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Article
THE ROLE OF ESTROGEN AND PROGESTERONE ON VAGINAL CYTOLOGY DURING PROLIFERATIVE AND SECRETARY PHASES OF MENSTRUAL CYCLE IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Authors: Huda R. Kareem هدى رشيد كريم --- Haider A. Jaafer حيدر عبدالرسول جعفر --- Zainab H. Hashim زينب حسن هاشم
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2017 Volume: 15 Issue: 1 Pages: 78-87
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:In the course of cyclic hormonal fluctuation, cytological changes in the vaginal epithelium can be correlated with the phases of the menstrual cycle, this can be utilized in diagnosis of hormonal status in women with pathological cycles as in polycystic ovarian syndrome (PCOS). Objective:To evaluate the effects of estrogen (E2) and progesterone hormones in PCOS on the vaginal cytology in different phases of menstrual cycle, and its relation to ovulation period.Methods:A non-random sample of one hundred women were enrolled in this study, divided into two groups; 50 women free from PCOS, and 50 were PCOS according to the criteria of Rotterdam 2003. All were underwent hormonal assay including estrogen and progesterone on 2nd and 21st day of the cycle respectively, vaginal smears cytology on the 2nd day, 14th and 21st day of the cycle, stained with H&E, the (parabasal, squamous, leukocytes) were identified and counted, ultrasound examination was done on 14th day of the cycle, that divide the sample into ovulatory and an ovulatory subgroups accordingly.Results:At the 2nd day of the cycle, there was a significant reduction in squamous cell count, highly significant increase in leukocyte, E2 hormone level increased markedly, with a significant negative correlation to leukocytes cells in patients' groups at P≤0.05. Squamous cells of vaginal smear attained more acidophilic cytoplasm and increase in nuclear pyknosis. At the 14th day of the cycle, a significant increase in squamous cells count at P≤0.05, cornified squamous cells predominantly seen associated with low ovulation rates of 44%. Ovulation showed significant reduction in parabasal cells count in patients group at P≤0.05. At 21st day of the cycle, progesterone level was reduced with a significant reduction in squamous cells, parabasal cells and leukocytes counts in patients, with no significant correlation between progesterone and vaginal cytology cells, squamous cells consisted of mature cornified cells that seen predominantly in vaginal smear.Conclusion:Hormonal changes in PCOS presented mainly by the effect of elevated E2 hormone, that associated with increase in squamous cells count and cornification, with reduction in leukocytes and parabasal cells toward mid cycle. Progesterone hormone exert no significant effect on vaginal cytology in PCOS.Keywords: PCOS, vaginal cytology, ovulation

Keywords

PCOS --- vaginal cytology --- ovulation


Article
Oxytocin (syntocinon) as stimulating factor for ovulation and uterine, mammary glands and placental development in white female mice
الاوكسيتوسين ( معجل الولادة ) كمحفز للتبويض وتطور الرحم والغدد اللبنية والسخد والحمل في اناث الفئران البيض

Author: Israa Hashim Ali اسراء هاشم علي
Journal: Tikret Journal of Pharmaceutical Sciences مجلة تكريت للعلوم الصيدلانية ISSN: 18172716 Year: 2017 Volume: 12 Issue: 2 Pages: 1-7
Publisher: Tikrit University جامعة تكريت

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Abstract

The effect of oxytocin were studied as astimulating factor on ovulation, In this study30 female mice were carried out on 2-3 months,old with 24-30 g weight, They weredistributed of two,groups the control and,experimental, The white mice inexperimental,group were injected with adose of 10 IU/g of oxytocin at proestrusphase. The results showed that the pregnancy ratio in the experimental group wasabout 64% and the born ratio was about 59% which were higher than the controlgroup and the weight of newborn pups was more than the control. Histologically, Inthe ovarian section there was more follicles in different stages development inexperimental group when the endometrium of uterus was thicker than the control andabout the mammary gland section there was increased in alveolar surface area, Inaddition the results showed that oxytocin affected on placenta, It appears larger andthicker in the cross sections for experimental group.

