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Article
STUDY THE EFFECT OF EXOGENOUS ESTROGEN ADMINISTRATION ON PROSTATE GLAND OF LABORATORY WHITE MICE (MUS MUSCULAUS)
دراسة تاثير الحقن الخارجي للاستروجين على غدة البروستات في الحيوانات المختبرية البيضاء

Author: Mukhallad A. Ramadhan مخلد عبد الكريم رمضان
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2013 Volume: 12 Issue: 1 Pages: 275-285
Publisher: Basrah University جامعة البصرة

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Abstract

A substantial advance in our understanding on the estrogen signaling occurred in the last decade. Estrogens interact with two receptors, ESR1 and ESR2, also known as ERα and ERβ, respectively. ESR1 and ESR2 belong to the nuclear receptor family of transcription factors. 24 male mice divided into four groups as following : negative control, low dose group, intermediate dose group and high dose group, the groups of treatment were injected with estrogen at different doses while the negative control group were injected with normal saline (by method of intramuscular injection for all groups) and after 6 weeks all animals had been killed and the prostate was picked up and sectioned to reveal the histopathological changes. the study found that the injection of exogenous estrogen result in marked hyperplasia of the prostatic tissue and the hyperplasia increased significantly with elevation of the estrogen dose. In conclusion injection of exogenous estrogen lead to prostate hyperplasia through its action on the estrogen receptors which present in both stromal and epithelial component of the prostate

Keywords

estrogen --- ESR1 --- prostate


Article
ESTIMATION OF ESTROGEN AND PROGESTERONE AFTER LAPAROSCOPIC OVARIOCTOMY IN BITCHES
تقييم المعايير الهرمونية (الاستروجين والبروجسترون )بعد استئصال المببيض بواسطة الجراحة المىظارية في إناث الكلاب

Author: Wisam Ghanim Sahar Abd Al Bari Abbas Al-fars وسام غانم سهر , عبد الباري عباس الفارس
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2013 Volume: 12 Issue: 2 Pages: 237-241
Publisher: Basrah University جامعة البصرة

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Abstract

This study was planned to assess the effect of laparoscopic ovarioctomy in bitches on estrogen and progesterone hormones levels pre and post operation .The hormonal analysis was performed by Serum which was extracted from blood samples , the hormonal test include ( estrogen and progesterone ) , by using a device called Mini vidas system hormones assay with the kit of Bio merio of same company and then results were recorded , which include decrease in level of ( estrogen and progesterone ) post operation in two groups , but the level of depression in group B ( bilateral laparoscopic ovarioctomy ) more than group A ( unilateral laparoscopic ovarioctomy

Keywords

Estrogen --- Serum --- Ovarioctomy


Article
Histological Evaluation of Local Estrogen Administration on the Healing of Trau-matic Alveolar Bone Defect in Rabbits (Experimental Study)

Author: Asmaa S Aldouri
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2013 Volume: 13 Issue: 21 Pages: 72-80
Publisher: Mosul University جامعة الموصل

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Abstract

Aims:This study carried out for histological assessment of the effect of local administration of estrogen hormone after mixing with collagen fiber of bovine bone on healing oftraumatic alveolar bone defect in the rabbits.Materials and Methods:Eight Rabbits were used, the vertical fissure was done in the man-dibular alveolar bone of the control group was filled with natural collagen fiber of bovinebone, while in the experimental group , this fissure was filled with estrogen hormone mixed with natural collagen fi-ber of bovine bone.Histological studies and statistical analysis were done.Results:The results showed that local administrations of estrogen hormone enhance new bone formation and new vascularization which is statistically significant when compare with control group.Conclusions: This study illustrate that the estrogen has an osteoinductive action to enhance bone healing process. Biostatistical analysis was shown significant relation; so bone healing enhanced by this material.

