research centers


Search results: Found 151

Listing 1 - 10 of 151 << page
of 16
>>
Sort by

Article
L-1α and IL-8 levels in leukopenic leukemic patients with bacteremia

Author: Sevan N. A. Abdallah
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 2 Pages: 128-131
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Interleukin-1α and Interleukin-8 are an inflammatory cytokines. They are a heterogeneous group ofhumeral mediators of the inflammatory response. In leukemic patient's leukopenia developed as aresult of cytotoxic chemotherapy and/ or disease itself. Therefore, those patients were suffering fromlow number of leukocytes in addition to defects in the function of these cells. Normally leukocytesare the main source of cytokines production.METHODS:IL-1α and IL-8 were studied in (84) adult patients, males and females and more than 15 years old.The leukemic patients were suffering from leukopenia and bacteremia. The study including (20)healthy. Interleukin-1α and interleukin-8 concentrations were measured by using a commerciallyavailable enzyme-linked immunosorbent assay (ELISA).RESULTS:Statistical analysis shows significant increase in the levels of IL-1α and IL-8 between leukopenicleukemic patients with bacteremia and healthy control group.CONCLUSION:Leukopenic leukemia patients strikingly show distinct increases in plasma IL-1α and IL-8 levelsduring bacteremia.

Keywords

Bacteremia --- Leukemia.


Article
Coagulopathy in Adult Acute Leukemia at Presentation in National Center of Hematology (NCH), Baghdad
تجلط الدم لدى المرضى البالغين المصابين بسرطان الدم الحاد في المركز الوطني لبحوث وعلاج امراض الدم / بغداد

Author: Abdulsalam Hatim Mohmmed د. عبد السلام حاتم محمد
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2013 Volume: 26 Issue: 2 Pages: 114-117
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Abstract: Background: Malignancy is associated with a hypercoagulable state and a high risk for thrombohemorrhagic complications, clinical complications may range from localized thrombosis more in solid tumors to bleeding of varying degrees of severity because of disseminated intravascular coagulation (D.I.C.) as in acute leukemia. Aim of the study: To search for the real cause of coagulopathy (bleeding or thrombosis) in patients with acute leukemia.Materials and methods: This study was conducted at the NCH between January 2010 and September 2011, 96 patients with acute leukemia where evaluated prospectively for hemostatic abnormality at presentation of which 43 (44.79 %) had acute lymphoblastic leukemia (ALL) and 53 (55.21 %) had acute myeloid leukemia of which 14 (14.58) were cases of Acute Promyelocytic Leukemia (APL).Results: At presentation 2 patients (2.3 %) with AML (M3, APL) subtype had bleeding manifestation (signs of intracranial hemorrhage) and died with in 24-48 hours in spite of urgent supportive managements, (94)patients (97.9 %) had variable abnormalities of coagulation indices which include prothrombin time (P.T.) , partial thromboplastin time (P.T.T.), plasma fibrinogen level and Factor VII levels, ranging from normal indices specially in ALL to slight increment in AML mainly M2 to moderate increase in some patients with M3 (bleeding manifestations noticed to be associated more in few AML M3 this was attributed to the procoagulant activity of cytoplasmic granules in the malignant promyelocytes. Conclusion: From the results obtained in this study which shows that the cause of bleeding is mostly associated with low platelets count , but not due to coagulation factors defects (as only PT was increased in some cases of AML) .Key words: Acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia.

مابين كانون الثاني 2010 وايلول 2011 تم فحص (96) مريضاً يعانون من سرطان الدم الحاد حيث تم اجراء تقييم مستقبلي لحالات شذوذ تجلط الدم في المركز اعلاه منهم (43)مريضاً (44,79%)يعانون من سرطان الدم اللمفاوي الحاد (ALL) و (53)مريضاً (55,21%) يعانون من سرطان الدم النقياني الحاد (AML) منهم (14) مريضاً (14,58%) يعانون من سرطان السلانف النقويه الحاده (APL) . في هذه الدراسه مريضان (2,3%) من مرضى سرطان السلانف النقويه الحادة (APL) اظهرا علامات نزيف حاد (علامات نزيف داخل الجمجمة) وتوفيا في ظرف 24-48 ساعه على الرغم من اجراء المحاولات الداعمة العاجله .(94)مريضاً (97,9%) أظهروا شذوذ متغير من المؤشرات التي تشمل اوقات التخثر مثل وقت البروثرومبين (P.T)، وقت جزيئية الثرومبوبلاستين (P.T.T)، مستوى الفايبرينوجين في البلازما ومستوى العامل السابع في مصل الدم، يتراوح هذا الشذوذ بين المستويات الطبيعية في كل شيئ خصوصاً في مرضى سرطان الدم اللمفاوي الحاد الى زيادة طفيفه في مرضى سرطان الدم النقياني الحاد }خصوصاً النوع الثاني منه (AML/M2){ الى زيادة متوسطة خصوصاً في النوع الثالث }(APL)AML/M3 { وقد عزي ذلك الى فعالية الحبيبات السايتوبلازمه الموجودة في الخلايا السرطانية .


