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Article
Preeclampsia and Consanguinity

Authors: Wisam Akram --- Fatin Al Defer
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2017 Volume: 16 Issue: 3 Pages: 1-10
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Type of the study: case controlAim: to evaluate the severity of imminent preeclampsia in consanguinity versus non consanguinity groupsDesign and patients methods: a highly selective criteria have been chosen for the women to be participated in this study. The study group (N=30) were not only cousins rather their parents were also cousins and most came from the rural area. While the control Group (N=30) were women in whm no consanguinity neither with couple nor their parents were selected. All women were primigravida 20- 30 years in age. They were all taken from labor ward after 37 weeks of gestation, and for each at admission systolic, diastolic blood pressure, serum uric acid, blood urea, blood platelets count and serum fibrinogen and SGPT with SGOT were initially taken at admission. Since all thepatients were in severe and imminent preeclampsia they were all pre prepared with MgSO4 as anti convulsant and during preparation serial reading were also taken for all the above parameters at 3 and 6 hours later to measure the area under curve profile AUC. Mean blood pressure was taken instead of systolic and diastolic and calculated by the well documented formula Results: The ODD ratio for the primary determinant of preeclampsia severity namely blood pressure and proteinurea were higher in the consanguinity group versus control; 6.58 for systolic; 6.73 for diastolic and 4.07 for protein/creatinine ration in urine, respectively. Serum uric acid and blood urea was also higher for their ODD ratio in the consanguinity group; 5.2 and 5.21 respectively.More importantly the markers of imminent preeclampsia were also significantly higher in the consanguinity group with odd ratio 2.22 and 2.61 for SGOT and SGPT respectively. Best subset regression was calculated for the best combination which correlates with mean blood pressure and serum SGPT with Blood urea combinations were having the lowest coefficient of Mallow (Cp); 32.23. From that independent variable a prediction table has been constructed to sort out all the patients with imminent preeclampsia who are most affected and near complications probably and expressed as column of intervals of bloodurea with corresponding 1,2.5, 5, 10, 90, 95,97.5 and 99 centile of serum SGPT. The area under 10th centile was shaded with green while above 90th centile with red and in between shaded with yellow color. It is probable that patients who’s reading in the red zone or upper yellow zone are at more risk for more serious complications of preeclampsia like adrenal hemorrhage and renal complications and better to expedite their delivery. Conclusion: this study hasshown that preeclampsia among consanguinity group was much more severethan those in non consanguinity couples. Yet by no mean that respect reflects the true picture in society. A table has been constructed and we over stress here that under no circumstances this table can be used for evaluating, modifying or changing the routine protocol of preeclampsia management.


Article
The Inheritance of Elbow Crease Trait in a group of families in Erbil city/ Iraq
دراسة توارث صفة خط الساعد في مجموعة من العوائل في محافظة اربيل / العراق

Author: Nihad A. Ameen نهاد احمد امين
Journal: Jornal of Biotechnology Research Center مجلة مركز بحوث التقنيات الاحيائية ISSN: 18151140 Year: 2013 Volume: 7 Issue: 2 Pages: 11-16
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

The present study aimed to know the inheritance method of elbow crease trait in human from parents to their offspring, our study included (100) families (parents, sons and daughters) however we have studied the effect of parent degree of consanguinity, blood groups on the transmission of this trait from parents to their offspring. The result indicates there was no significant association between parent’s degree of consanguinity and transmission of elbow crease because the ratio of randomly selected foreigner parents were %65. In addition our study involved the study of some other factors like blood groups which has also no significant effect. There were several significant association of presence of elbow crease in both parents and their offspring.

إستهدفت الدراسة الحالية بيان طريقة توارث صفة خط الساعد الرئيسي والثانوي لكلا الذراعين اليمنى واليسرى في 100 عائلة وشملت (الأب والأم والولد والبنت) حيث تمت دراسة تأثير كل من درجات القرابة الأولى والثانية والثالثة بين الوالدين وكذلك مجاميع دمائهم على انتقال و ظهور هذه الصفة في الجيل الناتج، وتبين عدم وجود أي تأثير معنوي للعاملين على توارث هذه الصفة حيث كانت نسبة الوالدين الغرباء المشمولين بالدراسة 65%. كما لوحظ وجود فروقات عالية المعنوية بين قيم المشاهدة والمتوقعة للمشاهدات التي شملتها الدراسة الحالية باستخدام اختبار مربع كاى حيث ظهر انتقال هذه الصفة من الوالدين إلى النسل الناتج في حالات عديدة وهذا يشير إلى أن وجود أو عدم وجود هذا الخط في النسل الناتج والذي لا يكون صدفة بل يبدو انه محكم بنظام وراثي معين، وقد يؤثر حدوث التغيير الجيني لهذه الصفة او عدم حدوثه اثناء فترة النمو الجنيني او اصابة الام ببعض الامراض الوراثية على ظهور او اختفاء هذه الصفة في النسل الناتج.


