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Article
The possible cancer risk factor of Helicobacter pylori infections in immunocompromised children

Author: Amer Naes Amer 1 , Janan G. Hassan 1 , Ihsan E. Al-Saimary 2
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2017 Volume: 16 Issue: 3 Pages: 248-254
Publisher: Baghdad University جامعة بغداد

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Abstract

The frequency of Helicobacter pylori in children with malignancy was evaluate in the present study. Among 51 children included in the study ,29 of them are in malignancy group (79.3% of them having positive one step diagnostic test) ,while 22 children were control group (54.5% of them having positive one step diagnostic test). H.pylori infection was significantly higher in the malignancy group compared to the control group(P<0.05) ; 44.8% having positive culture for H.pylori ,while only 18.2% of control having positive culture for H.pylori. the results showed that there is no significant association between H.pylori and the type of cancer with P > 0.05. And there is a significant association between H.pylori and age more than 5 years with p< 0.05 which is statistically significant among patient groups. results also showed that there is no significant association between H.pylori and sex among both patients and control groups with P> 0.05.


Article
Dermatofibrosarcoma Protuberans: "Epidemiological and Clinical Study"
الورم الجلدي الليفي الضام الناتئ الخبيث (دراسة وبائية –سريرية)

Author: Adil A. Al-Nuaimy د. عادل عبد الغفور النعيمي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2008 Volume: 21 Issue: 4 Pages: 335-338
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Dermatofibrosarcoma protuberans is a locally aggressive invasive dermal and subcutaneous mesenchymal neoplasm. Males are affected more often than females. It typically occurs during the third and fourth decades of life.Objective: To determine the clinical, histopathogical and epidemiological aspects of dermatofibrosarcoma protuberans in Iraqi patients.Patients &Methods: This case series study was carried out in the Department of Dermatology & Venereology-Baghdad Teaching Hospital during the period from June 2000 to December 2006.Twenty patients with dermatofibrosarcoma protuberans were included in this work. Socio-demographic information, full clinical, dermatological examination and biopsy were done for each patient. Results: Twenty patients were involved in the present work, all showed typical clinical features of the disease. Their ages ranged from 7-75 (mean ± SD) (38.55 ± 21.33) years, while the duration of the disease ranged from 3-24 (mean ± SD) (23.28 ±10.53) months. There were 14(70%) males and 6(30%) females with a male to female ratio 2.3:1. The geographical distributions of these cases were: 9(45%) cases from South of Iraq, 11(55%) patients from Baghdad.The main sites involved were the extremities 10(50%) and 5(25%) for each one of the trunk and head. The clinical features of the diseases were not much different from what have been published in medical literatures .Histopathological study of lesions revealed the typical histological features of dermatofibrosarcoma protuberans in all cases. Conclusion: The present study confirmed that dermatofibrosarcoma protuberans is disease of male and it is the first report from Iraq recording cases from Middle and South regions only. Keywords: dermatofibrosarcoma protuberans, malignancy, clinical, epidemiological.