Article
Evaluation of Fludarabine, and granulocyte colony

Author: Alaa Fadhil Alwan*, Adil siwan Alaqabi**,Azher Al-zubaidi**
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2012 Volume: 8 Issue: 2 Pages: 69-74
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Refractory/relapsed acute leukemia has always been a challenging problem for hematologist. Over the past decade emphasis has been made in the development of regimens containing fludarabine, combined with cytosine arabinoside for the treatment of refractory/relapsed acute leukemias. The aim of this study is to evaluate the efficacy and toxicity of the combination of fludarabine, high dose cytarabine, and granulocyte colony stimulating factor in refractory relapsed cases of acute leukaemia,Methods: a prospective study is being conducted at the national center of hematology and hematology unit /Baghdad teaching hospital from July 2008 to July 2010.Twenty Patients with refractory/relapsed acute leukemia were treated with fludarabine 30mg/m2 and cytosine arabinoside (AraC) 2 g/m2 for 5 days, and granulocyte colony stimulating factor G-CSF 300 microgram/day from day 0 till neutrophil recovery (ANC >1.0 x 109/l).Response was evaluated by bone marrow examination on day 30-post chemotherapy.Results: Patients included were refractory acute lymphoblastic leukemia (ALL) (n=5), relapsed ALL (n=4), refractory acute myeloid leukemia (AML) (n=8), relapsed AML (n=3). Complete remission (CR) was achieved in 9(45%) patients, 3 (15%) patients got partial remission. Three (15%) patients died of post chemotherapy complications and 5(25%) patient failed to achieve remission. Major complications encountered were: anemia, fever, bleeding, mucositis and bacterial infections.Conclusion: FLAG protocol is well tolerated and effective regimen in relapsed / refractory acute leukemias. The toxicity is acceptable, enabling most patients to receive further treatment, including transplantation proceduresKey words: FLAG, refractory acute leukemia, relapsed acute leukemia


Article
STATISTICAL AND CYTOGENETIC STUDY ON CHRONIC MYELOID LEUKEMIA PATIENTS IN IRAQ
دراسة احصائية ووراثية خلوية لمرضى ابيضاض الدم النقياني المزمن

Author: آمنــة نعمــة الثـويني
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2008 Volume: 7 Issue: 1 Pages: 21-37
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

This study was carried out on Chronic Myeloid Leukemia(CML) patients, who were attending the National Center of Hematology for the duration between 1/4/1999 to 1/10/2005, to shade light on the distribution of the disease in Iraq beside, studying the chromosomal aberrations in white blood cells of the patients . It includes (537) the total number of CML patients from all over the country, Chi- square test has been used in the statistical study. The ages of the patients arranged (8-75) year old . The results shows that, the highest incidence occurred among group (31-40) and (41-50)blood group(O) was the most affected than the other groups beside that male were more incident than female.

أجريت هذه الدراسة على مرضى ابيضاض الدم النقياني المزمن المراجعين للمركز الوطني لبحوث وعلاج امراض الدم في بغداد للمدة من 1999/4/1 ولغاية 2005/10/1 لتسليط الضوء على علاقة الإصابة بالمرض والعمر والجنس والتوزيع السكاني للمصابين في العراق فضلاً عن التعرف على التغايرات الكروموسومية الحاصلة في خلايا الدم البيض للمصابين بالمرض. أظهر المسح الاحصائي لمرضى ابيضاض الدم النقياني المزمن،إن مجموع المرضى المصابين كان (537) مريضاً، تراوحت اعمارهم بين 75-8عاماُ وقد بين فحص مربع كاي علاقة واضحة ومهمة إحصائياً بمستوى (P<0.001) بين الإصابة بالمرض وجنس المريض والفئة العمرية للمصابين إذ أظهرت الفئات العمرية (40-31) و(50-41) نسب إصابة مرتفعة بالمرض، وأظهر المرضى الحاملين لصنف الدم (O) نسبة إصابة أعلى من المتوقع فضلاً عن التوزيع الجغرافي للمرض في العراق.