Article
Types ,Frequency,Clinical Presentation of Congenital Central Nervous System Anomalies in Al- Kadmayhia Teaching Hospital

Author: Lamyaa Abdul Kareem Hamoodi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 4 Pages: 524-531
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:The central nervous system (CNS)anomalies are the most severe, difficult to detect its etiology, and predict its clinical presentation and course. OBJECTIVE:To find out the common types of congenital malformations in central nervous system.,determine the frequency and the clinical features of these malformations.And to study the risk factors associated with congenital central nervous system malformations.PATIENTS AND METHODS:This cross-sectional study was performed at Al-Kadhimiyia Teaching Hospital (Neonatal care unit) from the 1st of January to the 1st of July, 2011.One hundred newborn infants were proved to have congenital abnormalities by physical examination alone. Fifty five neonates were diagnosed as having CNS congenital anomalies.neonatal evaluation include: gestational age, sex, body weight, type of CNS congenital anomaly.Maternal age, parity, antenatal care, any history of abortion, previous baby with CNS congenital abnormality, still births, or drug intake during pregnancy.the residency of the family and consanguinity .RESULTS:The number of neonates delivered alive was 2700 neonates, one hundred of them (3.7% of total deliveries) were delivered with congenital anomalies, and 55 cases from those (2% from total deliveries / 55% from congenitally abnormal deliveries) have had CNS congenital anomalies,the most frequent anomalies aremeningocele 25( 45.5%),the second and third in frequency were hydrocephaly 12 (21.8%), and myelomeningocele 10 (18.2%) respectively.There were 34(61.8%) male and 21 (38.2%) female. There were 30(54.5%) full term and 25(45.5%) preterm.Thirty cases out of the total 55 cases (54.5%) with body weight 3-3.5 kg.Most of the affected neonates to mothers with an age range of 20-40 years where 34 mothers (61.8%) aged between 20-30 years .Most of the mothers were multipara (45 cases / 81.8%) .The majority of the neonates were the product of a consanguineous marriage 39 (70.9%).Maternal peri-conceptional folic acid supplementation was not taken in the vast majority of cases (43 cases / 78.2%).Positive family history of CNS congenital anomalies was reported in 4 cases only (7.3%) .Familial residence was documented as urban in 30 cases (54.5%), and rural in 25 cases (45.5%).CONCLUSION:The most common type of CNS anomalies is meningocele with relatively higher male to female ratio.These anomalies occur in full term multipara mothers. Occur more frequent in infants with larger body weight and to younger multipara mothers. Consanguinity is a major risk. There was a low utilization of maternal peri-conceptional folic acid supplementation


Article
A Prospective Study for the Outcomes of Thalassemia in Kirkuk 2016
دراسة مستقبلية لنتائج الثلاسيميا في مدينة كركوك ٢٠١٦

Author: Asal Aziz Tawfeeq أسل عزيز توفيق
Journal: kirkuk university journal for scientific studies مجلة جامعة كركوك - الدراسات العلمية ISSN: 19920849 / 26166801 Year: 2017 Volume: 12 Issue: 4 Pages: 140-156
Publisher: Kirkuk University جامعة كركوك

