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Article
Bronchial wash miR-21 as a potential biomarker for non-small cell lung cancer

Authors: Hussain Abady Aljebori --- Ban A. Abdulmajeed --- Adnan Aljubori
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2015 Volume: 4 Issue: 1 Pages: 39-60
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Lung cancer is one of the major health problems all over the world. Most ofcases are discovered at advanced stages because of late appearance of symptoms and the lackof efficient and effective methods for early diagnosis and screening of high risk groups. ThemicroRNA-21(miR-21) was stably present and reliably measurable in all samples of bronchialwash whether positive or negative (control) for lung cancer.Objectives: to evaluate the expressions of the miRNA-21 as a minimally invasive diagnosticbiomarker for non-small cell lung cancer (NSCLC).Results: Relative quantification of miR-21 gene showed overexpression in samples positivefor NSCLC (non-small cell lung cancer) and ROC study yielding 85% sensitivity and 98%specificity in distinguishing NSCLC patients from controls with p-value < 0.05.Conclusion: altered expressions of the miR-21 in samples of bronchial wash may provide apotential biomarker for detection of non-small cell lung cancer.


Article
The Role of Bronchial Wash Carcino-Embryonic Antigen Assay In The Diagnosis of Non-Small Cell Lung Cancer

Authors: Hashim Mahdi Hashim --- Ali Salih baay --- Ameer Kadhim Al-Humairi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 2 Pages: 540 -548
Publisher: Babylon University جامعة بابل

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Abstract

The bronchogenic cancer is one of the most common cancers in human kind & it represents a diagnostic challenge because of the most available tests are either yielding in the late stages or it is some of invasive nature ,so the need for diagnostic test in the early stages is mandatory, aim of the study is to assess the significance of bronchial carcino-embryonic antigen ( CEA) as a tumour marker for aiding the diagnosis of non-small cell lung cancer (NSCLC) and to see if there is any difference between the serum & bronchial CEA and between tumour and non-tumour sidesThirty patients were involved in this study ,divided into 3 groups according to their diagnosis as cancer ,airway disease & Tuberculosis groups, assessment of their socio-demographic features ,clinical features chest X ray ,computerized tomography (CT) scan , fibro-optic bronchoscopy were done & the carcino-embryonic antigen (CEA) level were tested in the samples taken from serum, tumour& non-tumoursides.There was a statistically significant difference in the level of the carcino-embryonic antigen in the bronchial wash of cancer patients group comparing to the serum of the same group & to the bronchial wash level in the other groups in favor of the cancer group patients, but no difference between the tumour& non tumour sides in the cancer group patients.The carcino-embryonic antigen assay in the bronchial wash may be helpful in the diagnosis of non-small cell lung cancer& may be take into consideration in the future work up

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