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Article
Study the some concentrations of Immunoglobulins IgG ,IgM ,IgA in Psoriasis Patients
دراسة تراكيز بعض الكلوبيولينات المناعية IgG ,IgM ,IgAعند مرضى الصدفية psoriasis

Author: Tamara Ala`a Hussein
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2013 Volume: 11 Issue: 2 Pages: 98-103
Publisher: Kerbala University جامعة كربلاء

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Abstract

This study designs to study the effect Psoriasis disease on the concentration of some immunoglobulins in human. The study divided into two groups : psoriasis patients group including 20 Randomly individuals of both sexes with different ages. and control group , which also included 20 normal individual from healthy individuals not infected with any skin disease and were races and ages approach to psoriasis patients.The study included some tests of the immunological examination by measuring the concentrations of immunoglobulins IgG, IgM and IgA in both groups. The results indicated the presence of significant change (p < 0.05) a change in the mean level of immunoglobulins in samples infected as compared with a control. also found two phases of infection psoriasis, one active and represents the acute phase, and the other inactive and represents the phase chronic infection has been found a difference in concentration standard tests studied in both phases. Because after the active phase increasing the concentration of IgG and IgA. The inactive phase of the study to increase the concentration of IgM.

أعدت هذه الدراسة لمعرفة مدى تأثير مرض الصدفية على تراكيز بعض الكلوبيولينات المناعية في جسم الإنسان تضمنت الدراسة مجموعتين : مجموعة مرضى الصدفية حيث أخذت 20 عينة عشوائية من المرضى المصابين بداء الصدفية إذ تم اختيارهم عشوائيا من الجنسين وبأعمار مختلفة , ومجموعة السيطرة التي تضمنت أيضا 20 عينة من أشخاص أصحاء غير مصابين بأي مرض جلدي أو غيره وكانوا بأجناس وأعمار مقاربة لمرضى الصدفية . تضمنت الدراسة إجراء بعض الفحوصات المناعية تمثلت بقياس معدل تركيز الكلوبيولينات المناعية IgM, IgG وIgA في كلا المجموعتين . أشارت النتائج إلى وجود تغير معنوية (p<0.05) في مستوى تراكيز الكلوبيولينات المناعية في عينات المصابين مقارنة بمجموعة السيطرة. كما وجد طوران للإصابة بالصدفية أحدهما نشط و يمثل الطور الحاد ، والأخر غير نشط و يمثل الطور المزمن للإصابة , وقد وجد اختلاف في تراكيز معايير الفحوصات المدروسة في الطورين كليهما. إذ اثر الطور النشط Active بزيادة تركيز IgA وIgG . أما الطور غير النشط فقد عمل على زيادة تركيز IgM


Article
Assessment of Soluble Fas in Patients with Chronic Myeloid Leukemia

Authors: SaharRadhi Yasir --- MaysoonAli Saleem --- Bassam Francis Matti
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2014 Volume: 3 Issue: 1 Pages: 51-55
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Soluble Fas was produced from the cell surface of malignant cells in a form lacking the 21 amino acidresidues containing the transmembrane domain by alternative splicing. Trimerization of Fas receptor can beinhibited by soluble Fas (sFas) that act as decoys, binding FasL and preventing association with transmembraneFas. So it is supposed to act as a FasL inhibitor to bind Fas and prevent Fas-mediated apoptosis.Objective: to evaluate serum soluble Fas (sFas) level in patients with chronic myeloid leukemiaMaterials and Method: Serum levels of sFas were measured by ELISA method after venous blood was collected from56 CML patients (newly diagnosed and optimally treated) and 28 healthy subjects as control group. Absorbancewas read at a wave length of 450nm using ELISA reader. Soluble Fas level was then calculated by plotting theoptical density (O.D.) of each sample against the concentration in the standard curve.Results: There were no significant increases in serum sFas patient compared to healthy control with P=0.09. When themean sFas concentration was obviously highest in newly diagnosed (1163.6pg/ml) followed by optimally treated(1021.7 pg/ml) and lowest in healthy control (970.1pg/ml).Conclusion: Production of sFas in tumor patients may be a key mechanism to inhibit Fas-mediated apoptosis. Theidentification of sFas levels as a predictor of outcome in malignant disease further establishes a connectionbetween Fas loss-of-function and tumor progression

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