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Article
Salivary Matrix Metalloproteinase-8 (MMP-8) in Relation to Periodontal Health Status Among a Group of Hypertensive Patients

Authors: Eman Zuhair AlMudaris --- Nadia Aftan AlRawi
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2018 Volume: 30 Issue: 3 Pages: 48-53
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Hypertension is probably the most important public health problem around the world. People with periodontal disease may be at greater risk of hypertension. The inflammatory effects of periodontal disease help to promote endothelial dysfunction in arteries which may lead to changes in blood pressure. Salivary MMP-8 has been associated with both periodontal disease and prevalent hypertension.Aim of study: This study was conducted to measure salivary matrix metalloproteinase - 8, in relation to periodontal health condition among a group of patients with hypertension in comparison with control group.Materials and methods: Ninety subjects, aged 45-50 years old were included in this study, seeking treatment for chest pain in Ibn-AlBaytar center for cardiac surgical treatments in Baghdad, Iraq. The subjects were divided into study group (45 patient) who were diagnosed to be a hypertensive patient, and a control group (45 subject), with no hypertension. Plaque status was evaluated according to the Silness and Loe, probing pocket depth and clinical attachment level. Unstimulated saliva was collected from all subjects to analyses MMP-8. Result: A high mean value of plaque index, clinical attachment level and probing pocket depth for the study group than the control group with statistically no significant difference. In addition to that, a significant positive correlation between the plaque index and the clinical attachment level among both groups. Salivary MMP-8 level showed a higher level in the study group than in the control group, with statistically significant difference between groups, and a significant positive correlation was detected between salivary MMP-8 with plaque index, among study group,Conclusions: Higher percentage of periodontal diseases was found among patients with blood hypertension. In addition, high level of salivary MMP-8 is potentially associated with periodontal status of the study group.


Article
Amlodipine and Oral Health

Authors: Nahla O Tawfik --- Rana Kh Atarbashe
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2014 Volume: 14 Issue: 1 Pages: 111-114
Publisher: Mosul University جامعة الموصل

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Abstract

To evaluate the oral side effect of amlodipine in patients with cardiovascular disease, also to study the effect of improving oral health on the possibility of development of gingival over growth. Materials and Methods: The study was conducted on 25 patients (pretreated group) with cardiovascular disease who had been prescribed amlodipine for the first time, aged ranged between 30-63 years. Clinical examinations (plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD) and gingival over growth scores) were conducted under standardized illumination with plain dental mirror and a periodontal probe. The screening was done twice, the 1st assessment was collected at base line (pretreatment) visit before the first dose of the amlodipine and they received non surgical periodontal therapy (scaling, root planning and home care instruction) to get them to base line, but the 2nd assessment was done at the end of trial period at 12 week assessments (post treated). Results: The result obtained showed that the mean values of PI and BOP in post group were significantly lower than pre group (p<0.05), While for the PPD, GO the mean values in the post group were higher than mean value in the pre group with significant difference for GO (p<0.05) and no significant difference for PPD (p>0.05).Conclusion: The study concluded that amlodipine therapy had got its influence on GO and that improvement in oral health represent a scientifically sound complementary intervention in reducing both the occurrence of GO and inflammatory levels in the systemic circulation.


Article
Evaluation of serum anti-cyclic citrullinated peptide antibodies level in rheumatoid patients with and without periodontitis

Author: Fatin M. Jarallah فاتن جار الله
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 4 Pages: 83-87
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Rheumatoid arthritis (RA) and periodontitis (PD) are widely prevalent diseases and are characterized bytissue destruction due to chronic inflammation. Recently, there is growing evidence that the two diseases sharemany pathological features. An association between periodontitis and rheumatoid arthritis has been consideredmany years ago. The current study was established to evaluate the serum ACCP levels in rheumatoid arthritis patientswith and without periodontitis, in addition to study the correlation between serum ACCP levels and periodontalparameters.Subjects and methods: A total of 95 subjects were enrolled in this study, age ranged (35 – 55) years divided into 3groups: Group I consist of 45 rheumatoid arthritis patients with periodontitis, while group II consist of 35 rheumatoidarthritis patients without periodontitis and group ÉÉÉ which consist of 15 apparently- healthy controls. . Periodontalparameters used in this study were plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinicalattachment level (CAL) and bleeding on probing (BOP). Blood samples were collected from each subject todetermine serum concentrations of ACCP by means of enzyme-linked immune-sorbent assay (ELISA).Results: present study revealed that serum ACCP levels were significantly higher in rheumatoid patients withperiodontitis (P<0.001) than that in other two groups. Regarding the correlation between serum ACCP levels andperiodontal parameters, the current study showed positive correlation between serum ACCP and each of plaqueindex, gingival index and probing pocket depth.Conclusion: The current results provide strong evidence of association between periodontitis and rheumatoid arthritis,and suggested that periodontitis may play an important role in activation and triggering immune response

Keywords

Background: Rheumatoid arthritis --- RA and periodontitis --- PD are widely prevalent diseases and are characterized by tissue destruction due to chronic inflammation. Recently --- there is growing evidence that the two diseases share many pathological features. An association between periodontitis and rheumatoid arthritis has been considered many years ago. The current study was established to evaluate the serum ACCP levels in rheumatoid arthritis patients with and without periodontitis --- in addition to study the correlation between serum ACCP levels and periodontal parameters. Subjects and methods: A total of 95 subjects were enrolled in this study --- age ranged --- 35 – 55 years divided into 3 groups: Group I consist of 45 rheumatoid arthritis patients with periodontitis --- while group II consist of 35 rheumatoid arthritis patients without periodontitis and group ÉÉÉ which consist of 15 apparently- healthy controls. . Periodontal parameters used in this study were plaque index --- PI --- gingival index --- GI --- probing pocket depth --- PPD --- clinical attachment level --- CAL and bleeding on probing --- BOP. Blood samples were collected from each subject to determine serum concentrations of ACCP by means of enzyme-linked immune-sorbent assay --- ELISA. Results: present study revealed that serum ACCP levels were significantly higher in rheumatoid patients with periodontitis --- P<0.001 than that in other two groups. Regarding the correlation between serum ACCP levels and periodontal parameters --- the current study showed positive correlation between serum ACCP and each of plaque index --- gingival index and probing pocket depth. Conclusion: The current results provide strong evidence of association between periodontitis and rheumatoid arthritis --- and suggested that periodontitis may play an important role in activation and triggering immune response

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