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PROTECTIVE EFFECT OF ETHANOLIC GINGER EXTRACT AGAINST CADMIUM TOXICIY IN MALE RABBITS
التأثير الوقائي للخلاصة الكحولية للزنجبيل ضد التسمم بالكادميوم في ذكور الأرانب

Author: Ahlam A. AL-Rikabi Ala AL-Deen H. Jawad * احلام علي علاء الدين حسن جواد
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: 18138497 Year: 2013 Volume: 12 Issue: 1 Pages: 13-29
Publisher: Basrah University جامعة البصرة

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Abstract

This study was done to evaluate the hypoglycemic potentials of ginger(zingiber officinale ) in controlling hyperglycemia ,hypoinsulinemia and theireffect on total cholesterol in cadmium-induced pancreotoxicity in male rabbitsTwenty four of adult male rabbits were divided randomly into four equal groups.Group 1 was given distilled water orally and considered as control group, group 2received 10mg/kg B.w of cadmium chloride, group 3 received 100mg/ kg B.w ofginger extract plus 10mg/kg B.w of cadmium chloride and group 4 received200mg/ kg B.w of ginger extract plus 10mg/kg B.w of cadmium chloride. Alltreatments were given a daily dose for 35 days.The blood sample was taken from these animal groups after 35 days of treatmentfor biochemical analysis to estimate : insulin hormone, blood glucose ,totalcholesterol, Aspartate amino transferase (AST) , Alanine aminotranferase(ALT)and Alkaline phosphatase (ALP).The results showed that cadmium chloride administration resulted in a decrease inthe level of insulin concentration associated with an increase in glucose and totalcholesterol concentration in rabbits .The enzyme activities of serum ALT, AST andALP were also significantly increased . While , the groups of animal that receivedginger showed significant decrease in serum glucose , cholesterol , AST, ALT andALP. The level of insulin was also increased in these groups of animal.

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