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Article
Vitamin C Supplementation in Relation to Subfertility and Ovarian Function

Author: Wasan Gh. Aboud وسن غازي عبود
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2014 Volume: 7 Issue: 1 Pages: 1786-1792
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: subfertility is a common medical problem affecting about 15-20 % of women consulting the gynecological outpatients in the whole world. Vitamin C is an important substance that plays different roles in the body and part of this action is in relation to subfertility. Objective: to evaluate the effect of vitamin C supplementation on the ovarian hormones estrogen and progesterone in subfertile women. Methods: This prospective study was carried out on thirty women attending private gynecological clinics, twenty of them were infertile and the other ten were normal fertile women as control group. They were subjected for the measurement of serum concentrations of both estrogen and progesterone. At the start, The investigations began at the 23rd day of a regular menstrual cycle(B), 5 ml of blood was taken for the measurement of the serum concentrations of both ovarian hormones. Each woman then took vitamin C tab. 1.5 gm (orally) daily and continued for the next 23rd day (AI), At the same day serum E & P was repeated and the vitamin C supplementation continues to the next 23rd dayof second period, a total period of 58±2 days (AII). So at this day hormonal assessment was repeated and vit C supplementation was stopped.Results and Discussion: The results showed that vitamin C supplementation causes an increased serum progesterone concentration significantly(p<0.05)after two months supplementation of oral vit C, as compared with the baseline serum level in both fertile and infertile women, while the effect of vitamin C supplementation on serum estrogen is increased significantly after the second months of the vitamin supplementation as compared with the baseline level in fertile women only. In this study, we found a role of vitamin C supplementation to affect the subfertility through increasing the endometrial thickness either directly by its antioxidant effect on endometrial cell or through increasing the level of progesterone.Conclusion: our study shows an effect of vitamin C on the progesterone level and hence this may play a role in infertility treatment as it will increase the receptivity and preparation of the endometrium to the fertilized ovum.


Article
Effect of Body Mass Index on Abnormal Ovarian Secretion Hormones among Iraqi Women with Polycystic Ovarian Syndrome (PCOS)

Authors: Alaa H. Badr --- Alaa H. Jawad --- Rania M. L. Faraj
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2019 Volume: 22 Issue: 1 Pages: 40-45
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Polycystic ovarian syndrome (PCOS) is the most common and complex endocrine disorder affecting women in the reproductive age. The etiology of this syndrome is not completely known, so there is a developing proof that supports genetic basis, PCOS has a strong familial preference. This study was carried out to investigate the effect of body mass index (BMI) on ovarian hormones in women with PCOS and healthy women. Eighty-three women aged (17-40) years were divided into two groups for testing (BMI less than 25 and more than 25). Hormonal study of Luteinizing hormone (LH), Androgen, Estradiol (E2) was done for each patient, the results of these hormones in patients compared with controls in both BMI groups with E2/T ratio showed a significant increase in patients women compared to controls in (p<0.05), While the results of Follicle stimulating hormone (FSH) and Total Testosterone (TT) showed an increase with not statistically significant. it has been concluded that the increase in BMI doesn’t show to have an opposite effect on FSH, Androgen, E2, and TT levels but the result of LH shows a highly significant increase in PCOS groups compared to controls when BMI˃25.

Keywords

Polycystic ovarian syndrome --- LH --- E2 --- FSH --- TT --- BMI --- ovarian hormones --- Androgen.

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