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Article
Clinical Evaluation of Melatonin Alone and in Combination with Pizotifen in the Prophylaxis of Migraine

Authors: Ashwaq N. Al-Jaff --- Salim A. Humadi --- Muqdam M.Mohamed Ali
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2007 Volume: 16 Issue: 1 Pages: 1-7
Publisher: Baghdad University جامعة بغداد

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Abstract

The treatment of migraine headache targets the neurovascular mechanism and involves the use of serotonin receptor antagonists. Some of these drugs are used for the treatment of acute attacks; while others are effective as prophylactic measures to decrease the duration and frequency of attacks. Pizotifen, a 5-HTA antagonist, is one of the prophylactic drugs for which the clinical use resulted in low outcomes in reducing migraine symptoms. Melatonin, a serotonin derived neurohormone, was reported to exert many functions like sleep induction, anti-inflammatory, neurovascular regulation, cytoprotection and modulation of neurotransmitter release. In the view of the involvement of serotonin in the pathophysiology of migraine and the properties of melatonin, the present study has been conducted to evaluate the effectiveness of melatonin alone or in combination with pizotifen for the improvement of migraine symptoms. The study was conducted on 72 patients, which were under neurologist supervision during the entire period of study. The patients were instructed to avoid any precipitating diet (chocolate, cheese,… etc) and where randomly divided into 4 groups each of 18. The first group was treated with melatonin (3mg, 30 minutes before bed time); the second with pizotifen (0.5mg twice daily); the third with melatonin (at night) and pizotifen (twice daily); and the fourth with placebo (at night). The treatment was continued for 42 days and was followed up and monitored each week. After a month of treatment, the severity, duration and frequency of migraine attacks were recorded using special migraine scoring system.The results revealed that melatonin alone significantly decreased the severity, duration and frequency of migraine attack by 48%, 53% and 45.75%, respectively; while these produced by pizotifen were significantly reduced by 25%, 45.3% and 27.5%, respectively. The effect of pizotifen was generally enhanced by the addition of melatonin and the improvement in migraine symptoms were, severity (59%), duration (62.7%) and frequency (58%). These effects were generally low in placebo treated group and the reduction in severity, duration and symptoms were (12.2%, 20% and 16.2%, respectively). The distribution of patients according to their response as complete or partial was significantly different among treated groups; and within the same group is differ according to the measured parameter suggesting involvement of factors other than treatment in the improvement of migraine symptoms such as psychological state, stress and others.The study has concluded the effectiveness of melatonin alone and in combination with pizotifen as a prophylactic measure in term of reducing the severity, duration and symptoms of migraine headache.

