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Article
Non CNS pediatric malignancies in Mosul

Authors: Sahar K. Omar سحر خطاب عمر --- Likaa Fasih Al-Kzayer لقاء فاصح --- Khalil I. Mahmood خليل ابراهيم محمود
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2010 Volume: 36 Issue: 1&2 Pages: 86-91
Publisher: Mosul University جامعة الموصل

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Abstract

ABSTRACT
Objectives: To find out the types of pediatric malignancies in patients from Mosul, their age and sex distribution as well as the death rate among these diseases with special emphasis on acute lymphoblastic leukaemia.
Patients and methods: A survey which was conducted in Mosul pediatric wards of oncology in Alsalam, Ibn Sina general hospitals and Ibn Alatheer hospital for pediatric diseases on 228 children of both sexes, their ages were less than 12 years from year 2001-2007. The clinical data were taken from their case sheets regarding age, sex, clinical presentation at time of admission and the lab tests including tissue biopsy as well as bone marrow examination.
Results: The commonest 3 types of these malignancies were acute lymphoblastic leukaemia (ALL) (43.4%), lymphoma (19.5%) and neuroblastoma (7.9%). The mean age of presentation was 65 months; the majority of cases were between 13 months - 6 years. Males predominate in a ratio of 1.28/1. Regarding ALL the main clinical features at presentation were fever, pallor, bone pain and bleeding. All cases were treated as inpatients. Death rate was high (35.08 %), the commonest causes were sepsis, bleeding and progressive disease.
Conclusion: There were different types of malignancies in children in Mosul, the commonest were ALL, Lymphoma and neuroblastoma, with high death rate.

Keywords: Pediatric, malignancies.

أهداف البحث: لمعرفة أنواع الأمراض السرطانية عند الأطفال في الموصل كذلك الأعراض السريرية لكل نوع مع تشديد خاص على ابيضاض الدم.التصميم والمشاركون: دراسة وصفية أجريت على 228 طفلا في ردهات الأطفال في مستشفيات السلام وابن سينا وابن الأثير والتي تعالج فيها سرطانات الأطفال لكلا الجنسين وأعمارهم أقل من 12 سنة بين عامي 2001-2007. وأخذت المعلومات من سجلات المرضى فيما يخص العمر، والجنس والأعراض السريرية وقت دخول المستشفى مع الفحوصات المختبرية التي أجريت ومن ضمنها الخزعة النسيجية وفحص نخاع العظم.النتائج: تبين ان الأمراض السرطانية الثلاثة الأكثر انتشارا عند الأطفال هي: ابيضاض الدم (43,4%)، السرطانات اللمفاوية )19,5%) وسرطان الغدد الكظرية (7,9%) وكان معدل عمر الأطفال وقت الدخول الى المستشفى هو 65 شهرا ومعظم الأعمار كانت تتراوح بين 13 شهرا -6 سنوات ومعظم الحالات كانت من الذكور بنسبة الذكورالإناث (1.28 1). بالنسبة لابيضاض الدم كانت أهم الأعراض السريرية وقت الدخول الى المستشفى هي الحمى، الشحوب، ألم في العظام والقابلية على النزف. جميع الأطفال المرضى بالسرطان أدخلوا المستشفى وعولجوا فيه. كانت نسبة الوفيات عالية (35,08%) وأهم أسباب الوفيات كانت خمج الدم، النزف، متلازمة تحلل الورم وتقدم المرض.الاستنتاج: أهم الأمراض السرطانية عند الأطفال في الموصل هي ابيضاض الدم، السرطانات اللمفاوية وسرطان الغدد الكظرية. نسبة الوفيات كانت عالية.

Keywords

Pediatric --- malignancies


Article
Oral malignant lesions in a sample of patients in the north of Iraq (Retrospective study)

Author: Ali I Al–Niaimi
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2006 Volume: 6 Issue: 8 Pages: 176-180
Publisher: Mosul University جامعة الموصل

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Abstract

Aim: To determine the frequency of occurrence and the distribution of different oral malignant lesions in a sample of patients in the north of Iraq. Materials and Methods: This study including the reviewof 6603 patients’ files with different types of malignant tumors of the body between the years 1995– 1999 and the cases affecting the oral cavity were isolated and undergo descriptive statistical analysis.Results: From the 6603 patients’ files reviewed, only 119 cases (2%) had malignant lesions of the oral cavity with age range between 2.5–90 years and the mean of age was 58.3 years. Male:female ratio was 1.2:1. Squamous cell carcinoma was the predominant tumor of the oral cavity. Lower lip was the most commonly affected site by the oral cancer. Conclusion: Oral cancer included many types of tumors but the predominant type is the squamous cell carcinoma that takes many forms. Although it show high occurrence over the age of 40 years but it may occur at any age and sex. The other types of cancer although they are rare in the oral cavity but they should be taken in consideration during diagnosis oforal cancer.


