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Article
Serum Magnesium Concentration in Patients with Leukemia and Lymphoma

Authors: Munaf S. Daoud --- Ali Y. majid** --- Wafa M. Merza
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 1 Pages: 101-104
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Leukemias and lymphomas are malignant disorders that occur in the blood forming organs and lymphoid tissue respectively. They are classified to types and several subtypes such as acute or chronic, lymphocytic or myelocytic and T-cell or B-cell lymphocytic for leukemias and histologically into Hodgkin’s and Non-Hodgkin’s for lymphomas. Literatures do not contain many research work on magnesium in patients with these disorders, although this mineral is essential for many metabolic, enzymic, regulatory and immune reactions in the human body. Therefore, the present study was aimed to evaluate the level of magnesium in the sera of patients with different types of leukemia and lymphoma. Patients and Methods: Fifty five patients with leukemia and lymphoma and twenty five healthy controls were studied. The patients were attendants of Baghdad Teaching Hospital and Pediatric Teaching Hospital from September 2006 to January 2007. The diagnosis was confirmed by examination of both peripheral blood, lymph node biopsy and/or bone marrow examination. Patients were categorized according to French-American-British Criteria. Thirty five patients with ALL, one with CLL, six with AML, three with CML, three with HL and seven with NHL. Venous blood was collected from each patient or control person and sera were obtained by centrifugation. S[Mg] was measured by Atomic Absorption Flame Spectrophotometry.Results:The Mean ± SD of S[Mg] in mg/dl of all types of leukemic and lymphomatous patients was lower than the controls. There was a high statistically significant difference (P<0.01) in patients with ALL and significant difference (P<0.05) in patients with AML and NHL and non-significant difference (P>0.05) in patients with CML and HL, compared with the control. Total patients group showed high significant difference (P<0.01) compared with control group. The mean distribution of S[Mg] among total patients indicated decreased (58.2%), normal (38.2%) and increased (3.6%) levels.Conclusion:The present study disclosed the existence of normal to decreased level of S[Mg] in patients with leukemia and lymphoma suggesting an influence of many variable factors. Although the decreased S[Mg] was statistically significant, it was still within lower normal range.


Article
Primary Gastric Lymphoma in North of Iraq (A Study of 34 cases in the surgical departments of Erbil and Mousl hospitals).

Author: Abdulqadir M.Zangana
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 4 Pages: 294-302
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Primary Gastric Lymphoma is an uncommon malignancy among gastric malignancies. Histology of the Primary Gastric Lymphoma is varied and the extranodal marginal zone B-cells lymphoma is especially significant on account of its potential remission with antibiotic therapy.OBJECTIVE:To study the incidence, staging, clinical presentation, histological and management of Primary Gastric Lymphoma in the North of Iraq.PATIENTS AND METHODS:From January 1988 to February 2005, A total number of 534 patients operated as gastric tumors, 34 (4%) diagnosed as Primary Gastric Lymphoma. at the surgical departments of Erbil and Mousl teaching hospitals.RESULTS:Out of 34 Primary Gastric Lymphoma,24 cases (70.5%) were located in the distal part of the stomach the most common cell type was B-cell type non-Hodgkin's lymphoma,.Surgery was the main method of treatment and followed by chemotherapy and radiotherapy. Helicobacter pylori were isolated from all 34 Patients.All patients received antibiotics for eradication for H. Pylori infection for 4-6 weeks.Long-term remission were induced in the low-grade MALT lymphomas in 73% of cases by the successful eradication of the H. pylori infection Operative mortality rates was12 %CONCLUSION:surgical intervention was confined to stage I&II while patients with stage III surgery was indicated mostly for complications like bleeding and perforationMucosa-associated lymphoid tissue tumor (MALT) had a better prognosis because it tends to be localized with a long survival period.

Keywords

gastric lymphoma --- primary


Article
Primary Burkitt's lymphoma of the ovary (Case Report)

Authors: Nada Hamza Shareef --- Qasim Dawood Al-Tameemi --- Jawad Kadim Al-Dhahri
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2011 Volume: 7 Issue: 12 Pages: 41-46
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Ovarian neoplasms are rare in children . We had reported a case of primary Burkitt's lymphoma of the ovary in a 3-year-old girl presented with chronic abdominal pain with fever, pallor, and abdominal mass which was proved after laparatomy and histopathological study of the excised tumour to be a primary Burkitt's lymphoma of the ovary.