ان العلاجات التقلیدیة لصداع الشقیقة تتجھ نحو الآلیة الوعائیة العصبیة المسببة لداء الشقیقة وتتضمن استخدام مغلقاتمستقبلات السیروتونین. بعض ھذه الادویة تستخدم لعلاج النوبات الحادة للصداع بینما البعض الاخر یستخدم كعلاج وقائي للتقلیل منفترات وتردد النوبات. أن عقار البیزوتفین ھو احد الادویة الوقائیة، الا ان استخدامھ السریري قلیل الفعالیة في خفض علامات داء الشقیقة.5- ). ان عقار المیلاتونین، وھو ھرمون عصبي مشتق من HTA) وھذا العلاج معروف باغلاقھ لمستقبلات السیروتونین نوعالسیروتونین، قد ثبت ان لھ وظائف متعددة مثل تحفیز النوم، كمضاد للالتھابات، تنظیم الاوعیة الدمویة العصبیة، وقایة الخلایا، وتحویرفي افراز النواقل العصبیة. في ضوء اشتراك السیروتونین في سببیة داء الشقیقة والخواص المعروفة للمیلاتونین فان الدراسة الحالیة قداجریت لتقییم الاستخدام السریري للمیلاتونین لوحده او مع البیزوتفین لعلاج علامات الشقیقة. اجریت الدراسة على 72 مریضاً وقد كانواتحت الاشراف الطبي لذوي الاختصاص العصبي خلال فترة الدراسة، وقد ارشدوا لتجنب الاغذیة المسببة للشقیقة (الشكولاتة، والجبن،وغیرھا) وقد صنفوا عشوائیاً الى 4 مجامیع كل منھا مكون من 18 مریضاً. عولجت المجموعة الاولى بالمیلاتونین ( 3ملغم قبل النومبنصف ساعة)، والثانیة بالبیزوتفین ( 0.5 ملغم مرتین یومیاً)، والثالثة بالمیلاتونین والبیزوتفین معاً وبالجرع اعلاه، والرابعة بالعلاج المموّهبشكل كبسولة لیلاً. استمر العلاج لفترة 42 یوماً بمتابعة اسبوعیة. بعد شھر من العلاج، تم تسجیل حدة وفترة وتردد نوبات (placebo)صداع الشقیقة باستخدام نظام تنقیط خاص. اثبتت الدراسة ان المیلاتونین لوحده قد ادى الى تقلیل منطقي في حدة وفترة وتردد نوبات45.3 % و 27.5 % على التوالي. وعلى ،% 45.75 % على التوالي، بینما كان التقللیل بالبیزوتفین بنسبة 25 ،%53 ،% الصداع بنسبة 48العموم فان تأثیر البیزوتفین قد ازداد باضافة المیلاتونین وان التقلیل في علامات الصداع كانت، الحدة ( 59 %)، الفترة ( 62.7 %) والتردد%58 ). ان ھذه التاثیرات كانت قلیلة جدا عن المجوعة المعالجة بالعلاج المموّه وكانت نسبة الانخفاض في الحدة، الفترة، والتردد ھي )%20 ، و 16.2 % على التوالي. ان توزیع المرضى بحسب استجابتھم للعلاج، ان كان جزئیاً او كلیاً، كان مختلفاً بصورة منطقیة ،%12.2بین المجامیع، وضمن المجموعة الواحدة فان التوزیع كان مختلفاً ایضاً بحسب المعیار المقاس مما یدل على تدخل عوامل اخرى غیرالعلاج في ھذا التباین مثل الحالة النفسیة، الاجھاد وغیرھا. یمكن الاستنتاج من ھذه الدراسة بان المیلاتونین لوحده او مع البیزوتفین قدأظھر فعالیة وقائیة في التقلیل من حدة، فترة، وتردد نوبات صداع الشقیقة.


Article
Migraine in epileptic Patients Epidemiology and Clinical Characteristics:

Authors: Louay hashim sheet --- Mohammad tawfik ridha
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 1 Pages: 25-31
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: OBJECTIVE.: To study the prevalence and clinical characteristics of migraine in epileptic patients and to compare these epidemiological and clinical data with those in general population BACKGROUND: Systematic investigation of the characteristics of seizure-associated headaches is rare. Although data on the prevalence and characteristics of migraine in general population are numerous, few studies have investigated the relation between migraine and epilepsy METHODS: One hundred seventy two epileptic patients (98 female and 74 male) participated in a semi-standardized interview and study about headaches particularly migraine type. RESULTS: Seventy four out of the 172 epileptic patients had headache of one type or another (57%), migraine occurred in 34 patients (19.7%),female migraineurs (24 cases) and male (10 cases) (female/male ratio 2.4:1). Migraine occurred in isolation in 18 cases and was mixed with other headache types in 16 cases. Migraine cases without aura constituted 67.7% (23 cases), and with aura 31.3% (11 cases). In non-aura cases female (18 cases) outnumbered male (5 cases), unlike in aura cases (6 female vs 5 male cases) CONCLUSION : Migraine is much more prevalent in epileptics (19.7%)than in general population (11-12%). Other wise migraine in epileptics has similar clinical characteristics to migraine in general population including clinical varieties and gender distribution