Article
The frequency of disseminated intravascular coagulopathy in newly diagnosed adult patients with haematological malignancies attending Nanakaly Hospital in Erbil
تواتر اعتلال تخثر الدم داخل الأوعية الدموية لدى مرضى البالغين الذين تم تشخيصهم حديثًا والذين يعانون من الأورام الخبيثة في مستشفى نانكلي في أربيل

Authors: Kawa Muhammedamin Hassan --- Reving Rebar Akram
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 2 Pages: 718-725
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Disseminated intravascular coagulation significantly contributes to the bleeding and thrombotic complications in patients with haematologic malignancies. This study was conducted to find out the incidence of disseminated intravascular coagulopathy in haematological malignancies before introduction of chemotherapy.Methods: A prospective case series study was performed at Nanakaly Hospital for Blood Diseases from April 30, 2011 to April 1, 2012. Seventy patients with different haematological malignancies were enrolled; they were assessed with clinical importance of global haemostatic laboratory tests.Results: Eighteen percent of studied patients had overt disseminated intravascular coagulopathy. The haemostatic measures were higher in overt disseminated intravascular coagulopathy cases than those with no evidence of disseminated intravascular coagulopathy cases (P < 0.001); and the highest incidence of disseminated intravascular coagulopathy cases was in acute promyelocytic leukemia's patients (77%, P = 039). Most of disseminated intravascular coagulopathy cases were clinically manifested with anemia, bleeding and rarely with thrombosis (100%, 69% and 7%, respectively).Conclusion: Disseminated intravascular coagulopathy is not uncommon in haematological malignancies before starting chemotherapy. Global haemostatic tests are helpful for diagnosis of disseminated intravascular coagulopathy side by side with clinical manifestations and medical history.


Article
Genetic variation in BRAF gene among Iraqi colorectal cancer patients.

Author: Israa S. Abbood1 , Ismail H. Aziz2
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2018 Volume: 17 Issue: 3 Pages: 78-84
Publisher: Baghdad University جامعة بغداد

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Abstract

The RAS/RAF/MEK/MAP kinase pathway is essential to intracellular signaling transduction regulating cell proliferation, differentiation and death. BRAF gene encodes a serine /threonine kinase and plays an important role in the mitogen-activated protein kinase signaling pathway. FrequentBRAF mutations were reported recently in a variety of human malignancies, including colorectal cancer (CRC).This study was designed to investigate the BRAF mutations in exon 15 in Iraqi colorectal cancer patients. Ninety samples of fixed formalin paraffin embedded tissue ( FFPE) were enrolled in this study and divided into three groups according to histopathology report (16 apparently healthy, 37 suffering colorectal cancer adenocarcinoma and 37 benign tumors).DNA from the FFPE samples were extract and the BRAF gene was screened for the presence of mutations using PCR technique and direct sequencing. The results revealed that there are no BRAF gene mutations in exon 15 in Iraqi colorectal cancer patients. These results were confirmed previous articles regarding low rate of BRAF gene mutation in Asia and south Iran. The results of colorectal cancer in Iraqi patients may be indicating the possibility of CRC patients treatment with monoclonal antibodies. Conclusion: Despite the limited study sample our data suggest that BRAF mutations might be less frequently than other genes in the RAF family in Iraqi CRC patients. Further researches involving large patient series will be necessary to confirm these findings and to asses possible ethinic/environmtal and lifestyle influences on BRAF mutagenesis.


