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Article
Effect of Imatinib therapy on liver enzymes and serum bilirubin in CML Iraqi patients
تأثير عقار ايماتنيب على انزيمات الكبد وخضاب الصفراء الكلي لدى مرضى ابيضاض الدم النقياني المزمن في العراقيين

Author: Adeeb Abass Al-Shami د. أديب عباس الشامي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2009 Volume: 22 Issue: 3 Pages: 206-209
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: The treatment of chronic myeloid leukemia (CML) has been revolutionized by Imatinib. Imatinib is a selective inhibitor of the BCR-ABL tyrosinkinase, it produce high response rate in patients with CML who have no response to interferon alfa. Imatinib is occasionally associated with hepatotoxicity. Objectives: The aim of this research is to study the effect of Imatinib therapy on liver enzymes and serum bilirubin in patients diagnosed in chronic phase myeloid leukemia.Methods: A sample of 100 Iraqi patients diagnosed with CML, selected at random, at the National Hematology Center in Baghdad were included for the period from August till the end of October 2008. They were diagnosed by peripheral blood and bone marrow aspirate examination and real-time PCR. 98 patients were started on Imatinib mesylate 400 mg and only 2 patients were started on oral 300 mg daily. Liver enzymes and serum bilirubin were measured before starting treatment and after three months of continuing on treatment.Results: Median age of patients was 35.5 years with 48 males and 52 females. The frequency of CML cases by residence was 46% from Baghdad and 54% from other regions of Iraq. The level of liver enzymes, serum alanine aminotransferase and serum aspartate aminotransferase was normal, serum alkaline phosphatase was normal in 94 patients, 5 patients had serum alkaline phosphatase less than 2 times elevated and one patient (18 years old) had 2 times elevates serum alkaline phosphatase level. The total serum bilirubin was normal in all patients.Key words: Imatinib, Liver enzymes

خلفية البحث:ان علاج مرض ابيضاض الدم النقياني المزمن قد تطور جذريا باكتشاف عقار الايماتنيب. عقار الايماتنيب ذو خاصيه اختياريه تثبيطيه على انزيم الجين BCR-ABL tyrosinkinase والذي يولد نسبه عاليه من الاستجابه عند مرضى ابيضاض الدم النقياني المزمن والذي لم يكن لديهم استجابه لعقار الفا-انترفيرون. ان عقار الايماتنيب قد يكون مصحوبا ببعض السميه للكبد.الهدف: تأثير عقار الايماتنيب على انزيمات الكبد(فوسفاتاز قلوية انزيم ,ناقل امين الانين انزيم , ناقل امين الاسبارتيك انزيم) وخضاب الصفراء الكلي في مصل الدم للمصابين بمرض ابيضاض الدم النقياني المزمن.طريقة البحث:اجريت الدراسه على عينه مكونه من مائة مريض عراقي اختيروا عشوائيا من المرضى المصابين بابيضاض الدم النقياني من الحاله المزمنه والذين يراجعون المركز الوطني لبحوث وعلاج امراض الدم في بغداد للفتره من شهر اب ولغايه نهايه تشرين الاول 2008. تم تشخيص المرض عن طريق اجراء فحص الدم مع عينه من نخاع العظم وكذلك جهاز عمليه تسلسل البلمره الكلي. وقد تم قياس مستويات انزيمات الكبد وخضاب الصفراء الكلي في مصل الدم قبل العلاج وبعد ثلاثة أشهرمن الاستمرار على العلاج.النتائج:ثمانيه وتسعون مريضا بدأو العلاج بجرعه 400 ملغم من عقار الايماتنيب وفقط اثنان بجرعه 300 ملغم يوميا وعن طريق الفم. كان وسيط عمر المرضى 35.5 سنه، 48 منهم من الذكور و 52 من الاناث وكان مكان اقامتهم بواقع 46% من بغداد والباقي من مختلف مناطق العراق. ان معدلات انزيمات الكبد وخضاب الصفراء الكلي في مصل الدم كانت طبيعيه لدى 94 مريضا, اما 5 مرضى وجد لديهم ارتفاع في فوسفاتاز قلوية انزيم اقل من ضعفين و مريض واحد (عمره 18 سنه) وجد لديه ارتفاع نفس الانزيم بمقدار ضعفين أما نسبة خضاب الصفراء الكلي فكانت طبيعيه لدى كل المرضى.

