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Article
The Cytogenetic Effects of Crude Ethanol Extracts of Petroselium Crspum Leaves on Bone Marrow In Mice (Mus Musculus)
التاثير الوراثي الخلوي للمستخلص الكحولي الاثيلي لأوراق المعدنوس Petroselium crispum في خلايا نقي العظم للفئران المختبرية Mus musculus

Authors: أفنان أسماعيل عبد الوهاب --- عباس عبد الله محمد --- شلال مراد حسين
Journal: Engineering and Technology Journal مجلة الهندسة والتكنولوجيا ISSN: 16816900 24120758 Year: 2011 Volume: 29 Issue: 1 Pages: 1-10
Publisher: University of Technology الجامعة التكنولوجية

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Abstract

This study aimed to investigate the cytogenetic effects of ethanol extractof Petroselium crispum leaves on somatic cells of albino mice Mus musculus.Fourdoses (250,500,1000,2000)mgkg were used.Three tests,mitoticindex,micronucleus formation and chromosomal aberration.Results indicated that the extracts have significant effects p<0.05 wereused. which inhibit somatic division in 250 and 500mgkg doses after 21 and 28days (P<0.05) of treatment by comparison with the control. Ethanolic leavesextract showed little effect on micronucleus formation and chromosomalaberration.It can be concluded that the crude extract of leaves for the above plant canbe used in cancer treatment of cancer since it has the ability in inhibition ofsomatic division which has.


Article
Cytogenetic Analysis of Children with Ambiguous Genitalia in Mosul
تحليل الوراثة الخلوية للأطفال الذين لديهم غموض في الأعضاء التناسلية لمدينة الموصل

Author: Sada J. Abdulameer صدى جاسم عبد الامير
Journal: Rafidain journal of science مجلة علوم الرافدين ISSN: 16089391 Year: 2012 Volume: 23 Issue: 3E Pages: 33-37
Publisher: Mosul University جامعة الموصل

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Abstract

The present study aim to investigate the causes and characteristics of ambiguous genitalia in newborn who were referred to cytogenetic laboratory. Cytogenetic analysis was performed for each case. All cases were analyzed by chromosomal study using GTG karyotype. All patients after cytogenetic analysis revealed 46, XX and 46, XY Karyotype. One individual carry a Y chromosome but phenotypically female and one case have a female karyotype but are phenotypically male. The cytogenetic analysis of children with suspected chromosomal aberrations is important to uncover the contribution of chromosomal disorder in genesis of sexual ambiguity and congenital malformation in children and prevent further potentially unpleasant investigation being undertaken

تناولت هذه الدراسة معرفة التركيب أو النمط الوراثي للأطفال حديثي الولادة مع أعضاء تناسلية غامضة ومشوهة من خلال تحليل الوراثة الخلوية عن طريق دراسة الهيئة الكروموسومية. وهي تعد الدراسة الأولى في الموصل. تضمن البحث عشرين طفل. استعملت طريقة التحليل الكروموسومي المباشرة لجميع الحالات.أظهرت النتائج 46XX , 46XY وهي نتيجة طبيعية لعدد الكروموسومات للإنسان الطبيعي لكن الفرق الذي تم الحصول عليه في الأطفال العشرين، ظهور حالة واحدة من الناحية الوراثية ذكر أي النمط أو التركيب الوراثي ذكر لكن النمط أو التركيب المظهري أنثى، وحالة واحدة النمط الوراثي أنثى والنمط المظهري ذكر.إن تحليل الوراثة الخلوية عن طريق دراسة الكروموسومات تدل على وجود خلل وراثي من خلال التغيرات التي حصلنا عليها والاختلاف في النمط المظهري والوراثي في حالات الأطفال مع الغموض والتشوهات في الأعضاء التناسلية لذا يعد هذا التحليل مهماً لمثل هذه الحالات.


