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Article
Assessment of Endometrial Thickness in Postmenopausal Women with and without Hypertension

Author: Nada Salih Amen
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 1 Pages: 39-44
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT :BACKGROUND:Hypertension in postmenopausal women is a risk factor for endometrial hyperplasia.OBJECTIVE:To examine whether the endometrium of hypertensive postmenopausal women is thicker than thatof non hypertensive postmenopausal women, to determine whether this thickening is directlyrelated to the antihypertensive drugs and whether is associated with abnormal pathology.METHODS:A Case control study of Forty five hypertensive asymptomatic postmenopausal women wasconducted in Al Yarmouk Teaching Hospital, (22) were treated with B- blockers combinationmedication and (23) were treated with other medications. They were compared with each and with(25) non hypertensive women. All women were interviewed; blood tests were performed andendometrial thickness in antero-posterior diameter was measured by vaginal ultrasonography.Endometrial sampling had been taken for those with increased endometrial thickness more than5mm.RESULTS:24.44% of hypertensive women and 4.00% of non hypertensive women had an endometrialthickness more than 5mm. There was no statistically significant difference between those whotreated with medication including B- blocker and those who were treated with other medication.The histological findings were mainly of endometrial hyperplasia for those with thickenedendometrium.CONCLUSION:Hypertension may have a role in endometrial thickness. We were unable to substantiate anassociation between the type of treatment administered and the increase in endometrial thickness.Those with increased endometrial thickness more than 5mm, the histological findings were mainlyof endometrial hyperplasia


Article
Transurethral Microwave Thermotherapy (TUMT) For Benign Prostatic Hyperplasia

Author: Firas Shakir Attar
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 1 Pages: 24-26
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Benign prostatic hyperplasia (BPH) is one of the most common diseases of the aging male. Minimally invasive therapies for treatment of BPH compete with the gold standard transurethral resection of the prostate (TURP). The aim of this study is to assess the efficacy of transurethral microwave therapy (TUMT) in patients with otherwise poor general health.METHODS:Thirty (30) patients with associated chronic medical diseases and lower urinary tract symptoms due to BPH were subjected for TUMT as an outpatient single session procedure, from June 2001 to August 2005. Follow up was performed 2 weeks, and then one month following treatment clinically and by assessing residual urine volume, maximal flow rate and prostate size.RESULTS:Out of (28) treated patients, (21) were labeled as non – responders as they were unable to pass urine freely 2-weeks after a trial of decatheterisation. In contrast (7) patients passed urine freely after decatheterisation. In the latter group, it was found that there was no statistical significance of the values of maximum flow rate, residual urine volume or prostate size between pre- and one month post TUMT.CONCLUSION:TUMT is a possible option for the treatment of BPH in poor general health patients or those refusing other surgical modalities. However, it did not prove to be effective for those patients with chronic urinary retention and BPH


Article
The Role of Celecoxib for Treatment of Refractory Nocturia Caused by Benign Prostatic Hyperplasia

Authors: Mohammed Bassil Ismail --- Adil Hefdhi Al.soufi --- Hasanin Farhan Hasan
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2014 Volume: 11 Issue: 2 Pages: 428-436
Publisher: Babylon University جامعة بابل

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Abstract

Objective: Nocturia is a well-recognized symptom in patient with benign prostatic hyperplasia ( BPH), which is commonly treated by alpha- blocker and/ or 5 alpha - reductase inhibitors. However, the effectiveness of these drugs for nocturia has been reported to be only 25%- 39%. The aim of this study was to investigate the efficacy of celecoxib, a cyclooxygenase -2 inhibitor, in the treatment of patient with BPH complaing of nocturia.Patients and methods: A prospective study of 50 men with signs tract symptoms and BPH of refractory nocturia to alpha- blocker and/ or 5 alpha reductase inhibitor more than two episodes of nocturia per night were involved for nocturia. Although these patients had received standard drug therapy for more than one month , they had still three or more episodes of nocturia. The patients took a single dose of 100 mg of celecoxib at night prior to sleep. and 2 week after the initiation of this therapy, the effects of this treatment were assessed by frequency chart and a questionnaire.Results: In the questionnaire ,32 of 50 patients (64%) had an excellent response with celecoxib treatment than previous treatments, 14 of 50 patients (24%) had an improvement with celecoxib treatment than previous treatments, 4 of 50 patients (8%) had no response with celecoxib treatment, Nocturnal frequency showed a statistically significant reduction from, baseline after two weeks treatment with celecoxib (P < 0.01), International Prostate Symptom Score( IPSS) showed a statistically significant reduction from baseline after two weeks treatment with celecoxib (P < 0.01), peak flow rate showed a statistically no response from baseline after two weeks treatment with celecoxib (P < 0.05).Conclusion: Celecoxib is effective in the treatment of patients with BPH complaining of refractory nocturia. The results suggest a novel treatment option for this common condition.