Keywords

Estrogen --- Alveolar Bone --- Healing


Article
Effect of Metronidazole drug in the Levels of some Pregnancy Hormones during Blastocyst Implantation in Rat Uterus
تاثير عقار الميترونيدازول في مستويات في بعض هرمونات الحمل خلال غرس الكيسة الاريمية في رحم الجرذ

Authors: Kadhim M. Haddao --- Akram Y. Yasear --- Hussain A. Abdullatif
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2014 Volume: 12 Issue: 3 Pages: 9-15
Publisher: Kerbala University جامعة كربلاء

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Abstract

This study aimed to determine the effect of metronidazole (MTZ) drug on the levels of progesterone and estrogen hormones during blastocyst implantation in the pregnant rat uterus during the implantation period. Understanding the roles of the variety of pregnancy hormones in uterine receptivity for implantation is essential to enhancing reproductive health and fertility in humans and domestic animals. Forty eight female rats of confirmed pregnancy have been used ,divided into two treated groups received oral dosage commercial drug, 9 mg / 200 gm of life body weight as treatment dose of drug, 18 mg as double the treatment dose and 27 mg as the triple treatment dose. The results of this study revealed that taking treatment dose and double dose of the drug for 7 dpc group of pregnant rats cause decrease the level value of estrogen hormone in blood serum but this decrease didn’t reach significant level p>0.05. It was significant p<0.05 at the triple dose, and it is significant p<0.05 inversely for 9 dpc period, It means that the estrogen hormone level was decreased when the drug dose was increased were there were significant decrease p<0.05 in the value of progesterone level of blood serum at treatment dose, double and triple dose of the drg. There was significant affect p<0.05 for the mean of progesterone level in blood serum of the treated animal.

هدفت الدراسة الحالية إلى تبيان اثر عقار الميترونيدازول التجاري على معدلات قيم مستويات هرموني البروجيستيرون والاستروجين خلال غرس الأجنة في رحم الجرذ في اليومين السابع والتاسع من الحمل، حيث ان تقبل الرحم لانغراس الكيسة الاريمية في هذين اليومين يعتمد على هذين الهرمونين وفهم ادوارهما وغيرهما في تقبل الرحم لانغراس الكيسة الاريمية ضروري إلى تَحسين صحة الحوامل والخصوبة في البشر والحيوانات الأليفة. تم استخدام 48 جرذاً أنثى جرعت فمويا 9 ملغم من العقار / 200 غم من وزن الحيوان الحي و 18 ملغم و 27 ملغم يوميا ولمدة سبعة أيام وتسعة أيام ومن اليوم الأول من تأكيد الحمل. اجريت الدراسة في 2012 بوحدة ابحاث الرزازة وغربي الفرات - جامعة كربلاء. أظهرت النتائج الاحصائية أن تجريع عقار الميترونيدازول بجرعة علاجية وضعفها أدى إلى انخفاض في مستوى هرمون الاستروجين في مصل دم الجرذان الحوامل الا انه لم يصل إلى مستوى المعنوية p>0.05 في حين أن تجريعها بثلاثة أضعاف الجرعة قد أدى إلى انخفاض معنوي p<0.05 في مستوى الهرمون. وعلاقة الارتباط r غير معنوية p>0.05 عكسية لفترة 7 أيام ومعنوية p<0.05 عكسية لفترة 9 أيام. وهذا يعني ان مستوى الاستروجين قد انخفض عند زيادة جرعة الميترونيدازول الى ثلاثة اضعاف الجرعة العلاجية . وان تجريع العقار بجرعة علاجية وضعفها وثلاثة اضعافها قد أدى إلى انخفاض معنويp<0.05 في قيمة مستوى هرمون البروجيستيرون بمصل الدم وان علاقة الارتباط معنوية p<0.05 عكسية


Article
In vivo histological evaluation of the effect of the topical application of estrogen hormone on wounds healing in ovariectomized rabbits

Authors: Bayan Jaber Al-Kadhimy --- Ban A. Ghani
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 1 Pages: 100-104
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Wound healing, as a normal biological process in the human body, is achieved through four preciselyand highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. Growth factors released inthe traumatized area promote cell migration into the wound area (chemotaxis), stimulate the growth of epithelialcells and fibroblasts (mitogenesis), initiate the formulation of new blood vessels (angiogenesis), and stimulate matrixformation and remodeling of the affected region. One of factors that effects on wound healing is a sex hormonesand one of these hormones is an estrogen hormone. A wide range of cutaneous cell types (eg, fibroblast,endothelial, epithelial, and inflammatory) expressed estrogen receptors, indicating potential estrogenresponsiveness.Materials and methods: Thirty two female New Zealand rabbits were used in this study. All animals wereovariectomized, and incisional wounds were done on the right (experimental for estrogen hormone application) andleft (control) sides of face for each animal, the control side was left to heal normally. Histological assessmentregarding the count of inflammatory cells was performed for healing intervals (3, 7, 10, 14 days).Results: Topical estrogen hormone application revealed enhancement of wound healing by reducing wound sizeand stimulating matrix deposition in comparison to control.Conclusion: Topical estrogen cream application results in significant progress of cutaneous wound healing, leavingno scar or crust formation and can minimize the probable wound complications


