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Crystalluria types and incidence in Basra City; southern of Iraq
البول البلوري(رمل الأدرار), أنواعه السائدة ونسبة حدوثه في مدينة البصرة جنوبي العراق

Author: Jubran K. Hassan جبران خليل حسن
Journal: Journal of Basrah Researches (Sciences) مجلة ابحاث البصرة ( العلميات) ISSN: 18172695 Year: 2011 Volume: 37 Issue: 5A Pages: 72-81
Publisher: Basrah University جامعة البصرة

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Abstract

In Basra City, Southern of Iraq there was increase in the incidence of urinary tracts problems, these problems include frequent urinary tract infection and crystalluria . The purpose from our study is to find out which predominant types of crystalluria and which gender and age has higher incidence values ; where 328 urine samples for males [n=91] and females [n=237] of different ages where analyzed by general urine examination, and sediment was identified by polarized optic microscope to differentiate types of crystals. The average age of patients, expressed as mean + standard deviation, was [38.05 + 17.57], and age range extended from ≤ 9-80 years and divided into seven age groups from ≤9 years old to equal to or greater than 60 years old .The data was analysed statistically by using t test and chi analysis of frequency at p<0.05. The results showed only two types of crystalluria are found. Which is uric acid that represented 96.03%, and Calcium oxalate that represented 3.97 % .There was no cysteine, or struvite crystals. Incidence percentage of uric acid crystals was greater in both genders (95.6% for males and 96.2% for females) as compared with the incidence percentage of calcium oxalate (4.4% for males and 3.8% for females) , and there was no significant difference between males and females in the incidence percentages for each type of crystalluria . The patients samples were then divided into seven age groups from ≤ 9 years old to equal to or greater than 60 years old and there were no significant differences (at p<0.05) among all age groups in the incidence percentage of each type of crystalluria. Our finding there were only two types of crystalluria are most predominant ; those are uric acid and calcium oxalate and the incidence of uric acid crystalluria was significantly greater than oxalate in both genders and age groups, which may be greatly different from that reported in several studies outside country .

في مدينة البصرة, جنوبي العراق هنالك زيادة في عدد الحالات التي سببها مشكلات في الجهاز البولي والتي قد تعزى الى التهابات المجاري البولية المتكررة والبول البلوري او مايطلق عليه ب( رمل الادرار).هدف الدراسة هو إيجاد نوع البول البلوري(رمل الادرار) السائد وتحديد الفترة العمرية وجنس المريض الذي لديه أعلى نسبة إصابة.فقد تم جمع328 عينة ادرار لــ 91 مريض و 237 مريضة لمختلف الأعمار, وقد تم فحص هذه العينات تحت المجهر لتحديد نوع البلورات في عينات الادرار. وكان معدل عمر المرضى (38+ 17,57) سنة و مدى الأعمار امتد من عدة ايام اإلى 80 سنة وقد تم تقسيم الفئات العمرية إلى سبعة فئات تبدأ من (أقل من9 سنة) وتمتد الى ما فوق ال 60 سنة, وقد تم التحليل الإحصائي باستخدام(t_ test and chi analysis of frequency at p<0.05) وكانت النتائج وجود نوعين فقط من البلورات السائدة والتي هي بلورات حامض البوليك (96,03%) و بلورات اوكزالات الكالسيوم (3,97%) ولم يوجد إي اختلاف معنوي بين جنسي المرضى لكل نوع من البلورات وكذلك لم يوجد اختلاف معنوي بين الفئات العمرية للمرضى حيث كانت البلورات حامض البوليك هي السائدة


Article
Role of Eruca sativa in prevention of induced nephrocalcinosis in rabbits
دور نبات الجرجير في منع التكلس الكلوي المحدّث في الأرانب

Author: Uday Abdul-Reda Hussein عدي عبد الرضا حسين
Journal: karbala journal of pharmaceutical sciences مجلة كربلاء للعلوم الصيدلانية ISSN: 70272221 Year: 2018 Issue: 14 Pages: 65-73
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background: Nephrocalcinosis is a clinical pathologic condition characterized by abnormal deposition of calcium phosphate or calcium oxalate in the renal parenchyma, which can result in impaired kidney function.Aim: This study aimed to evaluate the effect of Eruca sativa aqueous extract in prevention of nephrocalcinosis induced by a large dose of oxalic acid in rabbits. Materials and Methods: Twenty four healthy domestic rabbits were equally allocated into three groups and were distributed into: normal group (without drug), oxalic acid group and Eruca sativa group. Both the first and second groups were received distilled water, while the third group received aqueous extract of Eruca sativa for ten consecutive days. Single high dose of oxalic acid was given to induce nephrocalcinosis in rabbits of the second and third groups (except normal group) after 2 hours from receiving of distilled water and Eruca sativa extract at the first day. Blood samples were collected from all animals for biochemical analysis. Urine analysis and histopathological examination were performed for all rabbits to verify the presence of crystals in urine and renal tissues. Results: Eruca sativa aqueous extract produced highly significant reduction in blood urea nitrogen, serum creatinine , with significant reduction in serum Na+ , and highly significant elevation in serum Ca2+ and serum K+ levels, also it is produced highly significant reduction in the calcium oxalate crystals density in urine and renal tissues when compared with of oxalic acid group. Conclusion: Current study found that the aqueous extract of Eruca sativa effectively prevented the formation and deposition of calcium oxalate crystals in renal tissues, thus preventing the occurrence of nephrocalcinosis.

التكلس الكلوي، حامض الاوكزاليك، فرط أوكسالات البول، مستخلص نبات الجرجير، بلورات أوكسالات الكالسيوم.

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