الهدف: ان هدف الدراسة هو لتحديد فعالية عقار السيليكوكسب في معالجة التبول الليلي عند مرضى تضخم البروستات الحميد.منهج الدراسة: اشتملت الدراسة على 50 مريضا يعانون من التبول الليلي لاكثر من مرتين نتيجة لتضخم البروستات الحميد تتراوح اعمارهم بين (50-75). وقد جمع المرضى من الاستشارية البولية في مدينة الطب في بغداد للفترة من شهر حزيران 2010 الى شهر اب 2011. علما ان هؤلاء المرضى مستمرين على علاج تضخم البروستات الحميد التقليدي لاكثر من شهر وبالرغم من ذلك الا انهم ضلوا يعانون من التبول الليلي لاكثر من مرتين.اعطي هؤلاء عقار السيليكوكسب 100 ملغم مرة واحدة يوميا قبل النوم.وقمنا باحتساب عدد مرات التبول الليلي قبل وبعد اسبوعين اعطاء المرضى عقار السيليكوكسيب اظهرت النتائج بان 32 من المرضى ال50 كانت فعالية العقار عندهم ممتازة.نتائج الدراسة: حسب المقياس الشخصي اظهرت النتائج بان32 (64%) من المرضى كانت فعالية العقار لديهم ممتازة و14 (28%) من المرضى كانت فعالية العقار لديهم مقبولة و 4(8%) ليس لديهم اي استجابة للعقار.الاستنتاج: اثبتت الدراسة فعالية عقار السيليكوكسب في علاج التبول الليلي لدى المرضى الذين يعانون من تضخم البروستات الحميد.


Article
Study the Toxic Effect of Different Doses of Duprost in Liver and Blood of Albino Mice
دراسة التاثير السمي للجرع المختلفة من عقار Duprost في كبد ودم الفئران البيض

Authors: Ban Jasim Mohamad بان جاسم محمد --- Hind Hussein Obaid هند حسين عبيد --- Duha Ibraheem Mohamad ضحى ابراهيم محمد --- Maha Salim Yaseen
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2017 Volume: 58 Issue: 3B Pages: 1381-1392
Publisher: Baghdad University جامعة بغداد

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Abstract

The aim of this study is to investigate the effect of different doses of Duprost in the liver and blood of albino mice. The current study included twenty one albino mice, obtained and grouped into 3 groups: control (3 mice), acute group (12 mice) and chronic group (6 mice). The acute group was subdivided into 4 groups and each group of 3mice, was given a lonely oral dose of (0.25ml, 0.15ml, 0.1 ml and 0.05ml respectively) for 24 hours. Whereas the third group was subdivided into 2 groups and each set was given a daily dose of (0.15ml and 0.05 ml respectively) for 30 days. After the mentioned periods, blood samples from each animal were taken for blood analysis. Then, the mice of all groups were sacrificed and the livers were removed, processed, sectioned and stained for histological analysis. In acute group, all mice that dosed with (0.25 ml) dose, died after 15 minutes of dosing. Blood results showed significant decrease in Hb level, WBC's and platelets' count among acute subgroups in comparison with chronic subgroups which showed significant increase in WBC and platelets' count, but a significant decrease in Hb levels. The histological analysis of liver in acute subgroups showed different forms of liver inflammation among acute subgroups, in comparison with chronic subgroups which showed formation of granulomatous lesions in the liver parenchyma in high dose(0.15ml) but there were inflammatory cells' aggregation in liver parenchyma among lower doses.

