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Article
Subcutaneous Pancreatic Transplantation Shows Success In The Treatment Of Experimentally Induced Diabetes Mellitus In Golden Hamsters

Authors: Salim R Al-Ubaidy** ماهرة نوري، هدى الخطيب ، سالم رشيد العبيدي --- Huda M Al-Khateeb --- Mahera N Al-Shaik*
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 3 Pages: 287-292
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: to evaluate subcutaneous pancreatic transplantation in an experimentally induced diabetes mellitus in golden hamsters. Methods - many indexes (histological /using two stains, histochemical /using three enzymes, morphometrical and biochemical /blood glucose level) were employed in this assessment. Alloxan was used as ك-cytotoxic therapy (to induce diabetes mellitus), and cyclophosphamide was employed as immunosuppressive agent.
Results - high rate of success of transplantation (clearly evident by microscopical features of viable endocrine and exocrine tissue of transplanted pancreas and great tissue vascularization, normal enzymatic activities and significant lowering of blood glucose level) were elicited.
Conclusion – subcutaneous pancreatic transplantation should be thank about in treatment of diabetes mellitus.


Article
Evaluation of Patients with Liver InjuriesTreated by Perihepatic Gauze Packing

Author: Laith Naef Hindosh
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2008 Volume: 4 Issue: 2 Pages: 35-44
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The liver is one of the most common organs injured after blunt abdominal trauma. The control of severe hemorrhage remains a problem.
Methods: One-hundred thirty-eight patients diagnosed as liver injury between 09/2003 and 08/2006 had been evaluated prospectively in Al- Kindy Teaching Hospital.
A distinction was made between hemodynamically stable and unstable patients. Different modalities of surgical procedures were done concentrating on perihepatic gauze packing.
Results: (60 out of 138) patients included in the study were clinically evaluated as hemodynamically stable. The average abbreviated injury severity score (ISS) was 25. Twenty patients underwent abdominal surgery. In 12 of them additional liver treatment was performed. The mortality was three, all were non-liver related.
Seventy eight patients were considered to be hemodynamically unstable, and had an average ISS of 38. All of them needed abdominal surgery.
Gauze packing was used as initial therapy for bleeding control from injured liver in 34 patients of both hemodynamically stable and unstable groups with a mortality of 11 patients (32.7%).
Conclusion: perihepatic gauze packing is considered as a life saving and a quick method for controlling ongoing hemorrhage in the treatment of liver injuries before undertaking definitive repair under controlled conditions.
Key words: surgery, liver injury, and gauze packing.


Article
Evaluation of the Potential Role of Serum Seleniumin Diabetic Patients

Authors: * Abdul Kareem Y. J. Al-Sammraie --- Abbas M. R. Al-Mussawi --- Tawfeeq F. R. AL-Auqbi
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2008 Volume: 4 Issue: 2 Pages: 45-49
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The altered status of some essential trace elements observed in diabetes could have deleterious influences on the health of the diabetics.
Objectives: To estimate and study the potential role of serum Selenium in type 1, type 2 diabetics and healthy subjects; and its relation with lipid profile and glycemic index.
Methods: A case control designed study was carried out at the National Diabetes Center (NDC) / Al-Mustansiria University; on a total of 94 participants formed of 32 type 1 diabetics, 32 type 2 diabetics and 30 healthy control participants. Data collected about age, sex and BMI; also, blood samples examined for FPG, HbA1C, serum total cholesterol, HDL cholesterol, non-HDL cholesterol, serum triglyceride and sera were examined for Selenium by using atomic absorption technique.
Results: Type 1 and type 2 diabetic groups show respectively 75% and 65% decrement in S. Selenium, <70 µg/L. The mean of S. Selenium, age, BMI, waist/hip ratio, FPG, HbA1c, total cholesterol, triglyceride, HDL, Non-HDL and atherogenic index (total cholesterol/HDL cholesterol) for the type 1 and type 2 diabetics shows statistically significant differences from control group. Type 1 diabetics versus type 2 diabetics shows statistically insignificant differences between mean of the S.Selenium, total cholesterol, HDL cholesterol and atherogenic index (t-test, P > 0.05) while the mean of FPG, HbA1c and triglyceride show highly statistical significant differences (t-test, < 0.001).Simple linear correlation and regression analysis of FPG, HbA1c, total cholesterol, triglyceride, HDL, Non-HDL and atherogenic index of the studied groups shows weak to moderate correlation with their serum Selenium levels.
Conclusions: The inverse relationship between Selenium status and glucose tolerance suggest the potential role of Selenium in diabetics. Serum Selenium levels show high statistically significant differences from healthy subjects; while the differences between type1 and type 2 diabetic groups’ shows no statistically significant differences. Inverse correlations and regression were noticed between S.Selenium levels of all studied groups with their FPG, HbA1c, total cholesterol, triglyceride, HDL, Non-HDL and atherogenic index. Low S.Selenium and HDL-cholesterol plus an increase in total cholesterol, non-HDL and atherogenic index enhance risk of cardiovascular diseases progression among the diabetics.
Key Words: Serum Selenium, diabetes mellitus


