research centers


Search results: Found 8

Listing 1 - 8 of 8
Sort by

Article
Lupus Nephritis in Children Hospital Based Multicentre Study

Author: Nariman Fahmi *, Alyaa Hameed**,Wissam Fliah **
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2017 Volume: 16 Issue: 2 Pages: 198-203
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACK GROUND: Lupus nephritis is a common and serious feature of a chronic autoimmune disease characterized by multisystem inflammation (systemic lupus erythematosus).OBJECTIVE: Study he demographic, renal manifestations, laboratory findings and histopathological findings of patients with lupus nephritis.PATIENTS AND METHOD:This study was descriptive cross sectional study, conducted on 71 patients with lupus nephritis who were diagnosed and treated in four major pediatrics nephrology units in Baghdad, Children Welfare Teaching hospital, Central Teaching hospital, Al-karama Teaching Hospital and Ibn Albalady hospital. The collected data included: gender, age at diagnosis, renal and extra renal manifestations, laboratory findings, renal biopsy findings.RESULTS: Seventy one patients enrolled in this study with a mean age of 11.9 ± 2.7 years, the mean age at diagnosis was 9.6 ± 2.3years. Female to male ratio was 4:1.Nephrotic syndrome was the most common renal manifestation, it was found in 51 (71.8%), and reduced renal function was found in only in 17patients (23.9%). Antinuclear antibody was positive in majority of patients 66 (92.9%), followed by low C3, C4 in 58 (81.6%), positive Anti double stranded DNA in 58 (81.6%).Renal biopsy was done for 58(81.6%) patients and class II lupus nephritis was the most common histopathological class which was found in 25 patients (35.2%), the least common was Class V which was found in only 4 patient (5.6%).On the other hand, none of the patients had class VI. CONCLUSION: Nephrotic syndrome is the most common renal manifestation in lupus nephritis in children; class II lupus nephritis was the most common histopathological class and Positive ANA was found in majority of patients. early referral of the diagnosed patients to the nephrologist is important to ensure better management of those patients.


Article
RENAL AND MYOPATHY LESIONS OF DIROFILARIA IMMITIS IN NATURAL INFECTED DOGS

Loading...
Loading...
Abstract

BackgroundDirofilaria immitis has been increasingly recognized worldwide as inadvertent human pathogens. The epidemiological survey usual hosts of theses nematodes are domestic and wild carnivores. The disease is regarded as one of the most dangerous threat for the dog health. The adult worms take up residence in the heart, lungs and surrounding blood vessels.ObjectiveThis study attempts to shed the light on relationship between glomerular lesions and heart filarial (Dirofilaria immitis) infection.MethodsDirofilaria immitis was isolated from 98 dogs out of 457 dogs that were autopsied for the time between April 2008 and May 2010, in Al-Hindya area, Karbala province. Parameters concerning parasitological and pathological changes are used in this study to determine the significance of the results.ResultsGrossly many adult heartworms were found in the right ventricle of infected hearts and the cross section revealed body cavity, thick cuticle with coelomyarian and polymyarin muscle type, accompanied by infiltration of inflammatory cells mainly eosinophils and lymphocytes between muscle fibers. The microscopical changes in the kidney were necrotic and sloughing of epithelial cells, cystic dilation of collecting tubules of medulla containing hyaline casts, with glomeruli showing membranous nephropathy.ConclusionsThis is the first histological report of canine filariasis in Iraq particularly in Karbala province. It is important to keep in mind that pathologic changes in heartworm disease may be well advanced before the appearance of clinical signs of the disease. In heartworm disease the circulatory system is not the only system affected. The renal, hepatic & pulmonary systems can be secondarily affected. In our work the observations support the previous hypotheses of immature and possibly adult worms, contribute to the glomerulonephropathy.Key wards Canine heartworm, interstitial nephritis, membranous nephropathy.


Article
Evidence of Correlation between Some Auto Antibodies with Complement Component in Lupus Nephritis

Author: Nawar Abass Abud Noor
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 1 Pages: 54-57
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:lupus nephritis is a fatal complication of systemic lupus erythematosus (SLE), the serological hallmark of SLE is the presence of circulating autoantibodies directed against a wide variety of nuclear, cytoplasmic and plasma membrane antigens among which are anticardiolipin (ACL),anti-B2glycoprotein and anti-C1q antibodies, together with the consumption of complement component (C3 &C4) by immune complex mediated reaction.AIM OF STUDY:To shed light on the relations among these autoantibodies and with complement component in lupus nephritis patients.METHODS:Tthe study was conducted on 25 patients with lupus nephritis, attended the renal clinic in specialized surgical hospital/ medical city /Baghdad, 25 lupus patients without nephritia and 25 healthy controls.Enzyme linked immunsorbant assay was used for detection for ACL, anti-B2GP, anti-C1q, while single radial immundiffusion plates used for the estimation of C3& C4.RESULTS AND CONCLUSION:Anticardiolipin antibodies correlated significantly with anti-B2GP IgG & IgM (P<0.05), anti-C1q antibodies (P