Keywords

oxytocin --- ovulation --- endometrium


Article
Evaluation of the effect of using NSAIDs on ovulation in women during reproductive age: a case control study
تقييم تأثير استخدام مضادات الالتهاب غير الستيروئيدية على الإباضة لدى النساء خلال سن الإنجاب: دراسة مراقبة الحالة

Author: Saba Shamran
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2019 Volume: 15 Issue: 1 Pages: 109-112
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

AbstractBackground:Unovulation is an important cause of female infertility whether primary or secondary. Prostaglandins play an important role in normal physiology of ovulation. Non-steroidal anti-inflammatory drugs (NSAIDs) are often prescribed for treatment of a variety of medical conditions in the field of obstetrics and gynecology. Sufficient controversy about the role of NSAIDs on ovulation exists. Aim of the study:to evaluate rate of ovulation in two groups one was healthy fertile women receiving NSAIDs and the other group include healthy fertile women receiving placebo treatment.Patients and methods:The present case control study included two groups of healthy fertile women. The first groups included 30 women who were given the NSAIDdiclofenac sodium (olfen, Novartis) as 100 mg daily oral dose for 2 months duration and the other group included 30 women who were given placebo treatment for the same 2 months period. In the cycle following the completion of the intended period the following investigations were performed: serum progesterone level at day 10 and day 20 of menstrual cycle and ultrasound examination for identification of ovarian follicle size ate day 10 of the cycle and then at day 20 to confirm or exclude ovulation. The study extended from November 2017 to January 2018 and was carried out at Al-Diwaniyah maternity and child teaching hospital at Al-Diwaniyah province, Iraq. Results:Conclusion:TheNSAID diclofenac sodium interferes significantly with ovulation in women during their reproductive life and should be use with caution in women seeking pregnancy.

نبذة مختصرةالخلفية: الإباضة هي سبب مهم لعقم الإناث سواء الأساسي أو الثانوي. تلعب البروستاجلاندين دورًا مهمًا في فسيولوجيا الإباضة الطبيعية. وغالبا ما توصف العقاقير المضادة للالتهابات غير الستيرويدية (مضادات الالتهاب غير الستيروئيدية) لعلاج مجموعة متنوعة من الحالات الطبية في مجال التوليد وأمراض النساء. يوجد جدل كافٍ حول دور مضادات الالتهاب غير الستيروئيدية في الإباضة.الهدف من الدراسة: لتقييم معدل الإباضة في مجموعتين ، كانت المرأة الخصبة الصحية التي تتلقى مضادات الالتهاب غير الستيروئيدية والمجموعة الأخرى تشمل النساء الخصبات الأصحاء اللائي يتلقين العلاج الوهمي.المرضى والطرق: شملت دراسة مراقبة الحالة الحالية مجموعتين من النساء الخصيات الأصحاء. شملت المجموعات الأولى 30 امرأة تم إعطاؤهن NSAIDdiclofenac sodium (olfen، Novartis) كجرعة فموية يومية 100 ملغ لمدة شهرين ، بينما شملت المجموعة الأخرى 30 امرأة تلقين العلاج الوهمي لنفس فترة الشهرين. في الدورة التالية لاستكمال الفترة المقصودة تم إجراء التحقيقات التالية: مستوى هرمون البروجسترون في الدم في اليوم 10 واليوم 20 من الدورة الشهرية والفحص بالموجات فوق الصوتية لتحديد حجم بصيلات المبيض أكلت يوم 10 من الدورة ثم في اليوم 20 لتأكيد أو استبعاد الإباضة. امتدت الدراسة من نوفمبر 2017 إلى يناير 2018 ونفذت في مستشفى الديوانية للأمومة والطفولة في محافظة الديوانية ، العراق.النتائج:خاتمة: يتداخل TheNSAID ديكلوفيناك الصوديوم بشكل كبير مع الإباضة عند النساء أثناء حياتهم الإنجابية ويجب أن يستخدم بحذر عند النساء اللائي يسعين للحمل.

Keywords

NSAIDs --- ovulation --- reproductive age


Article
Ovulation detection through salivary levels of sialic acid and glycosaminoglycans

