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Article
Transurethral Microwave Thermotherapy (TUMT) For Benign Prostatic Hyperplasia

Author: Firas Shakir Attar
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 1 Pages: 24-26
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Benign prostatic hyperplasia (BPH) is one of the most common diseases of the aging male. Minimally invasive therapies for treatment of BPH compete with the gold standard transurethral resection of the prostate (TURP). The aim of this study is to assess the efficacy of transurethral microwave therapy (TUMT) in patients with otherwise poor general health.METHODS:Thirty (30) patients with associated chronic medical diseases and lower urinary tract symptoms due to BPH were subjected for TUMT as an outpatient single session procedure, from June 2001 to August 2005. Follow up was performed 2 weeks, and then one month following treatment clinically and by assessing residual urine volume, maximal flow rate and prostate size.RESULTS:Out of (28) treated patients, (21) were labeled as non – responders as they were unable to pass urine freely 2-weeks after a trial of decatheterisation. In contrast (7) patients passed urine freely after decatheterisation. In the latter group, it was found that there was no statistical significance of the values of maximum flow rate, residual urine volume or prostate size between pre- and one month post TUMT.CONCLUSION:TUMT is a possible option for the treatment of BPH in poor general health patients or those refusing other surgical modalities. However, it did not prove to be effective for those patients with chronic urinary retention and BPH


Article
The Role of Celecoxib for Treatment of Refractory Nocturia Caused by Benign Prostatic Hyperplasia

Authors: Mohammed Bassil Ismail --- Adil Hefdhi Al.soufi --- Hasanin Farhan Hasan
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2014 Volume: 11 Issue: 2 Pages: 428-436
Publisher: Babylon University جامعة بابل

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Abstract

Objective: Nocturia is a well-recognized symptom in patient with benign prostatic hyperplasia ( BPH), which is commonly treated by alpha- blocker and/ or 5 alpha - reductase inhibitors. However, the effectiveness of these drugs for nocturia has been reported to be only 25%- 39%. The aim of this study was to investigate the efficacy of celecoxib, a cyclooxygenase -2 inhibitor, in the treatment of patient with BPH complaing of nocturia.Patients and methods: A prospective study of 50 men with signs tract symptoms and BPH of refractory nocturia to alpha- blocker and/ or 5 alpha reductase inhibitor more than two episodes of nocturia per night were involved for nocturia. Although these patients had received standard drug therapy for more than one month , they had still three or more episodes of nocturia. The patients took a single dose of 100 mg of celecoxib at night prior to sleep. and 2 week after the initiation of this therapy, the effects of this treatment were assessed by frequency chart and a questionnaire.Results: In the questionnaire ,32 of 50 patients (64%) had an excellent response with celecoxib treatment than previous treatments, 14 of 50 patients (24%) had an improvement with celecoxib treatment than previous treatments, 4 of 50 patients (8%) had no response with celecoxib treatment, Nocturnal frequency showed a statistically significant reduction from, baseline after two weeks treatment with celecoxib (P < 0.01), International Prostate Symptom Score( IPSS) showed a statistically significant reduction from baseline after two weeks treatment with celecoxib (P < 0.01), peak flow rate showed a statistically no response from baseline after two weeks treatment with celecoxib (P < 0.05).Conclusion: Celecoxib is effective in the treatment of patients with BPH complaining of refractory nocturia. The results suggest a novel treatment option for this common condition.

الهدف: ان هدف الدراسة هو لتحديد فعالية عقار السيليكوكسب في معالجة التبول الليلي عند مرضى تضخم البروستات الحميد.منهج الدراسة: اشتملت الدراسة على 50 مريضا يعانون من التبول الليلي لاكثر من مرتين نتيجة لتضخم البروستات الحميد تتراوح اعمارهم بين (50-75). وقد جمع المرضى من الاستشارية البولية في مدينة الطب في بغداد للفترة من شهر حزيران 2010 الى شهر اب 2011. علما ان هؤلاء المرضى مستمرين على علاج تضخم البروستات الحميد التقليدي لاكثر من شهر وبالرغم من ذلك الا انهم ضلوا يعانون من التبول الليلي لاكثر من مرتين.اعطي هؤلاء عقار السيليكوكسب 100 ملغم مرة واحدة يوميا قبل النوم.وقمنا باحتساب عدد مرات التبول الليلي قبل وبعد اسبوعين اعطاء المرضى عقار السيليكوكسيب اظهرت النتائج بان 32 من المرضى ال50 كانت فعالية العقار عندهم ممتازة.نتائج الدراسة: حسب المقياس الشخصي اظهرت النتائج بان32 (64%) من المرضى كانت فعالية العقار لديهم ممتازة و14 (28%) من المرضى كانت فعالية العقار لديهم مقبولة و 4(8%) ليس لديهم اي استجابة للعقار.الاستنتاج: اثبتت الدراسة فعالية عقار السيليكوكسب في علاج التبول الليلي لدى المرضى الذين يعانون من تضخم البروستات الحميد.