Article
Precipitating risk factors for diabetic ketoacidosis in children with type 1 diabetes mellitus

Author: Salem Rahma سالم رحمة
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2005 Volume: 31 Issue: 1 Pages: 27-31
Publisher: Mosul University جامعة الموصل

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Abstract

ABSTRACT
Objective: To determine the precipitating risk factors for diabetic ketoacidosis (DKA) from medical and social points of view as well as risk of prolonged hospital stay.
Methods: Forty-eight patients were admitted to Basrah Maternity and Child Hospital for DKA. Over a 2 years period; September 2001 through to September 2003. Patient's age, sex and family socioeconomic status were identified. Duration of hospital stay was examined, prolonged duration of stay was defined as ،ف 7days.
Results: Forty eight patients with DKA, their ages ranged between 1 and 15 years, with a male to a female ratio 1.3:1.
More than half of the children (58.4%) were males and (60.5%) were from low social status. Poor compliance to continue the treatment and infections were the most common precipitating factors, being responsible for 54.2% and 25% of cases of DKA respectively
Children with prolonged hospital stay were significantly found to be of younger age and of low socioeconomic status.
Conclusions: DKA is still a commonly seen complication; it can be the presenting feature of
diabetes. Poor compliance and inadequate treatment are the leading precipitating factors in our patients.


Article
Helicobacter Pylori Infection in Diabetic Patients

Author: Sabeha M. Al-Bayati
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2010 Volume: 9 Issue: 1 Pages: 31-34
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background H Pylori infection could be regarded as the commonest infection worldwide, it had been suggested that H pylori infection is more frequent among diabetics. Objective This study had been designed to define any significant association between diabetes and H pylori infection, to evaluate different demographic features of patients with diabetes mellitus who have H pylori infection, assess any relation between H pylori infection and the metabolic control of diabetes mellitus and to estimate the frequency of different oesophagogastroduodenoscopy findings among diabetic population with H pylori infection. Methods This study enrolled 50 patients with diabetes mellitus and another 50 non-diabetic patients (as a control group). The patients attended Gastrointestinal unit at Al-Yarmouk Teaching Hospital Baghdad/Iraq during the period between the 1st of March2004, to the 31st of November 2004. Full history was taken and clinical examination, investigation to assess the glycemic control and esophagogastroduodenoscopy (OGD)had been done to all of them. H pylori status had been detected by positive Rapid Urease test and histopathology and/or ELIZA test for anti-H pylori IgG. Results This study revealed that 26diabetic patients (52%) were H pylori positive, while 14 non-diabetic patients (28%) were H pylori positive which is statistically significant (X2=6.0,P=0.01). patients aging 60 year old or more (24 patients, 48% of the sample) 18 of them had positive H pylori status, 20 patients out of the 26patients with positive H pylori status (76.9%) had poor glycemic control, 84.6% of those with positive H pylori status (22 out of 26 patients) had glycated hemoglobin level of 8% and greater, 61.8% of those with positive H pylori status (16 patients) were diabetic for more than 10 years. 61.5% of those with positive H pylori status had one or more of the chronic diabetic complications, 12 patients had OGD finding consistent with duodenitis, all of them were H pylori positive, OGD examination revealed 20 cases without active disease, 18 of them had negative H pylori status. Conclusions This study indicates that Helicobacter pylori infection is more common in diabetic patients. Frequency of H pylori infection is higher among elderly diabetics, those with long standing, poorly controlled and with diabetic complications.