Article
Assessment of cytogenetic response after treatment with imatinib mesylate in patients with chronic phase chronic myeloid leukemia

Author: Alaa Fadhil Alwan
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2014 Volume: 3 Issue: 1 Pages: 56-61
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Chronic myeloid leukemia (CML) is a myeloproliferative disorder affecting hematopoietic stem cells andaffects predominantly granulocyte progenitor line. It is characterized by acquired chromosomal abnormality which calledthe Philadelphia chromosome (Ph+) in 95% of cases. Imatinib mesylate is a powerful and selective competitive inhibitorof BCR-ABL tyrosine kinase. Imatinib mesylate is the first molecular target therapy for the treatment of CMLObjectives: The aim of this study was to evaluate the cytogenetic response in 58 patients with CML in chronic phasetreated with imatinib mesylate.Materials and methods: A prospective study conducted at the national center of hematology /Almustansiriya University,Baghdad, Iraq from April 2011 to December 2013, fifty-eight patients with CML in chronic phase (32 male and 26female) were enrolled in this study. All patients were carrying the BCR-ABL fusion gene and treated with Imatinibmesylate (Glivic® Novartis) at 400 mg daily for at least 12 monthsResults: There were 32 male and 26 female with male to female ratio (1.1:1).the median age was 36 year (range 14-64years). The median duration of treatment with imatinib was 18 months (range 12 to 32 months). Complete hematologicresponses (CHR) were attained in 54 of 58 (93%) patients treated during the first 3 months of imatinib therapy, where 11(19%) of patients reached CHR after 1 month, 35 (60%) got CHR within 2 months of treatment with imatinib.Cytogenetic response rates to imatinib therapy at 6 and 12months. : Major cytogenetic response achieved in 35 (70%), 48(92.3%) patients and minor cytogenetic response attained in 15 (30%), 4 (7.7%) patient at 6, 12 month respectively.Imatinib was usually safe and well tolerated. The vast majority of adverse effects were grade 1 and 2 and bone pain wasthe most common (86.2%).Conclusion: After a median follow-up of 18 months, this study confirm that imatinib therapy induced induce durableand sustained hematological and cytogenetic responses in a high proportion of patients with chronic-phase CML. theresponse rates of imatinib therapy were similar to those reported in other countries. Imatinib was safe and well-toleratedwith manageable side effects.

Keywords

cytogenetic response --- imatinib --- CML


Article
In Vivo Toxicity Study of Nerium oleander's Leaves and Flowers Aqueous Extracts in Mice (Cytogenetic, Biochemical and Hematological Study)
دراسة سمية داخل الجسم الحي لتاثير المستخلصات المائية لاوراق وازهار نبات الدفلة في الفئران (دراسة العوامل الوراثية الخلوية والكيموحيوية والدموية)

Author: Maha F. Altaee مها فخري مجيد
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2011 Volume: 8 Issue: 1عدد خاص بمؤتمر علوم الحياة Pages: 366-372
Publisher: Baghdad University جامعة بغداد

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Abstract

The present research was carried out to assess the toxic effect of oral administration of the aqueous extract of Nerium oleander leaves and flowers daily at doses of (25) mg/kg body weight for four weeks in mice. The toxicity of this plant parts was determined after two and four weeks by measuring the parameters of cytogenetic (mitotic index, micronucleus %), and serum levels of the hematological (RBC, Hb, WBC) and biochemical (GOT, GPT, ALT, AST) indexes in comparison with that of the control (normal saline), also clinical signs were determined. The results showed a significant decrease in mitotic index while an obvious raise was seen in micronucleus percentage in comparison with that of the control after the two periods of administration. More over significant marked changes was seen in the level of all the hematological and biochemical parameters when compared with the control. In addition to that, diarrhea with some organ lesions were also observed.

تم تنفيذ البحث الحالي من اجل الكشف عن التاثير السمي للمستخلص المائي لاوراق وزهورنبات الدفلة والمعطى عن طريق الفم وعند الجرعة (25) ملغم/كغم من وزن الجسم يوميا ولمدة اربعة اسابيع في الفئران. قيست سمية اجزاء هذا النبات عن طريق الفم بعد اسبوعان واربع اسابيع من خلال قياس معاملات الوراثة الخلوية (معدل الانقسام الخيطي والنواة الصغيرة) ومعدل التغيرات الدموية (Hb, WBCٌRBC, ) والمؤشرات الكيموحيوية (GOT, GPT, ALT, AST) ومقارنتها مع السيطرة (الدارئ الملحي). أظهرت النتائج وجود تأثير معنوي في اختزال معدل الانقسام الخيطي وزيادة نسبة النواة الصغيرة بالمقارنة مع السيطرة.كما اظهرت النتائج حدوث تغيرات معنوية في معدل جميع فحوصات الدم والكيموحيوية, مع ملاحظة اصابة الفئران بالاسهال وحدوث افات موضعية في بعض الاعضاء.


