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Article
Lipid Peroxidation and Oxidative Stress in Patients with Fibromyalgia Syndrome

Authors: Halla G. AL-Gebouri --- Zuhair AL-Mashhadani --- Mohammad H. AL-Osami* --- Kisma M. Turki
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 1 Pages: 101-105
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACK GROUND:Fibromyalgia (FMS) is a common, chronic widespread pain syndrome usually associated with other somatic and psychologic symptoms including fatigue, sleep disturbances, cognitive difficulties Oxidative stress means an alteration in the delicate balance between free radicals and the scavenging capacity of antioxidant enzymes in favor of free radical in the body system.OBJECTIVE:To evaluate and compare the antioxidants and lipid peroxidation in patients with fibromyalgia and healthy control.PATIENTS AND METHOD;The study has included sixty patients with FMS (40 females and 20 males) and thirty healthy subjects. The subjects were selected from people attending the out patients clinic in Medical City- Baghdad Teaching Hospital- Rheumatology& Rehabilitation Consultation Unit. Laboratory parameters included: uric acid,albumin,caeruloplasmin,total thaiol,malondiaaldehyde(MDA) and peroxinitrate(ONOO¯ ).RESULTS:MDA and uric acid levels in serum of patients with fibromyalgia were significantly higher than in the control group. While the levels of ONOO¯ GSH,CP,albumin in serum of patients with fibromyalgia were significantly lower than in healthy control.CONCLUSION:oxidative stress may have a role in the pathophysiology of fibromyalgia syndrome.

Keywords

lipidperoxide --- ONOO¯ --- GSH --- CP --- uricacid --- albumin --- fibromyalgia.


Article
•Oxidative stress and Lipid peroxidation in patients with Multiple

Authors: Halla G. AL-Gebouri --- Hedef EL-Yassin
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2011 Volume: 4 no 2 Issue: 10 Pages: 1073-1076
Publisher: Kerbala University جامعة كربلاء

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Abstract

Back ground: multiple sclerosis (MS) has a much higher incidence among Caucasians that in any other race. Females are much more susceptible than males and white females living in colder weather areas are much more susceptible than those living in warmer areas. Oxidative stress means an alteration in the delicate balance between free radicals and the scavenging capacity of antioxidant enzymes in favor of free radicals in the body system.Objective: To evaluate and compare the antioxidants and lipid peroxidation in patients with MS and healthy control.Patients and method: The study has included thirty patients with MS (16 females and 14 males) and thirty healthy subjects. The subjects were selected from people attending the out patients clinic of Baghdad Teaching Hospital in Medical City. Laboratory parameters included were: uric acid, albumin, and caeruloplasmin, total thaiol, malondiaaldehyde (MDA) and peroxinitrate (ONOO¯).Results: MDA and ONOO¯ levels in serum of patients with MS were significantly higher than in the control group. While the levels of GSH, CP, albumin, uric acid, iron, copper and zinc in serum of patients with MS were significantly lower than in healthy control.Conclusion: Oxidative stress may have a role in the pathophysiology of multiple sclerosis syndromes.

Keywords

lipidperoxide --- ONOO¯ --- GSH --- CP --- uric acid --- albumin --- multiple sclerosis

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