أساس البحث: الورم الجلدي الليفي الضام الناتئ الخبيث من الأورام الخبيثة الشديدة الاختراق الموضعي للأدمة والطبقة الدهنية للجلد.الذكور هم أكثر عرضة للإصابة بهذا الورم من الإناث.يحدث عادة في العقدين الثالث والرابع من العمر. هدف البحث: لتسليط الضوء على النواحي الوبائية السريرية والنسيجية للورم الجلدي الليفي الضام الناتئ الخبيث في المرضى العراقيين والذي لم يذكر سابقا في العراق. المرضى وطرائق البحث:هذه الدراسة(دراسة سلسلة حالات)أجريت في قسم الأمراض الجلدية والتناسلية في مستشفى بغداد التعليمي خلال الفترة من حزيران 2000لغاية كانون الاول2006.كان عدد المرضى المصابون بالورم الجلدي الليفي الضام الناتئ الخبيث في هذه الدراسة هوعشرون.جميع النواحي الاجتماعية والمعلومات السريرية والجلدية قد اخذت من كل مريض بالتفصيل وكل ما له صلة بالمرض.تم اخذ خزعة من كل مريض للتثبت من التشخيص.النتائج: عشرون مريضا تم فحصهم في هذا العمل واظهروا اكل الاعراض السيريه المثالية لورم الجلدي الليفي الضام الناتئ الخبيث.تراوحت اعمارهم بين7-75 سنة مع متوسط العمر وانحراف معياري 21,33سنه,.بينما ترواحت فترة المرض بين 3-24 شهر ±38,55 مع متوسط العمر وانحراف معياري 10,53 ±23,28شهر.اربعة عشر(70%) منهم من الذكور وستة(30%)من الاناث ونسبه الذكور للاناث هي 2,3:1.التوزيع الجغرافي للمرضى كان كالاتي:9(45%)حاله من جنوب العراق,11(55%) مريض من بغداد. كانت الاطراف الموضع الرئيسي في 10(50%) مرضى وفي خمس(25%) حالات لكل من الجذع والراس.الاعراض السريريه للمرض لم تختلف كثيرا عما منشور ومثبت في الادب الطبي.الفحص النسيجي للورم اظهرالصفات والعلامات المثالية والنموذجية للمرض في جميع الحالات.الاستنتاج: تم الاستنتاج من الدراسة المقدمة الورم الجلدي الليفي الضام الناتئ الخبيث هو مرض الذكور.وهذه اول دراسة تسجلهذا الورم من وسط وجنوب العراق فقط.


Article
Hepatitis Screen in Children with Malignancy at Al-Emamain Al-Kadimain Medical City

Author: Ali Saadi Salih, Sawsan Sati Abbas
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2018 Volume: 17 Issue: 1 Pages: 64-71
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND:Transfusion-transmitted infections continue to be a threat to the safety of the blood supply, in particular the risk is high for parent rally transmitted viral hepatitis in pediatric malignancy.OBJECTIVE:The aim is to estimate the prevalence of hepatitis in children with malignancy, identify some variables that could affect the prevalence of hepatitis in these patients, and to have an idea about the effect of vaccination in controlling hepatitis infection.PATIENTS AND METHODS:A cross sectional study was done over ten months period between December 1st, 2013 to September 30th, 2014 at the Pediatric Oncology Unit in Al- Emamain Al -Kadimain Medical City, A total of (54) children between the age of [1-15] years with malignancy who were diagnosed and treated at the pediatric oncology department before 6 months and more were studied. Information regarding age, gender ,residence, hepatitis vaccine received ,number of blood transfusion ,any surgical intervention for solid tumors and lymphoma was done, history of hepatitis screen at diagnosis were taken from hospital record and pediatric oncology consultation clinic files ,re- evaluation of hepatitis screen were done through with screen for HBs Ag , Anti HCV. Among those children with malignancy, testing for HBV and HCV were done through blood samples taken from the patients and sent to lab. of the hospital.RESULTS:From (54) patients with malignancy, 46 patients were with hematological malignancy(85%) and 8 cases(15%) with solid malignancy, from them 8 (14.8%) cases were HBV positive and 4 (7.4%) cases with HCV positive. Most of the patient were from Baghdad 37 cases (68.5%), male to female ration(1.7:1) and also most dominant age group was from (4-9 year).The number of blood transfusion had significant positive impact on prevalence of hepatitis virus infection , and also the vaccine status had significant positive influence.CONCLUSION: There is a low frequency of HBV &HCV infection in patients with malignancy treated in Al-Emamain Al- Kadimain Medical City with lower incidence of HCV infections than HBV. Blood transfusions (more than 3 times) is significantly increasing the incidence of HBV infection and HBV vaccine is significantly reducing the incidence of HBV infection.


Article
MULTINODULAR GOITER AND RISK OF MALIGNANCY, SURGERY OR FOLLOW UP ?

