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Article
Evaluate the level of Oxidative Stress markers and Lipids Profile in Patients with Bening Prostate Hypertrophy in Al-Khadhmyah Tteaching Hospital

Author: aHanan H. Fleih aWajeeh Y. Al-Ani bSaddam h. Al- ma’adhedy
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2014 Volume: 10 Issue: 1 Pages: 30-33
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Benign Prostate Hypertrophy(BPH)is a common urological problem worldwide which is defined as denomatous hyperplasia of the periurethralpart of prostate gland that occurs especially in men over 50 years old and that tend to obstruct urination by constriction the urethra Objectives: The study was aimed to investigate the level of Malondialdehyde (MDA), Nitric Oxide (NO) and Superoxide Dismutase (SOD) as an antioxidant, besides other factors such as the level of Lipids Profile (Total Chlosterol (TC), High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C), Very Low Density Lipoprotein Cholesterol (VLDL-C), and Triglyceride (TG))in patients suffer from BPH . Methods: In this study ;clinical ,specific prostate antigen and sonongraphy data of 80 persons were prospectively analyzed ; they are divided into two groups (40) male patients with Benign Prostate Hypertrophy (BPH) was previously diagnosed and another (40) healthy males as a control group .The study was performed at Al-Khadhmyah teaching hospital during the period from March 2001 till April 2003Results: The evaluated data recorded a significant increase in the levels of (MDA) and (NO), while a significant decrease in the level of (SOD) (P  0.001) in patients complain from BPH in comparison with the control group. Moreover, the results showed a significant increase in the levels of (TC), (TG) , (LDL-C) and a significant decrease in the level of (HDL-C) (P  0.001) in comparison with the control groupConclusions: Benign Prostate Hypertrophy (BPH) is the most common benign tumor in men and Malondialdehyde (MDA), Nitric Oxide (NO) ,Superoxide Dismutase and Lipid profile are beneficial markers to evaluate patients with BPH in comparison with those without BPH.


Article
Effect of Bay leaf (Laurus nobilis L.) and its isolated (flavonoids and glycosides) on the lipids profile in the local Iraqi female rabbits
تأثير ورق الغار (Laurus nobilis L.) والفلافونيدات والكلايكوسيدات المعزولة منه على وظائف الدهون في إناث الأرانب المحلية العراقية

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Abstract

The present study aimed to explain the effect of Bay leaf and its isolated flavonoids and glycosides on the levels of TC, TG, HDL-C, LDL-C and VLDL-C in the local Iraqi female rabbits. Isolation of flavonoids and glycosides from Bay leaf were carried out, the study design included four groups (n=6): Control group-C fed with standard pellet diet; group1-G1 orally administrated daily dose 100 mg/ml/kg of Bay leaf crude for 30 days; group2-G2 orally administrated daily dose 50 mg/ml/kg of isolated flavonoids for 30 days; group3-G3 orally administrated daily dose 12.5 mg/ml/kg of isolated glycosides for 30 days. TC, TG and HDL-C were determined by enzymatic colorimetric method. The results showed that oral administration of Bay leaf and its isolated flavonoids and glycosides reduced levels of TC, TG, LDL-C and VLDL-C compared to control, therefore Bay leaf useful agent in reducing hyperlipidemia.

هدفت هذه الدراسة إلى توضيح تأثير ورق الغار والفلافونيدات والكلايكوسيدات المعزولة منه على مستويات الكوليسترول، الكليسريدات الثلاثية، البروتينات الدهنية عالية الكثافة، البروتينات الدهنية واطئة الكثافة والبروتينات الدهنية واطئة الكثافة جداً في إناث الأرانب المحلية العراقية. تضمنت الدراسة عزل الفلافونيدات والكلايكوسيدات من ورق الغار، وشمل تصميم الدراسة أربع مجاميع (n=6): مجموعة السيطرة-C غُذيت نظام غذائي قياسي، مجموعة أولى-G1 جُرعت فموياً 100 ملغم/ مل/ كغم من ورق الغار الخام لمدة 30 يوماً، مجموعة ثانية-G2 جُرعت فموياً 50 ملغم/ مل/ كغم من الفلافونويدات المعزولة لمدة 30 يوماً، مجموعة ثالثة-G3 جُرعت فموياً 12.5 ملغم/ مل/ كغم من الكلايكوسيدات المعزولة لمدة 30 يوماً. قيست الدهون بواسطة الطريقة الانزيمية اللونية. أظهرت النتائج أن ورق الغار، الفلافونيدات والكلايكوسيدات المعزولة أدت الى انخفاض مستويات الكوليسترول، الكليسريدات الثلاثية، البروتينات الدهنية واطئة الكثافة والبروتينات الدهنية واطئة الكثافة جداً مقارنة مع مجموعة السيطرة، ولذلك يمكن استعمال الغار كمخفض للدهون.


Article
Effect of Garlic on Dyslipidemic Patients with Diabetes Mellitus (Type 2)

Author: Zuhair Maroof Hussien
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2014 Volume: 6 Issue: 1 Pages: 100-104
Publisher: Diyala University جامعة ديالى

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Abstract

Back ground: Garlic ( Allium sativum ) has been used in herbal medicine for treatment of cardiovascular diseases risk factors such as serum lipids , blood pressure and plasma viscosity .Aim: The aim of present study is to evaluate the effects of garlic on one of the major cardiovascular risk factors which is dyslipidemia in patients with type 2 diabetes mellitus .Materials and Methods: Type 2 diabetic patients with dyslipidemia were enrolled in this study. It covered 50 patients (35 males and 15 females) whose ages ranged between (40 – 75) years. Twenty clinically healthy individuals were included as a control group at the same above ages. Diabetic patients given garlic for period of 6 weeks and 12 weeks after which their serum lipid profiles where measured after fasting for 12 hours and comparisons was made between the treated and untreated patients . Results: It was found that the patients had a significant reduction in both total cholesterol (TC) and triglycerides (TG) (the main contributing factors to arteriosclerosis) in comparisons to the control group. The administration of garlic ( 1000 mg ) lowers the levels of low density lipoproteins cholesterol ( LDL – C ) and raise the concentrations of high density lipoproteins cholesterol (HDL – C) and so for the very low density lipoproteins cholesterol (VLDL–C) if compared with that of the control group .Conclusion: Garlic may play an important role in the treatment of dyslipidemic patients with type 2 diabetes mellitus.

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