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Article
Glycemic Control in A Sample of Iraqi Patients with Type 2 Diabetes in Response to Nateglinide: Preliminary Study.

Author: Fadhil Al-Douri
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 2 Pages: 182-186
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Nateglinide, structural derivative of the amino acid D-phenylalanine, is a stimulator that controls the meal time spikes to restore of the early phase of insulin secretion lost in type II diabetes.OBJECTIVE:To evaluate the efficacy and tolerability of nateglinide in combination with metformin in a sample of Iraqi type II diabetic individuals,and to look for its side effects.Setting: The Specialized Center of Endocrinology and Diabetes-Baghdad.Design: During the period between September 2001 and January 2002 a sample of ten type II diabetic patients whose glycemic control is poor on metformin glibenclamide combination. Glibenclamide was replaced by nateglinide. Postprandial plasma glucose levels were checked frequently, and glycosylated hemoglobin (HBa1c) was evaluated in the 24th and 32nd week of the study period.RESULTS:It has been found that using nateglinide in a dose of 120 mg before each main meal three times daily does not reduce plasma glucose HBa1c to the desired levels, but using it in a dose of 180 mg before each meal results in gradual satisfactory decrement in plasma glucose and HBa1c. No adverse effects were recorded and metformin - nateglinide combination was well tolerated.CONCLUSION:Nateglinide and metformin improve overall glycemic control. Nateglinide decreases meal time glucose excursions. Their combination has a complementary effect, improving HBa1c and postprandial hyperglycemia. No adverse effects were recorded and metformin - nateglinide combination was well tolerated.


Article
Use of Silymarine as Adjuvant in Type 1 Diabetes Mellitus Patients Poorly Controlled with Insulin

Authors: Saad A. Hussain سعد حسن --- Nasreen Sh. Mohammed نسرين محمد --- Naseer A. Hadi نصير عبد الامير هادي --- Ahmad T. Numan احمد نعمان
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 1 Pages: 74-78
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Glycemic control and prevention of secondary complications are the most important aims of using pharmacological treatments in diabetes mellitus. Due to the high incidence of inadequate response to insulin and, we try to evaluate the effects of adjunct use of silymarin with insulin on glycemic control, lipid profile and renal function in type 1 diabetes mellitus patients. Patients and Methods: Placebo-controlled, doubled blinded clinical trial method is utilized through which 60 type 1 DM patients allocated into two groups, 30 patients treated with insulin and silymarin 400 mg/day in two divided doses, while the other 30 patients treated with insulin and placebo for 60 days. Fasting serum glucose, HbA1c, C-peptide, lipid profile and microalbuminuria were evaluated at base line and after 60 days. Results: Compared with placebo, silymarin significantly improves the effects of insulin through the reduction of fasting serum glucose, HbA1c and increase C-peptide level, associated with improving lipid profile and renal function. Conclusion: Adjunct use of silymarin with insulin improves glycemic control associated with improving lipid profile and renal function, an effect that may be related to increased insulin sensitivity in peripheral tissues.Keywords: Silymarin, Type1 DM, Glycemic control