Article
Study the Toxic Effect of Different Doses of Duprost in Liver and Blood of Albino Mice
دراسة التاثير السمي للجرع المختلفة من عقار Duprost في كبد ودم الفئران البيض

Authors: Ban Jasim Mohamad بان جاسم محمد --- Hind Hussein Obaid هند حسين عبيد --- Duha Ibraheem Mohamad ضحى ابراهيم محمد --- Maha Salim Yaseen
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2017 Volume: 58 Issue: 3B Pages: 1381-1392
Publisher: Baghdad University جامعة بغداد

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Abstract

The aim of this study is to investigate the effect of different doses of Duprost in the liver and blood of albino mice. The current study included twenty one albino mice, obtained and grouped into 3 groups: control (3 mice), acute group (12 mice) and chronic group (6 mice). The acute group was subdivided into 4 groups and each group of 3mice, was given a lonely oral dose of (0.25ml, 0.15ml, 0.1 ml and 0.05ml respectively) for 24 hours. Whereas the third group was subdivided into 2 groups and each set was given a daily dose of (0.15ml and 0.05 ml respectively) for 30 days. After the mentioned periods, blood samples from each animal were taken for blood analysis. Then, the mice of all groups were sacrificed and the livers were removed, processed, sectioned and stained for histological analysis. In acute group, all mice that dosed with (0.25 ml) dose, died after 15 minutes of dosing. Blood results showed significant decrease in Hb level, WBC's and platelets' count among acute subgroups in comparison with chronic subgroups which showed significant increase in WBC and platelets' count, but a significant decrease in Hb levels. The histological analysis of liver in acute subgroups showed different forms of liver inflammation among acute subgroups, in comparison with chronic subgroups which showed formation of granulomatous lesions in the liver parenchyma in high dose(0.15ml) but there were inflammatory cells' aggregation in liver parenchyma among lower doses.

تهدف هذه الدراسة الى التحري عن تاثير الجرع المختلفة من عقار Duprost في كبد ودم الفئران البيض. شملت الدراسة 21 فارا تم تقسيمها الى ثلاث مجاميع هي : مجموعة السيطرة (3) فئران, مجموعة الاصابة الحادة (12) فأرا والتي قسمت بدورها الى 4 مجاميع ثانوية اعطيت كل مجموعة منها جرعة فموية واحدة من الحجوم التالية (0.05ml, 0.1 ml ,0.15ml ,0.25mlعلى الترتيبب) لمدة 24 ساعة. اما المجموعة الثالثة مجموعة الاصابة المزمنة ضمت (6) فئران والتي قسمت بدورها الى مجموعتين ثانويتين كل منهما ضمت 3 فئران وتم تجريعها يوميا بجرعة فموية واحدة من الجرع التالية (0.05ml, 0.15ml) لمدة 30 يوم. بعد انقضاء المدة المحددة لكل مجموعة تم سحب عينات الدم من كل فأر لاجراء التحاليل المختلفة وايضا تم تشريح الحيوانات واستخراج الكبد وتقطيعه الى شرائح وتصبيغها لغرض الدراسة النسيجية. اظهرت نتائج مجموعة الاصابة الحادة موت جميع الفئران التي جرعت بجرعة (0.25 ml) من الدواء بعد 15 دقيقة من التجريع. بينما اظهرت نتائج الدم حدوث انخفاض معنوي في مستوى الهيموغلوبين وكذلك تعداد الكريات البيض والصفيحات الدموية في مجموعة الاصابة الحادة مقارنة بمجموعة الاصابة المزمنة التي اظهرت ارتفاعا في مستويات الكريات البيض والصفيحات بينما كان هناك انخفاض في مستوى الهيموغلوبين فيها. اما نتائج الدراسة النسيجية في مجموعة الاصابة الحادة فقد اظهرت وجود اشكال مختلفة من الالتهاب في نسيج الكبد بين مجاميعها الثانوية بمجموعة الاصابة المزمنة التي اظهرت وجود اورام حبيبية في النسيج الحشوي للكبد عند الجرع العالية من الدواء في حين كان هناك تجمع للخلايا الالتهابية عند الجرع الاوطأ.


