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Article
A comparative study between the effects of two different antihypertensive drugs on the salivary flow rate and salivary compositions

Author: RafiL H. Rasheed رافل رشيد
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2005 Volume: 17 Issue: 1 Pages: 43-46
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: This study investigated the possible abnormalities and variations in salivary flow rate and compositions in two groups of patients under the effects of two different types of antihypertensive drugs (Atenolol and Captopril) one on hand compared with third group of normotensives (As control) on the other hand.Results: It was obvious that there is marked reduction in the salivary flow rate in those taken the antihypertensive drugs in comparison with control group of normotensives. Significantly elevated levels of potassium, phosphorus, and proteins had been realized as first result of this study which might be explained due to the continuous adrenergic over stimulation of salivary gland in hypertensives under taking Atenolol, magnesium in saliva appear reduced in treated hypertensives with Captopril than with Atenolol. Whereas there is dropping in the level of sodium in the two groups than in the control.


Article
Drugs Use for Diarrhoea In Children At Home

Author: Luay Al-Nouri
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 2 Pages: 122-127
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND :Children's acute diarrhea is an extensive global problem .It has increased in Iraq seventeen fold afterwars and economic sanctions. Proper management is important in saving lives and prevention ofcomplications. We wanted to see what drugs were used, how often and how it compared with oralrehydration use.METHOD:The mothers of 175 children who presented with diarrhoea of acute onset and admitted to theChildren Welfare Hospital, Baghdad, over a period of 8 months were interviewed.RESULTS:Apart from 39 children, who had parenteral infections, two had celiac disease and one accidentallyingested a laxative, the others were diagnosed as gastroenteritis at hospital. Of the 102 childrendiagnosed as gastroenteritis before admission, 29(28%) had their stools microscopically examinedand a parasite was found in 12. Seventy- three (75%) of those who did not have stools examined, and(59%) of those who had no parasites demonstrated in stool were given antibacterials (metronidazole,gentamicin, amoxycilin, +/- cloxacilin, co-trimoxazole). Many had antiemetics and anti spasmodics.Oral rehydration solution (ORS- WHO) was given to (46%) of patients.CONCLUSION:Seventy-Four (73%) of children with gastroenteritis were given anti bacterials at home and less thanhalf had ORS.

Keywords

Drugs --- Diarrhoea --- Children .


Article
A clinicopathological review of amiodarone-induced thyroid disorders

Authors: Mohanad M. Al-Hendawi --- Hussein H. K. Abbas --- Ammar W. Ashor
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2012 Volume: 11 Issue: 1 Pages: 1-4
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Certain drugs could disturb physiological function and anatomical structure of thyroid gland and; to some instance, the peripheral thyroid hormone metabolism as part of their adverse reactions. In fact, commonly prescribed drugs including anti-convulsants, non-steroidal anti-inflammatory drugs, Beta-adrenoceptor antagonists, steroid hormones and heparin may produce an abnormal thyroid function test, albeit an absence of detected clinical features for thyroid dysfunction. Therefore, it is recommended to undertake a routine monitoring of thyroid function test, both at baseline and every 3 to 6 months thereafter, in vulnerable individuals (for example, those with thyroid antibodies or euthyroid goiter) receiving such medication.

Keywords

Thyroid --- Drugs --- Amiodarone


Article
Low grade Gliomas Multi Modality Approach

Author: Ali K. AL-Shalchy* MBChB FlCMS FlCNS MRCSI د. علي كامل الشالجي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 3 Pages: 251-253
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:Background: Gliomas are brain tumours of supporting tissue of the brain. The management of low grade glioma is still a great debate ranges from just follow up to extensive surgery followed by DXT, with or without chemothery.Patients and Methods: 282 patients taken from neuro-surgical hospital between 1980-1990, divided to 3 groups with different modality of management & follow up for 15 years. Results: the five years survival and symptomatic improvement was higher in the group managed by extensive surgery and DXT with or without cytoxic drugs followed by group managed by biopsy and DXT with or without cytoxic.Conclusion: management of low grade glioma symptoms & out come (survival) is best by extensive surgery & DXT with or with out cytotoxic, followed by biopsy & DXT with or without cytotoxic drugs.Keywords: glioma, DXT, cytotoxic drugs.