Article
STUDY THE EFFECT OF FLAX LIGNAN EXTRACT OF LINUM USITATISSIMUM AND CONJUGATED ESTROGEN ON PHYSIOLOGICAL PARAMETERS IN FEMALE RATS

Author: Wafaa H. Haran Muna H. AL-Saeed Eman A. AL-Masoudi
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2017 Volume: 16 Issue: 1 Pages: 20-49
Publisher: Basrah University جامعة البصرة

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Abstract

This study was carried out in the animal house of the College of Veterinary Medicine /Basrah University to evaluate the effect of lignan extract of flax seed on haematological, biochemical parameters and histological examination in female rats, compared with conjugated estrogen drug. For this purpose, eighteen female rats weighed (180-200g) and aged (4-5 months) was divided into 3 equal groups (6 rats / group) for 14 days.First group: Drenched 1ml of normal saline (0.9% of NaCl)for 14 days.Second group: Drenched 0.10mg/kg B.W of conjugated estrogen dissolved in normal saline (0.9% of NaCl) for 14 days.Third group: Drenched 20mg/kg B.W of lignan extract of flaxseeds dissolved in normal saline (0.9% of NaCl)for 14 days. Blood samples were collected from heart by cardiac puncture from all experimental animals. These samples are used for the measurement of haematological and biochemical parameter as well as hormonal assy. Thyroid glands, liver, kidneys, ovaries and uterus were removed for histopathological study. The results revealed that, the female rats treated with lignan extract of flax seeds showed an increase in body weight. The result also showed that treated female rats with phytoestrogen had no significant effect on blood parameters except a significant effect on lymphocytes. (P≤ 0.05) in serum lipid profile except HDL compared to control. Moreover the results of biochemical parameters were indicated the affected in female rats treated with lignan extract that the revealed a significant(P≤ 0.05) decrease in serum lipid profile except HDL-Ch of female rats treated with lignan extract compared with the control group. Also the treatment with lignan extract caused significant (P≤ 0.05) increase in LH hormone, estradiol and progesterone compared with .While it has no significant effect on FSH. The treatment showed some ameliorative effect on histological structure of studied organs.


Article
Breast Carcinoma in Young Woman :Pathological and Immunohistochemical Study

Author: Sura Salman Ejam
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 3 Pages: 817-827
Publisher: Babylon University جامعة بابل

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Abstract

The aim of study is to study the pathological types and the immunohistochemical properties of breast carcinoma young women and compared it with older womenThis study included 80 paraffin embedded samples from female patients with breast carcinoma which were collected randomly from period of November 2010- November 2013 in AL-Hilla Teaching hospital. The clinical informations were collected including ages of the patients, histopathological types, & tumor grades from clinical reports of the hospital. A manual avidin biotin peroxidase complex procedure (ABC) system was used in the imunohistochemical analysis (Dako Cytomation Copenhagen, Denmark).In this study, the histopathological examination of the 80 cases revealed that , 5 (6.25%) cases were of the pure in situ ductal type, 65 (81.25%) cases were of the invasive ductal carcinoma not otherwise specified, 7 (8.75%) cases were of the invasive lobular carcinoma, and 1 (1.25%) case was of each of the medullary, mucoid, squamous (metaplastic) types.In the 80 cases of breast carcinoma that were studied, ER expression was positive in 8 cases (17.39%), PR expression was positive in 22 cases (27.5%), HER2/neu expression was positive in 20 cases (23.75%). There were higher proportion of ER and Her2 negative breast carcinoma in early aged patients than the older patients so the early onset breast according to the immuno -histochemical parameters have the worse prognonsis than the late onset group.