Article
The Role of Anticardiolipin and Anti-B2 Glycoprotein Antibodies in Clinical Complication of Lupus Nephritis

Author: Nawar Abass Abud Noor
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 1 Pages: 22-25
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Although there was confliction regarding the association of raised anticardiolipin antibodies (ACL)level with renal disease in systemic lupus erythematosus (SLE), the role of B2glycoprotein as acofactor for ACL binding is established.The presence of ACL &anti-B2GPІ may be directlyinvolved in pathogenesis of antiphospholipid antibodies associated symptoms like recurrent fetalloss, thrombocytopenia and thrombosis.AIM OF STUDY:To study the possible association between some auto antibodies with the most common clinicalcomplication of disease.PATIENTS AND METHODS:The study was conducted on 25 patients with lupus nephritis, attended the renal clinic inspecialized surgical hospital/ medical city /Baghdad, 25 lupus patients without nephritis and 25healthy controls. Enzyme linked immunsorbant assay was used for detection for ACL, anti-B2GP.RESULT:Although there was no significant difference in mean concentrations of ACL and anti- B2GPbetween lupus nephritis and without nephritis (P>0.05), lupus nephritis patients were more likelypositive for ACL. Positivity of 100% For ACL & anti- B2GPwere detected in thromboticcomplication, in fetal loss complication patients more likely to be positive for ACL (75%), anti-B2GP (50%), in thrombocytopenia positivity of ACL &anti-B2GP (75%).CONCLUSION:There was no association between anti-B2GP and renal disease and presence of both ACL &anti-B2GP carry higher risk for thrombosis and recurrent fetal loss.


Article
Clinicopathological Findings of IgA Nephropathy in Children and Adolescents; (Multicentn Study)

Author: Alaa M. Neamah*, Ammar A. Hussein** ,Hasanein H. Ghali*** , Qutaiba A. Hussein**
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2016 Volume: 15 Issue: 3 Pages: 338-343
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND: IgA nephropathy (IgAN) is the most common lesion found to cause primary glomerulonephritis throughout most developed countries of the world. Patients may present at any age, but there is a peak incidence in the second and third decades of life. OBJECTIVE:To study the demographic, clinical and laboratory findings of IgAN patients including children and adolescents.METHODS: The medical records of 30 patients with IgAN were retrospectively reviewed and assessed. Patients enrolled in this study were between 1-18 years old diagnosed as IgAN in the period from January 2010 to the end of December 2012 being treated and followed in the main three centers of treating cases of pediatric nephrology in Baghdad (Al-karama teaching hospital, Central Child Teaching Hospital and Baghdad Medical City) that receive referral cases from all Iraqi governorates. RESULTS: The total number of cases enrolled in this study was 30 patients, with males being 19 and females being 11. The male to female ratio was 1.72:1. Family history of chronic renal disease was found in 10 patients (33%). History of pharyngitis was found in 16 patients (53.3%). Macroscopic hematuria was found in 24 patients (80%), followed by edema in 18 patients (60%), and followed by hypertension in 15 patients (50%). The most common laboratory findings among study group was microscopic hematuria (29 patients, 96.7%), followed by proteinuria in 22 patients (73.3%). Renal biopsy was done for all patients for the diagnosis of IgAN. The distribution of histopathology staging system was: Stage (1) 14 patients, Stage (2) 8 patients, Stage (3) 5 patients, Stage (4) 2 patients and Stage (5) 1 patient (46.7%, 26.7%, 16.7%, 6.7% and 3.3% respectively). The study showed that 24 patients were found to have IgA deposited solely (80%). Out of the total 12 patients presented with hematuria, nine of them (75%) showed stage 1 disease on histopathology study. Two patients were noticed to have other associated autoimmune diseases, one with hepatitis and another with ulcerative colitis. CONCLUSION: Further studies in large number of patients are needed in order to confirm the findings in this study and to establish the best therapeutic choice for IgAN. The need for immunofluorescence examination of the renal biopsies in suspected cases is recommended.