Article
Association of human herpesvirus 6 with lymphoid malignancies in Iraqi patients

Authors: Hadeel M. Fiadh --- Alaa F. Alwan --- Dawood S. Dawood
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2015 Volume: 4 Issue: 2 Pages: 18-29
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Human herpesvirus type 6 (HHV-6) is associated with roseola infantumduring childhood followed by life-long latency that periodically reactivated inimmunocompromised individuals. In spite of several studies to establish the pathogenicrole of HHV-6 in lymphoid malignancies, the issue is still controversial.Objectives: This study was arranged to explore the association of HHV-6 infection inlymphoid malignancies using different serological and molecular techniques and toquantify the plasma viral load.Patients and methods: This cross-sectional case control study was conducted inNational Center for Hematological Diseases (NCHD) at Al-Mustansiriyah Universityand Baghdad Teaching Hospital (BTH) in Baghdad-Iraq from September 2013 tillApril 2015. The patient group consists of 11 patients with Hodgkin lymphoma and39 Non-Hodgkin's lymphoma of both sexes. The age range was between 15-80 years.The diagnosis of lymphomas was based on hematological and histopathologicalcriteria. 59 apparently healthy individuals were enrolled as control group. They werechosen from unpaid blood donors. The age range was between 18-59 years. Humanprivacy was respected by taken participant's oral consensus. The seropositivity rate ofanti-HHV-6 IgG and IgM antibodies were detected by enzyme linked immunosorbentassay (ELISA) and indirect immunofluorescent test (IFAT). The molecular detectionand determination of plasma viral DNA load was achieved by quantitative polymerasechain reaction (qPCR). All data were statistically analyzed, and P values < 0.05 wereconsidered significant.Results: The anti-HHV-6 IgG positivity rate by IFAT was insignificantly higher in HL(81.8% vs 61.0% p=0.186) and NHL (64.1% vs 61.0%, p =0.758) compared to controlgroup. The anti-HHV-6 IgG positivity rate by ELISA was 81.8% in HL, 84.6% inNHL versus 72.9 % in controls which were insignificant in both groups (p=0.534 andp=0.173) respectively. The anti-HHV-6 IgM positivity rate by ELISA techniqueamong patients with HL was significantly higher compared to controls (27.2% vs 6.8%,p= 0.038), but not significant in NHL (17.9% vs 6.8%, p= 0.086). HHV-6 DNA wasdetected in (27.3%) patients with HL by PCR technique, but none of the controls orNHL patients was positive. The plasma viral DNA load of the patient with HL was1.4± 0.3 x105 copies/milliliter.Conclusion: Although a higher anti-HHV-6 antibodies positivity rate among patientswith HL and NHL, the pathogenic role of the virus in the development of thesemalignancies was difficult to be ascertain.


Article
Resistance of Pseudomonas aeruginosa to multiple β-lactam antibiotics
تعدد مقاومة الزوائف الزنجارية لمضادات البيتالاكتام

Author: Venus Hassan Abdul Amir فينوس حسن عبد الأمير
Journal: journal of al-qadisiyah for pure science(quarterly) مجلة القادسية للعلوم الصرفة (فصلية). ISSN: 19972490 Year: 2016 Volume: 1 Issue: 21 Pages: 34-40
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

A total of 90 Pseudomonas aeruginosa (P.aeruginosa) strains clinical samples were collected from burn, ear, and foot diabetic samples in Al-Hilla, and Marjan teaching hospitals were identified to species level with a VITEK-2 system. The susceptibility to 11 antibiotics were tested using disc diffusion test resulting in 55.4% of 90 P.aeruginosa isolates were resistant to 11 antibiotics. Cefinase discs impregnated with nitrocefin method was used for the detection of β-lactamase production in antibiotics resistant 90 P.aeruginosa isolates. Results showed that 56% isolates were able to produce β-lactamase.

تم عزل 90 (90%) من الزوائف الزنجارية (P.aeruginosa) كانت مأخوذة من عينات الحروق ، الأذن و أقدام مرضى السكري في مستشفى الحلة ومرجان التعليمي وقد تم تشخيص أنواع الزوائف الزنجارية تبعا" لنظام الفايتك 2. تم اختبار استجابة 90 عزلة من P.aeruginosa تجاه 11 من المضادات الحيوية بواسطة فحص انتشار الأقراص فتبين إنها مقاومة بنسبة 55.4% لـ 11 من المضادات الحيوية. تم استخدام طريقة اقراص النايتروسفين للكشف عن قابلية العزلات المقاومة للمضادات الحيوية (90) على إنتاج البيتالاكتاميز وأظهرت النتائج أن هذه العزلات كانت قادرة على إنتاج انزيمات البيتالاكتاميز وبنسبة (56٪).

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