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Plateletpheresis adverse events in relation to donor and plateletpheresis session profile

Authors: Rajni Bassi --- Kusum K. Thakur --- Kanchan Bhardwaj
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2017 Volume: 6 Issue: 2 Pages: 38-42
Publisher: Al-Mustansyriah University الجامعة المستنصرية


INTRODUCTION: Increasing demand of platelet transfusions for patients has led to a trend in theincreased use of automated blood collections. These share many of the same reactions and injuriesseen with pooled platelets obtained from whole blood donation but also have unique complications.AIMS AND OBJECTIVES: To study the adverse events (AEs) of plateletpheresis procedure andtheir relationship with donor and plateletpheresis procedure session profiles.MATERIALS AND METHODS: This is a retrospective observational study conducted from January2016 to December 2016. A two-hundred and thirteen (213) plateletpheresis procedures wereperformed after taking informed and written consent from the donor. All the donors were male andselected according to the guidelines laid down by Director General of Health Services. The AEs wereclassified into donor related, kit/equipment related and technique related.RESULTS: A total of 13 AEs were noted; of which, 8 (61.53 %) events were associated with donors,3 (23.07 %) were owed to fault in kit/equipment and 2 (15.384 %) were due to technical aberrations.Donor related AEs included vascular injuries [n = 3 (1.40%)], vasovagal reactions [n = 2 (0.938%)]and perioral tingling sensation [n = 3 (1.40%)]. Technique related AEs [n = 2 (0.938%)] and kit/equipment related AEs [n = 3 (1.40%)] were due to faulty technique and defective kits respectively.CONCLUSION: Apheresis donations performed on cell separators are safe. Meticulous donorvigilance, superior technical personnel training and experienced transfusion medicine specialist’ssupervision will make donor’s experience more pleasant.

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