Authors: Rand M. Al-khafagy رند الخفاجي --- Sahar H. Al-Ani سحر العاني --- Ali Y.Majid علي ماجد
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 2 Pages: 66-69
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: One in ten couples of reproductive age encounter some level of infertility. Identification of the periodof ovulation in humans is critical in the treatment of infertility. Success in in vitro fertilization and embryo transfer hasbeen associated with the exact time of ovulation. Saliva is a unique diagnostic fluid, the composition of whichimmediately reflects the sympathetic nervous system, parasympathetic nervous system, hypothalamic- pitutaryadrenalaxis and immune system response to stress. The study aims at evaluating the changes in salivary sialic acidand Glycosaminoglycans in the regular menstrual cycle. Thus, the presence of these carbohydrates in the ovulatorysaliva makes the possibility to develop a biomarker for the detection of ovulation by noninvasive methods.Subjects, materials and methods: Randomly, seventy five volunteer females were recruited and divided into 5groups; each contains 15 subjects as follow: Nine years old females and postmenopausal females as control groups,pre-ovulatory period, ovulatory period and post-ovulatory period females as experimental groups. Each female, ofthe experimental groups, underwent sonographic examination to estimate her period regarding ovulation.Unstimulated whole saliva was collected using the spitting method. Colorimetric procedure was used for total sialicacid determination and for Glycosaminoglycans quantitative determination, the method of ELISA was used.Results: The concentration of sialic acid was significantly decreased in saliva of females in the ovulatory phase of themenstrual cycle; whereas, a significant increase in salivary sialic acid concentration was in the post-ovulatory phase.Glycosaminoglycan concentration showed a gradual increase from the pre-ovulatory phase then ovulatory to reachits maximum in the post-ovulatory phase with a significant difference between the pre-ovulatory and post-ovulatoryphases. A significant correlation was not found between sialic acid and Glycosaminoglycans in different studygroups.Conclusions: On the basis of the results arrived at, the study concluded that there are remarkable cyclic variations insialic acid and glycosaminoglycans during the menstrual cycle but in conclusion, glycosaminoglycans and sialicacid salivary levels cannot be used for the precise prediction of ovulation


Article
Improving an Ovulation Rate in Women with Polycystic OvarySyndrome by Using Silymarin

Authors: Manal K.Amin --- Yaser A.Atia --- Mohammed A.Taher محمد عباس طاهر
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2010 Volume: 19 Issue: 2 Pages: 11-18
Publisher: Baghdad University جامعة بغداد

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Abstract

Polycystic ovary syndrome(PCOS) is a heterogeneous disorder of uncertain etiology , it is the most common endocrinopathy in women and most common cause of anovulatery infertility ,characterized by chronic anovulation and hyperandrogenemia .The present study was designed to investigate the effect of silymarin which is known to have antioxidant and insulin sensitivity effects on the levels of glucose, insulin ,testosterone ,leutinizing hormone(LH) and progesterone .Ovulation rate and Homeostasis Model Assessment of insulin Resistance (HOMA) ratio were determined .A 3-months of treatment were conducted in 60 PCOS patients in three well-matched groups .The first one (n=20),received silymarin(750mg/day) .The second group received metformin(1500mg/day) while the third group treated by combination of metformin (1500mg/day )and silymarin (750mg/day). All these groups had taken the drugs in divided doses. The results showed significant improvement in all parameters at the end of treatment .The percentage of increment in progesterone levels after completion of treatment were 12.12, 15.9, and 17.51 in groups 1, 2, and 3 respectively and the number of patients ovulated after 3 months of treatment were 4,5, and 10 in groups 1,2, and 3 respectively. However they are more better in group of patients who were treated with combination of silymarin with metformin.In conclusion the addition of silymarin to metformin in treatment of PCOS patients has improving effect on disturbed hormones and ovulation rate.

إن متلازمة المبيض متعدد الأكياس هو اضطراب متغاير لأسباب غير مؤكدة.انه اعتلال هورموني شائع عند النساء وأكثر سبب شائع للعقم المصحوب بعدم الاباضة ويتميز بعدم اباضة مزمن وارتفاع الهورمون الذكري .أن الدراسة الحالية صممت لفحص تأثير السيلمارين وهو الذي يملك خاصية ضد التأكسد و زيادة لتحسس الأنسولين وتقليل المقاومة للأنسولين على مستويات السكر , الأنسولين , الهورمون الذكري, الهورمون اللوتيني والبروجيستسيرون. تم احتساب نسبة الاباظة ودليل مقاومة للأنسولين ( (HOMA أيضا.ثلاثة أشهر من العلاج أعطي ل 60 مريضة بمتلازمة المبيض متعدد الأكياس في ثلاثة مجاميع . المجموعة الأولى مكونة من 20 مريضة عولجن بعقار السيليمارين بجرعة 750 ملغم يوميا والمجموعة الثانية مكونة من 20 مريضة عولجن بعقار المتفورمين وبجرعة 1500 ملغم يوميا بينما المجموعة الثالثة والمكونة من 20 مريضة أيضا عولجن بمزيج الميتفورمين 1500 ملغم يوميا والسيلمارين بجرعة 750 ملغم يوميا .كل هذه المجاميع اخذت العلاج بجرع مجزئة .النتائج أظهرت تحسن المستوى لكل التحاليل بعد نهاية العلاج.ان زيادة نسبة مستويات البروجيستيرون ونسبة الاباضة كانت أفضل في مجموعة المريضات اللواتي عولجن بمزيج السيليمارين والميتفورمين .وفي الاستنتاج إن إضافة السيليمارين للمتفورمين لعلاج المريضات المصابات بمتلازمة المبيض متعدد الأكياس له تأثير حسن على الهومونات المضطربة ونسبة الاباضة.