Article
Novel Insulin & Better Glycemic Control in Type 2 Diabetics

Author: Hazim A. Abdulwahab
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2009 Volume: 8 Issue: 1 Pages: 8-12
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background Recently a new premixed insulin analogue has been introduced with good results achieved in different parts of the world particularly regarding good glycemic control and safety. Objective This clinical study was conducted to evaluate the effectiveness and safety of introducing new insulin (biphasic insulin aspart 70/30)for the treatment of type 2 diabetic patients. Methods This prospective follow up study included 68 type 2 diabetic patients who has been randomly selected from those attending the National Diabetes Centre (NDC)of Almustansiria University during the period between 1st of oct.2004 to 31st of march 2005.Each patient had been followed for an average period of 6 months. Detailed history had been recorded and thorough physical examination has been performed for each patient. Readings of fasting and postprandial plasma glucose (FPG,PPPG), HbA1c,body mass index (BMI), and the frequency of hypoglycemic attacks had been recorded at the baseline ,interim, and the final visit which had been separated by 3 months between each other. At the baseline visit , each patient has been instructed how to use insulin pen properly and biphasic insulin aspart 70/30 had been supplied to the patients included in this study freely. Statistical analysis using students t-test had been used to assess the difference between different means using a p value of less than 0.05 as the level of statistical significance. Results This study showed that there was significant difference between the mean human insulin dose used before the study(48.3u/day) and the mean premixed insulin Aspart (36.88u/day) P value less than 0.05.The use of insulin analogue was associated with significant reduction in FPG (130.5mg/Dl in the last visit ,compared with 216mg/Dl in the 1st visit )P value less than 0.001,and the PPPG (160.2mg/Dl compared with 280mg/Dl in the 1st and last visit respectively)P value less than 0.001, and the mean HbA1c (7.1% compared with 9.41%)P value less than 0.001.There was no significant difference between the 1st and last visit recordings of BMI (27.9Kg/m2 compared with 28.1Kg/m2 respectively )P value more than 0.05 ,and in the average incidence of mild hypoglycemic episodes (1.01 compared with 0.42 episode respectively)P value more than 0.05. Conclusion This study showed that the use of this type of insulin analogue for type2DM lead to marked and statistically significant improvement in the glycemic control ,mainly in the PPPG. In addition the use of this type of insulin was associated with only mild elevation in the BMI and slight lowering in the incidence of hypoglycemic episodes ,both non-significant statistically.


Article
Novel Insulin & Better Glycemic Control in Type 2 Diabetics

Author: Hazim A. Abdulwahab
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2008 Volume: 7 Issue: 2 Pages: 8-12
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Recently a new premixed insulin analogue has been introduced with good results achieved in different parts of the world particularly regarding good glycemic control and safety.Objective: This clinical study was conducted to evaluate the effectiveness and safety of introducing new insulin (biphasic insulin aspart 70/30)for the treatment of type 2 diabetic patients.Methods: This prospective follow up study included 68 type 2 diabetic patients who has been randomly selected from those attending the National Diabetes Centre (NDC)of Almustansiria University during the period between 1st of oct.2004 to 31st of march 2005.Each patient had been followed for an average period of 6 months. Detailed history had been recorded and thorough physical examination has been performed for each patient. Readings of fasting and postprandial plasma glucose (FPG,PPPG), HbA1c,body mass index (BMI), and the frequency of hypoglycemic attacks had been recorded at the baseline ,interim, and the final visit which had been separated by 3 months between each other. At the baseline visit , each patient has been instructed how to use insulin pen properly and biphasic insulin aspart 70/30 had been supplied to the patients included in this study freely. Statistical analysis using students t-test had been used to assess the difference between different means using a p value of less than 0.05 as the level of statistical significance.Results: This study showed that there was significant difference between the mean human insulin dose used before the study(48.3u/day) and the mean premixed insulin Aspart(36.88u/day) P value less than 0.05.The use of insulin analogue was associated with significant reduction in FPG (130.5mg/Dl in the last visit ,compared with 216mg/Dl in the 1st visit )P value less than 0.001,and the PPPG (160.2mg/Dl compared with 280mg/Dl in the 1st and last visit respectively)P value less than 0.001, and the mean HbA1c (7.1% compared with 9.41%)P value less than 0.001.There was no significant difference between the 1st and last visit recordings of BMI (27.9Kg/m2 compared with 28.1Kg/m2 respectively )P value more than 0.05 ,and in the average incidence of mild hypoglycemic episodes (1.01 compared with 0.42 episode respectively)P value more than 0.05.Conclusion: This study showed that the use of this type of insulin analogue for type2DM lead to marked and statistically significant improvement in the glycemic control ,mainly in the PPPG. In addition the use of this type of insulin was associated with only mild elevation in the BMI and slight lowering in the incidence of hypoglycemic episodes ,both non-significant statistically.


