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Article
The Efficacy of Dextran 70 on Reticuloendothelial System in Systemically Infected Mice with Klebsiella Pneumoniae

Author: Jamela Gh. Auda
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 3 Pages: 256-262
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND: The reticuloendothelial system (RES) play an important role in immunity against bacterial infection and Klebsiella pneumoniae one of the most common causes of hospital-acquired infections. Dextran70 (D70), a polysaccharide, may alter functions of this system through changing many biological activities in the tissues. OBJECTIVE: This study focuses on the prophylactic effects of D70 on RES in systemically challenged mice with K. pneumoniae which has been isolated from urine sample of patient with urinary tract infection. METHODS: Four groups of adult white mice were intravenously injected with K.pneumoniae. Three groups of them was preinjected intraperitonealy for three successive days with 0.5 , 1, and 2 mg D70/100 g body weight, and the fourth group was challenged only as a control group. The ratio of liver and spleen weights to body weight was calculated and histological sections for heart, lung, and kidney were examined after 24 and 48 hours from challenge in all groups. RESULT: The results revealed that an increasing in the ratio of liver weights to body weight in control group, while there is slight increase in the three groups treated with D70. The ratio of spleen weights to body weight was more increasing after 24 hours in both 0.5 and 2 mg D70/100 g body weight of treated groups. The histological study demonstrated suppurative lesions and abscesses in the heart, lung, and kidney due to K. pneumoniae infection in the control group, while pretreated mice with D70 have clearly demonstrated less pathological changes and more integrity of the tissues comparative to control group


Article
The effect of Aloe vera extraction on immunity
تأثير مستخلص الصبير على المناعة

Authors: Hanaa Saleem yossef هناء سليم يوسف --- Ibtisam Saleem yousif ابتسام سليم يوسف
Journal: Jornal of Biotechnology Research Center مجلة مركز بحوث التقنيات الاحيائية ISSN: 18151140 Year: 2014 Volume: 8 Issue: 3 Pages: 48-51
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Aloe vera aqueous extraction was examined for its immunomodulatory effect. Concentrated aqueous extraction was administrated orally 2ml/day for 30 days to the white mice, immunomodulatory effect was studied on total white blood cells (WBCs)count, phagocytosis, antibody titer and plaque forming cell (PFC). There is a significant increase in total count of WBC, reach 11300cell/ml3 at the day 28 after administration. Increase in phagocytosis activity was observed clearly after three and four week compared with control. Remarkable increase in the antibody titer against SRBCs for primary and secondary immune response (10.4±022, 14.2±2) respectively, and finally apparent effect on plaque forming cell (PFC) and maximum value was found after 5 days after immunization with SRBCs. It was 1200 PFC/106 of spleen cell.

لقد تم اختبار قابلية التغيير المناعي للمستخلص المائي لنبات الصبار.باستعمال الفئران المختبرية وبجرعة 2مل عن طريق الفم يوميا ولمدة شهر. تمت دراسة تاثير التغيير المناعي على العدد الكلي للخلايا البيض، عملية البلعمه، عيارية الاضداد واخيرا دراسة التاثير على الخلايا المكونه للويحات الخلايا البائية (الخلايا الفارزه للاضداد). وجد زياده ملحوظه في العدد الكلي لكريات الدم البيض بلغ عددها 11300 خليه/مل3 في اليوم 28 بعد التغذيه بالمستخلص المائي مقارنة بالسيطره. كما وجد زياده في كفاءة عملية البلعمه عند الاسبوع الثالث والرابع مقارنة بلسيطره. كما وجد تاثير واضح في زيادة عياريةالاضداد ضد كريات الدم الحمر للخروف عند الاستجابة المناعية الاولى والثانية حيث بلغ عند الاستجابة المناعية الاولى 0.22 ± 10وعند الاستجابة المناعية الثانيه 2±4.2 واخيرا وجد ازدياد في عدد الخلايا المكونة للويحات(الخلايا الفارزه للاضداد) عند اليوم الخامس للتمنيع بكريات الدم الحمر للخروف وكان العدد 1500 لكل مليون خليه طحال.

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