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Article
Histopathological and Serological Study of Goitre

Author: Talib Mohsin
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 1 Pages: 139-143
Publisher: Babylon University جامعة بابل

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Abstract

The correlation of histopathology and serology results in patient with goiter.Accurate detection of thyroid autoantibodies by enzyme linked immunosorbant assay technique namely thyroglobulin antibody, thyroid peroxidase antibody is crucial in the differentiation of autoimmune thyroid disorders from other form of thyroid diseases.Evaluation of the detection of thyroglobulin antibody and thyroid peroxidase antibody in different thyroid diseases using enzyme linked immunosorbant assay technique. Eighty patients admitted to Surgical Units of Al-Zahraa Teaching Hospital in Al-Kut from the period between august 2010 to August 2012 they were waiting to do thyroidectomy. They were chosen nonselective for serological evaluation of above autoantibodies, and correlation of the results with histopathological diagnosis. Colloid goiter is known cause of hyperthyroidism (5 were colloid goiter out of 10 total hyperthyroid patients) (50%), and still common thyroid surgery (60 were colloid goiterout of 80 thyroid surgery) (75%). 58 cases (72.5%) had colloid goiter, 11 patients had Graves' disease (13.75%), and 3 had lymphocytic thyroiditis (3.75%), 8 had thyroid neoplasia (both benign and malignant) (10%). The serological results; Antibodies results were positive in 7 patients (11%) in colloid goiter (p-> 0.05), 6 patients (66.6%) and 1 patient (33.3%) for Grave’s disease, and lymphocytic thyroiditis respectively (P-< 0.05)., while its all were negative in thyroid neoplasia. Serum thyroid autoantibodies determination is valuable test in clinical practice of autoimmune thyroid diseases.


Article
Chronic ulcerative Cutaneous Vasculitis of the legs Clinical and histopathological study

Authors: Husam A. Salman --- Hayder R. Al-Hamamy --- Thamir A. Hamed
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 1 Pages: 34-38
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Cutaneous small vessel vasculitis characterized by necrosis and inflammation of upper dermal blood vessels. It presents with ulcers and systemic manifestations after extensive acute onset. Many patients have a form of cutaneous vasculitis that presents with chronic painful ulcerations & purpuras involving the ankles without systemic manifestations, with some similarity in clinical presentation to livedoid vasculopathy. Patients and Methods: Thirteen patients were seen in the Department of Dermatology and Venereology, Baghdad Teaching Hospital, for a period extending from January 2004 to March 2005. They were evaluated clinically, histopathologically and other laboratory studies. In addition, evaluation of the clinical response to prednisolone 0.5mg/kg/day and azathioprine150mg/day was done.
Results: Thirteen patients were included in this study; eight females and five males, with male to female ratio of 1:1.6. Their ages ranged between 26-66 years with a mean ±SD of 42 ± 13.8 years. The duration of the disease ranged from 0.5 – 18 years with a mean ±SD of 38 ± 59.2 months.The clinical examination revealed multiple oval punched out ulcers, with an indurated base, and surrounded by a zone of erythema; affecting mainly the ankles and dorsa of feet. Histopathological evaluation showed upper dermal vessels' wall necrosis, fibrinoid deposition, obliteration of the lumen, extravasation of red blood cells, endothelial cells swelling with perivascular and vascular wall infiltration mainly by mononuclear cells.The treatment was started with prednisolone & azathioprine. The ulcers healed completely with residual hyperpigmentation - hypopigmentation, atrophy and scars within 10-15 weeks Conclusions: Chronic ulcerative cutaneous vasculitis is often a neglected and misdiagnosed variant of vasulitis. Histologically it has vascuiltic features, and clinically looks like livedoid vasculopathy.


