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Article
Oral lichen planus clinical study with the clinicopathological correlation in the diagnosis of O.L.P.

Author: Layla S. Y. Al-ani ليلى العاني
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2005 Volume: 17 Issue: 1 Pages: 57-60
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Oral lichen planus (OLP) is a chronic inflammatory disease with different clinical presentation.Objective: To evaluate the clinical-pathologic characteristic of OLP lesion and to study the correlation between-clinical and histopathologic assessment of OLP.Materials and Methods: A randomly selected biopsies of sixty-three OLP patients, who sent to college of dentistry / oral pathology department were studied.Results: Females were more frequently affected by OLP than males (female=52.38% , male=47.61%) and mostly at the middle age group (25.4%). OLP was more frequently found on the cheek, tongue than palate and lip. Statistically significant differences could be identified for OLP lesion in terms of age, sex, and site of location.Confirmation of clinical diagnosis of OLP by means of histopathologic study of a biopsy specimen is generally advised. However, hardly any data exist about the correlation between clinical and histopathologic diagnosis of OLP. In (42.31%) of case, in which the pathologist agreed about the histopathologic diagnosis being diagnostic of OLP, there was a lack of consensus on the clinical diagnosis. Conversely, about (38.46%) of case in which the clinicians agreed about the clinical and histopathologic diagnosis being diagnostic of OLP.Conclusion: Based on the finding of the present study, there appears to be lack of clinicopathologic correlation in the diagnostic assessment of OLP.


Article
Lichen Planus and Hepatitis in Iraqi Patients

Author: Mohammed Shahatha Nayaf
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2008 Volume: 21 Issue: 2 Pages: 148-152
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: With time, it is becoming that idiopathic lichen planus (L.P) is being observed more and more in conjunction with diseases of altered or disturbed immunity. Such autoimmune diseases include ulcerative colitis, alopecia areata, vitiligo, dermatomyositis, morphoea and lichen sclerosus.Objective: The aim of the study is to clarify the possible association between L.P and active chronic hepatitis especially hepatitis B virus (HBV) infection.Patients & Methods: Fifty patients with lichen planus attending Department of Dermatology at Tikrit Teaching Hospital were enrolled in this study in the period December 2006 through to December 2006; their mean age (42.72), with standards deviation (±12.72). A full history and clinical assessment for each patient with lichen planus and conforming diagnostic were performed. All patients were screened for hepatitis B surface antigen (HBs Ag), antibody to hepatitis B core antigen (anti-HBc), aspartate transaminase (AST), and alanine aminotransferase (ALT).Results: were that lichen planus most common between 21 and 60 years were 60% males and 40% females. The percentage of new cases were 2%, the nonfamilial cases were 90% and familial cases 10%, most lesions on the cutaneous and mucosal (oral and genitalia) involvement (66%) and cutaneous only (34%). The dysfunction of liver test were positive in 16% and only (6%) from them have had HBsAg and anti-HBc positive.Conclusions: It can be concluded that HBV infection is lower among lichen planus patients, only (6%) have had HBsAg and anti-HBc positive. Therefore, it seems prudent to screen all patients with lichen planus by liver function test. Liver disease may consider a risk factor for lichen planus although not a specific marker for it and should be receptive to signs or symptoms of liver disease when evaluating patients with lichen planus. The link between lichen planus and chronic active hepatitis infection continues to be investigated and debated.Key Words: Lichen planus, Hepatitis.

Keywords

Lichen planus --- Hepatitis.


Article
Assessment of the Immunohistochemical expression of EBV in oral lichen planus

Authors: Tania Abdulelah Al-Tahan تانيا عبد الله الطحان --- Ahlam Hameed Majeed احلام حميد مجيد
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 2 Pages: 98-100
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Oral lichen planus (OLP) is a chronic immunologic disease. The etiology of OLP is unknown, viralantigens (for example EBV) have been proposed as etiologic agents. OLP may get transformation to malignancy soresearch on the presence of these in OLP lesions seems to be necessary. The aim of this study was to evaluate EBVexpression immunohistochemically in OLP.Materials and Methods: Tissue specimens of 30 formalin fixed, paraffin-embedded tissue Blocks histologicallydiagnosed oral lichen planus was performed to evaluate EBV expression.Results: Expression of EBV was detected in epithelium of (46.6%) in the study samples in (OLP). no statisticallysignificant correlation was found with clinical parameters except for a significantly higher expression in females.Conclusions: Epstein Barr viruses were present in considerable amounts in oral lichen planus. Taking into account thepotential of viruses in OLP proving or disapproving or etiological role of viruses in OLP is continuously need to beexamined in further studies

Keywords

EBV --- lichen planus


Article
Oral lichenoid reactions: A clinico-pathological study

Authors: Sabah M SAKA --- Abbas F HUSSAIN
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2002 Volume: 2 Issue: 2 Pages: 198-200
Publisher: Mosul University جامعة الموصل

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Abstract

Eleven hypertensive and nine diabetic patients under treatment with appropriate therapy show oral mucosal lesions mimic lichen planus. The clinical and histological features of the lesions were studied. Stress was made on the type and distribution of the inflammatory infiltrate seen in the histologic section of the lesions. It was found that the infiltrates show features differ from the infiltrate demonstrated in conventional lichen planus.