Article
Lupus Nephritis, the therapy and the role of Rituximab in resistant cases
التناظر الكلوي لداء الذئب الاحمر ودور عقار الريتوكسيماب في علاج الحالات المستعصية

Author: Nadia A. Nasir نادية عزيز ناصر
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2013 Volume: 55 Issue: 4 Pages: 328-333
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background Systemic lupus erythematosus (SLE) is a common autoimmune disease that affects mainly young females and nephritis is an important complication of the disease that may end with end stage renal disease (ESRD). Early diagnosis and proper treatment is important in decreasing the morbidity. Multiple immunesupressor agents used and according to the histopathology stage of the disease, still the proper drug used and the duration and dose required not settled. Rituximab which is monoclonal antibody that reacts against CD20 antigen on lymphocytes that cause B cells depletion is recently introduced in treatment of lupus nephritis .Objectives: to see the effect of different immunosuppressive agents in lupus nephritis and any response of resistant cases to Rituximab Methods sixty three systemic lupus erythematosus (SLE) patients’ age 3-45 years, 54 females and 9 males referred to the Nephrology Center in AL Sader Hospital in AL-Najaf governorate from April 2009- June 2013 enrolled in this study. All patients had renal biopsy and had categorized in different histopathological classes, the patients in stages I and II were treated with prednisolone while patients with other stages were treated with prednisolone and immunosuppressive therapy. The patients were followed up clinically and by laboratory results for response to the therapy, those who respond to the treatment tapering of the steroid was done and patients follow up were continued. Patients who showed no response to prednisolone or to the immunosuppressive agent were given Rituximab.Results –Mean age of patients was 22 years with a standard deviation+ 9 years. The association between sex and prednisolone was statistically not significant. The association between immunosuppressor therapy and sex was statistically not significant. The association between rituximab and sex was statically significant (p value 0.03(. The response to steroid therapy & age was statistically not significant. The association between response to immunosuppressor therapy and age was statistically not significant .The response to immunosuppressor therapy in different histopathological stages was statistically significant (P value 0.03). Response to Rituximab therapy was statistically significant (P value 0.048).Conclusion: Immunosuppressor therapy may have an effect in treatment of lupus nephritis and Rituximab may be useful in treatment of resistant cases of lupus nephritis. Key words: Lupus nephritis, Rituximab

ملخص البحث :- داء الذئب الأحمر هو مرض شائع من أمراض المناعة الذاتية يصيب النساء عاده٬ وأهم تعقيدات هذا المرض هو التناظر الكلوي الذي قد يؤدي إلى عجز آو فشل كلوي .ان التشخيص المبكر والعلاج السريع مهم في تقليل العوق الناتج من هذا المرض . لقد استعملت أدويه كثيرة في علاج التناظر الكلوي لمرض داء الذئب الأحمر مثبطه للمناعة وفي السنين الأخيرة استخدام عقار روتوكسيماب الذي يعمل ضد الانتجين CD20 الموجود على خلايا اللمفوسايت وتسبب انخفاض كبير في خلايا اللمفوسايت نوع ب قد بدأ في علاج التناظر الكلوي لداء الذئب الاحمر. هدف الدراسة:- أن هدف البحث هو دراسة مدى نجاح مختلف أنواع الأدوية المثبطة للمناعة على داء الذئب الأحمر وفائدة استخدام عقار الروتوكسيماب في الحالات المقاومة للأدوية المثبطة للمناعة .طريقة البحث:- أجريت دراسة على 63 مريض9 ذكور 54 إناث أعمارهم من 3-45 سنة مصابين بتناظر كلوي بسبب داء الذئب الأحمر في مركز الأمراض البولية في مستشفى مدينة الصدر الطبية في محافظة النجف للفترة نيسان 2009 إلى حزيران 2013 أجريت لكل المرضى خزعه الكلية وقسموا إلى أنواع حسب التغير النسيجي للمرض وأعطيت للمرضى في الصنف الأول والثاني مادة بردنيزولون والمرضى في بقيه الأنواع عقارات مثبطة المناعة. تمت دراسة الاستفادة للعقارات بمستوى جيد أو استجابة جزئية أو عدم استجابة المرضى الذين لم تحصل لهم استجابة أعطي لهم عقار روتوكسيماب ودراسة حاله الاستجابة لهم وجد إن استجابة الصنف الأول والثاني لعقار البردنيزولون لم تكن جيدة وليس لها علاقة بجنس المريض والاستجابة للعقارات المثبطة للمناعة جيدة أو استجابة جزئية وذات إحصائية معتمدة ٬كما إن الاستجابة للعقارات المثبطة للمناعة لا علاقة لها بجنس المرض.نتائج البحث :- إن الاستجابة لعلاج روتوكسيماب للحالات المقاومة ذو إحصائية معتمدة وفي أنواع التغير المرضي النسيجي وله علاقة إحصائية معتمدة بجنس المريض. الاستنتاج : ان العقارات المثبطة للمناعة قد يكون لها تاثير في علاج التناظر الكلوي لداء الذئب الاحمر وان الريتوكسيماب قد يكون مفيدا في علاج الحالات المستعصية للتناظر الكلوي لداء الذئب الاحمر. مفتاح الكلمات : التناظر الكلوي لداء الذئب الاحمر ، ريتوكسيماب .