Article
The Necessity of Teaching Diabetic Patients the Correct way of Insulin Administration: A Clinical Trial to Improve Glycemic Control

Author: *Khalid Ibrahim Al- Lehibi FRCP (Edin),**Yousif Abdul Raheem FICMS/CM ***Ibtisam Shilbah Hussein
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2012 Volume: 8 Issue: 2 Pages: 137-146
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: It is important to achieve good glycemic control to avoid long-term diabetic complications. It has been largely debated about the role of correct way of insulin administration to get the desired glycemic control.Objective: To evaluate the effect of teaching diabetic patients who are on insulin therapy the correct way of injecting insulin and its effect on glycemic control.Methods: A non randomized clinical trial with 820 diabetic patients on insulin therapy on whom A1 c estimation was performed before and after three months of teaching them the right injection technique.Results : Sixty seven patients (8.17%) had A1 c 6.5% before they were enrolled in the study while the majority (753 patents, 91.82%) had A1 c 6.5% and the last group showed the best benefit of teaching them the correct way of injection when compared with first group (P= 0.0001). Also patient with age 20-40years showed the best results (P=0.0001), while the poorest results were observed in those aged 40 years and above. Conclusion: Teaching patients the right injection technique is important to achieve good glycemic control in those who already had poor one. Keywords: glycemic control, A1 c, injection technique.


Article
Relation of Oxidant-Antioxidant Status with Glycemic control in type 2 diabetic patients

Author: *Baydaa Ahmmad Abed بيداء احمد عبد
Journal: Al-Mustansiriyah Journal for Pharmaceutical Sciences مجلة المستنصرية للعلوم الصيدلانية ISSN: 18150993 Year: 2013 Volume: 13 Issue: 2 Pages: 48-57
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract:In diabetes mellitus, persistence of hyperglycemia was reported to cause increasedproduction of oxidative parameters, and decreased antioxidant status. Therefore, the presentstudy considered to evaluate the effect of glycemic control on oxidant-antioxidant status in type2 diabetic patients. The study examined 145 type 2 diabetic patients, who attend to the NationalDiabetic Center (Al-Mustansiyriah University). Patients were divided in two groups, as wellglycemic controlled (group1[75 patients]) (HbA1c< 7%, and FSG < 110 mg/dl) and poorlycontrolled (group2 [70 patients]) (had HbA1c≥ 7%, and FSG ≥ 110). All patients were reported inthe morning after overnight fast, and underwent physical examination and laboratory tests.Height and weight were noted for Body Mass Index (BMI), it was calculated as weight(Km)/height2 (m2).Laboratory evaluations consisted of measuring fasting serum glucose (FSG), glycatedhemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), malondialdehyde (MDA),erythrocyte-Glutation (GSH), ascorbic acid (AA), uric acid (UA), and cerulopalsmine (CP). Theresults indicate that fasting serum FSG, HbA1c, (MDA), (TC), and (TG), were increasedsignificantly (P<0.01 for FSG, HbA1c, MDA; and P<0.05 for TC, and TC) in poorly controlledsubjects comparing to well controlled. Instead of that there is significant increase in (CP)(P<0.05) in poorly controlled patients. On the other hand there is significant decreased in (GSH,(AA), (UA) (P<0.01 for GSH, AA; and P<0.05 for UA) in poorly controlled compared to wellcontrolled diabetic patients. Correlation analysis showed a significant positive correlation inserum HbA1c-MDA, GSH-AA (P<0.01; and P<0.05 respectively) in both group, while there isonly positive correlation in HbA1c-FSG (P<0.01) in well controlled patients, and positivecorrelation in HbA1c-TC in poorly controlled patients. On the other hand, there is a significantnegative correlation in MDA-GSH, MDA-AA, and MDA-UA in both studying group. Thepresent study concludes the increased risk of oxidative stress manifested by increased plasmaMDA, and decreased antioxidant levels in poor glycemic control. The study therefore suggests,the estimation of antioxidants levels with other routine investigations may be useful in reduce ofthe oxidative stress in diabetics.