Keywords

glioma --- DXT --- cytotoxic drugs


Article
Re evaluation Of The Activity Of Some Antibacterial Drugs Against Clinical Isolates Of Staphylococcus Aureus In Al_Najaf Al_Ashref Governorate

Authors: Adel .H. Sheeh --- Saif Jabbar Yasir --- Saad .B .Nashtar
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2013 Volume: 3 Issue: 2 Pages: 81-89
Publisher: University of Kufa جامعة الكوفة

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Abstract

Background: Staphylococcus aurous one of the most common pathogen that cause a wide range of infectionstarted by simple skin infection and end by septicemias and high possibility of death .The study aimed to: present study try to evaluate the sensitivity and resistance pattern of staphylococcusaureus against Gentamycin, Cotrimethoprim, Amoxicillin and Cefalexin .Methods: A 55 isolates of staphylococcus aureus obtained from urine, pleural fluid, joint aspiration, ear, skin,and pus, of indoor and outdoor patient in AL-SADER teaching hospital, AL-NAJAF AL-ASHREF, IRAQ.From a period extended between 9-1-2009---- 8-3-2010.And each isolate was tested for these 4 antibacterialdrug .Results: and results showed that Gentamycin has the highest percentage of sensitivity by staphylococcusaureus (34.83%) while Amoxicillin showed the highest percentage of resistance by staphylococcus aureus (30%).Conclusion: Gentamycin was the drug of choice in treatment of staphylococcus aureus infection in al-najaf alashref.Recommendation: we recommend further evaluation about antibacterial sensitivity together with college ofmedicine.

خلفیة البحث:المكورات العنقودیة واحدة من اكثرانواع البكتریا المسببة للأمراض في الإنسان وطبیعة الإمراض الناتجة منھا تمتاز بالمدى الواسعحیث تبدأ بالتھاب الجلد البسیط ویمكن أن تنتھي بتسمم الدم واحتمالیة الموت .ھدف الدراسة: في ھذه الدراسةا حاولنا اختبار مدى حساسیة البكتریا العنقودیة لأربعة أنواع من المضادات الحیویة وھي الجنتامایسینوالكوترامیثوبریم والاموكسسلین والسیفالكسین ومن خلال العینات البالغ عددھا 55 عینة من البول والفم والجروح والقیح من مرضى مستشفى. 2010-3 - 2009 لغایة 8 —1- الصدر التعلیمي في مدینة النجف الاشرف – العراق في الفترة الممتدة من 9النتائج: أظھرت الدراسة أن الجنتامایسین كان أكثر أنواع المضادات الأربعة تحسسا من قبل البكتریا وبنسبة تحسس مقدارھا 34.83 % بینما.% أظھرت الدراسة أن والاموكسسلین اظھر أعلى نسبة من المقاومة( مقارنة بباقي الأنواع من البكتریا ) ومقدارھا 30الاستنتاج: ان الجنتمایسین ھو المضاد الحیوي الافضل والانسب لعلاج التھابات المكورات العنقودیة في النجف الاشرف.التوصیات:نوصي ان تقوم الدوائر المعنیة باعادة تقییم دوري للمضادات الحیویة المستعملة بشكل دوري بالتعاون مع الباحثین في ھذا المجال فيكلیة الطب.


Article
Starch Sulfonation and Substitution with Amoxilline and Folic acid
سلفنة النشا وتعويضه بالاموكسلين وحامض الفوليك

Author: Shurooq S. Kadhim شروق صباح كاظم
Journal: journal of the college of basic education مجلة كلية التربية الاساسية ISSN: 18157467 Year: 2013 Volume: 19 Issue: 80 / علمي Pages: 851-858
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Starch was sulfonated and substituted by Amoxilline and folic acid as natural drug polymer . Starch derivatives were characterized using FT.IR and UV spectroscopies. The synthesis and behavior of bioactive polymeric systems have attracted great interest in this work because the drug is lined to the polymer back – bone via a degradable chemical bond and it is slowly released under appropriate condition. The intrinsic viscosities were calculated using Ostwald viscometer at 30ºC. The controlled drug release was studies in different pH values. Thermal analysis was recorded and physical properties were measured.

تمت سلفنة النشا وتعويضه بالاموكسلين وحامض الفوليك كبوليمرات دوائية معوضه , شخصت باستخدام الاشعة تحت الحمراء والاشعة فوق البنفسجية . ان تحضير بوليمرات فعالة بايولوجياً من الانجازات المثيرة للاهتمام بسبب ادخال وحدات دوائية ضمن الهيكل الرئيسي للسلسلة البوليمرية والتي تساعد على حصول تحلل من خلال الأواصر التي تساعد على التحرر الدوائي تدريجياً تحت ظروف مناسبة . قيست اللزوجة الجوهرية بدرجة 30ºم , ودرست سرع التحرر الدوائي المحكم بدوال حامضية مختلفة . سجلت التحاليل الحرارية للبوليمر المحضر , وقيست الخواص الفيزيائية للبوليمرات المحضرة .الكلمات المفتاحية : نشا , سلفنة , ادوية