Article
Prevalence of Silent Bacteriuria in Patients with Diabetes Mellitus

Author: Firas Elias Douri
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 1 Pages: 60-64
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Diabetes mellitus and it’s complications continue to carry a major health problem. There is evidence thatdiabetics are more prone to urinary tract infection.AIM OF THE STUDY:The study was done to assess the prevalence of significant bacteriuria in patients with no urinarysymptom.METHODS:Midstream urine samples were collected from 200 diabetic patients. There were 102 females and 98 malesand 80 urine samples from non diabetic persons as control were screened for bacteriuria.RESULTS:Out of 200 diabetic urine samples 18 patients [9%] had significant bacteriuria while 2 urine samples[2.5%] of non diabetic samples has significant bacteriuria. Three types of bacteria were isolated fromurine samples,Escherchia coli, Staphylococcus, and Proteus and Escherchia coli was the high in numberamong the other genera.CONCLUSION:Analysis of the results showed significant bacteriuria in diabetic patients compared with non diabeticpatients {p value < 0.05}.


Article
ANEMIA IN DIABETIC PATIENTS WITHOUT MICROALBUMINURIA; IN RELATION TO TYPE OF DIABETES, GLYCEMIC CONTROL AND hs-C REACTIVE PROTEIN LEVELS

Authors: Adeeb Abbas Al-Shami --- Abbas M. Rahma --- Shatha H. Ali --- Ali Mohammed Ali Hussein
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2010 Volume: 13 Issue: 3 Pages: 110-119
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Recent studies have highlighted on association between anemia and the development andprogression of diabetic nephropathy. There is also an increased cardiovascular risk in patients withdiabetic nephropathy and a clear association between anemia and abnormal cardiac function,although most patients in the previous studies have type 2 diabetes mellitus. The present studyfocused on the possible variations in hematological parameters as well as hs-CRP levels in anemictype 1 and type 2 diabetics without microalbuminuria, in relation to their glycemic indices.The study groups compromised of 50 diabetic patients (25 with type 1 and 25 with type 2) whohad been selected to have haemoglobin levels below the gender specific normal range with negativemicroalbuminurea, in comparism to two control groups of 16 and 18 healthy subjects,respectively,whom are age and sex matching of type 1 and type 2 patients.For this the patientsblood specimens were taken for testing blood levels of haemoglobin, red blood cellscount,reticulocyte count, Hb A1C levels; as well as fasting serum glucose, serum insulin, C-reactiveprotein levels.The results indicated that anemia in both types of diabetes was not related to any of the RBCindices(MCV, MCH, MCHC), results are not shown, but it s related to lowered total number ofRBC as compared to their controls. Meanwhile,their was no evidence of an increased reticulocyte inthe studied groups of either types of diabetes, indicating a defective erythropoiesis rate, although theselected patients were without detectable nephropathy (ve testing for microalbuminuria).Furthermore, the reduction in RBC count was not significantly correlated with glycemic indices(FPG, FPI, HbA1C, QUICKI). However, hs-CRP levels were significantly elevated in diabeticpatients, but CRP levels were significantly correlated with fasting serum insulin in type 2diabetics,but not in type1. Which may indicate a role for inflammation in type 2 diabetes incontribution to insulin resistance that may provide an additional risk factor for cardiovasculardiseases in this type of diabetic whom have anemia as well.

