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Article
Evaluationof Highly Sensitive C-Reactive Protein in Female Patients with Nodal Osteoarthritis

Authors: Ammar W. Obeid --- Munaf S. Daoud --- Mohammed H. Alosami
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 4 Pages: 479-484
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Nodal Osteoarthritis is a subset of OA characterized by polyarticularinterphalangeal and thumb base OA ,Heberden’sand Bouchard’s nodes formation.C-reactive protein (CRP) is one of the first acute phase response proteins to be elevated in an inflammatory processes.OBJECTIVE:The aim of this study is to investigate whether the inflammatory processes have roles in the development of nodal osteoarthritis (NOA) in Iraqi femalepatients using serum highly sensitive C-reactive protein as aninflammatory marker.SUBJECTS AND METHODS:The study included eighty four females, divided into two main groups,sixty were patients with (NOA), and twenty-four represented the control group. Other subdivisions were applied according to body mass index and menopause status. Measurement of serum (hsCRP), wasapplied to all subjects included in this study, by ELISA sandwich method.RESULTS:Serum highly sensitive C-reactive protein (hsCRP) level was significantly higher (18.08±8.15) (P value < 0.05) in patients with NOA in comparison to control group (2.23±1.73) .CONCLUSION:Highly significant elevated level of serum (hsCRP) observed in the NOA patients compared to control suggest that the inflammatory processes have roles in the development of NOA.


Article
THE ROLE OF ATORVASTATIN IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ELEVATED HIGH SENSITIVE C-REACTIVE PROTEIN

Author: Ali S. Baay علي صالح مهدي بيعي
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2016 Volume: 14 Issue: 4 Pages: 383-392
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:There is a growing interest in the potential beneficial effects of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors drugs (statins) in chronic obstructive pulmonary disease (COPD) as anti-inflammatory agent. The basis of the systemic inflammation in COPD comes from two possibilities: spill-over effect or inherent systemic-based pro-inflammatory state conferred by a genetic disposition. The inhaler-based therapy for COPD aims to reduce symptoms, improve quality of life and reduce hospitalization, but does not substantially change disease progression or reduce mortality.Objective:To assess the efficacy and safety of statin therapy in COPD patients with evidence of inflammatory markers.Methods:Ninety patients were included in the study, aged 40 years or more, who visit the outpatient private clinic in Babylon government, Iraq from September 2012 to April 2016. They were divided randomly for 3 groups (receiving 40 mg, 10 mg atorvastatin or placebo, respectively), in addition to their baseline treatment. Severity reassessment performed after 6 months' duration of treatment as well as hospitalization frequency and mortality. Results: Statin therapy showed a significant improvement in the both doses treated groups regarding the HsCRP, CAT (chronic obstructive airway disease assessment test) score and forced expiratory volume in first second after 6 months of treatment. This improvement fails to be reported significant effect on CAT score when compared to placebo group. Thus, statin treatment doesn’t show any symptomatic improvement as measured by CAT score over placebo treatment.Conclusion:The statin treatment in patient with chronic obstructive pulmonary disease can be useful in form of improvement of hospitalization, number of exacerbations but not mortality.Keywords: Atorvastatin, statins, COPD, high sensitive C-reactive protein.


Article
Salivary High Sensitive C-Reactive Protein and Gingival Health Status among a Group of Women with Polycystic Ovary Syndrome