تهدف هذه الدراسة الى التحري عن تاثير الجرع المختلفة من عقار Duprost في كبد ودم الفئران البيض. شملت الدراسة 21 فارا تم تقسيمها الى ثلاث مجاميع هي : مجموعة السيطرة (3) فئران, مجموعة الاصابة الحادة (12) فأرا والتي قسمت بدورها الى 4 مجاميع ثانوية اعطيت كل مجموعة منها جرعة فموية واحدة من الحجوم التالية (0.05ml, 0.1 ml ,0.15ml ,0.25mlعلى الترتيبب) لمدة 24 ساعة. اما المجموعة الثالثة مجموعة الاصابة المزمنة ضمت (6) فئران والتي قسمت بدورها الى مجموعتين ثانويتين كل منهما ضمت 3 فئران وتم تجريعها يوميا بجرعة فموية واحدة من الجرع التالية (0.05ml, 0.15ml) لمدة 30 يوم. بعد انقضاء المدة المحددة لكل مجموعة تم سحب عينات الدم من كل فأر لاجراء التحاليل المختلفة وايضا تم تشريح الحيوانات واستخراج الكبد وتقطيعه الى شرائح وتصبيغها لغرض الدراسة النسيجية. اظهرت نتائج مجموعة الاصابة الحادة موت جميع الفئران التي جرعت بجرعة (0.25 ml) من الدواء بعد 15 دقيقة من التجريع. بينما اظهرت نتائج الدم حدوث انخفاض معنوي في مستوى الهيموغلوبين وكذلك تعداد الكريات البيض والصفيحات الدموية في مجموعة الاصابة الحادة مقارنة بمجموعة الاصابة المزمنة التي اظهرت ارتفاعا في مستويات الكريات البيض والصفيحات بينما كان هناك انخفاض في مستوى الهيموغلوبين فيها. اما نتائج الدراسة النسيجية في مجموعة الاصابة الحادة فقد اظهرت وجود اشكال مختلفة من الالتهاب في نسيج الكبد بين مجاميعها الثانوية بمجموعة الاصابة المزمنة التي اظهرت وجود اورام حبيبية في النسيج الحشوي للكبد عند الجرع العالية من الدواء في حين كان هناك تجمع للخلايا الالتهابية عند الجرع الاوطأ.


Article
The Frequency of Histopathological Patterns in Endometriam Obtained from a Sample of Iraqi Women with Abnormal Uterine Bleeding

Author: Farah Falah Hassan
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2017 Volume: 10 Issue: 3 Pages: 3846-3856
Publisher: Kerbala University جامعة كربلاء

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background: Abnormal uterine bleeding is one of the most common and challenging problems to the gynecologist regardless of the age of the women. Histopathological evaluation of endometrium regarded as an important step in the diagnosis and management of endometrial causes of Abnormal Uterine Bleeding.Objective: To study the frequency of different histopathological patterns of endometrium in women with abnormal uterine bleeding across different age groups.Materials and methods: A retrospective age specific comparative analysis was done using a total number of women (85) presenting with abnormal uterine bleeding who underwent endometrial sampling during one year period from January 2015 to march 2016 in the pathology department of AL elwia teaching hospital. Endometrial curettages done for evaluation of products of conception were excluded. Endometrial samples were sent for histopathological examinations and different histological patterns were noted.Results: Abnormal uterine bleeding was found to be more frequent in women in age 41 to 60 years and less frequent in the age over 60 years. The most common histopathological feature present in the curetting materials of women with abnormal uterine bleeding was inadequate proliferative endometrium (which belong to inorganic cause of AUB*dysfunctional*) in both age group 20 to 40 years and 41 to 60 years, and represent (44.7%) of total samples, while none of the samples in women over 60 years showed inadequate proliferative endometrium. Endometrial carcinoma was diagnosed in five samples, representing (5.88%) of all samples, all were of grade I endometriod type and all were in the age group 41 to 60 years which represent (8.62% ) of all the samples in this age group. Only one sample (1.17%) showed malignant mixed Mullerian tumor. Regarding endometrial hyperplasia, 14 were simple hyperplasia without atypia representing 16.47% of all samples, all were without atypia, while only one sample (1.17%) showed complex atypical hyperplasia .This study also showed that 15 samples (17.64%) were due to endometrial polyps. Two samples (2.35%) showed irregular secretory endometrium. Three samples (3.52%) showed histological evidence of exogenous hormone administration, while six samples (7%) were not conclusive.Conclusions: Abnormal uterine bleeding in women below 60 years old is most commonly dysfunctional in origin. In addition, a good number showed underlying organic pathology, thus highlighting the importance of endometrial curettage and biopsy as a diagnostic procedure in the evaluation of women (particularly over 40 years old) with abnormal uterine bleeding for an early detection of ominous lesions such as endometrial adenocarcinoma and its precursors since histopathological findings of endometrium regarded as the main basis of management desescin


Article
P53 Expression in Endometrial Hyperplasia and Endometrial Carcinoma
التعبير P53 في فرط تنسج بطانة الرحم وسرطان بطانة الرحم