Article
INCREASED EXPRESSION OF ESTROGEN RECEPTORS AT THE MATERNO-FETAL INTERFACE IN PATIENTS WITH RECURRENT PREGNENCY LOSS
ارتفاع نسبة التعبير الموضعي لمتلقيات الايستروجين في حالات فقدان الحمل المتكرر

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Abstract

Background: Estrogen hormone has been implicated in the pathogenesis of different genital tract pathologies and in counteracting the progress of normal pregnancy.Objective: Localization and semi-quantization of estrogen receptors at the materno-fetal interface in patients with recurrent pregnancy loss (RPL).Methods: Immunohistochemistry analysis of estrogen receptors using paraffin embedded sections of curate samples obtained from 40 women, who where divided into three groups: 24 women with RPL, 10 women with abortion for the first time, and 6 women with induced abortion.Results: The mean value of the expression of estrogen receptors was (71.2 ± 2.3), which is significantly higher than that of the second group (52.2 ± 3.2), and the third group (43.7 ± 4.2), (p=0.001).Conclusion: High expression of estrogen receptors in women with RPL may give a clue to its prominent role in the pathology of pregnancy loss. Key wards: Estrogen receptor, RPL.

خلفية الدراسة: اوجدت الدراسات علاقة اعتراضية لهرمون الايستروجين واستمرارية الحمل بصورة طبيعية.هدف الدراسة: التحديد الموضعي وتقييم متلقيات الايستروجين في حالات فقدان الحمل المتكرر.المرضى وطريقة الدراسة: استخدمت تقنية التصبيغ الكميائي النسيجي المناعي لمتلقيات الايستروجين في عينات الجرف الرحمي والتي تم الحصول عليها من 40 امراة تم تقسيمهن الى ثلاثة مجاميع: 24 امراة حصل لها فقدان حمل متكرر، 10 نساء حصل لهن اجهاض تلقائي للمرة الأولى، و ستة نساء أجري لهن عملية انهاء حمل علاجي.النتائــج: كانت مستويات التعبير الموضعي لمتلقيات الايستروجين في حالات فقدان الحمل المتكرر ذات زيادة ملحوظة مقارنة مع المجموعتين الثانية والثالثة (p=0.001) .الاستنتاج: ان ارتفاع نسبة التعبير الموضعي لمتلقيات الايستروجين في حالات فقدان الحمل المتكرر قد يدل على دورها المهم والفعال في مرضية فقدان الحمل.مفتاح الكلمات: متلقيات الايستروجين, الاجهاض المتكرر


Article
Effects of estrogen replacement therapy on symptoms and clinical parameters in post menopausal women

Authors: Norjihan Ali Shaban --- Kawa Dizaye كاوة
Journal: Iraqi Journal of Pharmacy المجلة العراقية للصيدلة ISSN: 16802594 Year: 2011 Volume: 11 Issue: 2 Pages: 46-57
Publisher: Mosul University جامعة الموصل

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Abstract

Objective: To evaluate the effect of oral estrogen replacement therapy (ERT) in healthypostmenopausal women on lipid profile, body mass index (BMI), blood pressure, andblood glucose; and on postmenopausal symptoms.Subjects and Methods: This prospective cohort research was carried out over a periodof eight months, from Jun 2007 to February of 2008. Fifty six postmenopausal women(mean SD age of 53.3±3 years; mean menopausal period, 5 years); previously diagnosedby gynecologist were involved in this study. Thirty six postmenopausal women weretreated with oral conjugated equine estrogen (CEE) (premarin®) 0.625 mg daily for twomonths. Twenty postmenopausal women were served as control and received daily doseof placebo.Results: In postmenopausal women treated with conjugated equine estrogen, serum totalcholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were decreasedsignificantly as compared with placebo, while there was no significant change in theserum level of high-density lipoprotein cholesterol(HDL-c). In both groups, estrogeninduced changes in plasma triglyceride and reduced the size of LDL particles. Theseobservations suggest that the plasma TG increase may reduce the size of LDL particle.CEE lowered blood pressure, decreased fasting blood sugar and increased BMI ofpostmenopausal women . Significant positive correlation was found between the BMIand total blood cholesterol whereas significantly negative correlation was found betweenthe BMI and LDL of treated postmenopausal women. CEE effectively alleviatedbothersome symptoms of postmenopausal women such as hot flushes, night sweat andvaginal dryness. Whereas, it has no detectable effects in attenuating bone pain.Conclusion: CEE causes change in lipid profile, BMI, blood pressure and attenuatesbothersome symptoms in postmenopausal women.