Article
In vivo cytogenetic and genotoxic effects of curcumin on mouse bone marrow

Author: Mohammed Subhi Mohammed محمد صبحي محمد
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2013 Volume: 9 Issue: 16 Pages: 245-260
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Objectives: Studying the cytogenetic effects of Mytomycin-C by using 2mg/kg by study of (mitotic index, chromosomal aberrations and micronucleus assays) on mouse bone marrow cells (in vivo) and Studying the cytogenetic effects of crude extract of Curcuma longa on mouse bone marrow cells and Studying the ability of crude extract of C. longa in reducing the genotoxic effects induced by Mytomycin-C by combination treatment on mouse bone marrow cells.Material and methodology: Administrative Arrangement: analytical study to period )1 / 5 / 2011 to 1 / 1 / 2012(conducted in Al-Nahrain research Centre for biotechnology, Baghdad, Iraq . Methodology: distributed of mice on equal group each group contain five animals, negative control and injected Phosphate Buffer Solution only and positive control injecte Mitomycin - C 2mg/kg and four groups injected by ethanolic crude extract by uses concentration (400, 200, 100 and 50 mg/kg) depend on LD50 of curcumin extract and study interaction between crude extract and MMC after and befor treatment and determination of active the extract in preventiveor inhibition of side effect Mitomycin - C in vivo. Results: The results indicated that MMC has clear effects in reducing mitotic activity, increased spontaneous chromosomal aberration and increased micronucleus in mouse bone marrow cells (in vivo), these effects suggested that the drug has a genotoxic effect, the cytogenetic effects represented by mitotic index, chromosomal aberration and micronucleus (Mitotic Index, Chromosome abberations, Micro Nucleous) on mouse bone marrow cells (in vivo) of positive control Mitomycin-C use 2mg/kg for one day and gave 1.81% for MI and 4.12% for CAs and 8.13% for MN, and the cytogenetic effects of ethanolic crude extract of Curcuma long extract by administration the animals crude ethanolic extract at different concentration (50, 100, 200 and 400 mg/kg) for 7 days i.p., 50mg/kg was choice to as best dose which there ratio considered increase Mitotic Index (5.40%) and reduce Micro Nucleous (1.801%) and Chromosome abberations (0.774%) relatively was like negative control, the Interaction effect between extract administration pre and post treatment with drug (MMC) was estimated in cytogenetic parameters on mouse bone marrow cells, which gave a protective efficient against the genotoxic effect of Mitomycin - C in mouse bone marrow cells which gave 90% for M.I and 97.55% for CAs and 97.64% for MN, this effect was more efficient in post-treatment than in pre-treatment, ethanolic crude extract of C. longa extract had genotoxic effects at high doses exess of 50 mg/kg and showed Ethanolic crude extract C. longa was considered as fundamental biomutagene in the first degree and desmutagene in second degree as a result of its ability to increase mitotic activity, decrease micronucleus frequency and repair chromosomal aberration in mouse bone marrow cells.