Article
Histopathological evaluation of oral lichen planus

Author: Layla S. Yas ليلى ياس
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: special issue 2 Pages: 48-54
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Oral lichen planus( OLP) is a chronic inflammatory disorder affecting mucosal surfaces , which cancause an important discomfort to the patients . To highlight the most characteristic histopathological findings of OLPwhich are useful in making a diagnosis of OLP. In addition, by studying the association of these findings it was hopedthat information about pathogenic mechanism would be obtained.Material and Methods : In this study a retrospective analyses of 194 cases of OLP being diagnosed at Oral andMaxillofacial Pathology Department, College of Dentistry , were obtained over a period of 26 years , spanning from1985- 2010 . We analyzed the age and sex of the patients, clinical type of lichen planus, site and differenthistopathological finding, comparing them with each others.Results: (61%) of the patients are female and (39 %) are males, with an average age for both sexes (49.75 years).The most frequent clinical form is reticular, presented in (78%) of cases, and the most common location is buccalmucosa, presented in (60%) of the patients. The mononuclear infiltration beneath and adjacent to the epithelium,parakeratosis and degeneration of the basal layer of the epithelium were consistent features. Linear regressionanalysis revealed a positive correlation between basal degeneration and mononuclear infiltration and an inversecorrelation between the mononuclear infiltrate and the parakeratosis.Conclusion: Linear regression analysis of the parameters studied provided partial support for a cell- mediatedimmune mechanism


Article
Evaluation of the Level of Melatonin, Cortisol and IgA in Saliva of Patients with Oral Lichen Planus Lesions

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Abstract

Back ground: Oral lichen planus is a chronic inflammatory disease that affects the mucous membrane of the mouth.Several researchers suggest that oxidative stress is implicated in the pathogenesis of this disorder. It has beenhypothesized that melatonin is powerful anti-oxidants and can easily cross the cell membrane and is considered afree radical scavenger of Hydroxid, Oxygen and Nitrogen dioxide, cortisol as a stress hormone and theimmunoglobulin A as first line of defense and protection to the mucous membrane of the mouth are interrelatedfactors for the emergence of oral lichen planus. Aim of this study was to evaluate the level of melatonin, Cortisol andIgA in saliva of patients with oral lichen planus lesions in comparison with participants with normal oral mucosa.Materials and methods: In this study seventy five subjects with age 18 and over were included. The subjects weredivided into two groups; control group, this group comprised of 41 subjects with normal oral mucosa and the studygroup, which comprised of 34 subjects with clinically and histopathologically diagnosed oral lichen planus lesion. Thesamples were selected from patients attending College of Dentistry/University of Baghdad and cases that recruitedto the AL-Emmam Ali hospital / in Baghdad /Dermatology Department. Samples collection started from 2/ may 2013to 23/ January 2014.Saliva samples were collected between 10-12 Am. High performance chromatography (HPLC)analyzing technique was used for estimating the salivary melatonin and cortisol level. IgA level was measured byELIZA method.Results: The mean salivary melatonin level in patients with oral lichen planus was 4.786 μg/ml and the mean salivamelatonin level in normal person was 8.759 μg/ml. significant difference (p<0.01) was observed in the salivarymelatonin levels between the study and control group. The mean salivary cortisol level in patients with OLP was 0.730μg / ml and the mean saliva cortisol level in normal persons was 0.165 μg/ml. significant difference (p<0.01) wasobserved in the salivary cortisol levels between the study and control, group. The mean salivary IgA level in patientswith OLP was 221.4 μg/ml and the mean saliva IgA level in normal person was 125.8 μg/ml. There was a highsignificant difference (p<0.01) the study and control groups.Conclusions: The level of salivary melatonin was lower in patients with oral lichen planus, however cortisol and IgAwas higher when comparing the salivary level with that of the control groups

Keywords

lichen planus --- melatonin --- cortisol --- sIgA


Article
Prevalence of Hepatitis C Virus Antigen Among Patients with Lichen Planus in Alkhalis City