اورام المبيض نادرة في الاطفال . لقد وثقنا حالة لمرض (بيركت) اللمفاوي الابتدائي في مبيضي طفلة عمرها ثلاث سنوات كانت تشكو من الام مزمنة في البطن مع حمى وشحوب الوجه وورم في اسفل البطن . وبعد اجراء عملية فتح البطن الاستكشافي واستئصال الاورام وارسالها الى الفحص النسيجي تاكد بان المريضة مصابة ب ( ورم بيركت اللمفاوي الابتدائي في المبيضين ) .

Keywords

Burkitt --- ovary --- lymphoma


Article
Non-Hodgkin's Lymphoma: a Preliminary Morphometric Study
اللمفومة اللاهوجكنية : دراسة تمهيدية بقياس الأشكال

Author: Aiad Abdullah Abdulrazak أياد عبدالله عبدالرزاق
Journal: Al- Anbar Medical Journal مجلة الأنبار الطبية ISSN: PISSN: 27066207 / EISSN: 26643154 Year: 2013 Volume: Vol.11 Issue: 1 Pages: 62-68
Publisher: University of Anbar جامعة الانبار

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Abstract

Background: Assessment of nuclear morphology is crucial for the diagnosis of non-Hodgkin's lymphoma. However, it is often hampered by subjectivity and inter-obsever variation. Objectives: This work is aimed at studying the usefulness of nuclear morphometry as an objective approach to the diagnosis of non-Hodgkin's lymphoma.Material and Methods: Hematoxylin-Eosin stained sections from twenty-eight cases of non-Hodgkin's lymphoma was evaluated for nuclear size, area and perimeter by semi-automated image analysis system.Results: The parameters related to nuclear morphology (nuclear size, area, & perimeter) of neoplastic lymphocytes were significantly higher in large cell lymphoma as compared to small cell, intermediate cell & Burkitt's lymphoma but, not for mixed cell lymphoma. This finding was further substantiated when calculating the overlap index.Conclusion: This study supports the assumption that nuclear morphometry offers a more objective and reproducible diagnostic method for subcategorizing lymphoid tumors than is currently possible by conventional histopathological techniques

هذه الدراسة تدعم الإدعاء بان قياس أشكال النواة يمثل طريقة أكثر موضوعية وقابلة للتكرار لتشخيص وتصنيف الأورام اللمفاوية بالمقارنة مع الطرق التقليدية.الخلفية والأهداف: إن تقييم مورفولوجيا النواة أمر حاسم لتشخيص الأورام اللمفاوية اللاهوجكنية لكن غالبا ما تعوقه اللاموضوعية والاختلاف بين الفاحصين. يهدف هذا البحث إلى دراسة فائدة قياس أشكال الأنوية كنهج موضوعي لتشخيص الأورام اللمفاوية اللاهوجكنية.المواد وطريقة العمل: قيمت شرائح نسيجية مصبغة بالهيماتوكسلين والأيوزين لثماني وعشرين حالة ورم لمفاوي لاهوجكني وتم قياس حجم ومساحة ومحيط الأنوية باستخدام نظام تحليل الصور شبه آلي.النتائج: وجد بأن المعلمات المتعلقة بمورفولوجيا النواة (الحجم والمساحة والمحيط) للخلايا اللمفاوية الورمية أكبر في اللمفومة كبيرة الخلية بالمقارنة مع اللمفومة ذات الخلايا الصغيرة أو المتوسطة ولمفومة بيركت بفارق معتد إحصائيا لكن الفارق لم يكن ذو أهمية عند المقارنة مع لمفومة الخلايا المختلطة ، وتم أثبات هذه النتيجة عند حساب مؤشر التداخل

Keywords

Lymphoma --- Non-Hodgkin --- Morphometry


Article
Screening For HTLV 1 & 2 Among Iraqi Patients With Lymphoma And Leukemia
تحري فايروس اللمفومه وابيضاض الدم نوع 1 و2 لدى مرضى العراقيين المصابين بسرطان الغدد اللمفية وابيضاض الدم