Keywords

Epilepsy --- headache --- migraine


Article
EEG Changes in Patients with Migraine

Authors: Majeed Salih Hamad --- Nawfal M. Sheaheed --- Sarmed Mohammad Abdulrasool --- Akram M. Almahdawi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 2 Pages: 156-160
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND :migraine is a recurring syndrome of headache, nausea, vomiting, and/or other symptoms of neurological dysfunction in varying admixtures. Migraine, is one of the most common causes of headache, afflicts approximately 15% of women and 6% of men. OBJECTIVE:This study was designed to determine the EEG changes in a sample of migraineurs with their relation to its types. PATIENTS AND METHODS: This cross-sectional study was conducted in the department of neurology of Baghdad teaching hospital from December 2007 to February 2008. A total of 60 migraineurs were taken, aging (10-40) years, diagnosed according to International headache society (IHS) criteria. Patients with history of epilepsy, head injury, brain lesion and recurrent headaches not Compatible with IHS criteria were excluded from the study . EEG was performed, whenever possible, during headache and between attacks of headache. RESULTS: Sixty Iraqi patients with migraine were evaluated. Twenty patients (33.3%) were having migraine with aura (MWA) while 40 patients (66.7%) had migraine without aura (MWOA). Of the sixty studied patients 15 were having electroencephalographic finding. Among patients with MWA, 8 of them have abnormal EEG (40%), while in patients with MWOA, 7 of them have abnormal EEG (17.5%). Slow waves were found in 10 patients (52.64%), sharp waves in 8 (42.10%), and spikes in one patient (5.26%). It has been found that 9 patients (50%) have abnormality in occipital region, 6 of them (33.34%) in frontal region, and 3 of them (16.66%) in temporal region. CONCLUSION: EEG is not useful as a diagnostic tool for migraine, as the EEG changes found in migraine are not specific, they are infrequently associated, and there is no EEG difference between MWA and MWOA. So, clinical criteria are the only way for diagnosis of migraine. KEYWORDS: migraine, headache, EEG

Keywords

KEYWORDS: migraine --- headache --- EEG


Article
The value of highly specific C-reactive protein HS-CRP in migraine headache
قيمة البروتين سي التفاعلي HS-CRP المحدد للغاية في صداع الشقيقة

Author: Hussein Khalil حسين خليل
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2018 Volume: 14 Issue: 26 Pages: 1-5
Publisher: Al-Qadisiyah University جامعة القادسية

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AbstractBackground: Migraine is a well known neurologic disease, ordinarily portrayed by intermittent assaults of incapacitating headache and manifestations of autonomic nervous system disturbances. In about 33% patients, headache attacks are joined by transient “focal neurologic aura manifestations”. Migraine is a neurovascular disease accompanied by cranial vascular contractile dysfunction, neurogenic inflammation and cortical spreading depression. Brain tissue activation results in the production of peptides by the perivascular trigeminal areas which lead to an inflammatory response with dilation of extraparenchymal blood vessels. Inflammatory vasculopathy accompany repeated assaults of migraine attacks. A number of studies showed the elevation of certain inflammatory markers in association with migraine such as adhesion molecules, interleukins and C-reactive protein (CRP).Aim of the study: To evaluate the role of HS-CRP in patients with migrainePatients and methods:Current cased control study included 100 patients with migraine headache and 100 apparently healthy subjects. Variables included in the present study are: age, gender and the level of highly specific C-reactive protein (HS-CRP). The study was conducted at the neurology unit, Al-Dewaniyah teaching hospital, Al-dewaniyah province, Iraq. The study started on January 2018 and ended at June 2018.Results: Current study included 100 migraine patients with a mean age of 31.46 ±5.75 years and 100 control subjects with a mean age of 30.55 ±5.54 years and there was no significant difference in mean age between the two groups (P=0.255). Patients group included 23 men (23%) and 77 women (77%) whereas, control group included 24 men (24%) and 76 women (76%); no significant difference was encountered between the two groups with respect to gender (P=0.868). The level of Hs CRP in terms of median and inter-quartile range (IQR) in patients group was significantly higher than that of control group, 4.6 (4.9) versus 1.5 (2) µg/dl (P<0.001). There was no significant difference in the level of Hs CRP between men and women in patients group, 5.3 (5.7) versus 4.6 (4.8) µg/dl (P=0.680), as shown in figure 2. There was no significant correlation between age and level of Hs CRP in patients group (r = -0.056, P =0.581).Conclusion: The present study showed that Hs CRP is significantly higher in patients with migraine headache and this may explain the inflammatory role in the pathogenesis and prognosis of migraine headache.