Article
Rosiglitazone , Metformin or both for Treatment of Polycystic Ovary Syndrome
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Authors: Hillal Y. Al-Khairi --- Waleed R. Sulaiman --- Mohammed A.Taher محمد عباس طاهر
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2008 Volume: 17 Issue: 2 Pages: 80-86
Publisher: Baghdad University جامعة بغداد

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Abstract

This study was designed to show the advantages of using the combination of metformin and rosiglitazone over using each drug alone in treatment of women with polycystic ovary syndrome (PCOS).Forty four women with PCOS were classified into 3 groups , group 1 received rosiglitazone (4mg/day) for 3 months , group ةة received metformin ( 1500 mg/day)for three months and groupةةة received the combination ( rosiglitazone 4mg/day + metformin 1500 mg/day) for the same period of treatment . The blood samples were drawn before treatment and after 3 months of treatment . The fasting serum glucose , insulin , progesterone , testosterone , leutinizing hormone were measured before and after treatment. The reduction of serum insulin , glucose ,homostasis model assessment of insuline resistance ( HOMA-IR) , LH and testosterone levels were greater in the group received the combination of rosiglitazone with metformin than that those taken each one alone. Testosterone levels decreased significantly (P<0.05) from baseline level 1±0.04ng/ml to 0.073±0.32ng/ml after treatment with combination.The rate of ovulation is 29.4%,36.4% , 62.5% in rosiglitazone , metformin and combination of both, respectively.The combination of rosiglitazone with metformin has more beneficial effect on ovulation rate.

هذه الدراسة صممت لعرض الفوائد من استعمال خليط من الميتفورمين والروزيكليتازون على استعمال كل دواء منفردا عند علاج النساء المصابات بمتلازمة المبيض متعدد الاكياس. اربع واربعون امرأة مصابة بمتلازمة المبيض متعدد الاكياس قسمن الى ثلاث مجموعات : المجموعة الاولى تناولت الروزيكليتازون بجرعة 4ملغ يوميا لمدة ثلاثة اشهر و المجموعة الثانية تناولت الميتفورمين بجرعة 1500 ملغ يوميا لمدة ثلاثة اشهر اما المجموعة الثالثة فقد تناولت خليط من الروزيكليتازون بجرعة 4ملغ يوميا والميتفورمين بجرعة 1500 ملغ يوميا لنفس مدة العلاج. نماذج الدم سحبت قبل العلاج وبعد ثلاثة اشهر من العلاج.ان التغيرفي مستويات الكلوكوز , الانسولين, البروجيستسرون , الهورمون اللوتيني والتستوستيرون كان ملحوظا اكثرفي خليط الروزيكليتازون و الميتفورمين مما في حالة اخذ كل دواء منفردا.كما ان مستوى التستوستيرون يقل معنويا عن مستوى الشروع بعد العلاج بالمركب . وكانت نسبة القابلية على انتاج البيض هي29,4 ,36,4 , 62,5 في الروزيكليتازون والميتفورمين وكلتاهما معا على الترتيب ان خليط الروزيكليتازون و الميتفورمين له تأثير نافع على نسبة انتاج البيض.