Authors: Jamal R. Al-Rawi جمال رشيد الراوي --- Aymen M. Abdul Latief ايمن محمود --- Safaa Abdulkareem صفاء عبد الكريم
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2017 Volume: 30 Issue: 4 Pages: 165-168
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:Background: A number of viruses are known to infect human lymphocytes and other blood components causing lymphoma and leukemia, among them are Human T-lymphotropic virus type 1 (HTLV-1) and Human T-lymphotropic virus type 2 (HTLV-2).Objective: Find out the prevalence of HTLV 1&2 infections in Iraqi patients with lymphoma and leukemia and the association of this infection and the malignancy with other factors related to the patient himself or the surrounding environment he is living in.Methods: The study was conducted in The National Center of Hematology in Al-Mustansiriya University for the period from July 2008 to May 2009. The sample consisted of a total 250 patients with lymphoma and leukemia, 120 males and 130 females, their mean age was (40.76±14.58) years and age range (13-79) years, they were from all over the Iraqi governorates. All patients were interviewed directly by similar questionnaire, measurements (height and weigh) and a sample of blood was taken from every patient and tested for the presence of the virus using ELISA technique.Results: The study showed positive results for HTLV infection in 3 patients which is about (1.2%) of the sample Conclusion: HTLV 1&2 infection is present in Iraqi patients complaining of lymphoma and leukemia with a prevalence of 1.2%.This is the first report in Iraq regarding HTLV 1&2 positivity among leukemia and lymphoma patients, the prevalence was lower than other countries, All factors and characteristics of patients were consistent with other studies regarding lymphoma and leukemia

Keywords

HTLV --- Lymphoma --- Leukemia


Article
Non- Hodgkin's Lymphoma; Epidemiology and Presentation

Authors: Zead Ismael Ibrahim --- Allawi N. Hussein --- AbdulSattar I. AL-Kubaysi --- Tariq A. AL-Shujairi --- et al.
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2013 Volume: 2 Issue: 1 Pages: 1-6
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: The non-Hodgkin lymphomas (NHL) of childhood are a diverse collection of diseasesoriginating in the cells and organs of immune system.Objectives: To determine epidemiology and clinicopathological presentations of children with NHLadmitted to Child's Central Teaching Hospital.Methods: A retrospective study was done from 1st of January 2004 to the 31st of December 2009; thepatients with newly diagnosed NHL, age less than 15 years, who were admitted to thepediatric oncology unit in the Child’s Central Teaching Hospital.Results: The total number of patients was 84; the mean age at diagnosis was 6.3years, with a male tofemale ratio of 2:1. Most of patients were presented in stage III&IV (88%).Most commonpresenting features were abdominal distension or a mass in 51%.Burkitt lymphoma andBurkitt like lymphoma were the most common histological subtype (58.33%).Conclusions: The majority of cases were between 5-9 year age group, and the mean age atpresentation was 6.3 years old, with a male to female ratio of 2:1. The most commonpresenting site was the abdomen. The majority of cases were fallen in advanced stages(III&IV). Histopathologically Burkitt's lymphoma was the commonest subtype.


Article
Clinicopathological, immunohistochemical charachtaristic and the outcome of Hodghkin lymphoma patients in Erbil city, Iraq

Authors: Lilan Bahzad Mohammedzaki --- Kawa Muhammedamin Hasan --- Ranan Kardagh Polus --- Ahmed Khudair Yassin
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2019 Volume: 8 Issue: 1 Pages: 14-20
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