تهدف هذه الدراسة الى معرفة التاثيرات الوراثية الخلوية المتمثلة بمعامل الانقسام الخيطي , والانحرافات الكروموسومية , وتكوين النوى الصغيرة لخلايا نقي العظم للفئران ( داخل الجسم ) للمادة المطفرة (Mitomycin - C ) والمستخدم بتركيز 2mg/kg بعد حقن يوم واحد, والتاثيرات الوراثية الخلوية للمستخلص الايثانولي الخام بواسطة حقن الحيوانات للمستخلص الخام لنبات الكركم C. longa لتراكيز مختلفة (400, 200, 100, 50 mg/kg) لسبعة ايام بواسطة الحقن تحت الغشاء البريتون, ودراسة قابلية المستخلص الكحولي الخام لنبات الكركم في تخفيض التأثير الوراثي السمي الذي تم تكوينه في خلايا نقي الغظم في الفئران. لقد أظهرت النتائج أن العقار Mitomycin - C له تأثيرات سلبية تمثلت بانخفاض معامل الانقسام الخيطي, زيادة التغيرات الكروموسومية و زيادة نسبة تكوين النوى الصغيرة في خلايا نقي العظم في الفئران, هذه التأثيرات أشارت إلى امتلاك هذا العقار تأثيرات وراثية خلوية والذي اعطى 1.81% بالنسبة لمعامل الانقسام (Mitotic Index ) , 4.12% بالنسبة للانحرافات الكروموسومية (Chromosome aberations ), 8.13% بالنسبة لتكون النوى الصغيرة(Micro Nucleous ) بعد حقن يوم واحد. وأظهرت النتائج بان التركيز 50mg/kg كان افضل تركيز والذي اعطى زيادة في MI والتي بلغت 5.40% وانخفاض نسبة CAs, MN والتي بلغت 1.801% , 0.774 على التوالي والذي كان قريب من السيطرة السالبة . وان المستخلص الخام للكركم كان له تاثيرات سمية وراثية في التراكيز الاعلى من 50mg/kg , بينما في التركيز 50 ملغم/ كغم فقد اظهر نسبة حماية ضد التأثيرات السامة للعقار MMC في خلايا نقي العظم للفئران, والتي اعطت نسبة حماية ضد التناثيرات المطفرة ﻟﻠمايتومايسين C .


Article
Micronucleus formation assay and phagocytic index in mice administered water leaf extracts of Camellia sinensis

Authors: Bushra H. Saleh بشرى صالح --- Rukaya M. Ebraheem رقية محمد ابراهيم --- Shahlaa M. Salih شهلاء صالح
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2010 Volume: 52 Issue: 3 Pages: 355-358
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Green tea Camellia sinensis is non fermented tea. The tea is an infusion of flavorful leaves that has been consumed for centuries as a beverage and is valued for its medicinal properties. Over the last few decades green tea has been subjected to many scientific and medical studies to determine the extent of its long-purported health benefits, with some evidence suggesting regular green tea drinkers may have lower chances of heart disease and developing certain types of cancer. Green tea has also been claimed useful for weight loss management.Methods: Three doses of the hot water extract were used (19.2, 38.4 and 57.6 mg/kg) to investigate micronucleus formation and phagocytic index. Mice were divided into two groups. Group one; control and group two; mice were administered with three doses of the green tea extract orally as a single dose (0.1 ml) per day for 7 days. Then the mice were sacrificed in day 8 for immunological and cytogenetic assessments.Results: Results revealed that the first and third doses of green tea hot water extract were significantly effective in enhancing the values of phagocytic index and reducing micronucleus formation.Conclusions: Hot water may be a good solvent to extract active component from Camellia sinensis especially catechin, polyphenols, polysaccharides, flavonoids and vitamins. The high dose of hot water extracts of Camellia sinensis showed an excellent enhancing effects on the function of immune system of mice, moreover, reduction in micronucleus formation was recorded at such dose.Key words: Green tea, Cytogenetic, Immunological effect


Article
Study of Some Cytogenetic Parameters in Azoospermia and Severe-Oligospermia Patient

Authors: Hussien Jassim Obade --- Hazim I. AL-Ahmed --- Saad Mohamed Nada
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2016 Volume: 24 Issue: 2 Pages: 350-356
Publisher: Babylon University جامعة بابل

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Abstract

The aim of this study is to determined micronuclei index, sister chromatid exchange %, in infertile men (azospermai and severe-oligospermia) and compared with fertile men. Thirty patients (20 with azoospermia and 10 with severe oligospermia) and 15 control were studied in this project, The results show significant increase in micronuclei index, sister chromatid exchange %, in patients group compared with control.