Keywords

Imatinib --- Liver enzymes


Article
Effect of Trigonella Foenum-Graecum L. (Fenugreek) on Liver Enzymes in Ischemia-Reperfusion Injury

Author: Mustafa Taha Mohammed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: 1 Pages: 69-74
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Hepatic ischemia-reperfusion (I/R) injury may occur in a variety of clinical set¬tings and this remains a significant problem. Oxygen free radi¬cals, produced on reperfusion have been shown to play a major role in hepatic I/R injury. Various therapeutic effects have been described for Trigonella. Additionally, it has been presented that Trigonella has protective effect against ischemia reperfusion injury to various organs. Therefore, it seems possible that the administration of Trigonella might protect the liver against the ischemia reperfusion injury.OBJECTIVE:To determine whether Trigonella foenum-graecum L. (Fenugreek) prevents hepatic ischemia-reperfusion injury to the liver.METHODS: Thirty-six rats were divided into three groups as, (Group 1) control group, (Group 2)I/R group and (Group3) Trigonella foenum-graecum L. (Fenugreek) treatment group. All rats underwent hepatic ischemia for 60 min followed by 60 min period of reperfusion. Rats were internal infused with only 0.9% saline solution in group 2. Rats in group 3 received hydro alcoholic - extracted Trigonella foenum-graecum L. (Fenugreek) (500 mg/kg)internal, before isch¬emia and before reperfusion. Blood samples were harvested from the rats, and then the rats were sacrificed. Serum aspartate aminotransfera¬se (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined.RESULTS:The levels of liver enzymes in group 3 were significantly lower than those in the group 2.CONCLUSION: Our results suggest that Trigonella foenum-graecum L. (Fenugreek) treatment protects the rat liver against hepatic ischemia-reperfusion injury


Article
Effect Nigella Sativa (Black Seed) on Liver Enzymes in Ischemia Reperfusion Injury

Author: Mustafa Taha Mohammed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: supplement Pages: 654-657
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Hepatic ischemia-reperfusion (I/R) injury may occur in a variety of clinical settings and this remains a significant problem. Oxygen free radicals, produced on reperfusion have been shown to play a major role in hepatic I/R injury. Various therapeutic effects have been described for Nigella sativa. Additionally, it has been presented that Nigella sativa (orientalis) oil has protective effect against ischemia reperfusion injury to various organs. Therefore, it seems possible that the administration of Nigella sativa (orientalis) oil might protect the liver against the ischemia reperfusion injury . OBJECTIVE: To determine whether Nigella sativa (orientalis) oil prevents hepatic ischemia-reperfusion injury to the liver. METHODS: Thirty-six rats were divided into three groups as control (Group 1), I/R group (Group 2), and Nigella sativa oil (NS) treatment group (Group 3). All rats underwent hepatic ischemia for 60 min followed by 60 min period of reperfusion. Rats were intraperitoneally infused with only 0.9% saline solution in group 2. Rats in group 3 received NS oil (0.2 mL/kg) intraperitoneally, before ischemia and before reperfusion. Blood samples were harvested from the rats, and then the rats were sacrificed. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined. RESULTS: The levels of liver enzymes in group 3 were significantly lower than those in the group 2. CONCLUSION: Our results suggest that Nigella sativa oil treatment protects the rat liver against to hepatic ischemia-reperfusion injury.


Article
Changes of liver enzymes and serum bilirubin after laparoscopic cholecystectomy
تغيرات إنزيمات الكبد بعد عمليات رفع المرارة بالناظور

Authors: Salah O. Hamad صلاح عبيد حمد --- Khalaf R. Al-Luwaizi خلف رشيد اللويزي
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2013 Volume: 39 Issue: 2 Pages: 113-117
Publisher: Mosul University جامعة الموصل