BACKGROUND: Hodgkin lymphoma (HL) has unique epidemiological features with diversifiedpathologies and exhibits considerable clinicopathological variations in different parts of the world.OBJECTIVES: We aimed in this study to assess clinic-pathological features, immunohistochemistryand outcome of HL patients treated in Erbil, northren Iraq.PATIENTS AND METHODS: This was a retrospective study conducted in Nanakaly Hospital forblood diseases and oncology in Erbil, North Iraq; a total of 125 patients diagnosed between January2012 and December 2016 were involved; they were assessed for their clinical characteristics andhistopathology and immunophenotyping findings and their outcome was evaluated as well.RESULTS: The median age was 28 years (range: 18–71 years); 55% were male and 41% had StageII disease; common histological type is nodular sclerosis (51.2%) followed by mixed cellularity (43.2%);CD30 was positive in nearly all cases of classical HL, and CD15 was positive in 98.7% and CD20was positive in 75% in nodular lymphocyte predominant subtype. Most of the patients receivedadriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy, and the 5‑year overall survivalin our study is 70%. Advanced stage (IV), high lactate dehydrogenase level, low hemoglobin, andsplenomegaly are significant predictors for poor survival.CONCLUSION: Our patient exhibited outcomes that were lower to those reported in developedcountries.


Article
Class II Human Antigen in Iraqi patients with Hodgkin’s Lymphoma
دور الضد لكريات الدم البيض نوع II البشري في المرضى العراقيين المصابين بسرطان هوجكن اللمفي

Author: Haethem Qassim Mohammed هيثم قاسم محمد
Journal: Iraqi Journal of Cancer and Medical Genetics المجلة العراقية للسرطان والوراثة الطبية ISSN: 20786123 Year: 2010 Volume: 3 Issue: 2 Pages: 24-29
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Objective: To detect the association between human leukocyte antigen) HLA) class II and Iraqi patients with Hodgkin’s lymphoma (hl).Subject and methods: Study groups include 80 newly diagnosed Hodgkin’s lymphoma patients and two control group patients control which include 50 patients who were newly diagnosed to be affected by non Hodgkin’s lymphoma (NHL) and healthy individuals. Antibody mediated complement dependent cytotoxicity assay was done by treating sample of patients lymphocytes with a panel of anti-HLA antisera and complement.Results: The frequency expression of hla-dr3 and DQ1 was significantly greater in Hodgkin’s lymphoma patients thanhealthy control group with (p<0.001) for HLA-DR3 and (p<0.005) for DQ1.Conclusion: Hla-dr3 and dq1 are more related with Hodgkin’s lymphoma in Iraqi Arab population that reflect HLAalleles have immunogenetic factors of predisposition to Hodgkin lymphoma


Article
Immunohistochemical expression of P53, as a marker of apoptosis in Hodgkin’s and Non Hodgkin’s lymphoma of the head and neck region

Authors: Thaer K. Ali --- Bashar H. Abdulla --- Khitam R. Kadhim
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 4 Pages: 129-132
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Malignant lymphomas represent about 5% of all malignancy of the head and neck region which caninvolve lymph nodes as well as soft tissue and bone of the maxillofacial region. Apoptosis is considered a vitalcomponent of various processes including normal cell turnover, proper development and functioning of the immunesystem. Inappropriate apoptosis is a factor in many human conditions including neurodegenerative diseases,ischemic damage, autoimmune disorders and many types of cancer. Expression of p53 Proteins in Hodgkin ׳s and NonHodgkin ׳s lymphomas suggested that it can help in monitoring of patients and the markers may aid in controlling theprogression of lymphoma and detect the degree of aggressiveness of the disease to give suitable treatment andmanagement of patients.Material and methods: Sixty seven formalin-fixed, paraffin-embedded tissue, histopathologically diagnosedlymphoma blocks (head and neck lesions) as (24) Hodgkin’s Lymphoma and (43) Non Hodgkin’s Lymphoma.Immunohistochemical (IHC) technique was used for the evaluation of P53 monoclonal antibodies expression andcorrelated with the clinicopathological parameters.Results: The mean of expression of P53 in relation to tumor grades was different as it had a value of (51.2±13.5) in lowgrade tumors, (55.7±20) in the intermediate grade tumor and (45±17.6) in high grade tumors; consequently, thisdifference did not reached the level of statistical significance P(ANOVA) >0.05.Conclusions: This study had shown that there was no significant correlation between the mean of expression of P53 inHL and NHL

