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Article
Evaluation of laboratory examination of Bronchial Wash Versus Sputum Examination in Diagnosing Lung Diseases
تقييم الفحص ألمختبري للقشع مقارنة بفحص سائل غسول القصبات الهوائية في تشخيص أمراض الرئة في مستشفى الرمادي التعليمي.

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Abstract

Sputum study and bronchial wash study are considered two of the most common well known classic diagnostic tools in detecting various lung diseases among the wide and continuously expanding diagnostic procedures for detection of lung pathology.Sputum study still play a rule in diagnosis of lung diseases but the sensitivity of the sample is highly depended on the procedure of collection and the co-operation of the patient, the type and the site of lung lesion.Fiber optic bronchoscopy is another option providing both direct visualization of the trachea-bronchial tree and the bronchial wash collected by the fiber optic bronchoscopy provides important information for detection of various lung diseases. the study was conducted in ramadi teaching general hospital. This is a comparison prospective study of 45 consecutive patients whom underwent both sputum collection and bronchoscopy for bronchial wash collection and comparing the results of the patients which showed that among the 45 patients 33 patients had inconclusive or negative sputum studies while 12 patients had positive sputum study in comparison with bronchial wash which give positive results in 41 patients. This study confirms that the sensitivity of bronchial wash is much higher than bronchial wash is much higher than the sputum study in diagnosing lung diseases and the higher sensitivity usually associated with abnormal chest x-ray.the study confirms the importance of these tools for rapid diagnosis of a disease with starting immediate therapy, economic value in reducing time-admission period in the hospital with high necessity to support a staff well trained on bronchoscopy to ensure rapid and accurate diagnoses of chest diseases

یعتبر الفحص ألمختبري للقشع وكذلك فحص سائل غسول القصبات الهوائیة المستخرج عن طریق تنظیر القصبات اللیفيأحدا أهم الفحوصات المختبریة المستخدمة في تشخیص أم ا رض الجهاز التنفسي شیوعا وبالرغم من تعدد وتنوع الطرق التشخیصیة بقيهذان الفحصان یلعبان دو ا ر أساسیا في تشخیص أم ا رض الجهاز التنفسي.یستخدم فحص القشع على نطاق أوسع ولسهولة اخذ العینةأصبح مفضلا على فحص سائل غسل القصبات المأخوذ عن طریق الناظور.أجریت هذه الد ا رسة في مستشفى الرمادي التعلیمي شعبةج ا رحة الصدر وشملت ٤٥ مریضا أخذت لجمیع المرضى عینات من القشع وتم تعریف المرضى بكیفیة إعطاء القشع ولیس اللعابوتم إعطاء بعض المرضى الأدویة المقشعة لزیادة جودة العینة وتم إج ا رء تنظیر القصبات باستخدام ناضور القصبات اللیفي المرنوجریت على جمیع العینات الفحوص المختبریة والتي شملت فحص التدرن وز ا رعة العینة لكشف نوع البكتریا والفحص الخلوي للكشفعن الخلایا السرطانیة ، بینت الد ا رسة إن فحص القشع لم یبین نوع أو سبب المرض إلا في ١٢ مریضا وبقیت ٣٣ حالة مرضیة غیرمعروفة بینما أظهرت فحوص السائل المستخرج من غسل القصبات عن طریق ناضور القصبات المرن تحت التخدیر الموضعي أسبابوأع ا رض المرض في ٤١ مریضا.أثبتت نتائج هذه الد ا رسة أن هناك جدوى أكیدة على الصعید العلمي في سرعة تحدید المرض وسرعةالبدء في العلاج وجدوى اقتصادیة في تقلیل فترة الرقود في المستشفى وأكدت على ضرورة توفیر كوادر لها إلمام بتنظیر القصبات كونهأكثر سرعه ودقة في تشخیص الأم ا رض الصدریة.


Article
Bronchial wash miR-21 as a potential biomarker for non-small cell lung cancer

Authors: Hussain Abady Aljebori --- Ban A. Abdulmajeed --- Adnan Aljubori
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2015 Volume: 4 Issue: 1 Pages: 39-60
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Lung cancer is one of the major health problems all over the world. Most ofcases are discovered at advanced stages because of late appearance of symptoms and the lackof efficient and effective methods for early diagnosis and screening of high risk groups. ThemicroRNA-21(miR-21) was stably present and reliably measurable in all samples of bronchialwash whether positive or negative (control) for lung cancer.Objectives: to evaluate the expressions of the miRNA-21 as a minimally invasive diagnosticbiomarker for non-small cell lung cancer (NSCLC).Results: Relative quantification of miR-21 gene showed overexpression in samples positivefor NSCLC (non-small cell lung cancer) and ROC study yielding 85% sensitivity and 98%specificity in distinguishing NSCLC patients from controls with p-value < 0.05.Conclusion: altered expressions of the miR-21 in samples of bronchial wash may provide apotential biomarker for detection of non-small cell lung cancer.