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Abstract

Background: Thalassemia is one of the most globally common chronic hematological disorder. This inherited disorder is characterized by an abnormal production of hemoglobin protein resulting in a life-threatening disease of two main types α and β.In Kirkuk city it was found that, β-thalassemia was the most common disorder and various factors were found to be contributing to the counts of β-thalassemia including ethnic origins and migration that added more burden on the genetic pool of the region and on the inheritance of traits in that area. Objective: Evaluating the prevalence of thalassemia in Kirkuk city according to a number of parameters that included age, gender and ethnic background of patients along with the assessment of the effect of consanguinity marriage on the incidence of the disease.Patients &Methods: Total of (156) clinically diagnosed β-thalassemia patients attending “Thalassemia Unit “ in Azadi Teaching Hospital in Kirkuk City were questionaired and data were divided into four cohorts for evaluation; followed by statistical analysis.Results:No significant difference was detected in β-thalassemia distribution among males and females in Kirkuk city 2016; β-thalassemia was more prevalent in children born following the years of insecurity in the country generally and Kirkuk city especially. In addition, about (77.56%) of β-thalassemia patients were the outcomes of consanguinity marriage from the first degree cousin whom affected with β-thalassemia minor without their knowledge. Additionally, the distribution of β –thalassemia patients between different ethnic groups living in Kirkuk and the surrounding areas indicated a significant difference (p < 0.05) in the incidence of β –thalassemia in Turkman patients who had recorded the lowest incidence rate of (17.31%) compared to the Kurd patients where they recorded the incidence rate of (37.18%) and Arabs where they recorded the highest incidence rate of (45.52%) among total of (156) β –thalassemia patients where most of them came from rural areas or were internally displaced people.Conclusions: β- thalassemia disorder is one of the prevalent inherited diseases in Kirkuk city with increasing frequency among children in the ages of (1-3) years old. Besides, the distribution of β- thalassemia disorder did not vary among males and females in Kirkuk city in the year 2016 and it was concluded that, the frequency of β- thalassemia showed an increase in the years following wars and invasions in Kirkuk city. Moreover, consanguinity marriage increases the frequency of β- thalassemia incidence among both male and female patients. Additionally, individuals with minor β- thalassemia increase the ratio of β- thalassemia incidence among their children and the distribution of β- thalassemia differ according to different ethnic groups.

الثلاسيميا هو واحد من أكثر الاضطرابات المزمنة والاكثر شيوعا في العالم. يتميز هذا الاضطراب الوراثي بإلانتاج المشوه لبروتين الهيموغلوبين تكون نتيجته مهددة لحياة المريض بنوعيه الفا وبيتا . إن الثلاسيميا من نوع بيتا هي الاكثر شيوعا في مدينة كركوك وقد وجدت هناك عوامل كثيرة تؤدي الى زيادة أعداد المصابين بالثلاسيميا منها الاختلافات العرقية والهجرة والتي أضافت ضغوطات الى التنوع الوراثي للصفات في تلك المنطقة.الهدف من الدراسة: لتقييم نسبة انتشار الثلاسيميا في مدينة كركوك نسبة الى عدد من العوامل والتي تضمنت العمر, الجنس والاختلافات العرقية إضافة الى تقييم تأثير عامل زواج الاقارب. المرضى وطرق العمل:مجموع ١۵٦مريض مشخص سريريا يحضرون الى وحدة الثلاسيميا في مستشفى ازادي التعليمي في مدينة كركوك تم استبيانهم وتم تقسيم النتائج الى اربعة مجاميع لغرض التقييم وتم تحليل النتائج احصائيا.النتائج:لم تكن هناك فروقات احصائية في نسبة الاصابة بين المرضى الاناث والذكورالمصابين بالبيتا ثلاسيميا في مدينة كركوك في ٢٠١٦. كانت الاصابة بالبيتا ثلاسيميا اكثر شيوعا بين الاطفال المولودين في السنوات التي تعقب عدم الاستقرار الامني في البلد عموما وكركوك خصوصا. بالاضافة الى ذلك فقد كانت نسبة (۵٦,۷۷%) من المرضى المصابين هم نتيجة لزواج الاقارب من الدرجة الاولى من ابناء العمومة المصابين بالثلاسيميا الصغرى وبدون علمهم بالاصابة.وكذلك فإن نسبة الاصابة بالبيتا ثلاسيميا سجلت النسبة الاقل بين المرضى التركمان بنسبة (١٣,١۷%) يليهم المرضى الكورد بنسبة (١٨,٣۷%) والاعلى بين العرب بنسبة (۵٢,٤۵%) من مجموع ١۵٦مريض أغلبهم جاؤا من مناطق ريفية أو من النازحين. الاستنتاجات: البيتا ثلاسيميا واحد من الامراض الوراثية الشائعة في مدينة كركوك وإن نسبة هذا المرض تزداد في الاعمار (١-٣) سنة ولم تظهر النتائج فروقات معنوية في نسبة انتشار مرض الثلاسيميا بين الاناث والذكور في مدينة كركوك وكذلك فقد وجد ان نسبة انتشار المرض في المدينة تزداد في السنوات التي تلي الحروب والغزو وان زواج الاقارب يزيد من نسبة حدوث المرض وأن الافراد المصابين بالثلاسيميا الصغرى يسببون زيادة في نسبة الاصابة بالثلاسيميا بين اطفالهم بالاضافة الى اختلاف نسبة انتشار الثلاسيميا بين الاعراق المختلفة.