خلفیھ:اللمفوما الخبیثھ تمثل حوالي 5% من كل الامراض لمنطقة الرأس والعنق والتي یمكن ان تنطوي على العقد اللمفاویھ وكذلك الانسجھ الرخوه ومنطقة الوجھ والفكین. موت الخلایاالمبرمج یعتبر عنصر حیوي لكثیر من العملیات المتنوعھ من ضمنھا عملیة التحول الطبیعي للخلایا والتطور المناسب وعمل الجھاز المناعي. موت الخلایا المبرمج الغیر مناسب (امابصوره قلیلھ أو كثیره) ھو عامل في العدید من الحالات البشریھ من ضمنھا أمراض التحلل العصبي، التلف نتیجھ فقر الدم الموضعي ،حالات أضطراب المناعھ الذاتیھ وعدة أنواع منP في ھودجكن ولاھودجكن لمفوما مستعملین طریقة النسیجي المناعي الكیمیائي ، اقترحت بأن الدراسات المناعیھ النسیجیھ الكیمیائیھ لعامل 53 P السرطان. التعبیر عن بروتین 53وظھوره في أورام الانسجھ یمكن أن یساعد في رصد المرضى والدراسات وكذلك المعلمات ممكن أن تساعد في ضبط تقدم اللمفوما ونتحقق من درجة عدوانیة المرض لاعطاء العلاجالملائم وأدارة المرض.المواد والطرق: سبعھ وستین نسیج مثبت بالفورمالین ومطموره بشمع البرافین، مشخصھ نسیجیا من منطقة الراس والعنق.اربعھ وعشرون حالة ھودجكن لمفوما وثلاثھ وأربعونكمضاد احادي النسل وربط ذلك مع المعاییر العیادیھ المرضیھ. P لاھوجكن لمفوما. تقنیة المناعھ الكیمیائیھ النسیجھ قد استعملت لتقییم تعبیر 5317.6 في الورم ± 20 في الورم متوسط الدرجھ و 45 ± 13.5 في الورم واطيء الدرجھ و 55.7 ± وعلاقتھ بدرجھ الورم كانت مختلفھ كما كانت لھا قیمھ 51.2 P النتائج: معدل تعبیر 53. P> عالي الدرجھ: وكنتیجة الاختلاف لم یصل الى المستوى الاحصائي المھم 0.05في ھودجكن ولاھوجكن. P الاستنتاج: ھذه الدراسھ قد أظھرت بأنھ لم تكن ھناك علاقھ مھمھ بین معدل تعبیر


Article
Immunohistochemical and clinicopathological study of non-Hodgkin's lymphoma in Erbil, Kurdistan
دراسة كيميائية مناعية ونباتية لأورام ليمفوما اللاهودجكين في أربيل، كوردستان

Authors: Maysoon Alhaideri --- Rafal Abdul Razaq Al-rawi --- Tara Sirwan Kamil
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 2 Pages: 756-762
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Non-Hodgkin lymphoma is a cancer of the lymphatic system. Types of non-Hodgkin lymphoma vary significantly in their severity from indolent to very aggressive. The aim of this study was to investigate the incidence, immunohistochemical expression, clinical and histopathological prognostic factors of patients with non-Hodgkin lymphoma.Methods: A total of 59 patients with non-Hodgkin lymphoma cases were reviewed and investigated at Razgary Teaching Hospital in Erbil city during the period from January, 2011 to January, 2013. Data of patients were tabulated and distributed according to their age, sex, site, immunohistochemical expression and WHO classification.Results: Age of non-Hodgkin lymphoma patients ranged from 2 to 88 years with a mean of 45 year. Around 49% of the patients were of age group over 50 years and 54.2% of pa-tients were male. Immunohistochemical investigation indicated that 71.2% of non-Hodgkin lymphomas were of B cell type, the highest percentage (33.3%) of them was of diffuse large cell type. While the T cell type was found in 20.3%, the highest percentage (33.3%) of them was of Anaplastic lymphoma. CD20 and CD3 showed more consistent and strong expression for B and T cells non-Hodgkin lymphoma, respectively. Results showed high BCL2 expression. Nodal non-Hodgkin lymphoma account for 50.8% of the total cases.Conclusion: Most non-Hodgkin lymphomas were of B cell type and highest percentage is of diffuse large cell type. CD20 and CD3 were more reliable as an indicator of B and T cell lineage, respectively. Most non-Hodgkin lymphomas were of intermediate-high grade. Nodal site represent highest rate for primary non-Hodgkin lymphoma.

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