Authors: Rivan Hermiz Isaac --- Nadya Y. Ahmed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 2 Pages: 28-34
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: Mutations of the P53 tumor suppressor gene and altera-tions in its protein expression often occur in a variety of human malignant tumors, including endometrial carcinoma, but the practical implications of this phenomenon are yet to be fully exploited. This study was designed to evaluate P53 protein expression in normal, hyper-plastic and malignant endometrium by immunohistochemical study and to correlate P53 expression in endometrial carcinoma with other clinic-pathological prognostic parameters (age, histologic type, tumor grade, cervical & myometrial invasion, and tumor stage).Methods: The studied samples included 100 formalin fixed, paraffin embedded endo-metrial tissue specimens which were divided to the following diagnostic categories: - Pro-liferative endometrium (n=10); secretory endometrium (n=10); simple hyperplasia (n=10); complex hyperplasia without atypia (n=20); atypical complex hyperplasia (n=10) and endo-metrial carcinoma (n=40).Results: None of the normal endometrium, simple hyperplasia and complex hyperplasia without atypia showed P53 immunostaining, while 20% of atypical complex hyperplasia and 32.5% of endometrial carcinoma showed immunoreactivity for P53. In endometrial car-cinoma, significant correlation was observed between P53 expression and age at diagno-sis, histological grade,FIGO stage, myometrial invasion & cervical invasion ; but not with the histological type .Conclusions: The results indicated the validity & simplicity of the application of immuno-histochemistry in determining the status of P53 overexpresion which is strongly associated with endometrial carcinoma aggressiveness and high malignant potential.


Article
The Effect of Acute Urinary Retention on The Accuracy of Serum Prostate-Specific Antigen Level Measurements

Author: Ehab Jasim Mohammad
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 1 Pages: 118-122
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:The level of PSA in serum is increased by inflammation of the prostate, urinary retention,prostaticinfection, benign prostatic hyperplasia,prostate cancer, and prostatic manipulation. [3]OBJECTIVE:To study the effect of acute urinary retention on the serum prostate-specific antigen (PSA)concentration.METHODS:Blood samples for serum PSA measurement were obtained (PSA1), and an indwelling urethralcatheter was inserted for 2 weeks. Before catheter removal, a second blood sample for measurementof serum PSA level (PSA2) was obtained. In patients who were able to void, a third sample wasobtained 3 weeks later (PSA3). In the first and second visits, digital rectal examinations (DRE1,DRE2) were performed to assess prostate volume. Mean PSA levels (PSA1, PSA2, and PSA3) andprostate volumes (DRE1, DRE2) were compared.RESULTS:Fourty-two patients with a mean age of 70.18 years (range 56 to 85 years) participated in thisstudy.mean PSA level at the time of AUR (PSA1) was 7.02 ng/mL (median, 5.8 ng/mL; range, 0.9 to30.4 ng/mL). The mean PSA2 level was 5.5 ng/mL (median, 3.9 ng/mL; range, 0.7 to 39 ng/mL),lower than the PSA1 level .This association was statistically non significant P > 0.05. The meanprostate volume at the time of DRE1 (43.4 mL; median, 45 mL; range, 30 to 60 mL) wassignificantly higher than at DRE2 (37.8 mL; median, 40 mL; range, 25 to 50 mL) (P < 0.001).PSA3 was measured in 42 patients 4 weeks after retention (2 weeks after catheter removal). In thisgroup of patients, mean PSA2 and PSA3 levels were 5.5 ng/mL and 5.1 ng/mL, respectively (median,3.9 and 3.5, respectively, P > 0.05).CONCLUSION:Acute urinary retention can increase serum PSA levels. In this series, we found that this effect maycontinue up to 2 weeks.


Article
Effect of Iodine Overdose on Thyroid Hyperplasia

Author: Tala A. Abdul Wahab
Journal: nursing national Iraqi specility المجلة العراقية الوطنية للعلوم التمريضية ISSN: 18122388 Year: 2009 Volume: 22 Issue: 2 Pages: 1-10
Publisher: Baghdad University جامعة بغداد