Authors: Ali Yousif Alwajeeh --- Abutalib Bader Al Luaibi
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2019 Volume: 25 Issue: 1 Pages: 61-65
Publisher: Basrah University جامعة البصرة

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Abstract

MULTINODULAR GOITER AND RISK OF MALIGNANCY, SURGERY OR FOLLOW UP ? Ali Yousif Alwajeeh@ & Abutalib Bader Al Luaibi* @MB,ChB, CABS, Consultant General Surgeon. MB,ChB, FIBMS, General Surgeon, Almawanee Teaching Hospital, Basrah, IRAQ. Abstract Nodular goiter is one of the most common presentation of thyroid gland diseases. The risk of development of thyroid cancer is relatively rare (1%) of all types of tumors, however, it is the most common endocrine malignancy, and usually presented as multinodular goiter. Fine needle aspiration cytology (FNAC) considered as the golden tool in the diagnosis of thyroid nodule though, it still has false negative rate which is variable depending on the experience and the technique being used. This means that even if the FNAC done prior to surgery shows negative finding, this doesn't exclude the presence of carcinoma, especially in multinodular goiter where it is possible not to sample the involved area. In this prospective study which was done in Almawanee Teaching Hospital between 2012-2018, 69 patients with Multinodular goiter where considered for the risk of harboring an incidental malignancy. The results of patients with multinodular goiter of benign origin was 57 patients (82.86%) while multinodular goiter which has an incidental malignancy was 12 patients (17.14%). Conclusion: due to relatively high risk of malignancy in multinodular goiter especially with noncompliance for follow-up from patients and risk of missing incidental malignancy by FNAC in multinodular goiter, it is preferable to do total or near total thyroidectomy. Key words: Goiter, Malignancy, FNAC, Surgery, Incidence

Keywords

Goiter --- Malignancy --- FNAC --- Surgery --- Incidence


Article
Seroprevalance of Hepatitis B&C In Pediatric Malignancies

Authors: Nada Ali Ahmed AL-Ali --- Thalfaa Nathim Al-Kayatt
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 2 Pages: 262-267
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Children with cancer who are on intensive chemotherapy require multiple blood and its products transfusion which increases the risk of blood transmissible infection OBJECTIVE:To know the prevalence of HBV and HCV infection in pediatric malignancy after starting anti cancer therapy and To identify the risk factor, that increased the possibility of infectionDesign a Prospective interventional studyParticipants The present study was conducted on 85 children with malignancies who were attending the department of pediatric oncology in Mosul,(Ibn-Alather hospital) the age of the patients were between 1-15 years with male: female ratio of 1.5: 1 Main outcome measure. All our patients were tested for HBsAg and HCV antibodies at diagnosis of malignancy and before starting chemotherapy then after six and twelve monthsRESULTS:Two patients (2.3%) had HBV infection, and no patient had HCV infection initially, while after 6 month of receiving chemotherapy we have 8/70 (11.4) had HBV and also no patient with HCV, and after 12 months of receiving chemotherapy the percentage of patients with HBV and HCV were increase to 13/63 (20.6%) and 2/63 (3.2%) respectively .CONCLUSION:Its important to ensure on accurate screening of blood and its products before transfusion to these patients, and also ensure on the receiving HB vaccine before starting chemotherapy. Before this study, the prevalence of HBV and HCV infection in pediatric malignancy in Mosul city were unknown, the present study was designed to fill this gap..


Article
Immunohistochemical Expression of p53 in Squamous Cell Carcinoma of the Lip (A Clinicopathological Study)

Authors: Hanan A Abdulla --- Ameera K. Khaleel
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 2 Pages: 335-347
Publisher: Babylon University جامعة بابل