نبذة مختصرةخلفية: الصداع النصفي هو مرض عصبي معروف ، وعادة ما يصور من قبل اعتداءات متقطعة من الصداع والعجز ومظاهر اضطرابات الجهاز العصبي اللاإرادي. في حوالي 33 ٪ من المرضى ، ينضم إلى نوبات الصداع "مظاهر هالة عصبية بؤرية" عابرة. الصداع النصفي هو مرض وعائي عصبي مصحوب بخلل وظيفي في الأوعية الدموية في الجمجمة ، والتهاب عصبي وانتشار قشري. يؤدي تنشيط أنسجة المخ إلى إنتاج الببتيدات من المناطق الثلاثية المحيطة بالأوعية الدموية التي تؤدي إلى استجابة التهابية مع تمدد الأوعية الدموية خارج الحالب. اعتلال وعائي التهابي يصاحب الاعتداءات المتكررة على نوبات الصداع النصفي. أظهر عدد من الدراسات ارتفاع بعض علامات الالتهاب المرتبطة بالصداع النصفي مثل جزيئات الالتصاق ، الانترلوكينات والبروتين التفاعلي C (CRP).الهدف من الدراسة: تقييم دور HS-CRP في المرضى الذين يعانون من الصداع النصفيالمرضى والطرق: شملت دراسة المكافحة الحالية 100 مريض يعانون من الصداع النصفي و 100 موضوع صحي على ما يبدو. المتغيرات المدرجة في هذه الدراسة هي: العمر والجنس ومستوى البروتين سي التفاعلي محددة للغاية (HS-CRP). أجريت الدراسة في وحدة الأمراض العصبية ، مستشفى الديوانية التعليمي ، محافظة الديوانية ، العراق. بدأت الدراسة في يناير 2018 وانتهت في يونيو 2018.النتائج: شملت الدراسة الحالية 100 مريض يعانون من الصداع النصفي مع متوسط ​​عمر 31.46 ± 5.75 سنة و 100 شخص خاضع للمراقبة مع متوسط ​​عمر 30.55 ± 5.54 سنة ولم يكن هناك فرق كبير في متوسط ​​العمر بين المجموعتين (P = 0.255). شملت مجموعة المرضى 23 رجلاً (23٪) و 77 امرأة (77٪) ، بينما شملت المجموعة الضابطة 24 رجلاً (24٪) و 76 امرأة (76٪) ؛ تمت مصادفة أي فرق كبير بين المجموعتين فيما يتعلق بنوع الجنس (P = 0.868). كان مستوى Hs CRP من حيث المدى المتوسط ​​والرباعي (IQR) في مجموعة المرضى أعلى بكثير من مستوى المجموعة الضابطة ، 4.6 (4.9) مقابل 1.5 (2) ميكروغرام / دل (P <0.001). لم يكن هناك اختلاف كبير في مستوى HP CRP بين الرجال والنساء في مجموعة المرضى ، 5.3 (5.7) مقابل 4.6 (4.8) ميكروغرام / دل (P = 0.680) ، كما هو مبين في الشكل 2. لم يكن هناك ارتباط كبير بين العمر ومستوى Hs CRP في مجموعة المرضى (ص = -0.056 ، P = 0.581).الخلاصة: أظهرت الدراسة الحالية أن Hs CRP أعلى بكثير في المرضى الذين يعانون من الصداع النصفي وهذا قد يفسر الدور الالتهابي في التسبب والتشخيص من الصداع النصفي.