Article
Forensic Histopathological Approach to Electrocution

Authors: Muthana Abdul- Jabar Abdullah --- Nabeel Ghazi Hashim Al-Khateeb --- Raji Hussein Mohammad Al-Hadithi
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 3 Pages: 358-364
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Few Studies had been done on the role of histopathology in the medico-legal
diagnosis of Electrocution even abroad.
Aim of the study: To determine the main histopathlogical features in cases of electrocution
especially at the entry site of the electrical current which help in the diagnosis of those cases.
Methods: A full medico-legal autopsy had been done on 64 cadavers of persons died as a
result of electrocution chosen randomly out of a total number of 144 cases of electrocution
during the year 2005 in the medico-legal institute of Baghdad including histopathological
examination by ordinary method of different specimens from those cadavers at histopathology
department of the mentioned institute to reach the aim of this study.
Results: Electrocution constituted only 1.4% of all causes of death during the year 2005 in the
medico-legal institute of Baghdad. Males were more than females in a ratio of 2:1. The most
affected age group was 30- 39 years old. In 62% of the case the entry of the current was with
no exit. In 46.9% of the cases the entry site was in the form of charged centre surrounded by
gray elevated area and took other shapes in the rest of the cases. Microvesicural formation was
the commonest histopathological finding in the skin. Pulmonary edema was the commonest
histopathological finding in the lung.
Conclusions: Although they are non specific, histopatological features could help the forensic
pathologist in the medico-legal diagnosis of electrocution in addition with other findings
especially in cases with less typical gross features or with incomplete information about the
case, in addition to other conclusions of the study.


Article
THE CLINICAL AND HISTOPATHOLOGICAL EFFECT OF CHITOSAN APPLIED LOCALLY ON THE HEALING OF EXPERIMENTALLY INDUCED TEAT FISTULA IN GOATS.
دور الكايتوسان في معالجة ناسور الحلمة المستحدث تجريبيا في الماعز

Author: Ayad A.J AminAhmed Oglla Dawood أياد عبد الجبار أمين احمد عكلة داود
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2010 Volume: 9 Issue: 2 Pages: 9-21
Publisher: Basrah University جامعة البصرة

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Abstract

The clinical and histopathological the effect of chitosan applied locally on the healing of experimentally induced teat fistula in goats. Sixteen local breed goats have been used, aged range between (1.2-2) years with body weight (30+-5) kg. Animals were randomly allotted into two equal groups. An artificial teat fistula of one cm.length was done for all animals under the effect of local analgesia and deep sedation. The first group, fistula was treated with chitosan 0.5gm and then closed by suture; while the second group (control one), fistula was closed routinely "via suture without any addition. After daily clinical follow-up, mild local reaction include local redness and swelling of the operative site and systemic mild hyperthermia, decrease ruminal contraction, increase respiratory rate.Histopathological examinations were performed on all animals. Eight animals used for each group :( 2 for each period).Sections were stained with hematoxylin –eosin stain. Results of Histopathological examination in treated group reflected the presence of large numbers of neutrophilsIn the first three days postoperatively , granulation tissue were seen in the sixty days which converted to cellular connective tissue in the ninth day with congested blood vessels .in addition there are lymphocytic aggregations ,arrangement of collagen fibers and formation of new epidermis during the 12th .days.In conclusion we can say that chitosan play an important role in enhancing repair of teat fistula.

تضمن البحث دراسة التأثيرات السريرية والنسجية المرضية لأضافة مادة الكايتوسان موضعيا على التأم ناسور الحلمة المحدث تجريبيا في المعز. استخدمت ستة عشر معز من السلالة المحلية تتراوح اعمارها (1.2-2) سنة بمعدل وزن (30 ± 5) كيلو غرام. قسمت الحيوانات عشوائيا الى مجموعتين متساوية. تم استحداث ناسور الحلمة جراحيا بطول 1 سم لجميع الحيوانات تحت تأثير التخدير الموضعي والتسدير العميق. في المجموعة الاولى (مجموعة المعالجة) تم اضافة مادة الكايتوسان(0.5 غرام) بعد اغلاق الغشاء المخاطي في حين اغلقت مجموعة السيطرة بدون اضافة. تم متابعة الحالات يوميا من الناحية السريرية حيث لوحظ وجود تفاعل بسيط فبي موقع العملية متضمنا احمرار,انتفاخ لموقع العملية مع ارتفاع بسيط لدرجة حرارةالجسم وزيادة في سرعة التنفس مع انخفاض لتقلصات الكرش. تم اخذ خزعة نسيجية لثمان حيوانات بواقع حيوانين لفترات زمنية مختلفة. تم التقطيع النسيجي بالطرق الروتينية وصبغ الشرائح بصبغة هيموتوكسيلين ايوسين. كانت نتائج الفحوصات المرضية النسجية لمجموعة المعالجة وجود عدد كبير من الخلايا الالتهابية في الايام الثلاثة الاولى بعد العملية. في اليوم السادس بعد العملية لوحظ وجود نسيج حبيبي اخذ بالتحول الى خلايا نسيجية رابطة في اليوم التاسع مع وجود اوعية دموية محتقنة بالاضافة الى وجود تجمع من الخلايا اللمفاوية مع الياف الكولاجين مع تكون ادمة في اليوم الثاني عشر. استنتجت الدراسة بأن اضافة الكايتوسان موضعيا ساعدت وحسنت التأم واصلاح ناسور الحلمة.