الخلاصة:افادت دراسات عدیدة ان ارتفاع السكر بالدم للمرضى المصابین بداء السكر من نوع الثاني یؤدي الى زیادة معلماتالاكسدة وتراجع نسبة مضادات الاكسدة. لذلك اجریت ھذة الدراسة لتقییم مدى تاثیر سیطرة نسبة السكر في الدم لمرضىالنوع الثاني على معلمات الاكسدة ومضادات الاكسدة. شملت ھذه الدراسة 145 مریضمصاب بداء السكر من النوع الثاني منالمراجعین للمركز الوطني لعلاج وبحوث السكري/ الجامعة المستنصریة حیث تم تقسیم المرضى الى مجموعتین المجموعةذات G ذات السیطرة الجیدة ( 75 مریضا)(نسبة السكر بالدم < 110 وخضاب الدم المعسل< 7٪) والمجموعة الثانیة 2 G الاولى 1السیطرة السیئة( 70 مریضا )(نسبة السكر بالدم ≥ 110 وخضاب الدم المعسل ≥ 7%). اخذت جمیع العینات من المرضى بعدصیام 12 ساعة وبعد ان تم فحصھم سریریا ومختبریا. تم حساب معامل كتلة الجسم عن طریق اخذ الوزن والطول(الوزن علىمربع الطول بالامتار).اجریت للمرضى التحالیل التالیة (مستوى السكر بالدم, خضاب الدم المعسل,الكولسترول,الدھونحامض الاسكوربكِ,حامض الیوریك و ,erythrocyte–Glutation(GSH),(MDA)malondialdehyde, الثلاثیةاظھرت النتائج ان ھناك زیادة معنویة في مستوى كل من (السكر في الدم,خضاب الدم .ceruloplasmineالكولسترول والدھون الثلاثیة) حیث كانت ھنك زیادة معنویة عالیة جدا ,(MDA) malondialdehyde, المعس


Article
6.EFFECTS OF N-ACETYL-CYSTEINE (NAC) ADMINISTRATION ON GLUCOSE HOMEOSTASIS PARAMETERS IN PREDIABETIC PATIENTS

Authors: Ahmed R. Abu Raghif احمد رحمة ابو رغيف --- Yaseen A. Yaseen ياسين عبيد ياسين --- Muntadher H. Dawood منتظر حنون داود
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2018 Volume: 16 Issue: 4 Pages: 393-399
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Prediabetes is determined on the bases of glycemic parameters, which are above normal but below diabetic thresholds. Prediabetes is associated with the presence of insulin resistance and β-cells dysfunction. N-acetyl cysteine (NAC), as a safe and inexpensive medication, is commercially accessible since long-time ago. This drug is not found in natural sources, although cysteine is present in some meals like chicken and turkey meats, garlic, yogurt, and eggs. NAC prevents apoptosis and oxygen related genotoxicity in endothelial cells by increasing intracellular levels of glutathione and decreasing mitochondrial membrane depolarization reaction.Objective: To evaluate the effects of NAC administration on glucose homeostasis parameters in prediabetic patients.Methods: This study included, 25 patients treated with dietary control and life style modifications for 12 weeks, 25 patients treated with NAC (600 mg) oral tablets twice daily plus dietary control and life style modifications for 12 weeks. Other 20 in addition to 50 patients to have an idea about the normal values of study parameters and in order to assess how much the drug used in the study were able to normalize the abnormal parameters.Results: NAC demonstrated a significant decrease in the fasting blood sugar, HbA1c, fasting Insulin and insulin resistance at the end of 12 weeks (P<0.05) compared with baseline measurements.Conclusion: The results of the study showed that N-acetyl cysteine has an effective effect on glycemic control.Keywords: Prediabetes , N-acetyl cysteine , glycemic controlCitation: Abu Raghif AR, Yaseen YA, Dawood MH. Effects of N-Acetyl-Cysteine (NAC) administration on glucose homeostasis parameters in prediabetic patients. Iraqi JMS. 2018; 16(4): 393-399. doi: 10.22578/IJMS.16.4.6


Article
EVALUATION OF ZINC STATUS AMONG PATIENTS WITH DIABETES MELLITUS
حالة الخارصين مرضى السكري

Authors: HIVI M. MAHMOUD هيفي محمود --- DHIA J. AL-TIMIMI ضياء التميمي
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2011 Volume: 5 Issue: 2 Pages: 1-10
Publisher: University of Dohuk جامعة دهوك

