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Article
Determination of Stability for imines derived from carbonyl compounds by conductivity measurements
تعيين استقرارية الايمينات المشتقة من المركبات الكاربونيلية من قياسات المواصلة الكهربائية

Authors: A.S.P. Azzouz عادل سعيد عزوز --- D.B.AL-Bakzo دنيا بطرس ال بكزو
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2018 Volume: 23 Issue: 3 Pages: 43-47
Publisher: Tikrit University جامعة تكريت

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Abstract

The project explained for the first time, how conductivity method was used in the determination of stability of some imines derived from mother compounds 2-acetyl pyridine, 3 or 4 –hydroxy benzaldehyde, and others.The method as found, simple precise and fast for the determination of stability of imines in 10% ethanol aqueous medium, as measured by evaluation of their conductance. Different conductance values for 10-2 M imine solutions in the range (5.53-180) μmho were collected experimentally as interpreted and discussed.

يتضمن البحث وللمرة الاولى, كيفية استخدام المواصلة الكهربائية في تعيين استقرارية الايمينات المشتقة من المركبات الام 2-استايل بردين و3 او 4 هايدروكسي بنزالدهايد و مركبات اخرى.الطريقة المستعملة في البحث وجد انها بسيطة, دقيقة وسريعة في تعيين استقرارية الايمينات في وسط 10% ايثانول في الماء. تم الحصول على اختلاف قيم التوصيل الكهربائي عمليأ لمحاليل الايمينات وفي المدى (180-5,53) مايكرو موه و التي فسرت ونوقشت.

Keywords

Schiff bases --- oximes --- imines --- conductivity


Article
Synthesis of some New 3-Substituted Heterocyclic Compounds Containing Bridgehead Nitrogen from 2-Amino Pyridine with Study Their Biological Activity

Authors: Ahmad Shaker Mahmoud --- Naeemah Al-Lami
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2018 Volume: 00 Issue: 1 Pages: 26-36
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

New series of 3-substituted heterocyclic compounds containing bridge head nitrogen were synthesized through multi-step reactions. In order to prepare the starting 2-substituted heterocyclic compounds of pyridine, a known procedure was used by condensation of 2-amino pyridine with (4-bromo phenacyl bromide). Carbaldehyde group was introduced at position-3 of prepared 2-substituted imidazo / pyridine rings by Vilsmeier-Haack reaction. 3-Carbaldehyde derivatives underwent Claisen condensation with different aryl ketons to give unsaturated ketones of these derivatives, which on cyclization with urea and thiourea afforded 3-cyclic oxopyrimidines and thiopyrimidines derivatives of imidazo / pyridine rings. In addition, 3-carbaldehyde derivatives was reacted with hydrazine, semicarbazide and hydroxyl amine hydrochloride to yield new hydrazone, semicarbazone and oxime derivatives of imidazo / pyridine rings. All prepared compounds were characterised via FT-IR spectroscopy, some of them were characterised by 1H-NMR spectroscopy. These new 3-subistituted derivatives of imidazo /pyridine rings were tested in different species bacterial and fungi. Some of tested compounds showed strong activity while the other showed moderate against. Interestingly, All these new prepared compounds showed high activity against fungi.


Article
Thermodynamic study on pKa values of some imines and their acids conjugate derived from different aromatic carbonyl compounds
دراسة ثرموديناميكية لقيم pKa لبعض الايمينات واحماضها القرينة المشتقة من المركبات الكاربونيلية المختلفة

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Abstract

Abstract The project was concerned with synthesis of mono acidic or diacidic Schiff bases having oxime or phenol groups or a combination of them respectively . Other syn and anti oximes were derived from 2-acetyl pyridine , and others included and synthesized by a standard methods . Potentiometric titration was found previously , an accurate , simple and fast method for determination of pKa for acids or pKa for acid conjugates of Schiff bases using NaOH and HCl titrant respectively . This method was applied successfully in this investigation for the determination of ionization constants of imines in a range of temperature (293-313)K . This encourage the workers in this study to deal with thermodynamic parameters such as ∆Gْ , ∆Hْ and ∆Sْ for the ionization reactions of imines at 10% ethanol solvent as interpreted and discussed .

خلاصة يتضمن البحث تخليق قواعد شيف الحامضية او القاعدية و الحاوية على مجاميع اوكزيمية او فينولية او مجموع كليهما. كما يحوي البحث على اوكزيمات سين و انتي المشتقة من 2-اسيتايل بردين و مركبات اخرى و بطرق قياسية. لقد وجد ان التسحيح المجهادي هي طريقة دقيقة , سريعة و بسيطة في تقدير pKa للأحماض او pKàللاحماض القرينة و عند استعمال مادتي NaOH و HCl كمواد مسححة على الترتيب . الطريقة المذكورة طبقت بنجاح في تعين ثوابت التأين للايمينات في مدى من درجات الحرارة المطلقة و المحصورة بين 233-333. ذلك شجع الباحث بالدراسة الثرمو ديناميكية و لتفاعلات تأين الأيمينات في مذيب 10% ايثانول مع مناقشة و تفسير هذه المتغيرات.

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