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Abstract

ABSTRACTBackground: Laparoscopic cholecystectomy (LC) has become the standard treatment of benign gallbladder diseases. However, it has been noticed that following LC, the serum level of certain liver enzyme rises markedly in patients who had preoperatively normal liver enzyme values.Objectives: The study is aimed to evaluate the effect of pneumoperitoneum in LC on liver enzymes and serum bilirubin in comparison with open cholecystectomy (OC).Patients and methods: A prospective case control study involved 74 patients treated by LC, and, 30 patients treated by OC as a control group, during the period from October 2010 to October 2011 at the Department of Surgery, Surgical Unit Number One, Al-Jumhori Teaching Hospital, Mosul, Iraq. Blood samples were taken 24 hours preoperatively and 24 hours after operation for biochemical tests.Results: There were significant increases in serum bilirubin, Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and Lactate dehydrogenase (LDH) levels in LC group postoperatively when compared with the OC group, while there were no significant changes in serum alkaline phosphatase (ALP).Conclusion: It has been concluded that, serum bilirubin and liver enzymes elevation could be attributed to the negative effects of the pneumoperitoneum on the hepatic blood flow. Although these changes seem to be of no clinical importance, care should be taken before deciding to perform LC in patients with hepatic insufficiency. Keywords: Laparoscopic cholecystectomy, pneumoperitoneum, liver enzymes.

الخلاصةالخلفية والأهداف: لوحظ إرتفاع بعض إنزيمات الكبد في المصل بعد عملية إستئصال المرارة بالمنظار لبعض المرضى الذين كانت إنزيمات الكبد لديهم طبيعية قبل العملية. الهدف هو دراسة التغيرات الحاصلة في مصل الدم لهذه الإنزيمات للمرضى الذين أجريت لهم عملية إستئصال المرارة بالمنظار ومقارنة هذه التغييرات مع تلك التي تحدث بعد إستئصال المرارة عن طريق فتح البطن.المرضى وطريقة العمل: أجريت هذه الدراسة المستقبلية في الردهة الجراحية الأولى في مستشفى الجمهوري التعليمي- الموصل خلال الفترة من تشرين الأول سنة 2010 الى تشرين الأول سنة 2011. وشملت 74 مريضا ممن أجريت لهم عملية إستئصال المرارة بالناظور، وكذلك 30 مريضا خضعوا لعملية إستئصال المرارة عن طريق فتح البطن خلال نفس الفترة للمقارنة. عينات الدم أخذت قبل 24 ساعة وبعد 24 ساعة من العملية لإجراء الفحص المختبري عليهما.النتائج: تبين التحاليل الإحصائية زيادة ملحوظة في مستويات الالانين اماينوترانسفريز, اسبارتيت اماينوترانسفريز, والاكتيت ديهايدروجينيز في المجموعة التي أجريت لهم عملية إستئصال المرارة بالمنظار مقارنة مع المجموعة التي أجريت لهم عملية إستئصال المرارة عن طريق فتح البطن.الاستنتاج: نستنتج بأن إرتفاع مستويات الإنزيمات في الدم قد يكون سببه التأثير السلبي للغاز داخل الصفاق على جريان الدم للكبد. وعلى الرغم من أن هذه التغييرات لا تبدو ذات أهمية سريرية, ولكن يجب أن نكون حذرين قبل إتخاذ القرار لإجراء عملية إستئصال المرارة بالمنظار للمرضى الذين يعانون من قصور الكبد.


Article
Hepatoprotective Effect of Allopurinol against Paracetamol Induced Hepatotoxicity in Male Rats

Author: Sahar A Majeed
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2014 Volume: 7 Issue: 2 Pages: 1885-1890
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Liver is a vital organ regulating important metabolic functions. Anumber of chemical agents and drugs which are used on a routine basis cause cellularas well asmetabolic liver damage.Objectives: This study was undertaken to assess the hepatoprotective effect of allopurinoll in paracetamol induced hepatotoxicity in male rats.Material and method: A total of 18 adult male albino rats were randamized into 3 groupGroup1 was used as a control group ,group2: animals received an intraperitoneal injection of 300mg/kg paracetamol,group3 received 100mg/kg allopurinol orally( by oral gavage) 18 hrs before paracetamol administration.all the animals were sacrificed after 12 hr from paracetamol dose. Blood samples were collected by cardiac puncture. Serum was separated and analyzed for various biochemical parameters ( liver enzymes)liver was removed and kept in 10%formalin for histopathological study.Results: Treatment of male rats with paracetamol led to significant (p<0.05) increase the activities of serum enzymes level GPT,GOT, ALP levels compared with the normal rats, In contrast prophylactic used ofallopurinol at100mg/kg orally treated rat prevented the liver damage as judged by the significant (p<0.05) decreased these enzymes levels, histopathologically allopurinol showed protective effect against paracetamol induce liver damge.Conclusion: allopurinol could be beneficial for alleviating paracetamol toxicity. Further studies and parameter to measure oxidative strees are required, to explain these protective effects