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Abstract

Background and objectives A general observation in diabetes, type 1 as well as type 2 is hypozincemia which may be the result of increased urinary excretion or decreased gastrointestinal absorption of zinc or both. The resulting decrease in total body zinc maycontribute to diabetic complications. Hence, the present study was conducted to evaluate zinc status for diabetic patients, in an effort to identify diabetic group for whom zinc supplementation may be concern. The objective was to assess zinc status among randomlyselected diabetic patients of Duhok city.Methods Collection of data was carried out during the period from September 2009 to June 2010 at the Duhok Diabetes Center in Duhok Governorate/Kurdistan region/ Iraq. In the first part of the study (cross sectional study), a total of 362 subjects were involved. Among these, 206 were diabetic patients (type 1 DM, n=48; Type 2 DM, n=158) and the remainders were 156 apparently healthy subjects. In the second part of the study (intervention study), twenty eight type 2 diabetic patients were selected according to selection criteria and were supplemented with 40 mg elemental zinc as zinc gluconate per day for 3 months, from those 23 completed the trial. General information for each subject was obtained by questionnaire designed for the study. Fasting serum glucose (FSG), lipid profile, glycoselated hemoglobin (HbA1c) and serum zinc were measured for each subject.Results The prevalence of hypozincemia was 33.0% for the 362 individuals included in the study. The prevalence was significantly higher in diabetic patients than healthy controls (43.7% vs 19.9%, P<0.01). To evaluate changes of zinc levels, relating for someepidemiological variables. However, no statistically significant effect was found using a P value of 0.05; for sex, BMI, central obesity, physical activity, family history of diabetes mellitus, type of diabetes, and duration of diabetes mellitus. But, the mean serum zinc level was significantly lower (P<0.01) for elderly diabetic subjects compared with adults and children. The mean serum zinc level for low social status (based on crowding index) patientswas significantly lower (P<0.01), compared to the high social status patients. Significant difference was also noticed in mean ± SD values for serum zinc of good glycemic control and poor glycemic control of diabetics (p<0.01). The second part of the study showed that the mean value of serum triglycerides of the supplemented group decreased at the end of 90 days by 7.3%, whereas the mean values of serum zinc increased by 51.8%. In addition the mean values of serum glucose and HbA1c% of the supplemented group decreased by 6.6% and5.9% respectively.Conclusions Marginal zinc deficiencies were observed in the individuals studied with a higher prevalence in diabetic group. The measured zinc status is associated with the glycemic control of diabetes.

