني
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2012 Volume: 3 Issue: 1 Pages: 27-35
Publisher: Diyala University جامعة ديالى

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Abstract

The objective of the present study is to determine the frequencies of various benign breast diseases (BBD) in female patient in Tikrit city. A retrospective descriptive study of all female patients visiting surgical clinic with breast problems was performed. This study was conducted at Tikrit Teaching Hospital and the main private histopathological laboratory in Tikrit over the period from January -2000 to the end of December 2007. All the patients were diagnosed as carcinoma were excluded. A total of 485 patients were included in this study. About 35.7% (173/485) patients were belonged to the 3rd decade of life (age between 21-30 year), followed by 30.5% (148/485) were belong to 4th decade (age between: 31-40 years). Fibrocystic disease was the commonest of all benign breast disease, seen in about 33% (162/485) mainly in the 3rd, 4th &5th decades of life with peak at 31-40 years followed by fibroadenoma that is seen in 27.6%(134/485) of the cases mostly in the 2nd & 3rd decades of life. It is found that benign breast diseases are common problem in females of reproductive age.

تهدف هذه الدراسة الى تحديد تواتر الحالات المختلفة من أمراض الثدي الحميدة للأناث في مدينة تكريت و قد تم اجراء دراسة وصفية لكل النساء اللواتي زرن العيادة الجراحية بخصوص مشاكل الثدي.تم اجراء هذه الدراسة في مستشفى تكريت التعليمي وفي مختبر النسيج المرضي الخاص الرئيسي في مدينة تكريت للفترة من كانون الثاني 2000 الى نهاية كانون الأول 2007. تم استبعاد كل المريضات المشخصات بالاصابة بسرطان الثدي, وتضمنت الدراسة 585 حالة. 35.7% (173/485) من الحالات ضمن العقد الثالث من العمر (21- 30) سنة, يتبعها 30.5% (148/485)ضمن العقد الرابع(31-40)سنة. تم التوصل الى ان المرض التليفي التكيسي للثدي كان الأكثر شيوعا" من بين الأمراض الحميدة و يكون 33% (162/485)غالبا" في العقد الثالث والرابع والخامس من العمر وذروته بين 31-40 سنة يتبع هذا المرض الورم الليفي الغددي الحميد حيث لوحظ في 27.6% (134/485) من الحالات في العقدين الثاني والثالث من العمر.


Article
Discrimination of Malignant from Acute Benign Compression Spinal Fractures with Magnetic Resonance imaging

Author: Nadia Hassan Ali ALSalihi (FICMS) ( diag. rad)
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2014 Volume: 10 Issue: 1 Pages: 11-17
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Differentiation between malignant and benign vertebral compression fracture is often problematic. This is precisely difficult in elderly who are predisposed to benign compression caused by osteoporosis .Establishing correct diagnosis is of great importance in determining the treatment andprognosis.A study was performed to determine which magnetic resonance imaging findings are useful in discrimination between metastatic and acute osteoporotic compression fractures of the spine. Recently MRI is being increasingly used for evaluation of these fractures.Objectives: The aim of this study is to establish the correct diagnosis of malignant and benign compression vertebral fracture by MRI to determine treatment and prognosis.Methods: MRI of (45 )patients with vertebral compression fracture who underwent MRI of spine during 2 years period ( 2004-2006) in Neuro surgical hospital were retrospectively reviewed by an expedient radiologist , A collapsed vertebra were considered to be acute if there was recent history of back pain of less than 3moths. All MRI sequences needed for spine examination was done( T1WI SE, T2WI GE STIR, and Mylography ) and Gadolinium contrast medium was given to all patients..Results: Of total 45 patients (31male, 14 female, their age range between 18-72years) , The criteria used to differentiate between benign andmalignant collapse spine on MRI was based on the signal intensity, morphology and contrast enhancement for the correct diagnosis. Homogenous and diffuse abnormal signal intensity, posterior convexity and involvement of pedicles are sign that are strongly suggestive of malignant collapse .Conversely, a band like area of low signal intensity adjacent to depressed end plateand preservation of signal intensity of vertebra suggest benign nature of the collapse.Conclusions: We found that MRI features is helpful in differentiation of malignant and benign compression fractures in majority of cases, and if initial MRI finding are equivocal correlation with other images technique, follow up and biopsy in selected cases helpful in arriving correct diagnosis.


