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Effect of cigarette smoking on liver function test and some other related parameters
تأثير تدخين السجائر على اختبار وظائف الكبد وبعض العوامل الأخرى ذات الصلة

Authors: Bakhtiar M. Ahmed --- Sangar Najat Abdul-Razaq
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2013 Volume: 17 Issue: 3 Pages: 556-562
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Cigarette smoking is one of the 10 greatest contributors to global death and disease. Cigarette smoke consists of many chemicals, including cytotoxic, carcinogenic and free radicals, therefore it affects many organs if not all.This work is directed to evaluate the effects of dose response patterns of tobacco exposure on liver tissue, through assessing some serum biochemical parameters related with liver efficiency.Methods: This study was done in Kirkuk province. It was conducted on (110) healthy male subjects, their ages ranged from 20 to 40 years. They were divided into three groups; 40 heavy smokers, 30 moderate smokers and 40 non-smokers. Blood was withdrawn for estimation of serum liver function test, lipid profile, protein electrophoresis, and lipid peroxidation test (Serum Malondialdehyde; MAD level).Results: There were statistically significant elevations in serum alkaline phosphatase (ALP), alanine transaminase(GPT) and aspartate aminotransferase(GOT) activities in heavy smokers while serum total bilirubin significantly was lower comparing to non smokers. Serum total protein and albumin were significantly lower in heavy smokers comparing to non smokers. The results of serum protein agarose gel-electrohporesis showed significant changes in serum protein fractions in smoker groups. The mean level of serum total cholesterol, triglyceride, LDL, VLDL and malondialdehyde was significantly higher in heavy smoker group, while serum HDL level had a significantly lower value.Conclusion: Cigarette smoking can affect liver efficiency and functions. These effects are dose exposure depenent.


Article
Cigarette Smoking and Serum Liver Enzymes

Authors: Durar Kamil Jabbar --- Habeeb Kadhum Abdul-Hassan
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2017 Volume: 25 Issue: 3 Pages: 1111-1117
Publisher: Babylon University جامعة بابل

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Abstract

This project aims to study some of liver function represented by the enzymes GOT and GPT in smokers and non-smokers in a group consists of 25 smokers and 25 non-smokers in different ages, and to study the effectiveness of cigarette smoking on liver enzymes and liver functions by checking the secretion of the liver enzymes GOT and GPT and their levels in the serum. The study shows that heavy cigarette smoking was significantly associated with increased levels glutamic-oxaloacetic transaminase, or GOT (23 -48) mg/dl and glutamate pyruvate transaminase, or GPT (44-54) mg/dl (P < 0.0001) compared with non- smokers who had normal value for the above parameters.

يهدف هذا البــحث الى دراسة بعض وظائف الكبد المتمثلة بانزيمي (GOTوGPT ) لعينة تتكون من 25 شخص من المدخنين و25 من غير المدخنين باعمار مختلفة ، ودراسة تأثيرالتدخين على الكبد ووظائفه وتأثيره على أفراز الكبد لانزيمي GPT,GOT وقياس مستوى كل منهما في المصل . وقد أوضحت الدراسة ان هناك ارتفاعا معنويا في مستوى انزيم GOT اذ تراوح بين(23 - 48) mg/dl وكذلك في مستوى انزيمGPT اذ تراوح بين (44 - 54)mg/dl عند المدخنين مقارنة بالأشخاص غير المدخنين اذ بقيت المعايير اعلاه ضمن الحدود الطبيعية.

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