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Abstract

Objectives: study the relation between the effect of time (long time duration) with high concentration of iodine and study its effect on the activity of the thyroid gland (hormonal and histological changes).Methodology: An experimental study was done on (30) albino rats (8 weeks of age) to know the effect of high concentration of iodine on the activity of the thyroid gland (hormonal and histological changes) related with time. The study last for six months for the period of 1/2/2007 to 31/7/2007, the experiment was carried out in the research lab. of pathology department, College of Medicine, University of Baghdad. Results: The study shows changes in hormonal levels of thyroid hormones (T3 & T4) and also histological changes in the diameter and numbers of thyroid follicles and increase in the numbers of active hot follicles and decrease in the numbers of inactive cold follicles. The hot follicles takes faint blue colour after using the toluiden blue dye to stain the thyroid tissue while the cold follicles takes deep dark blue colour in the thyroid gland section when using the same dye. Recommendations: Carrying out such a study for long time duration (1year or more), and to study the correlation between the experimental results and the behavior of the human, and study the effect of iodine in different concentrations in mixture with thyroxin hormone.

الخلاصـة:الهـدف: دراسة العلاقة بين تأثير الوقت (طول المدّة الزمنية) مع مادة اليود بتركيز عالي ودراسة تأثيره على فعالية الغدة الدرقية والتغيرات من الناحية الهرمونية والنسيجية.المنهجيّـة: أجريت دراسة تجريبية على (30) جرذ أبيض من نوع الالباينو بعمر (8) أسابيع لمعرفة تأثير اليود بتركيز عالي على فعالية ونشاط هرمونات الغدة الدرقية والتغيرات النسيجية التي تحدث فيها وبالارتباط مع المدّة الزمنية (الوقت) واستمرت الدراسة لمدة ستة أشهر للمدّة من 1/2/2007 إلى 31/7/2007, وأجريت التجارب في مختبر الدراسات العليا في فرع الباثولوجي التابع لكلية الطب جامعة بغداد. النتائـج: تبين من الدراسة ظهور تغييرات في قراءات هرموني الغدة الدرقية (T3,T4) مع تغيرات نسيجية في نسيج الغدة الدرقية في قطر وعدد الجريبات المكوّنة للغدة وزيادة عدد الجريبات الحارة الفعالة active hot follicles وقلة في عدد الجريبات الباردة غير الفعالة inactive cold follicles حيث تأخذ الجريبات الحارة اللون الأزرق الفاتح أو الشاحب بعد تصبيغ النسيج بصبغة toluiden blue dye، بينما تأخذ الجريبات الباردة اللون الأزرق الغامق في المقطع النسيجي للغدة الدرقية باستخدام نفس الصبغة. التوصيات: إجراء دراسة مخطط أو تصميم التجربة لمدة زمنية أطول (سنة أو أكثر) لمعرفة تأثير اليود عالي التركيز على نسيج ووظيفة الغدة الدرقية مع دراسة العلاقة بين نتائج التجربة وسلوك الإنسان (تطبيق هذه الدراسة على الإنسان) كما ويوصى بدراسة تأثير اليود وبتراكيز مختلفة مع هرمون الثايروكسين على الغدة الدرقية.


Article
Evaluation of the hematological and histopathological effects of Teucrium polium on experimental hyperthyroidism rats

Author: Adaay*1 M.H., jaata 2 , T.A.l., Al-hindawi 2 ,S. H.
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2009 Volume: 12 Issue: 2 Pages: 273-281
Publisher: University of Kufa جامعة الكوفة

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Abstract

Mature Albino rats of both sexes were given 5mg/kg/day carbimazole orally for 15 days for experimental induction of hyperplasia. The animals divided to four groups, G1 served as a positive control and G2, G3 and G4 treated orally with 50, 100 and 200 mg/kg/day respectively of the aqueous extract of Teucrium polium for 45 days to evaluate its effects on Hb, RBCs, differential leukocytic count and thyroid gland after 15, 30 and 45 days of treatment. The results showed a decrease in Hb and RBCs values during the first two periods and an increase during the last period of the experiment, no significant changes on the differential leukocytic count whereas T4 and T3 revealed a significant increase during the first two periods and a significant decrease during the last period. histopathological preparations of the thyroid gland revealed a remarkable amelioration on the follicular cells in which they were refilled with colloid materials and become look like normal especially in the group treated with 100mg/kg.