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Abstract

Lip carcinoma is most commonly seen after skin carcinoma in the head-neck region. Mutation of the p53 gene has been reported in a variety of human malignant tumors like squamous cell carcinoma (SCC) and is frequently associated with over expression of p53 protein.The purpose of this study was to analyze the immunohistochemical over expression of p53 in SCC of the lip in relation with the clinicopathologic pictures.The materials used in this study consist of (40) formalin fixed, paraffin-embedded lip biopsy specimens of squamous cell carcinoma. p53 immunoreactivity was evaluated in 1000 cells examined under the microscope at 40 magnification and recorded as percentage of p53 positive tumor cells in relation to different clinical and histopathological factors. The p53 index for squamous cell carcinoma of the lip was ranging between 0.5%-58%, and (72.5%, 29 case) showed positivity for p53 and (27.5%, 11 case) were negative. The highest number and percentages of p53 positive cases were seen associated with males (74.19%), ≥60 year’s age group(73.33%), patients with outdoor occupations (100%), upper lip (75.0%), >2cm size lesions(73.68%), patients with palpable lymph node (74.91%), moderately and poorly differentiated type (77.78%), and positive involvement of surgical margins (78.57%). Statistical analysis showed no significant relation of the mean labeling indices with the sex, site, tumor size, the presence or absence of palpable lymph node, grade of differentiation, and involvement of surgical margins(p>0.05), but it showed significant relation with the patient age and occupation (p<0.05). The old age patients (≥60 years) and patients with outdoor occupations showed the highest p53 labeling index significantly.


Article
The Clinical Approach and Treatment of Benign and Malignant Parotid Masses

Author: Marwan G. Saied مروان غانم سيد
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 2 Pages: 84-91
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Parotid gland tumors account for 80% of all salivary gland neoplasms, 20% of these are malignant, butin daily clinical practice most parotid masses are operated on before obtaining the final histological diagnosis. Thisclinical setting further complicates the critical point of parotid surgery, which is the management of the facial nerve.Materials and methods: 45 patients underwent parotidectomy for benign and malignant neoplasms. A completehistory is collected from the patients with the duration and the site of the tumor, the facial nerve examined and itsassociations, a medical consultation done for opinion and management. Clinical examination with facial nerve wasmandatory to avoid any mistakes that may occur. The most significant single parameter in this series of malignanciesregarding disease specific survival was the clinical involvement of the facial nerve. Also for this reason, as there is noevidence that the facial nerve sacrifice improves prognosis, when it is not clinically involved, every attempt is madeto dissect and preserve it. A treatment plan was contemplated regarding nerve preservation for malignancy or withnerve sacrifice.Result: This study showed that females (62%) are more affected than males (38%),tumors occur at left parotid gland(65%) more than right parotid gland (35%), a malignancy affected the left parotid gland more than the right oneand a malignancy affected females more than males. Pleomorphic adenomas are the most frequent benign tumorswhile the adenocarcinoma most frequent malignant tumors.Conclusion: The most complicated situation concerning nerve preservation may be the recurrence of a benigntumor, in particular pleomorphic adenoma, which, in our series, has a higher incidence (62.5%) of permanent facialdysfunction, than surgery with nerve preservation for malignancy (37.5%) and to resects the nerve when is clinicallyinvolved and when is totally embedded in a clearly malignant neoplasm with attempt to preserve it in all other


Article
Cytological Diagnosis of Thyroid Cancer via Digital Optical Image Analysis
التشخيص الخلوي لسرطان الغدة الدرقية بواسطة تحليل الصورة الرقمية البصرية

Author: Salim J. Attia د. سالم جلود عطية
Journal: Journal of College of Education مجلة كلية التربية ISSN: 18120380 Year: 2015 Issue: 1 Pages: 179-186
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

This research explores the use of features of cells in digital optical images of human thyroid tissue as an important base to diagnose the cancer. It presents some efficient features of cell nuclei for detection of thyroid malignancy such as (radius, smoothness, compactness, expected value and variance). The cytological characteristics are very important and usual method to separate abnormal and normal cases in all diseases. The algorithm of neural network used to detect thyroid cancer successfully with accuracy of 99%.