Article
LAPAROSCOPIC LIVER RESECTION IN THE GOAT

Author: Abdulbari A. Al faris , Jinan A. bannai , Rana K. abdulsamd
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2015 Volume: 14 Issue: 1 Pages: 156-166
Publisher: Basrah University جامعة البصرة

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Abstract

The aim of this study is to evaluate application of laparoscopy in veterinary surgery and assess the feasibility safety of laparoscopic hepatectomy using thermal energy to control the bleeding after the partial hepatoctomy in the goats. liverenzymes and blood counts were drawn pre and postoperatively with recorded Rectal temperature, respiratory rate and pulse rate and record the time of returning to eat and drink post operation. The abdominal cavity was inflated by the introduction of co2 gas . The result showed that the laparoscopic partial hepatectomy can be easily done in goats without any complications. The mean time of the procedures was 45 minutes (range 40 to 60 min) . The physical parameters were measured preoperatively 1st, 2rd, and 3thdays postoperatively ,showed no significant increase in respiratory rate , plus rat and temperature .The Hematological parameters Hb, PCV and Biochemical tests AST,ALT,LDH, Showed no significant increase in number at day1,2,3 after the surgery From the results of this study, it was concluded that the laparoscopic partial hepatectomy can be easily done in goats without any complications.


Article
Biological effects of different doses of Piroxicam in albino males rats
التأثيرات الحيوية لجرعات مختلفة للبايروكسيكام في ذكور الجرذان البيض

Authors: Lina M. A. Majeed لينا محمد علي مجيد --- Amal K. Abass امال خضيرعباس
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2017 Volume: 58 Issue: 2C Pages: 1009-1019
Publisher: Baghdad University جامعة بغداد

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Abstract

Current study aimed to investigate the effect of piroxicam on some hematological and biochemcal parameters. For this reason forty males mature Sprage Dawlley rats were divided into four equal groups. control group administrated distilled water (G1), and three groups administrated (20mg/kg,30mg/kg,40mg/kg) body weight of piroxicam for 45 days. The results showed significant decrease (P<0.05) in hemoglobin (Hb) and packed ceq volume (PCV) in groups treated with (30,40)mg/kg of piroxicam, while the treated groups produced significant increease (P<0.05) in the total white blood cell count (WBC). On the serum biochemical porameters, Piroxicam caused increase in the level of liver enzyme amunotans ferase (ALT) and aspartate amintou (AST) Also recorded significant changes in the level of kidney function (creatinine, blood urea, uric acid). Histological studies appeared piroxicam caused more severe damage to the liver included depletion of glycoprotein, nearosis congestion, fatty change and inflammatory cell infiltration, kidney section appeared shrink of glomeruli, dilated renal tubules and necrosis were noticed in the renal tubules. Also the testes section appeared no effect in all the treatment groups except in the group which treated with piroxicam _40mg/kg) which showed thickening of somniferous tubules, shrink of leyding cells and necrosis of germ cells. This study shows that the toxic effect of piroxicam depends on time and conceutration of dose administration.

تهدف الدراسة الحالية الى دراسة تأثير البايروكسكام في بعض معايير الدم و المعايير الكيموحياتية تم اخذ 40 من ذكور الجرذان البيض وقسمت الى اربعة مجاميع متساوية جرعت المجموعة الاولى ,مجموعة السيطرة بالماء المقطر , اما المجاميع الثلاث الاخرى فجرعت بعقار piroxicam بتراكيز (20 ملغم/كغم, 30 ملغم/كغم, 40 ملغم/كغم) لمدة 45 يوما . اظهرت النتائج انخفاضا معنويا في ((p<0.05 في (Hb)و (PCV) في المجموعتين المعاملة بالبايروكسكام (30mg/kg, 40mg/kg) بينما اظهرت النتائج حصول ارتفاعا معنويا (p<0.05) في معدل (WBC) في المجاميع المعاملة بالبايروكسيكام بينما اظهرت النتائج الكيموحياتية ان البايروكسيكام يسبب ارتفاعا في معدل مستويات (ALT) و ((AST , ايضا سجل ارتفاعا في مستويات الكرياتنين و اليوريا و حامض اليوريك . اظهرت الدراسة النسجية ان البايروكسيكام يسبب اضرار لنسيج الكبد منها استنفاذ شديد في البروتينات السكرية نغيرات في الدهون , ارتشاح الخلايا الكبدية , اظهرت انكماش في الكبيبة مع توسع الانابيب الكلوية مع ارتشاح الخلايا الالتهابية, كذلك اظهرت مفاطع الخصية عدم وجود اي تأثير في نسيج الخصية ما عدا المجموعة المعاملة بالبايروكسيكام بتركيز mg/kg40 و التي اظهرت تسمك النبيبات المنوية, و انكماش في خلايا ليدنك lyding cells و تنخر في الخلايا الجرثوية germ cells , هذه الدراسة اظهرت ان سمية البايروكسيكام تعتمد على الجرعة و الزمن المعطاة.