Authors: Dr. Andalus Abid Hassan Tahir B.D.S. د. اندلس عبد حسن --- Dr. Baydaa Hussien B.D.S, M.Sc. د. بيداء حسين
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2016 Volume: 13 Issue: 1 Pages: 38-45
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrinedisorder affecting women in their reproductive years. It is a complex disorderaffects not only general health but also show a reciprocal link with the oral health.C-reactive protein is an acute phase protein which increase their concentrationduring certain inflammatory disorders and used as a biomarker of inflammation inthe body. The aims of this study were to assess the gingival health status among agroup of women with polycystic ovary syndrome as well as to estimate the levelsof salivary high sensitive c-reactive protein in unstimulated saliva in relation togingival health condition.Materials and methods: Sixty two females with an age range 20-25 years old andwith a body mass index range18.5-24.9 (normal weight) were included in thisstudy. They were divided into two groups; the study group which included thirtyone females with polycystic ovary syndrome, those females attended BabylonTeaching Hospital/ Infertility Center with regular cycles, without clinical orbiochemical features of hyperandrogenism and ultrasound exclusion of polycysticovary (without polycystic ovary syndrome). Collection of unstimulated salivarysamples was carried out under standardrized conditions, salivary high sensitive creactiveprotein levels were estimated. Plaque index of Silness and Lӧe (1964)was used to assess dental plaque. While gingival index of Lӧe and Silness (1963)was used to assess gingival inflammation.Results: Results showed that the mean value of plaque index was found to be higherin the control group (1.18±0.03) than that in the study group (1.00±0.08) withstatistically highly significant difference (p<0.01).While the mean value ofgingival index was higher among the study group (1.52±0.06) than that in thecontrol group (1.31±0.05) with statistically highly significant difference (p<0.01).salivary levels of high sensitive c-reactive protein among women with polycysticovary syndrome (1061.68±75.41 pg/ml) were found to be higher than that ofcontrol (930.51±94.65) with statistically highly significant difference(p<0.01).The results in this study showed that the correlations between salivaryhigh sensitive c-reactive protein with gingival index were statistically highlysignificant (p<0.01)in women with polycystic ovary syndrome.While statisticallyno significant correlation between plaque index and high sensitive C-reactiveprotein(p˃0.05).In order to assess the specificity and sensitivity of the use of salivary highsensitive c-reactive protein as a diagnostic tool, statistical analysis of ReceiverMDJOperative Characteristics Curve (ROC) was used and predictive ValueMeasurments were done in this study. The results showed that the area under thecurve for salivary high sensitive c-reactive protein test was (0.869) with highlysignificant p-value (p<0.01). The best optimal cut off point for salivary highsensitive c-reactive protein was (1009) with (71%) sensitivity and(96.8%)specificity, indicating a very good predictive capacity for using salivaryhigh sensitive c-reactive protein as a marker for the diagnosis of polycystic ovarysyndrome.Conclusions: It was concluded that gingival inflammation was high among womenwith polycystic ovary syndrome. Furthermore, salivary levels of high sensitive creactiveprotein were found to be high among women with polycystic ovarysyndrome. It was suggested that the measurement of salivary high sencitive creactiveprotein may be helpful in diagnosis of women with polycystic ovarysyndrome.


Article
Lipoprotein (a) and Inflammatory Markers in Hypertensive Patients
البروتين الدهني (أ) والدلائل الألتهابية لدى مرضى ارتفاع ضغط الدم

Author: Hind Shakir Ahmed د.هند شاكر أحمد
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2015 Volume: 28 Issue: 3 Pages: 139-144
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Hypertension is the most important public health problem in developing countries and one of the major risk factors for cardiovascular diseases. Lipoprotein (a) is a known risk factor for cardiovascular diseases and systemic inflammation such as interleukin-6 and high sensitive C-reactive proteinareimplicated in the development of hypertension.Objective: The aim of the present study wasto detectthe associations between inflammatory markers as interleukin-6 and high sensitive C-reactive protein with atherogenic indices in hypertensive patients and compared with the control.Patients and Methods: This study was conducted in Medical City Hospital during the period from November2013 until the end of June2014. Ninetyhypertensive patients were enrolledin this study(45 male and 45 female); their age range was (40-55) years and compared with 90 healthy subjects as control group. They studied for their serum lipoprotein (a) and lipid profile including total cholesterol, triacylglycerols, high density lipoprotein cholesterol, low density lipoprotein cholesterol, very low density lipoprotein, and non high density lipoprotein cholesterol in fasting state. Also inflammatory marker such as interleukin-6 and high sensitive C-reactive protein were measured in those patients and compared with the control group.Results:There was a significant increase in lipoprotein (a) levels, total cholesterol, low density lipoprotein cholesterol, non high density lipoprotein cholesterol, interleukin-6, and high sensitive C-reactive protein in hypertensive patients as compared to the control, (P=0.0001).Also, there wasa significant increase in lipoprotein (a) levels, total cholesterol, low density lipoprotein cholesterol, non high density lipoprotein cholesterol, interleukin-6, and high sensitive C-reactive protein in grade 3 hypertensive as compared to grade 1 and 2 hypertensive patients.Conclusions: It can be concluded thatlipoprotein (a) level was significantly higher in hypertensive patients as compared with the control group. So lowering its concentration would help prevention of cardiovascular diseases.Serum interleukin-6 and high sensitive C-reactive protein estimation can be used as potential tools for early identification of individuals at the risk for development of hypertension and eventually cardiovascular diseases.