Article
Detection of Hematological Biomarkers Associated with Lupus Nephritis in a sample of Iraqi Patients
التحري عن مؤشرات الدم السريرية المصاحبة لمرض داء الذئب الأحمراري الذي يصيب المفاصل والكلى في عينة من المرضى العراقيين

Loading...
Loading...
Abstract

This study was conducted on a sample of Iraqi patients with systemic lupus erythematosus (SLE) for both lupus arthritis and lupus nephritis. Blood samples were collected from 32 lupus arthritis patients with age ranged between 13 and 50 years, Female percentage was 96.87%. Another 32 blood samples were collected from lupus nephritis patients with age ranged between 16 and 65 years; Female percentage was 90.62%. For comparison, a total of 32 blood sample were also collected from normal individuals (healthy controls), with age ranged between 21 and 54 years, Female percentage was 53.12%. Relationship was studied between clinical blood parameters like total counts of white and red blood cells and platelets, hemoglobin concentration and erythrocytcite sedimentation rate (ESR) and the incidence of SLE. Results showed that there is no significant difference between count of WBC in lupus arthritis (8.47× 103 cell/ml ) and lupus nephritis patients (9.13× 103 cell/ml) and healthy controls (7.99× 103 cell/ml), while it was found that there is a significant decrease (P<0.01) in RBC count for both lupus arthritis (4.41× 106 cell/ml) and lupus nephritis patients (4.32× 106 cell/ml) in comparison with RBC count in healthy controls (4.98× 106 cell/ml). Results also showed that there is a significant decrease (P<0.01) in hemoglobin concentration in serum sample for both lupus arthritis (11.83g/dl) and lupus nephritis patients (11.79g/dl) in comparison with hemoglobin concentration (13.69g/dl) in healthy controls. On the other hand it was found that there is no any significant difference between platelets count in lupus arthritis (270.81×103 platelet/ml) and lupus nephritis patients (255.01×103 platelet/ml) and normal healthy controls (275.94× 103 platelet/ml). Results also showed that there is a significant increase (P<0.01) in ESR for both lupus arthritis (38.53mm/hr) and lupus nephritis patients (44.0 mm/hr) in comparison with ESR for healthy controls (13.09mm/hr). According to these results, clinical blood parameter including RBC count, hemoglobin concentration and ESR were regarded a clinical parameter for detecting SLE in Iraqi patients.

أجريت الدراسة على عينة من المرضى العراقيين المصابين بداء الذئب الأحمراري الذي يصيب المفاصل والكلى، حيث جمعت عينات الدم من 32 مريض بداء الذئب الأحمراري الذي يصيب المفاصل تراوحت أعمارهم بين 13 و 50 سنة، بلغت نسبة الإناث فيهم 96.87%. كما جمعت 32 عينة دم أخرى من مرض داء الذئب الأحمراري الذي يصيب الكلى تراوحت أعمارهم بين 16 و 65 سنة، بلغت نسبة الإناث فيهم 90.62%. ولغرض المقارنة فقد جمعت 32 عينة دم أخرى من الأشخاص السليمين (السيطرة) تراوحت أعمارهم بين 21 و 54 سنة بلغت نسبة الإناث فيهم 53.12%. درست العلاقة بين عدد من مؤشرات الدم السريرية مثل أعداد خلايا الدم البيض والحمر والصفيحات الدمية وتركيز الهيموغلوبين ومعدل ترسيب كريات الدم الحمر والإصابة بداء الذئب الأحمراري الذي يصيب المفاصل والكلى. وقد أشارت النتائج الى عدم وجود اختلاف معنوي إحصائي في أعداد خلايا الدم البيض في كل من عينة مرضى المفاصل (8.47×310خلية/مل) وعينة مرضى الكلى (9.13×310خلية/مل) وعينة السيطرة (7.99× 310خلية /مل)، في حين أشارت النتائج الى حدوث انخفاض معنوي (P<0.01) في أعداد خلايا الدم الحمر لكل من عينتي مرضى المفاصل (4.41×610خلية /مل) ومرضى الكلى (4.23×610خلية/مل) مقارنة بعينة السيطرة (4.98×610 خلية/مل). كما أشارت النتائج الى حدوث انخفاض معنوي (P<0.01) في تركيز الهيموغلوبين في عينة الدم لكل من عينتي مرضى المفاصل (11.83 غم/ديسيلتر) ومرضى الكلى (11.79 غم/ديسيلتر) مقارنة بعينة السيطرة (13.69 غم/ديسيلتر). في حين لم يلاحظ أي فرق معنوي بين أعداد الصفيحات الدمية في كل من عينة مرضى المفاصل (270.81×310صفيحة/مل) وعينة من مرضى الكلى (255.01×310 صفيحة/مل) وعينة السيطرة (275.94×310 صفيحة/مل). وقد أشارت النتائج أيضاً الى وجود ارتفاع معنوي (P<0.01) في معدل ترسيب كريات الدم الحمر في عينتي مرضى المفاصل (38.53 ملم/ساعة) ومرضى الكلى (44.0 ملم /ساعة) مقارنة بمعدل ترسيب كريات الدم الحمر في عينة السيطرة (13.09ملم/ساعة). وفقاً لهذه النتائج تعد مؤشرات الدم الكيموحيوية المتمثلة بأعداد كريات الدم الحمر وتركيز الهيموغلوبين ومعدل ترسيب كريات الدم الحمر من المؤشرات السريرية المهمة لتشخيص الإصابة بداء الذئب الأحمراري في عينات المرضى العراقيين.