Keywords

Starch --- Sulfonation --- Drugs


Article
Compliance to Antituberculous Drugs among Patients in Erbil, Kurdistan Region of Iraq

Author: Shapol Jalal Kokha Ubed, Hamanejm H. Jaff
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2019 Volume: 16 Issue: 2 Pages: 99-103
Publisher: Babylon University جامعة بابل

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Abstract

Introduction: In Erbil, Kurdistan region of Iraq, some patients registered with tuberculosis (TB) diagnosis in Chest and Respiratory DiseasesCenter have interrupted treatment before completing their course, and many patients take their treatment irregularly due to different reasons. Inthis study, we try to determine the percentage of patients who are noncompliant to antituberculous drugs, to know the causes of noncomplianceand to compare the outcome of patients taking drugs irregularly to those who take them regularly. Materials and Methods: Patients enrolled inthis study were those who were diagnosed as having TB and registered in Erbil Chest and Respiratory Center during the years 2015 and 2016.Data were collected from patient forms and registers. For most patients, the causes of interruption in the course of treatment are not documentedin the registers, and thus patients had been called by phone to know factors behind that. Results: Among 394 patients registered in this study,it was found that 57 patients (15%) registered to having TB have been registered as default from the treatment and 14 patients (3.55%) haveinterrupted their treatment because they had been wrongly diagnosed as TB. Fifteen patients (3.8%) have completed their treatment, but theirfollow‑up was not documented. One (0.25%) of the patients completed his treatment outside Iraq. Another patient was originally from othergovernorates (Al‑Anbar) and completed his treatment when he returned to his governorate. Two (0.5%) were non‑Iraqi patients who returnedto their countries and their outcome is unknown. Five (1.27%) of the patients stopped treatment due to side effects of drugs; three (0.8) of themwere told by the referring doctor to stop treatment. Conclusion: Most TB‑infected patients who were registered in Erbil Chest and RespiratoryDiseases Center were compliant to the treatment but with occasional interruptions. Not all patients who were registered as default were reallydefaulters as many of those have completed their treatment, but their follow‑up was not documented, and many were misdiagnosed as TB


Article
Prevalence of Anemia among Iraqi Patients after Renal Transplantation

Authors: Intisar Y. Al-Ani --- Qais H. Al-Tai --- Makarim Q. Al-Lami مكارم اللامي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2011 Volume: 53 Issue: 2 Pages: 121-125
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Although the issue of anemia after renal transplantation (RT) has received increasing attention lately, the data on the exact prevalence of post-transplantation anemia (PTA) in the Iraqi patients are limited.Objective: In this study we sought to determine the prevalence of PTA among Iraqi patients and to correlate the renal allograft function measurements and the use of immunosuppressant with the prevalence of anemia.Patients and Methods: One hundred and twelve (74 male, 38 female) kidney transplant recipients (KTR) attending the kidney transplant center at surgical specialties hospital were studied. All patients were on maintenance, combined immunosuppressive therapy. The renal function tests [blood urea, serum creatinine, and creatinine clearance] and the hematological tests [Hb, HTC, and white blood cell count (WBC)] were determined in all patients. Anemia was defined according to the gender-specific K/DOQI classification. Results: In this study, we identified anemia (Hb < 12 g/dl in males and Hb < 11 g/dl in females) in 25% of the patients (28 out of 112).The anemic patients had a significantly higher mean blood urea and serum creatinine levels and lower mean creatinine clearance level than the non-anemic patients. Among the immunosuppressant drugs, patients on tacrolimus combined with mycophenolate mofetil (MMF) had significantly lower Hb and HTC compared with patients without such treatment. Conclusion: Anemia is common in Iraqi patients after RT. The PTA is associated with impaired renal allograft function when compared with non-anemic RTR. Immunosuppressant including tacrolimus combined with MMF was correlated with decreased Hb and HTC concentrations.


Article
SPECTROPHOTOMETRIC ASSAY OF SOME SULPHONAMIDE DRUGS VIA OXIDATIVE COUPLING

Authors: Saladdin M.AL. Talib --- Deia. A.A Youns --- Razan Y. Q. Al – Abachi
Journal: AL-TAQANI مجلة التقني ISSN: 1818653X Year: 2009 Volume: 22 Issue: 2 Pages: 9-16
Publisher: Foundation of technical education هيئة التعليم التقني

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Abstract

sulphonamide drugs in aqueous solution is described. The method is based on the oxidative coupling reaction of phenothiazine with sulphonamide drugs in the presence of N-chlorosuccinimide as oxidizing agent forming an intense green, water- soluble dye and has a maximum absorption at 610 nm. The molar absorptivities range from 16.23×103 to 25.99×103 l.mol-1. cm-1 and Sandell sensitivities range from 0.986 X 10-2 to 1.542×10-2 μg .cm-2. The method is applied successfully for the determination of sulphonamide drugs in bulk and some of their pharmaceutical preparations with comparable to the standard method (Bratton-Marshall).