Article
Intrauterine insemination outcome with and without ovulation induction treatment

Author: Adeela h H. Hussein *, Inas T. Ahmed **, Abeer A. Mahmood
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2015 Volume: 11 Issue: 2 Pages: 76-81
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:: Infertility is a very common condition affecting approximately 13-14% of couples in the reproductive age. In general population; about 85% of couples have achieved conception within a year. Intrauterine insemination is one of the procedure which have a role in the treatment of infertile couple.Objectives:is to confirm that the use of ovulation induction in the course of intrauterine insemination elevates the pregnancy success rate.Method:This study had been conducted between December 2013 till December 2014 in AL-Elwiyah maternity hospital and AL-Samaraii hospital / Baghdad.On history and clinical examination; the chosen couple had the following criteria; primary infertility for more than one year, no previous IUI trials, husbands with normal seminal fluid analysis, wives in reproductive age group; with regular cycles of 24 – 35 days, body mass index (18-26)kg/m2, normal body contour, no galactorrhea nor hirsutism, normal uterine cavity and patent fallopian tubes by hysterosalpingography. Total number of cases is 76; had been divided into two groups who underwent IUI schedule, 38 cases preceded by ovulation induction and the other 38 cases had spontaneous ovulation by showing a single dominant Graffian follicle size of 18 mm measured by daily vaginal ultrasound.Results:During the study period; the total number of married women participated in the study were 76; divided into two groups. The first group contains 38 women who had the inclusion criteria of our research, underwent IUI after follow up and confirmed spontaneous ovulation, the second group included 38 women who also had the same inclusion criteria and underwent IUI after effective ovulation induction. 5 cases became pregnant while 33 cases didn’t conceive, while in the second group with ovulation induction; 12 cases became pregnant while the remaining 26 cases failed to conceive;Theoverall pregnancy rate was highest(31%) in the group treated with ovulation induction and intrauterine insemination in comparison with the other group which revealed a pregnancy rat.e of only (13%).Conclusion:For fertile couple in which no recognized cause for her infertility ;as for history;clinical examination and investigation are concerned, then combination of ovulation induction with intrauterine inseminationis an effective means for achieivingpregnancyrate by 31%compared with only 13%pregnancy rate in naturally ovulation cycle.


Article
Myo-inositol in patients with polycystic ovary syndrome: A novel method for ovulation induction

Author: Sumaya Tahir Saihood*
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2016 Volume: 2 Issue: 2 Pages: 210-215
Publisher: Tikrit University جامعة تكريت

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Article
THE ROLE OF METFORMIN IN INDUCTION OF OVULATION IN OBESE INFERTILE PATIENTS WITH POLYCYSTIC OVARY SYNDROME

Authors: Huda Moosa Omran --- Fouad Hamad Al-Dahhan
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2006 Volume: 12 Issue: 1 Pages: 93-97
Publisher: Basrah University جامعة البصرة

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AbstractThis study aimed to find the effective method of induction of ovulation; in obese infertile patients with polycystic ovary syndrome. It is a prospective case-control study done at Infertility clinic of Basra Maternity and Child hospital.Sixty obese, hirsute infertile patients for more than two years; with ultrasound findings of polycystic ovary syndrome, subjected to the following investigations: Serum LH, FSH, Testosterone, Prolactin &fasting blood sugar. All investigations were carried on early follicular phase of the cycle. Patients were divided randomly into two groups: Group A and group B. All patients received clomiphene citrate 50-150mg for five consecutive days beginning on day 5 of the cycle. The patients with group B also received 500mg of Metformin tablet three times daily for 6 months. Ovulation- which assessed by transvaginal folliculometry, and ovarian artery Doppler velocimetry; triggered with hCG when one or more follicle measuring ≥ 18 mm in diameter, and blood flow indices of the active ovary; showing the dominant follicles were good; on ultrasonic examination. Ovulation response and pregnancy rate were assessed in both groups.Results obtained from this study pointed out the beneficial effect of Metformin on ovulation induction in obese hirsute women with PCOS.It is concluded that PCOS remains an enigmatic disease. Once considered relatively benign, PCOS is implicated in medical disorders related to hyperinsulinism and hyperandrogenemia. Restoring fertility and treating abnormal hair growth remain important considerations in the physical and psychological health of reproductive-age women. Metformin has shown great promise in the treatment of insulin-resistant PCOS, but whether it would benefit all women who have PCOS remains unclear. Weight loss is the most important primary recommendation that can be made in the treatment of PCOS.