خلفية واهداف البحث: كمعاينه عامه لداء السكري, النوع الاول وبالاضافه الى النوع الثاني هو نقص الخارصين في الدم نتيجة أما الى كثرة تدرر الخارصين او نقص أمتصاصها عن طريق الامعاء او الاثنين معا. النقص للخارصين في عامه الجسم قد يكون السبب لظهور مضاعفات المرض. ولذلك’ تمت هذه الدراسه لتقييم حاله الخارصين في مرضى السكري’ في محاوله لتعريف عينه مرضى السكري لمن هم بحاجه الى اعطائهم الخارصين. الهدف كان لتقييم حالة الخارصين في الدم في عينة مختاره عشوائيا لمرضى السكري في مدينه دهوك. طرق البحث: تمت جمع البيانات ما بين الفترة من تشرين الاول 2009 و حزيران 2010 في مركز دهوك للسكريشخص. cross sectional study) في محافظة دهوك/أقليم كردستان/العراق. تضمن الجزء الاول من الدراسة( 362بينهم 206 مصابون بمرض السكري(النوع الاول, عدد 48 ; النوع الثاني، عدد 158 ) والاخرين كانوا 156 اشخاص تم اختيار 28 مريض سكري من النوع الثاني ،(intervention study) اصحاء ظاهريا. في الجزء الثاني من الدراسة كل (zinc gluconate) حسب الصفات المختارة وتم اعطائهم 40 ملغم من عنصر الخارصين كسكرات الخارصين يوم لمدة ثلاثة أشهر, ومنهم 23 مريض كملوا المحاولة. تم اخذ معلومات عامه من كل شخص عن طريق استبيان ومستوى الخارصين لكل HbA1c صمم خصيصا لهذه الدراسه. تم قياس مستوى السكر في الدم’ ملف الدهون و شخص.النتائج: نسبه انتشار نقص الخارصين في الدم كان 33.0 % لل 362 شخص تضمنوا في هذه الدراسه. نسبه انتشار .(p<0.01 ،%19.9 vs النقص كان أعلى بشكل ملحوظ في مرضى السكري مقارنه بالأشخاص الأصحاء ( 43.7 لتقييم التغيرات في مستويات الخارصين, علاقة ببعض المتغيرات. مع ذلك لم يتواجد أي تأثير ملحوظ باستعمال 0.05 للجنس و مؤشر كتله الجسم و البدانة ألوسطيه’النشاطات الفيزيائيه’ وجود مرض السكري في سجل العائله ( (P للقيمه و نوع مرض السكري و فترة المرض . ولكن معدل القيمة لمستوى الخارصين في الدم كان اقل بشكل في مرضى السكري المسنون مقارنه مع ألأشخاص البالغين وألاطفال . معدل القيمة لمستوى ( p< ملحوظ( 0.01 في ألأشخاص ذوي الطبقة الفقيرة (اعتمادا على مؤشر ( p< الخارصين في الدم كان اقل بشكل ملحوظ( 0.01 الازدحام) مقارنة للاشخاص ذوي الطبقة الغنية. اختلاف ملحوظ وجد أيضا في معدل القيم لمستوى الخارصين في الدم الجزء الثاني من . ( p< في مرضى السكري من ذوي السيطرة السكرية الجيدة والسيطرة السكرية السيئة ( 0.01الدراسة أظهرت بأن معدل القيمة لمستوى الشحوم الثلاثية في الدم للأشخاص الذين تم إعطاءهم الخارصين انخفضت في نهاية اليوم التسعون بنسبة 7.3 % بينما معدل القيمة لمستوى الخارصين في الدم ارتفع بنسبة 51.8 %. بألأظافه في الدم للأشخاص الذين تم إعطاءهم الخارصين انخفضت بنسبة %HbA1c إلى أن معدل ألقيمه لمستوى السكر و %6.6 و 5.9 % بالتسلسل.الاستنتاجات: نقص ألخارصين الحافي تم مشاهدته في الاشخاص المشمولين في هذه الدراسه مع نسبه انتشار اكثر في عينة مرضى السكري. حاله الخارصين المقاسه لها علاقه مع السيطرة السكريه لمرض السكري.


Article
Serum Cortisol in Type 1 Diabetic females
مصل الكورتيزول في الإناث نوع السكري 1

Authors: Abbas AL-Musawi عباس الموسوي --- Perry H. Saif Ullah --- Ekhlas Abdu Allah Hassan اخلاص عبدالله حسن
Journal: Diyala Journal For Pure Science مجلة ديالى للعلوم الصرفة ISSN: 83732222 25189255 Year: 2012 Volume: 8 Issue: 1 Pages: 97-102
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Diabetes mellitus is regarded as one of the commonest metabolic disorder all over the world. It can cause various endocrine disorders by affecting the secretion, metabolism, clearance or bioavailability of hormones. Aim of study: This study is to answer if type1 diabetes changes cortisol level in female diabetic patients who have different degrees of glycemic control. Subjects, Materials and Methods: This study includes (81) female subjects, age ranged from (15 to 37) years. (20) subjects are apparently healthy chosen as control group and (61) patients with type 1 diabetes mellitus were divided into two groups according to their glycemic control : (16) with poor glycemic control (HbA1c>8%) and (45) with acceptable glycemic control (HbA1c<8%) . In this study Cortisol was quantitatively determined in patients and healthy subjects by Enzyme-Linked Immuno sorbent Assay [ELISA] test using commercially available kits. In addition to that, the duration of disease, fasting plasma glucose (FPG) ,Glycated hemoglobin (HbA1c), and body mass index (BMI) were identified in the patients. RESULTS: In poor glycemic control group, Cortisol level (267.89±16.60 ng/ml,p<0.05) was higher than in acceptable glycemic control group (126.84±4.55 ng/ml,p>0.05) and in nondiabetic patients (123±6.13 ng/ml ,p>0.05). CONCLUSIONS In type 1 female diabetic subjects, adrenal activity is enhanced in patients with poorly controlled patients diabetes and the degree of cortisol secretion is related to the glycemic control