Article
Serum Magnesium Concentration in Patients with Leukemia and Lymphoma

Authors: Munaf S. Daoud --- Ali Y. majid** --- Wafa M. Merza
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 1 Pages: 101-104
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Leukemias and lymphomas are malignant disorders that occur in the blood forming organs and lymphoid tissue respectively. They are classified to types and several subtypes such as acute or chronic, lymphocytic or myelocytic and T-cell or B-cell lymphocytic for leukemias and histologically into Hodgkin’s and Non-Hodgkin’s for lymphomas. Literatures do not contain many research work on magnesium in patients with these disorders, although this mineral is essential for many metabolic, enzymic, regulatory and immune reactions in the human body. Therefore, the present study was aimed to evaluate the level of magnesium in the sera of patients with different types of leukemia and lymphoma. Patients and Methods: Fifty five patients with leukemia and lymphoma and twenty five healthy controls were studied. The patients were attendants of Baghdad Teaching Hospital and Pediatric Teaching Hospital from September 2006 to January 2007. The diagnosis was confirmed by examination of both peripheral blood, lymph node biopsy and/or bone marrow examination. Patients were categorized according to French-American-British Criteria. Thirty five patients with ALL, one with CLL, six with AML, three with CML, three with HL and seven with NHL. Venous blood was collected from each patient or control person and sera were obtained by centrifugation. S[Mg] was measured by Atomic Absorption Flame Spectrophotometry.Results:The Mean ± SD of S[Mg] in mg/dl of all types of leukemic and lymphomatous patients was lower than the controls. There was a high statistically significant difference (P<0.01) in patients with ALL and significant difference (P<0.05) in patients with AML and NHL and non-significant difference (P>0.05) in patients with CML and HL, compared with the control. Total patients group showed high significant difference (P<0.01) compared with control group. The mean distribution of S[Mg] among total patients indicated decreased (58.2%), normal (38.2%) and increased (3.6%) levels.Conclusion:The present study disclosed the existence of normal to decreased level of S[Mg] in patients with leukemia and lymphoma suggesting an influence of many variable factors. Although the decreased S[Mg] was statistically significant, it was still within lower normal range.


Article
Serum Zinc in Iraqi Acute Leukemic Patients

Author: Shatha Salah Asa,d شذى صلاح اسعد
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2009 Volume: 5 Issue: 1 Pages: 5-7
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Leukemia is a group of malignant disorders associated with increased numbers of blood white blood cells. Acute leukemia occurs at all ages. Because zinc influences many body systems and functions, zinc is an essential nutrient for tissue growth, cellular division, protein synthesis DNA and RNA replication it also ought to play a critical role in the growth of tumor. In this study, serum zinc was estimated in leukemic patients and compared with healthy subjects.Methods: The subjects in the present study were; fourty-four depressed patients aged (14-48 year), thirty-one apparently healthy subjects were selected as control group. Their sex and age were comparable to that of patients. Determination of serum zinc was carried out using flame atomic absorption spectrophotometer.Results: The results showed a significant decrease in serum zinc at (p<0.05) in leukemic patients as compared with healthy control.Conclusion: The decrease in serum concentration of zinc in leukemia can be explained by means of the changes in immunity system and the need for zinc to synthesize nucleic acid and tumor cell division in this disorder in addition to other possible mechanisms.

Keywords

leukemia --- zinc --- inflammation


Article
Enamel hypoplasia in patients with acute lymphoblastic leukemia

Authors: Ban Abd Al-Ghani بان عبد الغني --- Nada M. Hasan ندى حسن --- Jaffer M. Hassan جعفر حسن
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2005 Volume: 17 Issue: 3 Pages: 53-55
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Dental abnormalities that affect the children with acute lymphoblastic leukemia were detected. The severity of this abnormality showed a linear relation between the time of receiving treatment (chemotherapy and radiotherapy) and the stage dental development. The aim of this study was to determine the prevalence of enamel hypoplasia in children with acute lymphoblastic leukemia.Materials and methods: Forty eight children with acute lymphoblastic leukemia were examined clinically for the presence of enamel hypoplasia.Results: 37.5 % of these patients have enamel hypoplasia and a significant correlation was found between increments of duration of disease with the severity of enamel hypoplasia.Conclusion: Oral health care with frequent dental observation is important to patients with acute lymphoblastic leukemia


