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Article
The Seroprevalence of IgM Among Iraqi Aborted Women Infected with Human Cytomegalovirus

Author: Maysara S.Khalf
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 1 Pages: 123-129
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Fetal loss and abortion are responsible for significant emotional distress for couples desiring children.There are many documents which support the role of some certain asymptomatic infections such asCytomegalovirus (CMV) in spontaneous abortion.OBJECTIVE:This study was aimed to evaluate the prevalence of seropositivity of specific IgM antibody for CMVby ELISA in the sera of (108) women with recurrent abortion associated with obstetric complications.METHODS:This study was carried out in two central hospital in Baghdad (Al-Elwea& Baghdad teaching hospitals)during (2009-2010).A number of (108) women with definite diagnosis of previous abortion ,35womenwith recurrent abortion , 30 women with premature delivary and 43women with intra uterine death.compered to (50)women with history of normal full term delivary and negative history of miscarrageas control groups .Serum samples were collected and then tested by using ELISA for detection of anti-CMV IgM antibodies .RESULTS :Cytomegalovirus (CMV)specific IgM antibody was detected in (15.7%) of the 108 women studied,while the women with obstetric complications were positive for CMV specific IgM antibody thesecompriesdof(16.6%)with premature delivary ,(14%) with recurrent abortion and (16.2%) with intra uterine death .these result statistically significant (P<0.05) .Our data faild to found asignificant association betweenthe Cytomegalovirus infection with age and residence of patients (p>0.01).CONCLUSION :Higher seropositivity for cytomegalovirus (CMV)in women with spontaneous abortion compared towomen with normal obstetric history suggests that cytomegalo virus Plays a sigificant role in abortion


Article
The intra-uterine transmission of Leishmania major in BALB/c mice.
الانتقال المشيمي لداء اللشمانيا الجلدي المتسبب عن سلالة Leishmania major في الفئران ألمختبريه BALB/c mice.

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Abstract

The result of the present study showed that the transmission of Leishmania major from infected mated mice to their babies takes place through the intra-uterine methods.The clinical manifestations of the infected mice includes , skin lesion erythema and nodules with redness .

اظهرت نتائج الدراسه الحاليه انتقال داء اللشمانيا الجلدي المتسبب عن سلالة Leishmania major من أزواج الفئران المختبريه المصابة الى الفئران الرضع خلال الانتقال المشيمي . اظهرت الفئران المصابه مظاهر مرضيه منها افات جلديه متقرحه ,وعقد جلديه مع احمرار.


Article
HUMAN CYTOMEGALOVIRUS INFECTION AMONG NEONATES WITH SYMPTOMATIC CONGENITAL INFECTIONS AND BIRTH DEFECTS

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Abstract

Background:Human cytomegalovirus (HCMV) is the major viral etiology of congenital infection and birth defects, during current maternal infection the fetal transmission is high (30-40%) and the symptomatic neonates have diseases involving the neurologic, hematopoietic, respiratory and other organ systems, causing high mortality and long-term sequelae.Objective:To measure the frequency of congenital and perinatal HCMV infection among symptomatic neonates and its possible burden of disease among them.Methods:A total of one hundred ninety-eight symptomatic neonates with clinical manifestations of overt congenital infection enrolled in this study from September 2014 to March 2015. Serum samples were obtained from each subject targeted in this study. HCMV infection was defined as HCMV-IgM antibody positive by Electrochemiluminescence Immunoassay (ECLIA) techniques. Results:The prevalence of HCMV infection among symptomatic neonates with congenital infection was 25 (12.6%). The average age of HCMV detection was 9.96 (SD 6.73) days with a median of 7 days, a minimum of 3 days and a maximum of 28 days. Jaundice was the most predominant clinical finding 14 (56%), followed in order of frequency by hepatomegaly 9 (36%) and pneumonitis 7 (28%).Conclusion:The high prevalence of neonatal HCMV infection among neonates with symptomatic congenital infections could indicate a high rate of maternal HCMV primary or current infection among our population.Keywords: HCMV, congenital infection, neonates, clinical finding.

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