Article
STUDY OF SOME PATHOLOGICAL CHANGES IN MICE GROUPS INDUCED BY MYCOBACTERIUM TUBERCULOSIS AND TREATED WITH ETHAMBUTOL
دراسة بعض التغيرات المرضية لمجاميع الفئران المصابة بجرثومة السل البشري والمعالجة باستعمال عقار الايثامبيتول

Author: Suhair H. Al-kutbi سهير الكتبي
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2010 Volume: 9 Issue: 2 Pages: 48-61
Publisher: Basrah University جامعة البصرة

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Abstract

The main objective of this study is to demonstrate the histopathological changes and the efficacy of ethambutol of treatment mice infected with mycobacterium tuberculosis. Thirty of white Swisrland mice is 6-8 weeks age, weighted 20-25gm were used they were randomly divided into 3 groups contain of 10 animals for each group. -The 1st group (infected animal group) were inoculate.ed with 0.1 ml of bacterial suspension contain 1x108 cfu/ml intraperitonialy.-The 2nd group (group of infected-treated animal) were also infected as the fist group but after 30 day of infection were treated with 0.1 ml of ethambutol was given orally for 1 30 days.-The 3rd group maintained as a control and were inoculated with 1 ml of sterial normal saline intraperitonealy. At 60 day post infection all animals were sacrified and samples from different organs (liver, lungs, kidncys, spleen, intestine) were isolated for that histopathological examination.The result showed sever pathological lesion such as granulomatous lesions in lungs and livers of infected animals, with depletion of white pulp of spleen and conjestion with degenerative changes seen in kidneys and intestine with infiltration of inflammatory cells. While the infected-treated animals show mild or no pathological lesion in their internal organs.

لغرض دراسة التغيرات المرضية النسيجية ومعرفة تاثير عقار الايثامبيتول على اعضاء الفئران المصابة بجرثومة السل البشري mycobactoriam tuberculosis ، استخدم 30 من الفئران السويسرية البيضاء ومن كلا الجنسين والتي تتراوح اعمارها بين 6-8 اسبوع وباوزان 20-25غم، قسمت هذه الحيوانات عشوائيا الى ثلاث مجاميع ضمت كل منها 10 حيوانات:المجموعة الاولى: (مجموعة الاصابة) تم اصابتها بجرثومة السل البشري بطريقة الحقن داخل الخلب بجرعة 0.1مل من العالق الجرثومي الحاوي على 1x10 8Cfu من الجراثيم.المجموعة الثانية: وهي مجموعة (الاصابة والعلاج ) تم اصابتها كما في المجموعة الاولى وبعد مرور 30 يوم على الاصابة عولجت بعقار الايثامبيتول بجرعة 5 ملغم/كغم يومياً عن طريق التجريع بالفم.المجموعة الثالثة: عدت بوصفها مجموعة سيطرة للمجاميع المصابة حيث حقنت بـ 1 مل من المحلول الفسلجي المعقم داخل الخلب.وبعد مرور 60 يوماً من الاصابة تم قتل حيوانات المجاميع الثلاث واخذ عينات من الاعضاء الداخلية (الكبد، الرئتين، الكلى، الطحال، الامعاء) لغرض دراسة التغيرات المرضية.اظهرت النتائج حدوث افات مرضية شديدة تميزت بالافات الحبيبية المنتشرة في اكباد ورئات الحيوانات المصابة اضافة للاحتقان والتغيرات للتنكسية وارتشاح الخلايا الالتهابية في الطحال والكلى والامعاء.اما مجموعة الاصابة والعلاج فقد اظهرت تغيرات وافات مرضية تراوحت بين الشدة الاقل والشفاء التام.