Article
Effect of Rosiglitazone on Insulin Resistance, Ovulation and Pregnancy in Women with Polycystic Ovarian Syndrome
تأثير عقار روزكلاتيزون على حساسية الانسولين ووظائف المبيض والحمل للنساء المصابات بمتلازمة المبيض متعدد الاكياس

Author: Wasan Wajdi د.وسن وجدي أبراهيم
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2011 Volume: 24 Issue: 1 Pages: 35-38
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Objective: To evaluate the effects of rosiglitazone on insulin resistance, reproductive disturbance in women with polycystic ovarian syndrome (PCOS). Design: prospective study.Setting: women with PCOS attending as out patients of private clinic and Baghdad teaching hospital. Patient & Methods: this study included thirty obese PCOS women with an age ranging from (18-37) years old. The body mass index and waist/ hip ratio of patients were calculated before and after 3-6 months of rosiglitazone therapy. Venous blood sample for fasting glucose, fasting insulin, fasting insulin/ fasting glucose ratio, HbA1C, LH, SHBG, DHEA-S, total and free testosterone were evaluated before and after 3-6 months of 4mg daily treatment with rosiglitazone. In addition, Transvaginal ultrasound was done at mid cycle to demonstrate dominate follicle. Midluteal progesterone was also measured to detect ovulation. Result: A significant decrease was observed in serum fasting insulin, fasting glucose/ insulin ratio, DHEA-S, total and free testosterone and waist / hip ratio after 3-6months of rosiglitazone therapy.-BMI (body mass index) remained unchanged. -Six of thirty patients studied reverted regular ovulatory cycle after 3months of treatment while other sixteen patients reverted ovulation after 6 months of treatment. Conclusion: rosiglitazone is a promising insulin sensitizer increase ovulatory frequency and ameliorate hyperandrogemia in obese women with PCOS.Key wards: polycystic ovary syndrome insulin resistance rosiglitazone, ovulation, pregnancy.

غاية الدراسة: ان الغاية الاساسية من اجراء هذه الدراسة هو لتقييم تأثير عقار روزكلاتيزون على حساسية الانسولين ووضائف المبيض والحمل للنساء المصابات بمتلازمة المبيض متعدد الاكياس.الطريقة المتبعة: لقد اشتملت الدراسة على ثلاثين مريضة تتراوح اعمارهن بين(18-37) سنة مصابات بمتلازمة المبيض المتعدد الاكياس ولكن يعانين من العقم الاولي والثانوي واضطرابات الدورة الشهرية بالاضافة الى اعراض اخرى متفرقة.نماذج الدم سحبت من المريضات الصائمات على الاقل لمدة (12) ساعة. هذه النماذج اخذت قبل العلاج وبعد (3-6) اشهر من العلاج مع عقار روزكلاتيزون وتشتمل:-الهرمون اللوتيني في المصل, الهرمون الدكري (تيستيستيرون) في المصل, نسبة السكر في المصل, نسبة الانسولين في المصل.بالاضافة الى ما سبق تم قياس دليل كتلة الجسم ونسبة الخصر الى الورك قبل العلاج وبعده, بالاضافة الى الفحص بالامواج فوق السمعية (سونار مهبلي) في اليوم الحادي عشر من الدورة الشهرية لاكتشاف الجريبات الناضجة ومن ثم اجراء هرمون البروجستيرون في المصل من اليوم العشرين الى اليوم الرابع والعشرين من الدورة الشهرية لاكتشاف التبيض.النتائج: ان مستوى القيم لدليل كتلة الجسم لم تتغير, اما نسبة الخصر الى الورك فقد تناقصت بعد العلاج بعقار روزكلاتيزون.اظهرت الدراسة تناقض مستويات الانسولين ونسبة الانسولين الى السكر بعد العلاج بعقار روزكلاتيزون, اما بالنسبة الى الهرمون الدكري (تيستيستيرون) فقد تناقصت خلال فترة العلاج.ان الفحص بالامواج فوق السمعية (السونار) قد استعمل لتوضيح اكتساب الجريبات الناضجة بعد العلاج(ستة مريضات اظهرن الجريبات الناضجة بعد ثلاثة اشهر من العلاج, وستة عشر اخريات بعد ستة اشهر من العلاج).الاستنتاج: ادى عقار روزكلاتيزون الى زيادة التبيض وقلل من الهرمونان الدكرية عند المريضات المصابات بمتلازمة المبيض المتعدد الاكياس.

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