Keywords

Hs CRP --- Migraine --- Headache


Article
Autonomic Dysfunction in Interictal Period

Author: *Dr.Bassam Mahmood Flamerz M.B.Ch.B , F.I.B.M.S**Dr.Akram M. Ibrahim Al-Mehdawi,
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2012 Volume: 8 Issue: 1 Pages: 18-23
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: migraine is a chronic neurovascular disorder characterized by intermittent attacks of sever headache with or without aura that can include various combinations of neurological, gastrointestinal tract (G.I.T), and autonomic changes, without evidence of primary structural abnormalities. The Autonomic nervous system involvement suggested by many symptoms and signs including nausea, diarrhea, constipation, coldness in the extremities, paroxysmal tachycardia and chest pain.Objectives: To evaluate autonomic functions in patients with migraine and to clarify the autonomic dysfunction weather its sympathetic, parasympathetic, or combined. Also to assess the severity of this dysfunction and its relation to age, gender and type of migraine.Methods: This study enrolled 60 patients with migraine, 42 females and 18 males with an age range between 14-45 y. with 30 healthy volunteer as control group, The using of a questionnaire paper, autonomic nervous system disability scale and set of autonomic cardiovascular reflexes test were also applied .Results: The migraineurs with disabling attack may be prone to autonomic nervous system hypofunction which may be either a risk factor for migraine headache, or be a consequence of frequent disabling attacks, moreover autonomic nervous system dysfunction and migraine may share a common neural substrate. The Parasympathetic part of autonomic nervous system is affected more than sympathetic according to Ewing classification of autonomic function tests which is significant statistically in comparison to control, and 16(26.7%) of patients showed definite dysautonomia(score >2) while 44(73.3%) of patients were normal. Palpitation and postural dizziness are the most frequent symptoms in patients with migraine . Autonomic dysfunction among migraineurs is not rare also prolong course of illness is strongly correlated with autonomic dysfunction which is affect parasympathetic part more than sympathetic, for this reason the clinician should look carefully for the autonomic symptoms when they assess patient with migraine because most of those symptoms were disablingConclusions: The assessment of autonomic function tests should be a routine work in patient with migraine. The heart rate response to deep breath and valsalva are simple informative and beside to evaluate the parasympathetic part of autonomic nervous systemKey words: migraine, autonomic dysfunction, sympathetic, parasympathetic.


Article
Impact of Chronic Headache( Migraine) onDaily Activity of Adult Patients in Baghdad City
تأثير الصداع المزمن(الشقيقة ) على النشاط اليومي للبالغين المصابين بالشقيقة في مدينة بغداد

Author: WissamJabbarQassim
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2014 Volume: 4 Issue: 3 Pages: 131-140
Publisher: University of Kufa جامعة الكوفة

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Objectives: The study aimstoassess the impact of(migraine) on the daily activityof patients withmigraineatprimary health care centersin Baghdad city,and to findout the relationship between their demographic characteristicswhich as age, sex, occupation, family history .Methodology: A descriptive study was conducted to assess the impact of (migraine) on the daily activity of adultpatients in primary health care centers in Baghdad city. The study was conducted from 1st September, 2012 to March18th, 2013.The study sample included 100patients were collected from four centers of primary health care in Baghdad city. The data was collected through the use of constructed questionnaire, which consists of two parts. Part I : deals the socio-demographic characteristics which as 6 items: gender, age, marital status, occupation , using of drugs and duration of headache attack.Part II: quality of life questionnaire assessment tool was used to measure the extent to which chronic headache are affecting the ability to function.Results:The results showedthat more thanhalf of thosestudymales(60%), while theiragefor more thanone-third ofthe samplerangedfrom20-30years (38%).More thanhalf of themaremarried (58%).Thestudy also showed thatnearly half ofthe study samplewasemployed(56%), while theuse ofthe vast majority ofthe study sampleuse medications (90%).Conclusions: Most of the affected by headache were males,greatest of clients who suffer from chronic headache was using medications. Majority of the patients have headache attack lasted less than one day. Recommendations:The study recommendedthe needto conductregular monitoring ofchronicheadachein order tohelpto reducethe problems andcomplicationsthat can ariseas a result ofa headache, andthere will be aneedto theimplementation ofeducational programsfor the diagnosis ofheadachesand how totreat.