أشارت الدراسات الحديثة على وجود علاقة بين كلمن فقر الدم وظهور وتطور أمراض الكلى لدى المصابينبداء السكري. إضافة إلى زيادة نسبة الخطورة في مرضىالسكري الذين يعانون من اعتلال الكلى نتيجة السكريبسبب وجود علاقة واضحة بين كل من فقر الدم واختلالوظيفة القلب، على الرغم من إن معظم هذه الدراسات تمتعلى النوع الثاني من السكري. ان هذه الدراسة التي تركزعلى احتمالية ظهور اختلافات في بعض مؤشرات الدم وكذلك بمستوى البروتين – سي الفعال في مصل المرضىلكلا النوعين الاول والثاني من السكري من المصابين بفقرالدم بدون اعتلال الكلى (عدم وجود آثار للألبومين فيالادرار).تضمنت الدراسة 50 شخصا من المصابين بالسكري25 منهم من النوع الاول و 25 من النوع الثاني) تم )اختيارهم ليكون مستوى خضاب الدم لديهم اقل من مستواهالطبيعي حسب جنس المريض، من الذين اظهروا نتائجسلبية في فحص وجود آثار للألبومين في الادرار. تماستحصال نماذج الدم بعد الصيام لقياس مستويات كل من خضاب الدم وعدد الكريات الحمر وعدد الخلايا الشبكية فيالدم اضافة الى مستوى الخضاب المرتبط بالسكر وكذلكمستويات كل من السكر والانسولين والبروتين – سي الفعالعالي الحساسية.أظهرت النتائج ان فقر الدم في المجاميع المدروسة لمتبين اي اختلال في معايير الكريات الحمر (معدل حجمالكرية، معدل الخضاب فيها، معدل تركيز الخضاب فيها) –لم تبين النتائج هنا. ولكن كان فقر الدم يعزى بالدرجةالاساس الى انخفاض في تعداد الكريات الحمر لدىالمرضى من كلا النوعين عند المقارنة بالاصحاء.على الغممن عدم وجود اي مؤشر لزيادة مستوى الخلايا الشبكية فيالدم في اي من المجاميع المدروسة من مرضىالسكري.مما قد يؤشر وجود خللا في عملية صنع الخلاياالحمر، على الرغم من اختيار المرضى غير المصابينباعتلال الكلي حسب الفحص السلبي لأثار الالبومين فيالادرار. كما ان تناقص اعداد الكريات الحمر لم يكنمرتبطا احصائيا بأي من المؤشرات علي درجة سكرية الدم(فحص السكر، مستوى الانسولين،مستوى الخضاب المرتبطبالسكر، معدل التحسس للانسولين). في حين كان مستوىسي- بروتين الفعال عالي الحساسية شديد الارتفاع فيالمرضى حين المقارنة بالاصحاء، وكان ايضا مرتبطابمستوى الانسولين في حالة الصيام لدى مرضى النوعالثاني من السكري فقط مشيرا الى احتمالية وجود دورلعملية الالتهاب في مقاومة الانسولين والتي قد تزيدعاملخطورة اومؤشرا اضافيا للاصابة بامراض القلب فيمرضى النوع الثاني من السكري المصابين بفقر الدم


Article
Serum copper levels in Non-Insulin Dependent Diabetes Mellitus

Author: HAZZIM H. EDAN
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2006 Volume: 6 Issue: 1 Pages: 36-41
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: The findings of previous research on the status of trace elements in diabetic patients have been controversial.A comparative study of serum copper in diabetic patients and healthy Iraqi controls is becoming important, particularly after the dietary shortage, as sequel of 13 years of sanctions.Objective: To study the difference of serum copper between the diabetic patients and healthy Iraqi people.Method: This is an outpatient-based study; it was carried out in AL-Rhasid Military Teaching Hospital during a period from March 2002 till February 2003 the study included seventy –four non insulin dependent diabetic patient (NIDDM) aged (40-62) year, forty – four from which have retinopathy and twenty – four have albuminuria (>50 mg/day) other seventy normal healthy control with comparable age (38-65) year. Blood samples were drowning fasting and the blood was left at room temperature for 10 minuets. Centrifuged 3000 rpm for 10 minuets, then serum was separated and stored at –20c0. The urine sample taken freshly, randomly on early morning and urine albumin was measured quantitatively by Lowry method, data were analyzed and compared with previous study resultConclusion: The clinical significance of serum copper in diabetes mellitus remain conflicting as well as controversial and many questions still remain unanswered but the decreased serum copper found in NIDDM in our study may merit further investigation of the relationship between copper and non-insulin dependent diabetes.