Authors: Hayder Mahdi Idan --- Mohammed Ahmed Mahdi
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2014 Volume: 6 Issue: 1 Pages: 60-65
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Lichen planus is an idiopathic inflammatory disease with characteristic clinical and pathologic features affecting the skin, mucous membranes, nails, and hair. It is likely that both endogenous (genetic) and exogenous (environmental) factors such as some drugs or some infection(s) may interact to elicit the disease.Objectives: To determine the prevalence of hepatitis C virus antigen among the patients with lichen planus and comparison with healthy control group. Materials and methods: Twenty patients with lichen planus were included in this study (12 males and 8 females) and (40) healthy control (28 males and 12 females), their ages ranged from (15-60) years, obtained from Alkhalis hospital during the period from 1st February to 30th September 2013, using enzyme linked immunosorbent assay (ELISA) technique to detect anti HCV antibody in patients serum and control group. Results: Two (10 %) had positive results for hepatitis C virus antigen (2) out of (20) patients suffering from lichen planus, while none of the within healthy control group had positive result. Statistically significant relationship was observed between both of them.Conclusion: The frequent study showed a difference in prevalence of hepatitis C virus in patients with lichen planus and healthy control.


Article
Occurrence of lichen planus in diabetes mellitus

Author: Tahrir N. Aldelaimi طاهر الدليمي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2005 Volume: 17 Issue: 3 Pages: 62-65
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Lichen planus is common mucocutaneous disorder that affects oral & skin areas and relatively linked to diabetes mellitus &hypertension to find that diabetes mellitus may contribute to development of lichen planus.Materials and method: 324 patients (112 diabetic patients & 112 non- diabetic patients serve as controlled group, aged 18 yrs old and above were obtained from Ramadi General Hospital and College of Dentistry from November 2000 to December 2002Results: 11(9.8%) patients with diabetes mellitus had lesions that fit the criteria of lichen planus.Conclusion: There is no statistically significance association between the presence of lichen planus lesions & diabetes mellitus.


Article
SELENIUM LEVEL IN LICHEN PLANUS AND IN PSORIASIS AND ITS RELATION TO CHRONICITY AND SEVERITY OF BOTH DISEASES

Author: Nadheer A. Matloob نظير احمد مطلوب
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2011 Volume: 9 Issue: 1 Pages: 11-17
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Lichen planus characterized by its violaceous color most commonly seen on the flexor surfaces of the upper extremities, the genitalia and the mucous membranes. Psoriasis is a common, chronic, relapsing, inflammatory skin disorder with a strong genetic basis. Plaque type of psoriasis is the most common. Selenium is a component of the enzyme glutathione peroxidase, and is important in protection against damage by peroxides and free radicals.Objectives: To measure selenium level in Iraqi patients with lichen planus and in patients with psoriasis and its relation to the chronicity and the severity of both diseases.Methods: One hundred twenty patients were included in this study, 68 males and 52 females, with ages between 18-54 years. Full history and examination, including dermatological examination, were done for all patients. The patients were divided into three groups. The first group includes lichen planus patients, the second group includes psoriasis patients and the third group was a control group study. Serum selenium level was measured for all patients by spectrophotometer.ResultsSerum selenium level was decreased in 20 (50%) patients of the first group, in 32 (80%) patients of the second group and 14 (35%) of the third group. The results were of high statistical significance when compared between groups 2 & 3 but it was insignificant when compared between groups 1 & 3. Selenium level was decreased in 12 of the first group who had the disease for two years and above while it was decreased in 18 of the second group who had psoriasis for two years and above, selenium level was decreased in patients with severe and diffuse variants of both lichen planus and psoriasis.Conclusion: Serum selenium level was decreased in both lichen planus and psoriasis but it was more significant in psoriasis and this decrease was related to both chronicity and severity.Keywords: Selenium, Lichen planus, Psoriasis, Chronicity, Severity.


Article
Immunohistochemical expression of Cyclooxygenase 2 and Caspase 7 in oral lichen planus

Author: Muna S. Merza منى ميرزا
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: special issue 2 Pages: 61-64
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Oral lichen planus (OLP) is one of the most common dermatological diseases presenting in the oralcavity. Although relatively frequent, OLP is the target of much controversy, especially in relation to its potential formalignancy. This study was conducted to find biological changes in the expression of caspase 7 andcyclooxygenase 2(cox2) in OLP by immuohistochemistry and to explore the correlation between them.Materials and Methods: Fifteen cases of randomly chosen paraffin embedded tissue blocks of OLP with 5 normal oralmucosa cases were included in this study. Immunohistochemistry was performed to evaluate Cox2 and caspase 7proteins expression.Results: The expression of cox2 was positive in all studied cases of OLP with negative expression in normal oralmucosa. Caspase 7 expression was positive in (73%) of the cases of which (36.5%) showed strong positive expressionscore. Non-significant positive correlation was found between the two markers.Conclusion: This study provided further evidence that epithelial cells in OLP undergo apoptotic death, on the otherhand they develop high rate of inflammation which may create a good environment for malignant transformation

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