عوملت الجرذان البالغة من كلا الجنسين بعقار الكاربمازول 5ملغم/كغم/يوم عن طريق الفم لمدة 15 يوم للتحفيز التجريبي لفرط التنسج . قسمت الحيوانات الى مجموعة سيطرة ايجابية وثلاثة مجاميع عوملت عن طريق الفم بالمستخلص المائي لنبات الجعدة وبجرع 50و 100 و200 ملغم/كغم/يوم لتقييم التاثيرات المحتملة على الهيموغلوبين وكريات الدم الحمراء والحساب التفريقي لكريات الدم البيضاء والغدة الدرقية بعد 15و30 و45 يوم من المعاملة. اظهرت النتائج انخفاض في قيم الهيموغلوبين وتعداد كريات الدم الحمراء خلال الفترتين الاوليتين من التجربة وارتفاع في تلك القيم للفترة الاخيرة من التجربة، لم تظهر تاثيرات تذكر على الحساب التفريقي لكريات الدم البيضاء بينما ارتفعت قيم هورمونات الثايروكسين والثايرونين ثلاثي اليود بشكل ملحوض خلال الفترتين الاوليتين من التجربة وانخفضت تلك القيم خلال الفترة الاخيرة من التجربة. التحضيرات النسيجية للغدة الدرقية اظهرت تحسن ملحوظ للخلايا الحوصلية حيث اعيد امتلائها بالمواد الغروية واصبحت تبدو مشابهة للطبيعية وخاصة في المجموعة المعاملة بجرعة 100ملغم/كغم/يوم.


Article
Histological Changes in the Thoracic Aorta of Adult Rats Treated with Melatonin
التأثيرات النسيجية لهرمون الميلاتونين على الأبهر الصدري للجرذان البيض

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Abstract

Background: The main pineal hormone, Melatonin, is an important cardioprotective hormone whose receptors have been located in the vasculature & have been suggested to inhibit vascular reactivity through different mechanisms. It can prevent the initiation & the progression of atherogenicity.Objective: the study aims to explore the histological effects of pharmacological & high doses of dietary melatonin on the thoracic aorta of adult rats.Materials & Methods: melatonin was given to adult albino rats for successive 4 weeks at daily single doses ranging from 250-1000 µg / kg body weight. The thoracic aorta was then studied under light microscopy for histological changes.Results: Studied specimens showed that 250 µg / kg body weight doses didn’t cause a significant change in the histology of the vasculature while 500 µg / kg body weight doses resulted in significant but regular vascular thickening. The high doses resulted in irregular smooth muscle hyperplasia, disruption of the connective tissue patterns & signs of intimal injuries.Conclusion: Low doses of melatonin may be protective & supportive to the vasculature but higher doses carry the risk of vascular damage.Key Words: Melatonin, vasculature, thoracic aorta, smooth muscle hyperplasia.

يعتبر الميلاتونين من الهرمونات الحامية للجهاز القلبي الوعائي و تلعب مستقبلات هذا الهرمون الموجودة في جدران الأوعية الدموية دورا في منع الاستجابة الوعائية للمحفزات من خلال آليات متعددة و منها دوره في منع حدوث أو تطور التصلب الشرياني.الأهداف: تهدف الدراسة لكشف التغيرات النسيجية للجرع العلاجية و العالية للميلاتونين على الأبهر الصدري للفئران البيض.طريقة العمل: تم إعطاء الميلاتونين للفئران البيض البالغة لمدة 4 أسابيع متتالية و بجرع يومية تترواح من 250 الى 1000 مايكروغرام لكل كغم من وزن الجسم حيث اعتبرت الجرعتان 250 و 500 مايكروغرام جرع علاجية و الجرعتان 750 و 1000 مايكروغرام جرع عالية. تم بعد ذلك دراسة الأبهر الصدري نسيجيا باستخدام المجهر الضوئي وقياس سمك الطبقة الشريانية الوسطى من الأبهر الصدري.النتائج: لوحظ عدم وجود تغيرات نسيجية تذكر عند الجرعة المنخفضة 250 مايكروغرام بينما ظهرت زيادة في سمك الجدار الشرياني عند الجرعة 500 مايكروجرام. أما عند الجرع العالية 750 و 1000 مايكروغرام فقد أظهرت العينات وجود فرط تسنج في العضلات الملساء للجدار الشرياني مع تمزق في الطبقات المرنة للشريان و إصابة مرضية محتملة للطبقة الوعائية الداخلية بالإضافة الى زيادة إحصائية مهمة في سمك الطبقة الشريانية الوسطى للمجموعات التى تلقت جرعا تزيد عن 250 مايكروجرام.الاستنتاج: قد توفر الجرعات العلاجية المنخفضة للميلاتونين فائدة أو حماية للجهاز الوعائي و لكن الجرعات العالية أو العالية تحمل خطر تدمير التركيب النسيجي للشرايين

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