Article
STUDY THE N - ACETYLCYSTEINE EFFECTS ON GASTRECTOMY AND SOME BIOCHEMICAL PARAMETERS IN DOGS
دراسة تأثير N - acetylcysteine على استئصال المعدة وبعض المعايير الكيموحيوية في الكلاب

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The project of research was carrying out to study the effect of N-acetylcysteine on the wounds which developed in the stomach after gastrotomy. Dogs were used in this study as experimental animals. Dogs were divided into two groups' treatment and control; each group contains 5 animals. The surgical incision was closed by two layers of sutures using absorbent sutures then closed the muscle and skin using traditional steps. The treatment group was treated using 3% of N-acetylcysteine fluid topically on site of operation, as well as N-acetylcysteine (140 mg/kg/ day) was administrated orally for 7 days. Gross examination and clinical signs were recorded after 7 days of operation. Blood samples were collected before the surgery and 7 days after the surgery for complete blood studies on blood samples in both groups. Additionally, tissue samples were taken from operation areas to study the histological change. Results of this study show that the healing of treated groups with N-acetylcysteine was disappeared after 3 days while in control groups the healing sings continued until 7 days after surgery. The mucous membranes in the group treated with N-acetylcysteine were healthier comparative to the control group after 7 days of operation. Openings of the surgical area in the control group suffered from adhesions led to hemorrhage during their separation while in the treated group there were no adhesions. Blood analysis and liver enzymes tests showed an absence of inflammation and regularity of all liver enzymes in the treated group. Finally, the treated groups showed the normal arrangement of tissue layers and no adhesion or increasing in collagen fibers.

هدفت هذه الدراسة إلى تنفيذ تأثير N-acetylcysteine على الجروح التي تكونت في المعدة بعد استئصال المعدة. استخدمت الكلاب في هذه الدراسة كحيوانات تجريبية. تم تقسيم الكلاب إلى مجموعتين : مجموعة العلاج ومجموعة السيطرة. كل مجموعة تحتوي على 5 حيوانات. تم إغلاق الشق الجراحي بواسطة طبقتين من الخيوط الجراحية باستخدام خيوط ماصة ثم أغلقت العضلات والجلد باستخدام الخطوات التقليدية. تمت معالجة مجموعة العلاج باستخدام 3 ٪ من سائل N-acetylcysteine موضعيا في موقع العملية، وكذلك كان يعطى N-acetylcystine 140 ملغم / كغم / يوم) عن طريق الفم لمدة 7 أيام. تم تسجيل الفحص الإجمالي والعلامات السريرية بعد 7 أيام من العملية. تم جمع عينات الدم قبل الجراحة و بعد 7 أيام من الجراحة لإجراء دراسة الدم بشكل كامل على عينات الدم في كلا المجموعتين. بالإضافة إلى ذلك، أخذت عينات الأنسجة من مناطق العمليات لدراسة التغير النسيجي. أظهرت نتائج هذه الدراسة أن شفاء المجموعة التي عولجت بـ N-acetylcysteine قد شفيت بعد 3 أيام بينما استمرت مجموعة السيطرة بالشفاء حتى 7 أيام بعد الجراحة. كانت الأغشية المخاطية في المجموعة المعالجة أكثر صحة مقارنةً بمجموعة السيطرة بعد 7 أيام من العملية. الشق الجراحي في المنطقة الجراحية في مجموعة السيطرة عانت من الالتصاقات أدت إلى نزيف أثناء الانفصال بينما في المجموعة المعالجة لم تكن هناك أي التصاقات. أظهرت اختبارات تحليل أنزيمات الكبد والدم غياب الالتهاب وانتظام جميع إنزيمات الكبد في المجموعة المعالجة. أخيرًا أظهرت المجموعات المعالجة الترتيب الطبيعي لطبقات الأنسجة وعدم الالتصاق أو الزيادة في ألياف الكولاجين.