Article
THE SULFONAMIDE EXPOSURE AND THE HISTOPATHOLOGICAL ALTERATIONS OF DOMESTIC PIGEON
التعرض للسلفونمايد والتغيرات المرضية النسجية في الحمام المستأنس

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Abstract

A two months Toxicologicl pathology study of sulfonamide in domestic pigeons by oral intubation were done. The study was done at two dosage levels as intermediate 40mg/kg and high 80mg/kg with untreated control as third group. Clinical observation of treated birds did not show significant changes only the birds appeared to be quite after dosing for short time. Grossly, no obvious changes could be detected. Microscopically, Showed histopathological changes in pigeons represent of nephrotoxic effects characterized by degenerate and/or dilated cortical tubules in intermediate while, high dose groups appeared glomerular atrophy some with dilated Bowmans space, the severity of the changes were higher in the high dose group. In liver, peri portal and septal fibrosis in treated groups, some with parenchymal foci of inflammatory cell and vaculation of hepatocytes, while in pancreas, there was degenerate vacuolated islets of Langerhans in both treated groups, also in brain vacuolation of neurons and vacuoltion of nerve fiber in white matter of spinal cord. The severity of all above changes were higher in high dose than intermediate dose. Finally , the present study showed that domestic pigeons can tolerate varying toxic levels of sulfonamide with no mortality.

دراسة المرضية السمية للسلفونمايد لمدة شهرين في الحمام المستأنس بأستخدام التجريع الفموي. الدراسة شملت 3 مجاميع. جرعت المجموعتين الأولى والثانية بالجرعة المتوسطة 10 ملغم/وزن الجسم (40 ملغم/كغم) والجرعة العالية 20ملغم/وزن الجسم(80ملغم/كغم) بالأضافة الى المجموعة الثالثة كمجموعة سيطرة جرعت بالماء فقط. المشاهدات السريرية في الطيور المجرعة لم تلاحظ تغيرات واضحة،فقط ان الطيور كانت هادئة بعد التجريع لفترة وجيزة. عيانيا ،لم تلاحظ تغيرات عيانية. مجهريا،الدراسة النسجية للمرضية السمية للسلفونمايد أظهرت تغيرات سمية كلوية تتصف بوجود تنكس في نبيبات القشرة في المجموعة المجرعة المتوسطة والمجموعة المجرعة العالية ، مع ضمور في الكبيبات بالأضافة الى توسع النبيبات القشرية وتوسع في فراغ باومن للكبيبات. في الكبد لوحظ تليف ماقبل البوابي والحويجزات الليفية الناتجة في المجاميع المجرعة مع بؤر لخلايا التهابية وتجوف في خلايا الكبد. في البنكرياس وجد تنكس في جزر لانكرهانس في المجاميع المجرعة بالسلفونمايد. في الدماغ وجد تجوف في الخلايا العصبية وتجوف في الألياف العصبية في العمود الفقري. كانت شدة كل التغييرات المذكورة أعلاه أكبر في الجرعةالعالية من الجرعة المتوسطة وفي النهاية أظهرت الدراسة أن الحمام المستأنس يتحمل جرع سمية مختلفة من السلفونمايد مع عدم هلاكها .