Article
Bacteriological and Cytological study For bronchial washes from lung cancer patients
دراسة خلوية وبكتريولوجية لسوائل تنظير القصبات لمصابي سرطان الرئة

Authors: Amna M.Ali آمنة محمد علي --- Mohsn A.Ali محسن عبد علي --- Sawsan S.AL-Jubori سوسن ساجد الجبوري
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2011 Volume: 8 Issue: 1عدد خاص بمؤتمر علوم الحياة Pages: 406-415
Publisher: Baghdad University جامعة بغداد

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Abstract

The study included the collection of 75 bronchial wash samples from patients suspected to have lung cancer. These samples were subjected to a diagnostic cytological study to detect the dominant type of lung cancer. It was noticed that 33 patients proved to have a lung cancer out of 75 (44%) of these, 19 cases (57.6%)were diagnosed having Squamus cell carcinoma,7cases (21.21%) showed Adenocarcinoma ,6 cases (18.18%) were having small cell carcinoma while only one case (3.03%)was large cell carcinoma .Nearly 70% of cases were correlated with smokers .Bacteria were isolated from 53 patients in which 33 isolates were associated with the cancer cases while 20 of them from non infected patients. By using different morphological ,biochemical tests followed by api20 ,the bacterial isolates correlated with cancer were diagnosed and were characterized as 12 isolates (36.36%) of Pseudomonas aeruginosa ,6 isolates (18.18%) were Klebsiella pneumoniae ,Pseudomonas fluorescence and Esherichia coli for each while only 3 isolates (9.09%)of Acinetobacter baumannii were isolated. Some of bacterial virulence factors were determined in which,24 isolates (72.7%) were capable of agglutinating red blood cells, 16 isolates (48.5%) had the ability to adhere to epithelial cells , in addition ,15 isolates (45.5%) proved to have capsule and 24 isolates(72.7%) gave a positive results in heamolysin test beside ,25 isolates (75.8%) were ß –Lactamase producers. The isolates were highly resisted Ampicillin, Amoxicillin and Cefotaxime while they were inhibited by low concentrations of Ciprofloxacin and Cefepime the 4th generation cephalosporins.

تضمنت الدراسة جمع 75عينة من سوائل تنظير القصبات لمرضى مشكوك بأصابتهم بسرطان الرئة.اجريت على العينات دراسة تشخيصية خلوية لمحاولة التعرف على نوع سرطان الرئة السائد اذ تبين وجود33مصاب بسرطان الرثة من مجموع 75(44%) توزعت ما بين 19اصابة (57.6%) لسرطان الرئة الحرشفي ,7 اصابات (21.21%) للنوع الغدي , 6 اصابات (18.18%) لسرطان الرثة ذو الخلايا الصغيرة وحالة واحدة (3.03%) لسرطان الرئة ذو الخلايا الكبيرة ارتبطت معظم الحالات (70%) مع المدخنين . امكن عزل 53 عزلة بكتيرية ارتبطت 33 منها بحالات السرطان فيما عزلت 20 عزلة من غير المصابين. بأجراء عدد من الفحوص المورفولوجية والكيموحيوية المتبوع بالتشخيص بعدة .api2مكن تشخيص العزلات المتزامنة مع السرطان وكانت بواقع 12 عزلة (36.36%) لبكتريا Pseudomonas aeruginosa و6 عزلات (18.18%) لكلا من بكتريا Pseudomonas fluorescence, Klebsiella pneumoniae و Escherichia coliمقابل3 عزلات (9.09%) الى Acinetobacter baumannii .حددت بعض من عوامل الضراوة المنتجة من قبل الانواع البكتيرية المعزولة اذ لوحظ قابلية 24 عزلة (72.7%) على تلزين كريات الدم الحمراء, فيما استطاعت 16 عزلة (48.5%) من الالتصاق بالخلايا الطلائية ,وامتلكت 15 عزلة (45.5%) للمحفضة فيما اعطت 24 عزلة (72.7%) فحصا موجبا للهيمولايسين.كما انتجت 25عزلة(75.8%) انزيم البيتالاكتاميز. أتسمت العزلات بمقاومتها العالية سيما لمضادات Ampicillin ,Amoxacillin ,Cefotaxime في الوقت الذي ثبطت بتراكيز قليلة من Ciprofloxacin وال Cefepim وهو من سيفالوسبورينات الجيل الرابع .


Article
The Role of Bronchial Wash Carcino-Embryonic Antigen Assay In The Diagnosis of Non-Small Cell Lung Cancer

Authors: Hashim Mahdi Hashim --- Ali Salih baay --- Ameer Kadhim Al-Humairi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 2 Pages: 540 -548
Publisher: Babylon University جامعة بابل

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Abstract

The bronchogenic cancer is one of the most common cancers in human kind & it represents a diagnostic challenge because of the most available tests are either yielding in the late stages or it is some of invasive nature ,so the need for diagnostic test in the early stages is mandatory, aim of the study is to assess the significance of bronchial carcino-embryonic antigen ( CEA) as a tumour marker for aiding the diagnosis of non-small cell lung cancer (NSCLC) and to see if there is any difference between the serum & bronchial CEA and between tumour and non-tumour sidesThirty patients were involved in this study ,divided into 3 groups according to their diagnosis as cancer ,airway disease & Tuberculosis groups, assessment of their socio-demographic features ,clinical features chest X ray ,computerized tomography (CT) scan , fibro-optic bronchoscopy were done & the carcino-embryonic antigen (CEA) level were tested in the samples taken from serum, tumour& non-tumoursides.There was a statistically significant difference in the level of the carcino-embryonic antigen in the bronchial wash of cancer patients group comparing to the serum of the same group & to the bronchial wash level in the other groups in favor of the cancer group patients, but no difference between the tumour& non tumour sides in the cancer group patients.The carcino-embryonic antigen assay in the bronchial wash may be helpful in the diagnosis of non-small cell lung cancer& may be take into consideration in the future work up

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