خلفية البحث يعتبر داء السكري من أكثر الأمراض شيوعا في العالم والذي يعزى الى عمليات أيضيه غير طبيعيه. يسبب داء السكري خلل في الغدد الصم وذلك عن طريق تأثيره على إفراز وايض والفعالية البيولوجية للهرمونات .الهدف من الدراسة هذة الدراسة كانت اللأجابة فيما اذا كان مرض السكري من النوع الاول يغير تركيز الكورتيزول للمريضات بدرجة سيطرة مختلفة من المرض .العينات ، المواد وطرائق العمل : هذه الدراسةِ تَضمّنتْ (81) امرأة ًبمدى العُمرِ بين (15-37) سَنَه ، (20)امرأة صحيحة كمجموعةضابطة و(61) مصابة بداء السكري"النوع الاول" ، مجموعه المرضى قسّمت إلى مجموعتين وفقا لدرجةالسيطرة على السكري(16) مصابة ذات سيطرة ضعيفة (خضاب الدم المعسل<8%) .(45) مصابة ذات سيطرة جيدة (خضاب الدم المعسل>8%) . في هذه الدراسة تم تعين مستويات هرمون الكورتيزول وكان التقييم بواسطة فحص (ELISA) عن طريق العدد المختبرية التجارية المتوفرة. وقيمت أيضا فترة الإصابة بالمرض ,سكر بلازما الدم الصائم ,خضاب الدم المعسل((HbA1c.,دالة كتلة الجسم (BMI في مصل الدم.النتائج : يوجد اختلاف معنوي في مستوى الكورتيزول لمجموعة المصابات ذات السيطرة الضعيفة(267.89±16.60 ng/ml,p<0.05) عند مقارنتهم مع مجموعه المصابات ذات السيطرة المقبولة(126.84±4.55 ng/ml,p>0.05) ومجموعة الأصحاء(123±6.13 ng/ml ,p>0.05)..الأستتناج:في النساء المصابات بمرض السكري من النوع الأول زيادة فعالية القشرة الكظرية تكون في مجموعة المصابات ذات السيطرة الضعيفة وزيادة درجة إفراز الكورتيزول تكون متعلقة بدرجة السيطرة على المرض


Article
The Significance of Lipid Abnormalities in Children with Insulin-Dependant Diabetes Mellitus

Author: Salem Rahma
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 3 Pages: 289-294
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:To evaluate serum lipids in children with type 1 diabetes mellitus and its relation to glycemic control, in comparison with sex and age matched non-diabetic children.METHODS:Fasting blood glucose, glycosylated haemoglobin (HbA1c) and lipid profile were estimated in 45 children (20 males and 25 females) with type 1 diabetes attending diabetic clinic at Sulaymani children hospital from the period of November 2005 till Jully 2006. Fifty health children (23 males and 27 females) admitted to the same hospital with acute illnesses like respiratory tract infections were randomly selected as controls.RESULTS:Mean total cholesterol, triglycerides, LDL-C, VLDL-C, and LDL-C/HDL-C ratio were significantly higher in diabetic children compared to the control. However, there was no significant difference in the levels of HDL-C in both groups .In addition to that, diabetic patients with poor control have a significantly higher levels of blood glucose, total cholesterol, triglycerides, LDL-C and LDL-C/HDL-C ratio as compared to those with good control. A significant correlation between most lipid variables and HbA1c was observed in diabetic patients.CONCLUSION:Children with type 1 diabetes should be screened for serum lipids as significant lipid abnormalities are related to glycemic control. Both can be improved with dietary guidelines and insulin therapy.

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