Article
Trends of Neonatal Mortality and Factors Related with Neonatal Mortality Among Neonates admitted to the Neonatal Care Unit of Fatima Al Zahraa Hospital in Baghdad During 2017

Author: Kholod Dhaher Habib, Malik Jamel Kanoon, Ahmed Salih Marzoog, Wafaa Toma Hurmiz
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2018 Volume: 17 Issue: 4 Pages: 348-354
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACK GROUND:The neonatal mortality rate is a key outcome indicator for newborn care and directly reflectsprenatal, natal, and postnatal care. Early neonatal deaths are more closely associated withpregnancy related factors and maternal health, whereas late neonatal deaths are associatedmore with factors in the newborn`s environment.OBJECTIVE:To find out the neonatal mortality rate and to identify the factors related with neonatalmortality among neonates admitted in the Aseptic Neonatal Care Unit of Fatema AL ZahraaHospital.METHODS:A cross - sectional hospital-based study was done depending on data collected from records ofthe Aseptic Neonatal Care Unit (ANCU) of Fatema AL Zahraa Hospital in Baghdad, to findout the number of deaths within the neonatal period (0-28 days) that was conducted from 1st ofJan 2017 to 31st of Dec 2017. Data was also, collected from Obstetrical Ward to determine thenumber of live births for the same period. The data was collected by using special formincluding; the number of deaths in neonatal period, cause of death, neonatal gender, gestationalage, birth weight, mother`s age, educational level, history of congenital anomaly in previouspregnancy , antenatal care, parity, consanguinity, type of delivery, pregnancy outcome, totalnumber of live births, and history of medical disease during pregnancy .RESULTS:The Neonatal Mortality Rate (NMR) was 14.37 per 1000 live birth. NMR was very highamong low-birth-weight preterm infants, (50%) of mothers completed the primary school,(71.89 %) of mothers had positive history for Consanguinity,15% of mothers had positivehistory of congenital anomaly in previous pregnancy,(70.41%) of mothers were in the (20-35years) age group. Normal vaginal delivery (NVD) in (63.01%) of cases. The most commoncause of neonatal deaths in the preterm delivery was respiratory distress syndrome (RDS), andin the full term delivery was asphyxia.CONCLUSION:The neonatal mortality rate was 14.37 per 1000 live birth. The maternal and neonataldemographic data that were related with increased NMR were prematurity, lack of antenatalcare, multipara mother, repeated CS, mother`s hypertension, and consanguineous marriage..


Article
A Study of the Association of Parental Consanguinity with Birth Defects and Neonatal Medical Problems in Babylon Province

Authors: Sijal Fadhil Farhood Al-Joborae --- Ehab Raad Abbas al-Sadik --- Ameer Kadhum Hussein Al-Humairi --- Hadeel Fadhil Farhood Al-Joborae --- et al.
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2018 Volume: 26 Issue: 6 Pages: 143-153
Publisher: Babylon University جامعة بابل

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Abstract

A cross-sectional study of 138 married couples and their offspring was done in Babylon Province from the period between the first of February till the end of April 201 6 .The parents; who were either consanguine or no consanguine, came from mixed urban and rural backgrounds. Socio -demographic and obstetric data were recorded. Neonatal data were extracted from the medical records of the labor and neonatal care wards. The incidence ofcongenitalandbirthdefectswassignificantlyhigherforthoseborntoconsanguineparents especially for first cousin couples. The incidence of congenital abnormalities in newborns of all non-consanguineous parents was 7.1% as compared to 23.2 % for newborns of all consanguineous group. In addition prematurity, history of previous prenatal mortality, and low birth weight were more common in the consanguineousgroup.

شملت هذه الدراسة المقطعية 138زوج وذريتهم في محافظة بابل من الاول من شباط لغاية نهاية شهرنيسان من العام 2016 وقد كان هؤلاء الاباء والامهات خليطا من مختلف مناطق مركز محافظة بابل حيث تم اخذ المؤشرات الديموغرافية لهؤلاء الازواج كما تم اخذ المعلومات الصحية للأمهات واطفالهن وكان مصدر هذه المعلومات هي ردهات العناية بالأطفال حديثي الولادة وكذلك صالات الولادة.وجدت الدراسة ان نسبة عيوب الخلق الولادية كانت اعلى بكثير إحصائيا الازواج الاقرباء مقارنة مع غير الاقرباء وخاصة في زيجات ابناء العم وابناء الخال حيث وجدت الدراسة ان نسبة عيوب الخلق الولادية هي 7.1% في جميع زيجات غير الاقرباء بينما كانت النسبة 23.2% في جميع زيجات الاقرباء.وجدت الدراسة ايضا ان هنالك عوامل مساعدة في زيادة نسبة التشوهات وهي الولادات الخديجة ,وجود وفيات في الاحمال السابقة و نقص الوزن الولادي حيث كانت اكثر في زواج الاقرباء.

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