الاهداف:تهدف الدراسة الى تقييمتأثيرالصداع المزمن(الشقيقة ) علىالنشاط اليوميللبالغين المصابين بالشقيقة في مراكز الرعاية الصحية الاولية في مدينة بغداد وايجاد العلاقة بين الخصائص الديموغرافية (العمر والجنس والمهنة والتاريخ الطبي)و تأثير الصداع المزمن (الشقيقة) على فعاليات الحياة اليومية.المنهجية:دراسة وصفيةأجريت لتقييمآثارالصداع المزمن(الشقيقة) على فعاليات الحياة اليوميةللمرضى فيمراكز الرعايةالصحية الأوليةفي مدينةبغداد.وقد أجريتالدراسةللمدة من 1أيلول 2012 إلى18 اذار2013شملت عينة الدراسة(100) مصاب بالشقيقةلاربع مراكزللرعايةالصحية الأوليةفي مدينةبغداد.جمعتالبياناتمن خلال استخدامالاستبيانتتألف من جزأين.الجزء الأول: الخصائص الاجتماعية والديموغرافية التي تكونت من6فقرات: الجنس والعمر والحالة الاجتماعية، والمهنة، و استعمال العلاجاتومدةالصداع.الجزء الثاني: تم استعمالاستبانةنوعية الحياةلتقييممدى قوةالصداعالناتج من الشقيقة و تأثيره علىالفعاليات اليومية بشكل طبيعي.النتائج: وكانمعظمالعينة الذين يعانون من الصداع هم من الذكور ،واكثر المصابينالذينيعانونمنالصداعالمزمنهم من يستخدمالأدوية. وكانتالغالبيةالعظمىمنالمرضىهم من الذينلديهمالصداع يستمرأقلمنيومواحد.الاستنتاجات: أظهرت نتائج الدراسة أن أكثر من نصف المرضى من الذكور (60٪)، فيما كانت اعمار أكثر من ثلث العينة تتراوح من 20-30سنةوبنسبة (38٪ )، فيما كانت اكثر من نصف العينة من المتزوجين (58٪)، وأظهرت الدراسة أيضا أن أكثر من نصف عينة الدراسة كانت من الموظفين (56٪)، في حين أن الغالبية العظمى من عينة الدراسة اشاروا باستعمالالعلاجات (90٪) .التوصيات:أوصت الدراسة بالحاجة لاجراء الرصد المنتظم للصداع المزمن كي تساعد للحد من المشكلات والمضاعفات التي يمكن أن تنشأ نتيجة الصداع، وستكون هناك حاجة للعمل على تنفيذ برامج تثقيفية لتشخيص الصداع وكيفية معالجته.


Article
Relationship between sex hormones and migraine
العلاقه بين داء الشقيقه والهرمونات الذكريه والانثويه

Author: Gheyath AlGawwam غياث شلال
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2015 Volume: 57 Issue: 1 Pages: 31-34
Publisher: Baghdad University جامعة بغداد