Article
Evaluate the level of Oxidative Stress markers and Lipids Profile in Patients with Bening Prostate Hypertrophy in Al-Khadhmyah Tteaching Hospital

Author: aHanan H. Fleih aWajeeh Y. Al-Ani bSaddam h. Al- ma’adhedy
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2014 Volume: 10 Issue: 1 Pages: 30-33
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Benign Prostate Hypertrophy(BPH)is a common urological problem worldwide which is defined as denomatous hyperplasia of the periurethralpart of prostate gland that occurs especially in men over 50 years old and that tend to obstruct urination by constriction the urethra Objectives: The study was aimed to investigate the level of Malondialdehyde (MDA), Nitric Oxide (NO) and Superoxide Dismutase (SOD) as an antioxidant, besides other factors such as the level of Lipids Profile (Total Chlosterol (TC), High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C), Very Low Density Lipoprotein Cholesterol (VLDL-C), and Triglyceride (TG))in patients suffer from BPH . Methods: In this study ;clinical ,specific prostate antigen and sonongraphy data of 80 persons were prospectively analyzed ; they are divided into two groups (40) male patients with Benign Prostate Hypertrophy (BPH) was previously diagnosed and another (40) healthy males as a control group .The study was performed at Al-Khadhmyah teaching hospital during the period from March 2001 till April 2003Results: The evaluated data recorded a significant increase in the levels of (MDA) and (NO), while a significant decrease in the level of (SOD) (P  0.001) in patients complain from BPH in comparison with the control group. Moreover, the results showed a significant increase in the levels of (TC), (TG) , (LDL-C) and a significant decrease in the level of (HDL-C) (P  0.001) in comparison with the control groupConclusions: Benign Prostate Hypertrophy (BPH) is the most common benign tumor in men and Malondialdehyde (MDA), Nitric Oxide (NO) ,Superoxide Dismutase and Lipid profile are beneficial markers to evaluate patients with BPH in comparison with those without BPH.


Article
EVALUATION OF THE EFFICACY OF TADALAFIL IN IMPROVING LOWER URINARY TRACT SYMPTOMS IN PATIENTS WITH SYMPTOMATIC BENIGN PROSTATIC ENLARGEMENT

Author: Firas Shakir Attar
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2015 Volume: 21 Issue: 2 Pages: 70-75
Publisher: Basrah University جامعة البصرة

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Abstract

Abstract Lower urinary tract symptoms (LUTS) are common bothersome association with benign prostatic enlargement (BPE). The relationship between erectile dysfunction(ED) and LUTS/ BPE has been studied in the Multinational Survey of the Aging Male and in several epidemiologic studies, suggesting that the two diseases may share a common pathophysiology. The aim of the present study is to evaluate the efficacy and safety of use of tadalafil monotherapy in improving LUTS in patients with symptomatic BPE. Sixty patients aged more than 50 years with symptomatic BPE with LUTS more than 6 months were included from January 2013 to May 2015. These patients were assessed for their International Prostate Symptoms Score (IPSS) which was ≥7 and maximum urinary flow rate (Q max) which was >10 and < 20 ml/s. Patients were given tadalafil tablet 5 mg once daily without other therapy. The treatment was continued for three months and the patients were asked to come back for follow up each four weeks. Among the 60 patients, 50 (83.3%) showed significant improvement in their IPSS by achieving ≥3- points total IPSS improvement in symptoms. There was also significant improvement in the maximum urinary flow rate. The end point was at 12 weeks. It is concluded that, Tadalafil 5 mg once daily can be considered as an option for relieving LUTS in patients with symptomatic BPE

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