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Article
Angiotensin Converting Enzyme Inhibitors, to Continue or Discontinue on the Morning Day of Surgery

Authors: Sabah Noori Al-saad --- Arkan Muhammed Mahdi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: 2 Pages: 208-212
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND:Angiotensin converting enzyme inhibitors(ACEI) play a pivotal role in the management ofhypertension(11). whether to continue or discontinue them before surgery is an everyday encounteredquestion of both surgeon & patient, this issue is continuously submitting to debate & controversy.OBJECTIVE: To compare between the incidence of intra-operative hypotension in hypertensive patients whocontinue to take ACEI. & those who discontinue, & are undergoing general anesthesia for non-cardiacsurgery.PATIENTS AND METHOD:A comparative study consist of 40 patients presented to the Medical City, Baghdad Teaching Hospital& Surgical specialty Hospital between July 2011,to March 2012.the age of patients range from 38-70years old, they were 10 (25 %) men and 30 (75 %) women , they were divided into two groups;according to mode of medication, cases ( who were continued taking medication ) and control (whowere discontinued medication),twenty patient each, all patients underwent different surgicalinterventions under general anesthesia, they were studied & monitored intra-operatively regardingdevelopment of hypotension, this was done at time interval of 5 minutes & at starting point prior toinduction of general anesthesia until 20 minutes after.RESULTS: By comparing the mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) in betweenboth groups of patients, those who were continued ACEI (group A) or those who werediscontinued(group B), it had been found that no significant differences in mean SBP neither preoperativelynoratdifferenttimeintra-operatively.P.valueinallcomparisonswas>0.05.CONCLUSION:Continuingor discontinuing ACEI before non-cardiac surgery under general anesthesia has nostatistical significance regarding concern of developing intra-operative hypotension.


Article
Studying the effect of Metformin and Enzyme inhibitor drags on the level of aromatase Enzyme in the women have hormone disorder the Kirkuk city
دراسة تأثير عقارMetformin و مثبط الإنزيم على مستويات إنزيم Aromatase Enzyme في النساء المصابات باضطرابات هرمونية في مدينة كركوك.

Author: Saria Naji Muhsin ساريا ناجي محسن
Journal: Univesity of Thi-Qar Journal مجلة جامعة ذي قار العلمية ISSN: 66291818 Year: 2019 Volume: 14 Issue: 1 Pages: 62-71
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

This study included ( 100 ) samples of women used drugs Metformin, enzyme inhibitor in (Azadi General Hospital) (20) blood samples aspirated from healthy women as control sample. The samples were divided into three groups; the first group (40) women used Metformin (have primary infertilits), the second group (40) women used Letrazole (have Secondary infertilits). The third group was the healthy women(control). The results of the study indicated a significant decrease (p<0.05) in the Activity of Aromatase level in Primary infertile women age groups (18-25), (26-35) and (36-45). the results of this study reveal that three is significant decrease in the Activity of Aromatase (p<0.05) in women who have Secondary infertility with age groups (18-25), (26-35) and (36-45). This Drugs causes decreasing the level of the Estrogen by inhibiting the Aromatase Enzyme . The Drugs also called as (Enzyme inhibitor) because they inhibit Aromatase enzyme, This proves that the Letrazole Drugs has an effective role in stimulating ovulation in women who have primary and secondary infertility

شملت هذه الدراسة (100) عينة من النساء يستخدمن عقاري Metformin ومثبط الإنزيم في (مستشفى أزادي العام) في مدينة كركوك.(20) عينة دم سحبت من نساء غير مصابات كعينة ضابطة.العينات قسمت إلى ثلاثة مجاميع’المجموعة الأولى(40)من نساء يستخدمن عقار Metformin (مصابات بالعقم الأولي),المجموعة الثانية:(40)من نساء يستخدمن عقار مثبط الإنزيم(مصابات بالعقم الثانوي), والمجموعة الثالثة (20) من نساء غير مصابات كعينة( ضابطة) .لقد بينت نتائج البحث بوجود انخفاض معنوي في مستوى فعالية إنزيم الارومتيزعند مستوى(p<0.05) في مجموعة النساء المصابات بالعقم الأولي للفئات العمرية (18-25), (36-45)’ (26-35). و أظهرت نتائج البحث أيضا انخفاضاً معنوياً p <0.05) ) في مستويات فعالية إنزيم الأرومتايز في مجموعة النساء المصابات بالعقم الثانوي للفئات العمرية (18-25), (36-45)’ (26-35). هذا العقار يسبب انخفاض عالي في معدلات الاستروجين بواسطة تثبيط فعالية إنزيم الأرومتايز,وكذالك يدعى هذا العقار (Enzyme inhibitor) لأنه يثبط إنزيم الأرومتايز .وهذا يبرهن إن عقار Letrazole له دور فعال في تحفيز الاباضة في النساء المصابات بالعقم الأولي والنساء المصابات بالعقم الثانوي .

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