Article
Some Biochemical and Histopathological Changes in Liver of Pregnant Female Rats Following Fluoroquinolones Administration
بعض المعايير الكيمياحيوية و التغيرات النسيجية في أكباد إناث الجرذان الحوامل بعد المعالجة بالكوينولينات المفلورة

Author: Ashwaq Jabbar Al-Miahy
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2012 Volume: 4 Issue: 2 Pages: 32-35
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

The present study was designed to investigate the possible effects of fluoroquinolones (Norfloxacin, Ciprofloxacin, and Enrofloxacin) on some biochemical and histopathological changes of liver in pregnant female rats (Ratus norvigicus). 40 pregnant rats weighing 175-185 gm, and 10-12 weeks old in age, were divided equally in to control and three experimental groups. Control group treated with dimethylsulphoxide (DMSO) at a dose 0.5 ml/animal/day while the experimental animals treated with oral doses of (700 mg/Kg b.w. of Norfloxacin, 550 mg/Kg b.w. of Ciprofloxacin, and 750 mg/Kg b.w. of Enrofloxacin, all groups were administered these substances from the day 1 till the day 15 of gestation. Dissection was performed on day 15 of gestation after 4 hours from the last dose. Results revealed a significant (p<0.05) decrease in total protein content in serum of the treated groups (NFX, CPX) when compared with control, while ENX treated group showed a decrease in total protein but not significant. Assessment of globulin in all treated groups showed a significant decrease as compared with the globulin of control. Histopathological changes in liver sections of these females were in the form of dilatation of central and portal vein, and sinusoidal spaces, congestion in blood vessels, degenerated hepatocytes with necrotic nuclei. These results revealed the toxic effects of fluoroquinolones on the livers of pregnant female rats.

صممت ﮬذه الدراسة للكشف عن التأثيرات المحتملة للكوينولينات المفلورة (النورفلوكساسين, والسبروفلوكساسين, والانروفلوكساسين ) في بعض المعايير الكيمياحيوية والتغيرات النسيجية للإناث الحوامل في الجرذان المختبرية. قسمت 40 من إناث الجرذان من النوع النرويجي الأبيض بوزن ( 175-185 كغم ) وبعمر ( 10-12 ) أسبوع قسمت إلى مجموعة سيطرة وثلاث مجاميع اختبارية. أعطيت مجموعة السيطرة بمادة ثنائي اوكسيد سلفات المثيل وبجرعة 0.5 مل لكل حيوان في اليوم الواحد عن طريق الفم(وهي من المركبات العضوية الواسعة الاستعمال لإذابة المواد العضوية بالإضافة إلى الماء وليس لها أي تأثير سلبي) , بينما المجاميع الاختبارية الثلاثة الأخرى فقد أعطيت جرع يومية من (النورفلوكساسين 700 ملغم/كغم, والسبروفلوكساسين 550 ملغم/كغم, والانروفلوكساسين 750 ملغم/كغم) من اليوم الأول للحمل ولغاية اليوم الخامس عشر منه, ثم قتلت تلك الحيوانات في ﺬلك اليوم بعد 4 ساعات من آخر جرعة ,أظهرت النتائج انخفاضا معنويا (p<0.05في نسب بروتينات الدم الكلية لمصول دماء الحيوانات المعاملة بالنورفلوكساسين والسبروفلوكساسين عندما قورنت بمجموعة السيطرة, بينما مجموعة الانروفلوكساسين قد أظهرت انخفاضا في نسب البروتين الكلي لمصل الدم مقارنة بمجموعة السيطرة ولكن لم يكن معنويا. اظهر تقدير الكلوبيولين انخفاضا معنويا (p<0.05)في جميع المجاميع المعاملة عندما قورنت مع مجموعة السيطرة. أما نسيجيا فقد أظهرت نماذج أنسجة الكبد المأخوذة من الحيوانات المعاملة توسع الأوردة والجييبات الكبدية,واحتقان في الأوعية الدموية الكبدية, وتنخر في خلايا الكبد وتنكز أنويتها واحتقان الأوردة البوابية, من الممكن استنتاج أن تلك العقاقير لها تأثير سمي على بيوكيميائية الدم ونسيج الكبد في إناث الجرذان الحوامل.