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Abstract

Back ground: Migraine is a common chronic episodic disabling primary headache disorder with associated Symptoms. The neuroendocrinological alterations, disorders of the hypothalamic-hypophysial axis are believed to be implicated in the pathogenesis of primary headache syndromesObjective: The aim is to determine the effect of sex hormones on migraine.Patients and methods: Twenty seven adult patients with migraine and 20 controls were assessed for prolactin,testeron,,LH,FSH were tested with immunofluorometric assay.Results: This study found that migraine is associated with elevated level of FSH, prolactin and testerone P= (<0.05), (<0.05) and (<0.05) respectively .however there was no significant association between LH levels and migraine P (>0,05).Conclusion: There is a significant correlation between levels of hormones and migraine.Key word: Migraine,hormones

الخلاصه: الشقيقه تعتبر من الامراض المزعجه والتي توثر على انجاز الاعمال اليوميه ,التغيرات الهرمونيه العصبيه تعتير من الاسباب لحدوث الصداع الاولي .الاهداف: ايجاد العلاقه بين داء الشقيقه ومستوى الهرمونات الذكريه والانثويهالطريقه: 27 مريض بالغ ذكر وانثى تم تشخيصهم بداء الشقيقه و20 شخص بالغ ذكر وانثى سليم تم قياس مستوى الهرمونات الذكريه والانثويه في مستوى الدم لديهم والمقارنه النتائج: هذه الدراسه تبين ان هناك علاقه بين الشقيه وارتفاع الهرمون المحفز للبويضه وولكن لاتوجد علاقه مهمه بين الشقيقه والهرمون الابيض وايضا يوجد علاقه مع الهرمون المحفز للحليب وايضا علاقه مهمه مع الهورمون الذكريالاستنتاج: يوجد علاقه مهمه بين الهرمونات الذكريه والانثويه مع داء الشقيقهمفتاح الكلمات : داء الشقيقه,الهرمونات


Article
Migraine In Systemic Lupus Erythematosus in Rheumatological outpatients unit

Author: Ameer Shaker*, Akram Mohammed Al-Mahdawi**, Hayder Adnan Fawzi ***
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2017 Volume: 13 Issue: 1 Pages: 51-55
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Migraine is common in systemic lupus erythematosus.It is a significant source of patient disability.Objective: To determine the rate of migraine in patients with systemic lupus erythematosus, to assess migraine type, severity, and the association between migraine and patient’s characteristics.Type of the study: Cross-sectional study.Methods: 100 subjected were recruited and divided into two groups; fifty patients with the diagnosis of systemic lupus erythematosus were recruited from the Rheumatologic department of medicine,and another 50 normal subjects, then complete medical and drugs history were taken from them. Results: Fifty patients completed the questionnaire. Thirty percent of systemic lupus erythematosus patients and 12% of normal subjects had migraine. Of the patients with migraine 80%, 13.3% and 6.7% met criteria for migraine without aura, migraine with aura and retinal migraine respectively. The moderately severe migraine was commonly observed (53.3%). There were significant associations between migraine and systemic lupus erythematosus patients who have Raynaud’s phenomenon, and cardiolipin antibodies.There were no statistically significant associations between migraine, systemic lupus erythematosus duration and patient’s age,sex, and anti-dsDNA. Conclusions:A high rate of migraine in patients with systemic lupus erythematosus.Migraine associated with Raynaud’s phenomenon, and cardiolipin antibodies.


Article
Evaluation of Electromyoghraphy Guided Botolenium Toxin Type A Injection in Treating Chronic Migraine in Babylon Province

Author: Farah Nabil Abbas
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 3 Pages: 442 -449
Publisher: Babylon University جامعة بابل