ان الهدف من البحث لتحديد فحص دليل تكوين النويات الدقيقة والنسبة المؤية لتبادل الكروماتينات الشقيقة لبيان الدمج في الماده الوراثية. تم دراسة 30 مريض (20 يعانون من انعدام الحيامن و10 مرضى من قلة الحيامن الشديدة) و15 رجال طبيعيين. اظهرت نتائج الدراسة وجود زيادة معنوية في النسبة المؤية للدليل الانقسام الخلوي ، تكوين النويات الدقيقة ونسبة التبادل الكروماتينات الشقيقة للمرضى الذين يعانون من انعدام الحيامن وقلة الحيامن الشديدة مقارنة مع الرجال الطبيعيين.


Article
Cytogenetic Effects Of Tacrolimus After Chronic Oral Administration In Male Albino Rats

Authors: Ali Ibrahim Mohammed AL-Ameedi --- Falah Muosa Kadhim AL-Rekabi --- Zahraa Mohammed Ayad
Journal: Kufa Journal For Veterinary Medical Sciences مجلة الكوفة للعلوم الطبية البيطرية ISSN: 20779798 Year: 2015 Volume: 6 Issue: 2 Pages: 75-80
Publisher: University of Kufa جامعة الكوفة

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Abstract

This study was carried out to investigate cytogenetic effects of chronic exposure of an immunosuppressant Tacrolimus in male albino rats. Thirty albino male rats were divided into 3 equal groups, the first one (T1) administrated orally therapeutic dose 70µg/kg.BW of Tacrolimus. The second group(T2) dosed double dose 140 µg/kg.BW of Tacrolimus, while the third group dosed distilled water with drops of ethanol as solvent like in treated groups and considered as control one(C). cytogenetic study included mitotic index, chromosomal aberration and blast index, the mitotic index showed significant decrease in both treated groups compared with the control one, the blast index showed significant decrease in T2 group compared with T1 and the control group. Chromosomal aberration in the stem cells of bone marrow represented by ring chromosome observed in T2 group which received double dose of drug. In conclusion Tacrolimus chronic exposure in rats indicate some genetic effect which needed more investigations in other species and even man.

اجريت هذه الدراسة لتقييم بعض التاثيرات السمية للتعرض المزمن للمثبط المناعي (التاكروليمس) في ذكور الجرذان المهقاء. استخدم في هذه الدراسة ثلاثون من ذكور الجرذان المهقاء .قسمت هذه الجرذان الى ثلاث مجاميع متساوية حيث جرعت المجموعة الاولى بجرعة علاجية قدرها 70 مايكرو غرام من وزن الجسم في حين جرعت المجموعة الثانية بجرعة مضاعفه قدرها 140 مايكرو غرام لكل كيلو غرام من وزن الجسم ,اما المجموعة الثالثة فجرعت بالماء المقطر مع قطرات من الايثانول المخفف كمذيب كما هو الحال للمجاميع المعالجة وعدت مجموعه سيطرة, تمت دراسة التأثيرات الخلوية عن طريق حساب معامل الانقسام الخلوي ومعامل انقسام الخلايا المولدة للخلايا اللمفاوية اظهر معامل الانقسام الخلوي نقصانا معنويا في كلا المجموعتين الاولى والثانية المعالجة بالعقار مقارنة بمجموعة السيطرة وكذلك اظهر معامل انقسام الخلايا المولدة للخلايا اللمفاوية نقصانا معنويا في حيوانات المجموعة الثانية التي جرعت بضعف الجرعة العلاجية فقط مقارنة بحيوانات المجموعة الاولى التي جرعت بجرعه علاجيه ومجموعة السيطرة . وقد سجلت بعض الزيخ الصبغي في الخلايا الجذعية لنخاع العظم في حيوانات المجموعة الثانية متمثلة بصبغيات حلقيه. نستنتج من هذه الدراسة وجود بعض التاثيرات السمية الجينية لهذا العقار بعد التعرض المزمن حيث تحتاج المزيد من الدراسات على حيوانات اخرى او حتى على الانسان.


Article
Cytogenetic studies of the drug methotrexate (MTX) on the blood lymphocytes of colon cancer patients .