خلفية البحث: ارتفاع ضغط الدم هو مشكلة صحية عامة وتعد الأكثر أهمية في البلدان النامية واحد عوامل الأصابة الرئيسية بالأمراض القلبية الوعائية. ويعد البروتين الدهني (أ) هو أحد عوامل الخطر المعروفة للأمراض القلبية الوعائية والأنظمة الألتهابية مثل الأنترلوكين -6 والبروتين- Cالتفاعلي شديد الحساسية ممكن أن تساهم في تطور ارتفاع ضغط الدم. الهدف من البحث: معرفة الارتباط بين الدلائل الألتهابية مثل الأنترلوكين-6 و والبروتين- Cالتفاعلي شديد الحساسية مع مؤشرات تصلب الشرايين لدى مرضى ارتفاع ضغط الدم ومقارنتها مع مجموعة السيطرة. المرضى وطرق العمل: أجريت هذه الدراسة في مستشفى مدينة الطب خلال الفترة من تشرين الثاني 2013 حتى نهاية حزيران 2014. تضمنت الدراسة تسعون مريضاً مصاباً بارتفاع ضغط الدم (45 من الرجال و 45 من النساء)؛ وكان معدل أعمارهم يتراوح بين (40-55) سنة، وتمت مقارنتهم مع 90 شخصاً من الأصحاء كمجموعة سيطرة. تم قياس البروتين الدهني (أ) والدهون التي تضمنت الكوليسترول الكلي، الدهون الثلاثية، البروتين الدهني عالي الكثافة، البروتين الدهني منخفض الكثافة، البروتين الدهني شديد انخفاض الكثافة، والبروتين الدهني غير عالي الكثافة في حالة الصيام وأيضا تم قياس الدلائل الألتهابية مثل الأنترلوكين-6 والبروتين- Cالتفاعلي شديد الحساسية لدى هؤلاء المرضى ومقارننهم مع مجموعة السيطرة. النتائج: كانت هناك زيادة كبيرة في مستويات البروتين الدهني (أ)، الكوليسترول الكلي، البروتين الدهني منخفض الكثافة، البروتين الدهني غير عالي الكثافة، الأنترلوكين-6، والبروتين- Cالتفاعلي شديد الحساسية لدى مرضى ارتفاع ضغط الدم بالمقارنة مع مجموعة السيطرة،(P=0.0001) ، أيضا كانت هناك زيادة كبيرة في مستويات البروتين الدهني (أ)، الكوليسترول الكلي، البروتين الدهني منخفض الكثافة، البروتين الدهني غير عالي الكثافة، الأنترلوكين-6، والبروتين- C التفاعلي شديد الحساسية لدى مرضى ارتفاع ضغط الدم من الصنف الثالث بالمقارنة مع الصنف الأول والثاني من المرضى. الاستنتاجات: ويمكن أن نستنتج أن مستوى البروتين الدهني (أ) كان أعلى بكثير لدى مرضى ارتفاع ضغط الدم بالمقارنة مع مجموعة السيطرة. لذا فأن خفض تركيزه ممكن أن يساهم في الوقاية من الأمراض القلبية الوعائية. ومن الممكن ان يستعمل تقدير الأنترلوكين-6 والبروتين- Cالتفاعلي شديد الحساسية في إمكانية التعرف المبكر على خطر تطور ارتفاع ضغط الدم وبالتالي الأمراض القلبية الوعائية.

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