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Article
Treatment of low serum ferritin in females with alopecia by oral iron.

Authors: Wisam Ali Ameen --- Hassanain H. Al-Charrakh
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2015 Volume: 4 Issue: 1 Pages: 126-136
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Hair loss affects over 25% of women in developed countries. Three hairdisorders, androgenetic alopecia, telogen effluvium and alopecia areata which account formost cases of nonscarring alopecia in women. Iron deficiency has been reported in themajority of women presenting with diffuse hair loss. Iron has important function in oxidationreductionreactions, collagen synthesis, and as a co-factor for enzymes.Objectives: To assess the percentage of the low serum ferritin hair loss females and theirresponse to oral iron replacement therapy.Materials and methods: a prospective cohort study conducted in at Marjan teaching hospitalfrom August 2013 to January 2015. It included 72 female complained from diffuse hair losswere enrolled in this study. Full history was taken from all patients and physical examinationswere done both general examination and local examination of the scalp including pull test.Patients were sent to complete blood examinations, serum ferritin. Patients divided in to threegroups according to their response to treatment. Before the treatment the severity of hair losswas assess by VAS.Results: Fifty two patients met criteria of inclusion. Their serum ferritin levels range between(1.4-14.4) with mean 6.16±3.30 their hemoglobin levels were (8.3-13.4) with mean ±SD11.98±1.22. Group I patients included 27 patients (51.9%), their severity of hair loss beforetreatment was assess by VAS which was 9.18±0.84, after two week of treatment the scorebecome 7.33±1.03, P value is < 0.0001; confidence interval 95% = ( 1.477 to 2.277). in groupII patients which included 12 patients (23%), their severity of hair loss before treatment wasassess by VAS which was 9.33±0.49, after two week of treatment the score become 9.08±0.66,P value is 0.081 considered not significant; confidence interval 95% = (-0.037 to 0.537). Theother thirteen patients (25%) represented the third group. All the patients in this group didn’tshow any response to treatmentConclusion: Measurement of serum ferritin level should be done to all patients with chronictelogen effluvium before starting other anti-hair loss modalities. Iron replacement is a safedrug with a few side effects and indicated to all females with low serum ferritin level.

Keywords

ferritin --- female --- hair loss


Article
The Relationship between −330 Interleukin‑2 Gene Polymorphism and Its Plasma Levels in Patients with Alopecia Areata

Author: Sarah Isam Al‑Rubaye, Abdulsamie Hassan Alta’ee, Zena Saeed Al‑Fadhily
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2019 Volume: 16 Issue: 4 Pages: 292-295
Publisher: Babylon University جامعة بابل

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Abstract

Background: Alopecia areata (AA) is an autoimmune, dermatological, chronic, inflammatory disease that attacks hair follicles and causeshair loss. Hair loss usually occurs on the scalp, but it can also affect the beard, eyebrows, and other areas of the body. Interleukin‑2 (IL‑2) isa cytokine that contributes to the regulation of the immune system and is classified as a proinflammatory factor. IL‑2 is an autocrine secretaryelement produced from activated T‑cells, exhibiting growth factor characteristics. Objective: The objective of this study was to investigatethe effect of the −330 IL‑2 gene polymorphism (rs2069762) on plasma IL‑2 levels in Iraqi patients with AA. Materials and Methods: Inthis study, 100 patients with AA and 100 ethnicity‑, age‑, and sex‑matched healthy controls were selected. Blood samples of all individualswere collected in EDTA tubes. The restriction fragment length polymorphism–polymerase chain reaction method was applied to determinevarious alleles and genotypes in these individuals. Plasma concentration of IL‑2 was measured in all the samples using human IL‑2 kit.Results: The frequency of −330 G/T IL‑2 genotype was higher in patients with AA compared to normal individuals. Accordingly, the plasmalevels of IL‑2 were significantly higher (P < 0.0090) in patients when compared to the control group. Conclusion: In case of patients withAA, the −330 G/T IL‑2 genotype is associated with higher plasma levels of IL‑2.

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