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Abstract

BOTOX is the first and only FDA-approved preventive treatment for chronic migraine. It's also the only treatment for people with chronic migraine. Current migraine preventive therapies are often unsatisfactory because of their limited efficacy, adverse effects, and drug interactions., Migraines typically present with pulsing head pain, nausea, photophobia (sensitivity to light) and phonophobia (sensitivity to sound). The aim of this study to evaluate the benefit of Botox injection in patients presented with chronic migraine and to determine the efficacy and safety for this kind of treatment in Babylon province. This was an interventional study of 37 subjects with a history of chronic migraine (28 female and the other 9 were male), The patients received botulinum toxin type A, 100 U into 21 intramuscular injections using a 0.5-inch-long needle EMG guided connected to the machine. and for 3 months following injection, subjects kept daily diaries in which they recorded headache frequency, duration, severity, and the occurrence of associated symptoms. The study were done during the period from January/ 2017 until July/2017. There were significant differences in patients with chronic migraine before and after treatment , in which there is significant decrease in migraine attacks per month, with reduction severity of these attacks, a significant decrease of hours in each attack and reduced incidence of migraine-associated symptoms.Pericranial injection of EMG guided BTX-A, 100U, was found to be a safe treatment that significantly reduced migraine frequency, duration, migraine severity, and reduced associated symptoms.


Article
Comparison of plasma lipid peroxidation between migraine and tension type headache in Iraqi patients.

Author: Suaad Muhammed Abd - Alqader سعاد محمد عبدالقادر
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2013 Volume: 3 Issue: 4 Pages: 74-83
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

The oxidant-antioxidant balance disorders underlie a number of acute and chronic diseases of the central nervous system (CNS). It is believed that oxidative stress plays a role in the pathogenesis of migraine. The study objective is to assess the processes of lipid peroxidation with malondialdehyde (MDA) as its major indicator. The study was carried out on Iraqi patients to estimate the level of lipid peroxidation in three groups include control group (41subjects), tension-type headache (TTH) (41patients) and migraine (31patients). The migraine, TTH, and control groups were significantly different on the measures of MDA. The study showed that the migranieurs were significantly different from other two groups with respect to MDA (p<0.001). No significant difference between males and females within each of the three groups (p >0.05). The only significant difference between females’ age-groups was reported between (15-27years) and (28-40years) years old-groups (according to Games-Howell test (P=0.013) while Tukey HSD and Dunnett test contradicted the exits of any differences between them (P>0.05). According to the major similarity between aged-groups for both males and females in the three groups, it can be concluded that MDA level is not affected by age.

ان اختلالات الاتزان بين المؤكسدات – مضادات الاكسدة تندرج تحت عدد من الامراض الحادة والمزمنة التي تصيب الجهاز العصبي المركزي (CNS) ثمة اعتقاد ان التاكسد الناشيء عن الاجهاد يسهم في الاصابة بمرض الشقيقة . هدف الدراسة هو تقيم (LipidPeroxidation) مع مالون ثنائي الديهايد (MDA) كمؤشر رئيسي له . اجريت الدراسة لحساب مستوى (Lipid Peroxidation) في ثلاث مجاميع تشمل المجموعة القياسية (Control)41 مريضا ، مجموعة الصداع التوتري (TTH) 41 مريضا ، ومجموعة مرضى الشقيقة (Migraine) 31 مريضا .تباينت مجاميع الشقيقة ، الصداع التوتري والمجموعة القياسية بفارق ذي معنى في مقياس (MDA). حيث ان قيمة الـ( MDA) الأعلى لوحظت بين مرضى الشقيقة. أظهرت الدراسة ان مرضى الشقيقة كانو مختلفين بشكل معنوي عن المجموعتين الاخريتين من حيث مستوى MDA (P<0.001) . لايوجد فرق معنوي بين الرجال والنساء ضمن كل مجموعة من المجاميع الثلاث (P>0.05) . الفرق المعنوي الوحيد تم تسجيله بين الفئتين العمرية (27- 15سنة) و (40 – 28سنة) بحسب اختبار Games – Howell ( P=0.013 ) على المجاميع العمرية للنساء في حين عارض الفحصان Tucky HSD و Dunnett وجود أي فرق أحصائي بينهما. بناءا على التشابهة بين المجاميع العمرية بالنسبة لكلا الرجال والنساء في المجاميع الثلاث ، يمكن الاستنتاج ان الـ MDA لايتاثر بالعمر.

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