يتضمن البحث طريقة طيفية بسيطة وسريعة وحساسة لتقدير بعض أدوية السلفانوميد في محلول مائي. تعتمد الطريقة على تفاعل أقتران تأكسدي لأدوية السلفانوميد مع الفينوثايزين بوجود N- كلوروسكسيناميد كعامل مؤكسد حيث تكونت صبغة خضراء ذائبة في الماء تعطي أعلى امتصاص عند طول موجي مقداره 610 نانوميتر. تراوح معامل الامتصاص المولاري بين 16.23×103 الى 25.99×103 لتر. مول-1 . سم-1 وتراوحت حساسية سياندل بين 0.986×10-2 الى1.542 x 10-2. مايكروغرام. سم-2 . طبقت الطريقة بنجاح في تقدير أدوية السلفانوميد غير المعبئة وبعض مستحضراتها الصيدلانية بمقارنة النتائج مع الطريقة القياسية ( براتون – مارشال ) .


Article
THE EFFECT OF AQUEOUS AND ALCOHOLIC EXTRACT OF CYPERUS LONGOUS (CYPERACEAE) AND TOW DRUGS (TINIDAZOLE AND PRAZIQUANTEL) ON KILLING THE PROTOSCOLICES OF ECHINOCOCCUS GRANULOSUS IN VITRO.
تأثيـر المستخلـص المائــي والكحولي لنبات السِعد

Author: Fatin Abdul.Jabbar-Mustafa فاتن عبدالجبار مصطفى
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: 18138497 Year: 2009 Volume: 8 Issue: 2 Pages: 148-160
Publisher: Basrah University جامعة البصرة

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Abstract

The protoscolices of Echinococcus granulosus in vitro compared with the two drugs Tinidazole and Praziquantel using the concentrations (5 , 10 , 15 , 20) % of the plant extracts and (1.25 , 1.8 , 2.5) % for Tinidazole and (0.1 , 0.15 , 0.2) % for Praziquantel respectively. The study shows that the aqueous extract at 20% have showen highest protoscolicidal activity. All the protoscolices were killed in the first day after treatment. While the concentration 5% shows the lowest activity in killing the protoscolices which was in the 6th day , while the time of killing protoscolices was in the 3rd day and 2nd day at the concentration (10 , 15)% respectively. There is no significant differences between aqueous and alcoholic extract of Cyperus longous P< 0.01 , so aqueous extract used in our study because of its lower price and its safety. Tinidazole and Praziquantel have showen the great activity on killing the protoscolices in the 30 & 60 minutes at (2.5 , 0.2) % respectively. The preservative solution (Hankُ s solution). Keep the protoscolices viable 59% to 21 days.

أختير نبات السِعد Cyperus longous (Cyperaceae) والمتواجد في محافظة البصرة لغرض تقييم فعالية مستخلصه المائي والكحولي ضد حيوية الرؤيسات الأولية لطفيلــي المشوكة الحبيبية Echinococus granulosus في المختبر مقارنة مع فعالية العقارين تينيدازول وبرازيكوينتل وذلك باستعمال التراكيز (20 , 15 , 10 , 5) % للمستخلص النباتي المائي والكحولي و (2.5 , 1.8 , 1.25)% , (0.2, 0.15 , 0.1)% للعقارين تينيدازول وبرازيكوينتل على التوالي . أظهرت نتائج الدراسة أن المستخلص المائي بتركيز 20 % يملك أكبر فعالية في قتل الرؤيسات حيث قتلت جميع الرؤيسات الأولية في اليوم الأول من المعاملة بينما أظهر التركيز 5 % أقل فعالية في قتله للرؤيسات الأولية وكان في اليوم السادس من بدء المعاملة بينما تراوح زمن قتل الرؤيسات في اليومين الثالث والثاني عنـد استعمال التراكيز (15 , 10) % على التوالي . ولا توجد فروق معنوية عند استعمال المستخلص الكحولي للنبات ولنفس التراكيز أعلاه عند المستوى P<0.01 فلهذا اعتمد على دراسة المستخلص المائي لقلة تكلفته ولضمانته . عقاري التينيدازول و البرازيكوينتل أظهرا فعالية كبيرة في قتلهما للرؤيسات الأولية فقد كان زمن قتلهما في الدقيقة 30 والدقيقة 60 عند التراكيز (0.2 , 2.5) % على التوالي , حافظ المحلول هانك على حيوية الرؤيسات بنسبة 59 % لغاية اليوم 21 .

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