Article
STUDY SOME PHYSIOLOGICAL VARIABLE OF BLOOD IN THE LACTATINGWOMEN (BREASTFEEDING) DURING LACTATION
دراسة بعض المتغيرات الفسلجية لدم النساء المرضعات (رضاعة طبيعية)خلال فترة الرضاعة.

Authors: Mohammed Q. Al-Ani محمد قيس العاني --- Naheda I. Al-Dulaymi ناهدة ابراهيم الدليمي
Journal: Journal of university of Anbar for Pure science مجلة جامعة الانبار للعلوم الصرفة ISSN: ISSN:PISSN: 19918941/EISSN: 27066703 Year: 2008 Volume: 2 Issue: 2 Pages: 25-28
Publisher: University of Anbar جامعة الانبار

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ABSTRACT:This study was done on twenty five lactant women and twenty five as control )not marriage) from General Ramadi Hospital to study some biochemical variable such as
(PCV, Hb, sugar, cholesterol SGPT, SGOT, S.Alk.ph, and hormone of prolactin ) during lactation. The results of this study as following: no significant differences in level of PCV, Hb, SGPT,and cholesterol while significant differences in level of blood sugar, SGOT, and prolactin hormone were recorded in this study.

الخلاصة:اجريت الدراسة على ٢٥ امرأة مرضعة و ٢٥ امرأة اخرى استعملت كتجربة ضابطة (نساء غير متزوجات ) منمستشفى الرمادى للنسائية والاطفال لدراسة بعض المتغيرات الفسلجية للدم شملت ( حجم كريات الدم الحمر المضغوط،و هرمون SAlk و SGPT و SGOT الهيموكلوبين، سكر الدم ، وتركيز الكوليستيرول وانزيمات المصل شملتالبرولاكتين ) خلال فترة الرضاعة. بينت النتائج عدم وجود تغيرات معنوية فى مستوى حجم كريات الدم الحمر المضغوطةفي (P< ، الهيموكلوبين، والكوليستيرول ، كلوتاميك بايروفيت ترانس امينيز بينما كانت هناك فروقات معنوية ( 0.05و هرمون البرولاكتين. SAlk و SGOT مستوى السكر و


Article
ENZYMATIC LIVER CHANGES AMONG WORKERS EXPOSED TO VINYLCHLORIDE

Authors: Saad K Kareem سعد كاظم كريم --- Muataz AM Al-Qazzaz معتز عبد المجيد القزاز --- Ali AA Sahib علي عبد علي صاحب
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2012 Volume: 10 Issue: 1 Pages: 75-82
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

BackgroundPolyvinyl chloride (PVC) is used in production and manufacturing of many essential tools for example plastic pipes, fabric, cables, decorative products etc.). Its production is impossible without the use of vinyl chloride monomer (VCM), which can cause liver damage in long-term.ObjectiveTo assess the effects of mild to moderate long term exposure to VCM on liver and to assess the importance of liver enzyme measurements as screening tools.MethodsIn this study, measurement of serum levels of liver enzymes of 64 exposed workers and 61 control workers was carried out starting from the first of October 2010 till the end of January 2011. All of the studied cases were worked in a poly vinyl chloride (PVC) production unit in three polyvinyl chloride factories and considered as target population for detection of any possible industrial vinyl chloride associated liver enzymes changes. The controls were randomly selected from office personnel of the same factories. Biochemical paramedics and a questionnaire method were used for analysis and in both groups.ResultsBoth groups have a similar age structure. Statistical difference was noted between the alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) mean values for both the exposed and non-exposed groups. The mean values for alpha-2-globulin and gamma-globulin in both exposed and non exposed groups of serum electrophoresis were statistically significant. The relative risk for the exposed workers was higher than that one for all other variables. It was the highest and most significant for gamma-globulin abnormal values associated among the exposed group followed by the relative risk of alpha-2- globulin.ConclusionLiver function tests with serum protein electrophoresis are useful to detect hepatic damage among workers exposed to polyvinylchloride.Key wordsLiver Enzymes, Workers, Protein Electrophoresis, Vinyl Chloride

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