Author: Zainab M. T. Jaafer , Eshmail K. Shubber
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2017 Volume: 16 Issue: 3 Pages: 1-11
Publisher: Baghdad University جامعة بغداد

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Abstract

The aim of study is to investigate the cytogenetic parameters in order to define the effect of methotrexate (MTX) on blood lymphocytes, manifested by blast index (BI), mitotic index (MI), replicative index (RI), and sister chromatid exchanges (SCEs). The results showed significant reduction in BI and MI and RI indices with MTX concentrations (0.0, 0.2 ,0.5 ,1, 2, 4, 8, µg/ml) in comparison with the control. The results of BI showed significant reduction according to increasing of concentration. Of the drug in colon cancer patients, it gave 28.6 %, 18.6 %, 14.5%, 10.4%, 6.8 % , 6.7 %, 3.3% respectively. The results of (MI ) gave 3.6 %, 2.3%, 1.6%, 0.18%, 0.22%, 0.0%, 0.0 % respectively. The values of (RI(, gave 0.72% at zero concentration and 0.44% at concentration of 0.2µg/ml of M% TX and 0.27 % at concentration of 0.5µg/ml. On the other hand the SCE showed increases in the SCEs frequency in colon cancer samples in MTX concentration (0.0, 0.2, 0.5, µg/ml) which gave 8.47, 10.41, 10.49. respectively. The SCEs in the high concentration of drug (1,2,4,8 µg/ml) cannot be detected due to its toxicity of the drug. The mutation fraction increased in colon cancer patient which gave 9 at 0.2 µg/ml, and 15.72 at 0.5 µg/ml and 4.1 in 1 µg/ml. The conclusion demonstrated decreasing in (MI), (BI) and (RI) and increasing in the SCEs frequencies and mutation fraction in colon cancer patients in comparison with the control. The presence of mutant cells in lymphocytes of colon cancer that resistant to MTX, gave an idea about amplification in DHFR gene that regulate the activity of DHFR enzyme and also indicated the resistance of cancer cells to drugs.


Article
Cytogenetic Effects of Gestogens on Women with Threatened Miscarriage in Duhok Province, Kurdistan Region, Iraq

Author: Hayat S. Ahmed, Dian J. Salih, Iman Yousif Abdulmalek1, Asaad A. Alasady
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2019 Volume: 16 Issue: 1 Pages: 41-46
Publisher: Babylon University جامعة بابل

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Abstract

Background: Gestogens have been recommended to have a place in the prevention of threatened miscarriage and spontaneous pregnancyloss during the first 3 months of pregnancy. Certain studies consider that this steroid hormone has genotoxic effect because they directlyinvolved in the change of DNA structure. Objectives: This study aims to investigate the cytogenetic effects of gestogens on peripheral bloodlymphocytes of pregnant women, by damaged cells and chromosomal aberrations, as well as evaluate the models for hormonal therapy in vivo.Materials and Methods: Blood sample from 30 women with threatened miscarriage, who received gestogen therapy in the first 3 months, Weretaken. Cytogenetic analyses and karyotyping were performed for Each patient Before and after therapy. Results: The numerical chromosomalaberrations which found in blood lymphocytes of women before taking gestogens were 44,XX and 48,XX. The same result was observed aftertaking gestogens. The percentage levels of structural chromosomal aberrations were ring chromosome (2.06%), chromatid breaks (12.47%),chromatid gaps (1.65%), dicentric (0.55%), acentric chromosome (4.02%), and interchange chromosome (12.5%). Whereas, the abnormalitiesafter treatment with gestogens were ring chromosome (5.31%), chromatid breaks (42.19%), chromatid gaps (20.86%), dicentric (7.50%),acentric chromosome (17.75%), and interchange chromosome (43.97%). Conclusion: Gestogens as hormonal substitute therapy do notinduce numerical chromosomal aberrations but have a significant increase of structural chromosomal aberrations Gestogens have genotoxiceffects on human lymphocyte chromosomes at wide range of concentrations. So the potential benefits and side effects of it must be weighedup against the deleterious effects.

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