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Sirtuin1, Inducible Nitric Oxide Synthase in Newly Diagnosed Iraqi Diabetic Patients

Authors: Mahmood Abdulhameed Hazim --- Perry H. Saifullah --- Beydaa Ahmed Abd
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2018 Volume: 21 Issue: 1 Pages: 1-7
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

In Mammals Sirtuins (SIRTs) are members of the silent information regulator two family Sirtuin1 regulate a variety of cellular functions. It shows anti-oxidative, anti-inflammatory, and anti-apoptotic effects against cellular damage.SIRT1 conserves the cells by the mitochondrial biogenesis organizing, cellular energy and oxido reduction state. Vascular tissues are protected by SIRT1 too. In diabetic patients mutation in exon1 of SIRT1 (L107P) in insulin-generating cells conducted in over production of nitric oxide synthase (iNOS), TNF-α.Assessment of SIRT1 protein levels in newly diagnosed Iraqi diabetic in regards to family history Age, gender, and duration of disease, and its correlation with biochemical parameter in the same group. Measurement of iNOS, TNF-α.This study involved totally 40 volunteers. This group were subdivided (20) volunteers as newly diagnosis (DMT1) duration disease ˂1 year, group1 was subdivided to 10 male and 10 female: (10 with family history and 10 without family history) and group two healthy volunteers. Group1 All DMT1 were under insulin treatment. Healthy Volunteers (20) included in this study as control groups. None Healthy Volunteers were alcoholic, smoke, or having a history of (CVD) cardiovascular disease, thyroid disease, and hormonal abnormalities problems were exempted from this study.In the present study SIRT1, TNF-alpha, iNOS were measured by enzyme linked immune absorbent assay (ELISA). Biochemical parameters fasting glucose, body mass index (BMI), urea, creatinine and lipid profile that were measured by spectrophotometer technique in patients and healthy volunteers groups.The Statistical Analysis System- SAS (2012) program was used to effect of difference factors in study parameters. Least significant difference –LSD test (ANOVA) was used to significant compare between means. Estimate of correlation coefficient between difference parameters in this study.The results showed that a highly significant increase in levels of FBG, Urea, creatinine and lipid profile except HDL was decrease levels, BMI was decrease in newly diagnosis DMT1 with healthy volunteers groups. A significant decrease in SIRT1 protein, and a highly significant increase in TNF-alpha and iNOS in newly diagnosis DMT1 with healthy volunteers groups. A highly negative significantly correlation coefficient between SIRT1 and F.G., TG., VLDL,TG/HDL, A.I. and negative significantly correlation duration, urea, creatinine,T.CH., LDL. And non-significant correlation with age, BMI, HDL, CH/HDL and LDL/HDL.. Effect of gender were insignificant of SIRT1. Effect of family history in patients. SIRT1 were all insignificant in patients with family history as with non-family history group. SIRT1 could decreases in the sera of DMT1 patients with family history, the decreased SIRT1 level reflect a mutation in SIRT1 gene, the decreases in SIRT1 on increases the incident of DMT1 complication

Keywords

SIRT1 --- DMT1 --- iNOS --- alfa-TN --- lipid profile --- body mass index.


Article
4-Hydroxy-2-Nonenal, Indused Nitric Oxide Synthase Statues in Hypertension Patients

Authors: Ali D. Hammed --- Alaa H. Jawad --- Perry H. Saifullah
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2017 Volume: 20 Issue: 3 Pages: 6-11
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

The oxidative stress is one of the main cause for cardiovascular diseases (like Hypertension) also one of the results of these diseases. This study involved 56 subjects matched ages and sex divided into two groups; 28 hypertensive subject and 28 healthy subject as control group. The following analysis was done: 4-Hydroxy-2-nonenal (4HNE), Induced nitric oxide synthase (iNOS) and albumin. The results show that there is a significant increase in (4HNE) between patients group and control group. INOS was significantly higher in patients compared to controls while there were no significant difference found in albumin between patient and control group. The increase in 4HNE which is a product of lipid peroxidation is attributed to destruction in body cell caused by due to the increase in stress events. And the increase in iNOS because iNOS produces large amounts of NO as a defense mechanism in response to cytokines and is an important factor in the response of the body to attack by parasites, bacterial infection, and tumor growth. It has been concluded that is important nappy on ideal weight, because obesity considered main factors for heart disease and hardening of the arteries. There is a positive relationship between oxidation results from hypertension and their developments. The aim of this study was to investigate the relationship between of some oxidative stress markers and cardiovascular diseases


Article
8.4-Hydroxy-2-nonenal, Induced Nitric Oxide Synthase Status in Hypertension with Kidney Disease Patients

Authors: Ali D. Hammed علي ظافر حميد --- Alaa H. Jawad علاء حسين جواد --- Noor M. Ali نور مصطفى علي
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2019 Volume: 17 Issue: 2 Pages: 146-152
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:The oxidative stress is one of the main reasons for cardiovascular diseases and also one of results of these diseases, its development (like kidney disease).Objective:To identify the effect of oxidative stress nitric oxide and reactive oxygen species on cardiovascular diseases.Methods:The study involved 56 subjects comparable in age and sex divided into two groups; 28 hypertensives subjects with kidney disease and 28 apparently healthy subjects as control group. The following analysis was done: 4-Hydroxy-2-nonenal (4HNE), Induced nitric oxide synthase (iNOS) and albumin.Results:There was a significant increase in (4HNE) between patients' group and control group. iNOS was significantly higher in patients as compared to controls while there were no significant differences found in albumin between patient and control group. There is a positive relationship between oxidation results from hypertension and their developments. There is a positive correlation between BMI and disease.Conclusion:Based on this study is important on ideal weight, because obesity considered main factors for heart disease and hardening of the arteries. In addition, the effect of oxidative stress, which leads to high blood pressure and thus chronic kidney disease.Keywords;Chronic kidney disease, hypertension, 4-Hydroxy-2-nonenal (4HNE), Induced nitric oxide synthase (iNOS), albumin, creatinine, reactive oxygen speciesCitation:Hammed AD, Jawad AH, Ali NM. 4-Hydroxy-2-nonenal, induced nitric oxide synthase status in hypertension with kidney disease patients. Iraqi JMS. 2019; 17(2): 146-152. doi: 10.22578/IJMS.17.2.8

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