Article
Urinary RBC Count As a Guide to Follow The Activity of Lupus Nephritis
RBC البولية عدد كدليل لمتابعة النشاط من التهاب الكلية الذئبة

Author: Dhiyaa A. Alhamadani,
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2007 Volume: 2 Issue: 132 Pages: 59-64
Publisher: Tikrit University جامعة تكريت

Loading...
Loading...
Abstract

Some patients with systemic lupus erythematosus may show hematuria and proteinuria due to renal involvement regardless of the underlying renal histopatholgical lesion. The prognosis and the treatment depend on type and activity of underlying renal lesion. Usually the active lesion shows response to treatment in contrast to chronic lesion which does not. .Renal biopsy seems to be essential procedure in the initial evaluation of renal lesion but not as repeated procedure to follow the lesion. In this study the relation between the activity of renal lesion and its clinical evidence studied in 30 patients with SLE. Renal lesions classified according to WHO classification of lupus nephritis. Hematuria was more common in classes iii and iv both of them show increasing activity score and hematuria show striking correlation with histological activity(r = 0.71). Proteinuria was the most common finding and had a significant association with chronicity score .Serum creatinine had a weak association with both activity and chronicity score .These results show that urinary RBC could be used as a guide to monitor disease activity and response to treatment in stead of serial renal biopsy.

قد يكون بعض المرضى الذين يعانون من الذئبة الحمامية الجهازية تظهر بيلة دموية وبروتينية بسبب تورط الكلوي بغض النظر عن آفة الكامنة histopatholgical كلوي. ان تشخيص والعلاج يعتمد على نوع ونشاط الآفة كلوي الكامنة. وعادة ما تظهر الآفة نشط الاستجابة للعلاج على النقيض من الآفة المزمنة التي لا تفعل ذلك. . خزعة الكلى ويبدو أن الإجراء ضروري في تقييم أولي لآفة الكلوي ولكن لم تتكرر مثل إجراء لمتابعة الآفة. في هذه الدراسة العلاقة بين النشاط من آفة الكلوي وأدلته السريرية درس في 30 مريضا مع SLE. الآفات الكلوية وفقا لتصنيف منظمة الصحة العالمية تصنيف التهاب الكلية الذئبة. وبيلة دموية أكثر شيوعا في صفوف الثالث والرابع كل منهما إظهار زيادة درجة النشاط وبيلة دموية تظهر ارتباط مع المضربين نشاط النسيجية (R = 0.71). وكان بروتينية الاستنتاج الأكثر شيوعا، وكان لها ارتباط مهم مع درجة الإزمان. مصل الكرياتينين كان له ارتباط ضعيف مع كل من النشاط ودرجة الإزمان. وتبين هذه النتائج التي يمكن أن تستخدم RBC البولية كدليل لرصد نشاط المرض والاستجابة للعلاج في المكان خزعة من الكلى المسلسل.

Listing 1 - 8 of 8
Sort by
Narrow your search

Resource type

article (8)


Language

English (6)

Arabic (1)


Year
From To Submit

2017 (2)

2016 (1)

2013 (1)

2011 (1)

2008 (1)

More...