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Article
The Role of Estrogen Receptors Immunohistochemical Study in Prognosis of Bladder Transitional Cell Carcinoma

Authors: Ahmed Aswed Hussein --- Nemah Hassony Al-Jubori --- Ali Hasan Al-Timimi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 4 Pages: 882 -889
Publisher: Babylon University جامعة بابل

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Abstract

Urothelial Bladder cancer (UBC) is a common and complex disease that have various internal and external risk factors and represent 90% of bladder cancer.Various studies involving immunohistochemical staining of estrogen receptors(ER) have rendered inconsistent results regarding the expression of ERα and ERβ for different bladder cancer stages and grades.Ninety five Paraff in embedded blocks of UBC (68 male and 27 female) were studied by immunohistochemical technique for detection of estrogen receptor expression and its correlation to some of prognostic parameters such as sex, age, grade and stage of UBC. The study was carried out in the Department of Pathology College of Medicine Babylon University during the period from November 2013 to Augest 2015. Mean age of all cases was 64.6 and they ranged from 30 to 90 years old. The results showed that there were low rate of estrogen receptor expression (only 15 positive cases) and no significant correlation between estrogen receptor expression and the involved prognostic parameters (p value > 0.05). So estrogen receptor expression cannot be used to assess the prognostic outcome for Urothelial bladder cancer.


Article
Immunohistochemical Localization of Epstein Barr Virus- Latent Membrane Protein 1 in Breast Cancer Tissues

Author: Saad Hasan Mohammed Ali *,Shakir H. Mohammed Al-Alwany**, Ghanim I.A. Al-Wadi *
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2016 Volume: 15 Issue: 2 Pages: 234-240
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACK GROUND:Epstein- Barr virus (EBV) is well known to infect the vast majority of the world's adult population and has recently been reported in many literatures for its association with a broad spectrum of benign and malignant tumors, including breast cancer. OBJECTIVE: To analyze the relations and impact of Epstein Barr Virus- latent membrane protein 1(EBV-LMP 1) expression on a group of tissues with primary invasive breast cancers.PATIENTS AND METHODS: Forty- nine (49) formalin-fixed, paraffin- embedded breast tissues were obtained in this study; (34) biopsies from breast cancers (BC) and (15) from apparently normal breast autopsies control group. Detection of expression of Epstein Barr Virus- latent membrane protein 1(EBV-LMP 1) was done by HRP/DAB immunohistochemistry detection kit (an immunoenzymatic antigen detection system for immunohistochemistry techniques) using specific primary antibodies for EBV-LMP 1.RESULTS: Detection of EBV-LMP 1 - immunohistochemical (IHC) reactions in tissues with BC was observed in 11 out of 34 (32.4%), while in healthy breast tissues in the control group was detected in 13.3% (2 out of 15). The difference between the percentages of EBV-LMP 1 detection in BC tissues & control group was statistically not significant (P >0.05).While no significant differences were observed between EBV-LMP 1 detection in BC tissues & the age of patients as well as grade of invasive breast cancers (P value > 0.05).CONCLUSION: Our results indicate that EBV could have a role in the pathogenesis of subset of breast cancers and contribution in their carcinogenesis. .

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