يكشف هذا البحث استخدام خصائص نوى الخلايا في الصور الرقمية البصرية لنسيج الغدة الدرقية البشري كقاعدة اساسية لتشخيص السرطان. البحث يقدم بعص الخصائص المهمة لكشف الحالة الخبيثة للغدة الدرقية مثل (نصف القطر، النعومة، الاكتناز، القيمة المتوقعة والتغاير). ان تحديد الخصائص الخلوية هي طريقة مهمة ومعتادة لفصل الحالات الطبيعية وغير الطبيعية لجميع الامراض. استخدمت خوارزمية الشبكات العصبية لكشف سرطان الغدة الدرقية بنجاح وبدقة 99%.


Article
Clinical Predictors of Malignancy in Solitary Thyroid Nodule, A Study of 146 Cases

Author: Ibrahim Falih Noori
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 1 Pages: 99 -112
Publisher: Babylon University جامعة بابل

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Abstract

Although most of thyroid nodules are benign, 5-10% are malignant. It is important to predict the risk factors and malignant potential of STN to avoid unnecessary surgery with its complications. A prospective study was conducted to assess the rate and malignant potential of STN in 146 patients. They submitted to thorough investigations including a detailed history and clinical examination, thyroid function test, ultrasound examination and FNAC. There were 126 females and 20 males with female to male ratio about 6:1.The rate of malignancy in STNs was 8.9% with males affected more than female (15% Vs7.9%), and more with age above 40 in both sexes. History and clinical exam suspect malignancy in 6% of cases. All patients were euthyroid. Ultrasonic features such as Ill-defined margin, microclcifications, marked hypoechogenecity, and cervical lymphadenopathy are helpful features for prediction of malignancy, but none of these features are specific or pathognomonic. The results of FNAC in this study were:76 benign colloid goiter, 24 follicular tumor, 18 suspicious aspirate ,6 papillary carcinoma and 22 indeterminate cytology. The sensitivity , specificity and accuracy rate of FNAC in this study were 86.4%,96.3 and 92.3% respectively. History and examination are poor predictors of malignancy in STN. Male and increasing age are proved to be risk factors for malignancy in STN. Certain ultrasonic features are helpful in predicting malignancy but neither specific nor characteristics. These include ill-defined and irregular margin, microcalcification, marked hypoechogenecity, hyper-vascularity and cervical LAP. FNAC is highly sensitive in predicting malignant nodule. FNAC must be the first and could be the only test required to evaluate STN.


Article
Gastric Malignancies and the Trend of Gastric Carcinoma in Duhok City-Iraq

Authors: Alaa Hani Raziq --- Sefar Mohammed Haj --- Sardar Hassan Arif --- Odeesh Yuhanna Odeesh
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 1 Pages: 162 -168
Publisher: Babylon University جامعة بابل

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Abstract

Gastric cancer is one of the common human malignancies particularly gastric adenocarcinoma. The stomach also represents the commonest gastrointestinal site for extra-nodal non-Hodgkin’s lymphoma. This study aims to find out the major types of gastric malignancies in Duhok city, their age and gender distribution and the trend of the types of gastric adenocarcinoma over a six year period from January 2008 till December 2013. This study included nearly all cases of gastric malignancies diagnosed in Duhok City and enrolled 155 cases. The type of malignancy was diagnosed by histopathological examination and supported in some cases by immunohistochemical staining procedures and investigations. The trend of the two major types of gastric carcinoma was determined over this six year period. The results of this study showed that the carcinoma constitutes the largest proportion of gastric malignancies (87.7%), followed by lymphoma (6.5%), then Gastrointestinal stromal tumor (GIST) (4.5%) and lastly neuroendocrine tumors (1.3%). The mean age of the intestinal type (62.1 years) was higher than that of the diffuse type (50.15 years) and the difference was statistically significant (P: < 0.05). Similarly the diffuse type was more common in women than men and also the difference was statistically significant (P: < 0.05). The results of this study show that the trend of intestinal type over a six year period is on the rise side while the trend of the diffuse type is more or less the same. Gastric carcinoma is the most common gastric malignancy in Duhok City with a male predominance and most patients had some bad prognostic factors and there is no decline in the prevalence of the intestinal type.

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