Article
Patients with Childhood Leukemia are at High Risk for Transfusion-Transmitted HBV and HCV Infections

Author: Ruqia M. Al-Barzinji
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 4 Pages: 442-446
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:This work presents estimation to the number of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among polytransfused leukemic children, who received chemotherapy.METHODS:A total of 88 serum specimens were collected from children with leukemia aged between 1-12 years (60 males and 28 females), attending Al-Mansoor Teaching Hospital, seen during the period from January to October 2004 to determine if the patients with childhood leukemia are at high risk for transfusion- transmitted HBV and HCV infections. Enzyme linked immunosorbent assay (ELISA) test was used to determined infected and non infected individuals.RESULTS:Out of the 88 children studied, Hbs Ag was detected in 18 (20.45%) including 12 (66.6%) males and 6 (33.3%) females, whereas anti HCV was detected only in 4 (4.54%) children including 3 (75%) males and 1 (25%) female. The peak prevalence of HBV infection was recorded in children of age 9-12 years and reached (23.33%) while in HCV the peak prevalence was in age group (6-9), being (66.6).CONCLUSION:In this study, the prevalence of anti HCV and Hbs Ag were high in patients who were treated for children leukemia. The high incidence of hepatitis infections was recorded in polytransfused leukemic children.

Keywords

HBV --- HCV --- Leukemia --- Children


Article
Nosocomial Bacteremia in Leukopenic Patients with Leukemia in Baghdad Teaching Hospital

Author: Sevan N. A. Abdallah
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 4 Pages: 327-331
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:The incidence of nosocomial bacteremia continues to increase despite antimicrobial therapy and supportive care; it remains a major cause of death in hospitalized patients who are undergoing chemotherapy. The prolonged survival of leukemia patients who have disturbance in their innate immune system increased the factors of risk.OBJECTIVE:This study was conducted to assess the epidemiological features of Bacteremia in adult patients with leukemia and the species distribution and antimicrobial susceptibilities of causative pathogens. In addition, nosocomial bacteremia was compared to community acquired bacteremia.METHODS:A total of (84) adult leukemic patients more than 15 years old, males and females, feverish or with hypothermia and leukopenic. Bacteremic cases were obtained by culturing blood samples aerobically and anaerobically. The identification of blood isolates and susceptibility testing were performed by the routine methods in use at the affiliated laboratories.RESULTS:It has been found that 15 out of 28 (53.57%) patients with bacteremia acquired the infection during hospitalization, while the 13 (46.42%) patients acquired the infection out side the hospital. Table (1)CONCLUSION:High incidence rate of nosocomial infection (hospital acquired infections) in leukopenic leukemic patients with bacteremia.

Keywords

nosocoial --- bacterimia --- leucopenia --- leukemia


Article
Hypolipoproteinemia as Biological Marker in Acute Leukemia

Authors: Azher Sabih Zubaidy --- Adil Siwan Aqabi --- Majid Hameed AL Maini
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 4 Pages: 456-459
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Acute leukemia is a clonal hematopoietic malignant disease that arises from malignant transformation of an early hematopoietic stem cells .Seeking for biochemical markers that are associated with acute leukemia may help us for better understanding of the leukemic process &improve our lines of management.Hypolipoproteinemia is one of these markers&it is the target of this study.OBJECTIVE:To study the association between the hypolipoproteinemia &acute leukemia &the ability of using hypolipoproteinemia as a biological marker that is helpful in follow up of acute leukemia.PATIENT&METHODS:A total of fifty patients with acute leukemia diagnosed by blood film&bone marrow examination were compared with control group of twenty healthy persons regarding fasting lipid profile(TC total cholesterol,LDL low density lipoprotein,HDL high density lipoprotein,TG triglyceride).RESULTS:In this study there is close association between hypolipoproteinemia&acute leukemia. The mean values of lipoproteins were significantly lower in patient with acute leukemia compared to control group(P value is 0.0001 for total cholesterol&0.045 for triglyceride).CONCLUSION:These data suggest that hypolipoproteinemia could be useful as a marker for follow up of acute leukemia.

Listing 1 - 10 of 151 << page
of 16
>>
Sort by
Narrow your search

Resource type

article (150)

journal (1)


Language

English (129)

Arabic and English (7)

Arabic (3)


Year
From To Submit

2019 (4)

2018 (15)

2017 (12)

2016 (14)

2015 (16)

More...