الهدف: لتقييم تأثير العلاج التعويضي لعقار الاستروجين عن طريق الفم في النساء في سن الأمل على واجهة الدهون ومؤشر كتلة الجسم وفرط الدم الشرياني ومستوى السكر قي الدم وعلى أعراض سن الأمل.الأشخاص وطرق العمل: أجريت هذه الدراسة المستقبلية نوع كوهرت خلال فترة ثمانية أشهر من حزيران 2007 ولغاية شباط 2008. وشملت الدراسة 56 من النساء في سن الأمل ( معدل العمر ± الانحراف المعياري:53± 3 سنة ومعدل فترة سن الأمل 5 سنوات). وكانت الدراسة تحت إشراف أخصائية في الأمراض النسائية. وأعطي عقار الاستروجين المتحد والمشتق من الخيل وبجرعة 0,625 ملغم في اليوم ولمدة شهرين ل 36 امرأة. أما العينة الضابطة فقد شملت 20 امرأة في سن الأمل وأعطيت جرعة كاذبة يوميا ولمدة شهرين.النتائج: أدى علاج النساء في سن الأمل لعقار الاستروجين المتحد والمشتق من الخيل إلى خفض مستوى الكولسترول الكلي ومستوى البروتين ألشحمي خفيض الكثافة مقارنة بالمجموعة الضابطة. بينما لم يكن هناك تغيير معنوي في مستوى البروتين ألشحمي عالي الكثافة. كما ان الاستروجين المتحد قلل من فرط الدم الشرياني ومستوى السكر في الدم ورفع مؤشر كتلة الجسم. كما قلل الاستروجين المتحد من الأعراض المزعجة المرافقة لسن الأمل مثل الاحمرار الحار وألتعرق الليلي والجفاف المهبلي بينما لم يؤثر العقار على الم العظام.الاستنتاج: سبب الاستروجين المتحد والمشتق من الخيل تغييرا في واجهة الدهون ورفع مؤشر كتلة الجسم وبينما قلل من فرط الدم الشرياني ومستوى السكر في الدم و من أعراض سن الأمل عند النساء.


Article
Study the Pathological Effects of the Combination of Estrogen and Progesterone Hormones on Some Organs Experimentally Induced in Mice
دراسة التاثيرات المرضيه المستحدثه تجريبياً لخليط هرموني الاستروجين والبروجسترون على بعض الاعضاء في الفئران

Author: Hana Kudair Abbas هناء خضير عباس
Journal: The Iraqi Journal of Veterinary Medicine المجلة الطبية البيطرية العراقية ISSN: 16095693 Year: 2012 Volume: 36 Issue: 1 Pages: 128-136
Publisher: Baghdad University جامعة بغداد

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Abstract

The aim of this study was design to investigate the pathological changes for one month after therapeutic and toxic doses of subcutaneous injection of estrogen and progesterone combination hormones in mice, on the target organs testis and epidydimus in males and uterus and ovary in females. As well as the effects on non-target organ of Brain, liver spleen, intestine, stomach, kidney and lung in both sexes. The results showed sever pathological changes in male's testis and epidydimus and in females, uterus and the ovary. It is characterized by some pathological changes in toxic group less severity than in the therapeutic group. Also, in non-target organs brain and spleen of toxic group of males and females showed some pathological changes while therapeutic group almost appear normal. The liver and kidney were affected in both groups (therapeutic and Toxic) in males and females. Other organs like intestine stomach, Lung doesn't showed any change in both groups

هدفت هذه الدراسة الى التحري عن التغيرات النسجيه المرضية الناجمة عن حقن هرموني الاستروجين والبروجسترون في الفئران لمدة شهرتحت الجلد، تم أخذ الخصي والبربخ في الذكور والارحام والمبايض في الاناث وكذالك تاثيرها على الدماغ والكبد والطحال والامعاء والكلى و المعدة والرئة في كلا الجنسين . نتائج التجربة تشيرالى وجود تغيرات شديدة في المجموعة السمية, اما في المجموعة العلاجية كانت اقل حدة. اما الاعضاء الاخرى الغير مستهدفة كالدماغ، والطحال، والكبد، والرئة، والمعدة ،والامعاء، والكلى، فقد وجدت التجربة وجود تغيرات مرضية في الدماغ، والطحال في المجموعة السمية في كلا الجنسين، الامر الذي لم يلاحظ في المجموعة العلاجية. اما الاعضاء الاخرى كالكبد، والكلية فقد وجدا متأثرين في كلا المجموعتين، وفي كلا الجنسين. بالنسبة للأعضاء الاخرى كالمعدة، والامعاء، والرئة فلم تظهر اية تغييرات نسجية.

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