Article
Histopathological and Histochemical Changes of the Popliteal Artery in Diabetic Patients

Authors: Payman Jamal Muhamad Ameen --- Talib Jawad Kazim --- Hewa Baker
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2014 Volume: 7 Issue: 1 Pages: 8-17
Publisher: Diyala University جامعة ديالى

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Abstract

Back ground: A lot of previous researches studded the endoneural microangiopathy and small vessels diabetic pathological change, but little studded about the diabetic angiopathy of the larger vessels like popliteal artery and related diabetic risk factors .Accordingly the present work designed to study the structural and histochemical changes of the popliteal artery as one of the medium size vessels.Objective: Evaluation of the histopathological and histochemical measurement, of the popliteal artery in diabetic male and female patients with different duration of the diseases, in comparison with normal non diabetic samples. Patient and methods: Histological sections, taken from amputated legs of 30 diabetic patients (8 females and 22 males) at age of (55-75) years, and 30 cadavers (4 females and 26 males) at age of (25-50) years as control group. Results: Histological sections from the popliteal artery of diabetic patients, showed marked decrease in the diameter of the lumen, reduced thickness of tunica media and adventitia, but increase in the thickness of tunica intimae and basement membrane. The loss of endothelium in some places, cellular infiltrations in tunica media with Periodic Acid Schiff positive particles, and in more advance cases calcifications, and organized thrombus was also detected. The multiple regression analysis, showed significant effect of duration of diabetes on the diameter of the lumen, and thickness of the wall and the tunica intima and media of the popliteal artery.


Article
Gynecomastia Treatment Should it be Individualized? A Prospective Study

Authors: Riyadh M Hassan --- ,Zuhair B Kama --- Wisam Abdul lateef Hussein*
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 3 Pages: 394-402
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND :Gynecomastia is a benign enlargement of the male breast.OBJECTIVE:Was to analyze a 3 year period of gynecomastia patients in Al-Kindy Teaching Hospital and the surgical approach used and its outcome.PATIENTS AND METHODS:A prospective study of patients consulting Al-Kindy Teaching Hospital because of gynecomastia between October 2007and August 2010 was done. Data were analyzed for etiology, grade of gynecomastia, surgical technique, complications, and histological results.RESULTS:A total of 64 patients with 86 operations were included. Techniques included subcutaneous mastectomy alone, or subcutaneous mastectomy with wise pattern "inverted T incision". Atypical histological findings were found in 3.12% of the patients (papilloma, fibrolipoma). Surgical revision among all patients was 7%. Body mass index higher than 25kg/m2 was found as significant risk factors for complications (p.043), and that higher grades of gynecomastia (grade IIb and III )had higher statistical incidence of complications p= 0.01CONCLUSION:The treatment of gynecomastia requires an individualized approach. Caution must be taken in high BMI and higher grades, which are associated with increased complication rates. Histological tissue diagnosis should be routinely performed in all true gynecomastia corrections, because histological results may reveal atypical cellular pathology.


Article
Histopathological evaluation of oral lichen planus

Author: Layla S. Yas ليلى ياس
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: special issue 2 Pages: 48-54
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Oral lichen planus( OLP) is a chronic inflammatory disorder affecting mucosal surfaces , which cancause an important discomfort to the patients . To highlight the most characteristic histopathological findings of OLPwhich are useful in making a diagnosis of OLP. In addition, by studying the association of these findings it was hopedthat information about pathogenic mechanism would be obtained.Material and Methods : In this study a retrospective analyses of 194 cases of OLP being diagnosed at Oral andMaxillofacial Pathology Department, College of Dentistry , were obtained over a period of 26 years , spanning from1985- 2010 . We analyzed the age and sex of the patients, clinical type of lichen planus, site and differenthistopathological finding, comparing them with each others.Results: (61%) of the patients are female and (39 %) are males, with an average age for both sexes (49.75 years).The most frequent clinical form is reticular, presented in (78%) of cases, and the most common location is buccalmucosa, presented in (60%) of the patients. The mononuclear infiltration beneath and adjacent to the epithelium,parakeratosis and degeneration of the basal layer of the epithelium were consistent features. Linear regressionanalysis revealed a positive correlation between basal degeneration and mononuclear infiltration and an inversecorrelation between the mononuclear infiltrate and the parakeratosis.Conclusion: Linear regression analysis of the parameters studied provided partial support for a cell- mediatedimmune mechanism

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