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Plateletpheresis concentrate produced with Fresenius cell separator Iraqi experience

Author: Nidal Karim Al-Rahal
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2012 Volume: 11 Issue: 1 Pages: 27-32
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Various types of plateletpheresis instruments are available for single donor plateletpheresis. In plateletpheresis blood is withdrawn from the donor in anticoagulant solution and separated into components. Platelets are retained and the remaining components are returned to the individuals.Aims: Evaluation of Fresenius COM.TEC; apheresis machine in regard to processing time, platelet (plt) yield efficiency, white blood cell (WBC) content and safety.Patients and Methods: Twenty two healthy male donors included in single donor plateletpheresis by Fresenius COM.TEC between February 2006 and July 2006 at bone marrow transplantation Center, Medical City Hospital, Baghdad / Iraq.The donor’s age, height, weight, complete blood count, blood group &Rh & vital signs were recorded and they were observed throughout the procedure. Plateletpheresis operational variables and the product variables were assessed.Results: The plateletpheresis product data which includes, donor platelet count with mean 229.424 x10³/cmm (range 185-336 x10³/cmm), product platelet count x10³/cmm mean 1268.5 x10³/cmm (range 604-2525 x10³/cmm), Platelet yield with mean 3.39 x10¹¹/cmm (range 2.51-7.57 x10¹¹/cmm), 90.90%of the product >3x10¹¹plt. No. of yield with WBC <1x106 18 out of 22 donors (81.18%), collection efficiency the mean 48,85% (range 32.18-60.28), the collection efficiency >50% was seen in 13 out of 22 donors (59.09%).Few donors exhibited adverse reactions mainly circumoral paresthesia in two donors (9.09%) mild pain at the phlebotomy site in three donors (13.63%). Only one had dizziness which account for 4.54%.Conclusions: Fresenius COM.TEC; apheresis instrument collected platelets safely, efficiently, with consistent leukoreduction product according to the AABB (American Association of Blood Banks) & with short time.

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