Article
ROLE OF VISFATIN IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS

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Background:The recently discovered adipocytokine visfatin has insulin-like properties. It lowers blood glucose and improves insulin sensitivity; however, clinical data on visfatin are limited.Objective:To evaluate the role of visfatin in GDM (gestational diabetes mellitus), we determined visfatin levels in women with GDM and healthy pregnant women.Methods:A total of 60 women were evaluated: 30 women with gestational diabetes mellitus and 30 healthy pregnant women to serve as control subjects. Serum visfatin concentrations were analyzed using an enzyme-linked immunosorbent assay the study was done in Al-Yarmouk Teaching Hospital during the period from November 2010 to March 2011.Results:Serum visfatin concentrations were significantly lower in the gestational diabetes mellitus group (0.27±0.1 ng/ml) than in the healthy control group (1.37±0.25ng/ml) (P=0.0001). Conclusions:Our results show that there are decreased concentrations of serum visfatin in gestational diabetes mellitus subjects and this may indicate that visfatin plays a role in the pathogenesis of gestational diabetes mellitus .However; further experiments are needed to clarify this role.Key Words:Visfatin, Gestational Diabetes Mellitus


Article
The Pattern of Skin Lesion in a Sample of Iraqi Diabetic Patients
نمط إصابات الجلد في عينة من مرضى داء السكري العراقيين

Authors: Khalil l. Hamdi د. خليل إسماعيل الحمدي --- Sarkis K. Strak د. سركس
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2006 Volume: 19 Issue: 1 Pages: 78-80
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract: Five hundred thirty two diabetic patients were studied during a period of 3 years their ages ranged between 11-74 years with a mean age of 37.8 years. The male: female ratio was 1.5:1.The diabetes in 186 patients (34.9%) was of insulin dependant type while in the remaining 346 patients (65.1%) the disease was of non-insulin dependant variety. The duration of the disease among our patients varied from six month to 19 years. The skin lesions were detected in 294 (55.3%) of the patients. The dry scaly skin with exaggeration of normal markings and varia1ble degree of hair loss particularly affecting the skin of the lower Limbs, in addition to shin spots and increased susceptibility to various infections were the commonest skin lesions reported in the patients.The occurrence of skin lesions in diabetic patients was found to be proportional to the duration, type and the state of the control of the disease. In conclusion, skin should not be forgotten as a common site for long term diabetic complication.Key Words: skin lesion, diabetes mellitus

الملخص: تمت دراسة 532 مريضا مصاب بداء السكري خلال ثلاث سنوات وكانت أعمارهم تتراوح بين 11-74 عاما وبمتوسط عمر يساوي 37.8 سنة كما كانت نسبة الذكور الى الاناث 1:1.5 ان داء السكري في 186 مريضا (34.9%) كان معتمدا على الأنسولين في علاجه بينما كان الباقون (346 مريضا) لا يتعاطون الأنسولين وكانت مدة المرض في المرضى المشمولين في الدراسة تتراوح بين 6 شهور-19 عاما0 لقد عثر على الطفح الجلدي في 55.3% من المرضى المصابين بداء السكري وكان جفاف البشرة وتقشعرها مع زيادة وضوح خطوط الجلد وفقدان الشعر بدرجات متفاوته وخصوصا في الأطراف السفلى بالإضافة الى بقعة الساق وازدياد الإصابة بالتهابات الجلد الخمجية اكثر الإعراض الجلدية انتشارا بين مرضانا0أثبتت الدارسات كذلك آن مدة الإصابة بداء السكري ونوع العلاج ودرجة السيطرة على مرض السكري هي اكثر العوامل تاثيرا في نسبة الإصابة بالطفح الجلدي ذي العلاقة بهذا المرض0 ويمكننا الاستنتاج بأننا يجب آن لا ننسى الجلد كموقع محتمل لمضاعفات السكري على المدى البعيد وقد تهدد إصابات الجلد هذه حياة المريض

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