Article
The Effect of Acute Urinary Retention on The Accuracy of Serum Prostate-Specific Antigen Level Measurements

Author: Ehab Jasim Mohammad
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 1 Pages: 118-122
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:The level of PSA in serum is increased by inflammation of the prostate, urinary retention,prostaticinfection, benign prostatic hyperplasia,prostate cancer, and prostatic manipulation. [3]OBJECTIVE:To study the effect of acute urinary retention on the serum prostate-specific antigen (PSA)concentration.METHODS:Blood samples for serum PSA measurement were obtained (PSA1), and an indwelling urethralcatheter was inserted for 2 weeks. Before catheter removal, a second blood sample for measurementof serum PSA level (PSA2) was obtained. In patients who were able to void, a third sample wasobtained 3 weeks later (PSA3). In the first and second visits, digital rectal examinations (DRE1,DRE2) were performed to assess prostate volume. Mean PSA levels (PSA1, PSA2, and PSA3) andprostate volumes (DRE1, DRE2) were compared.RESULTS:Fourty-two patients with a mean age of 70.18 years (range 56 to 85 years) participated in thisstudy.mean PSA level at the time of AUR (PSA1) was 7.02 ng/mL (median, 5.8 ng/mL; range, 0.9 to30.4 ng/mL). The mean PSA2 level was 5.5 ng/mL (median, 3.9 ng/mL; range, 0.7 to 39 ng/mL),lower than the PSA1 level .This association was statistically non significant P > 0.05. The meanprostate volume at the time of DRE1 (43.4 mL; median, 45 mL; range, 30 to 60 mL) wassignificantly higher than at DRE2 (37.8 mL; median, 40 mL; range, 25 to 50 mL) (P < 0.001).PSA3 was measured in 42 patients 4 weeks after retention (2 weeks after catheter removal). In thisgroup of patients, mean PSA2 and PSA3 levels were 5.5 ng/mL and 5.1 ng/mL, respectively (median,3.9 and 3.5, respectively, P > 0.05).CONCLUSION:Acute urinary retention can increase serum PSA levels. In this series, we found that this effect maycontinue up to 2 weeks.


Article
Isolation & Partial Purification of Testosterone Receptors in Benign & Malignant Prostatic Tumors

Author: Omar F. Abdul‐Rasheed
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2009 Volume: 8 Issue: 1 Pages: 46-52
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background A gel filtration technique has been used for the isolation and purification of soluble testosterone receptors from benign and malignant prostatic tumors. Two types of testosterone receptors from benign and malignant prostatic tumors were eluted from the sephadex G-200 column. This work was carried out to characterize and quantify human nuclear androgen receptors from benign and malignant prostatic tumors. Methods The study involved twenty five patients with benign prostatic hyperplasia (BPH) and thirteen patients with prostatic adenocarcinoma (PCA) attending Al-Kadhimiya teaching hospital from the period of November 2005 till july 2006. Results The purification folds of two benign separated receptors (BI & BII) were 11.588 and 19.582 fold respectively whereas for the two malignant separated receptors (MI & MII) were 24.280 and 29.111 fold respectively.The choice of most appropriate conditions of the binding of 125I-testosterone with its receptors were also carried out.The concentrations of binding sites and the equilibrium dissociation constants for the binding between 125I-testosterone and its purified receptors have been determined using Scatchrad analysis and the specificity of the binding has been examined. The concentrations of two benign separated receptors (BI & BII) were 0.931 and 1.140 pmole/mg protein respectively whereas separated malignant receptors (MI & MII) have 1.056 and 2.163 pmole/mg protein respectively at 37ºC. Conclusions Gel filtration technique and Scatchard analysis confirmed the presence of two types of testosterone receptors in each tumor type. The first eluted receptor (I) has a relatively higher molecular weight with a lower affinity constant for testosterone binding than the other(II).


Article
Isolation & Partial Purification of Testosterone Receptors in Benign & Malignant Prostatic Tumors

Author: Omar F. Abdul-Rasheed
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2008 Volume: 7 Issue: 2 Pages: 46-52
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: A gel filtration technique has been used for the isolation and purification of soluble testosterone receptors from benign and malignant prostatic tumors. Two types of testosterone receptors from benign and malignant prostatic tumors were eluted from the sephadex G-200 column. This work was carried out to characterize and quantify human nuclear androgen receptors from benign and malignant prostatic tumors.Methods: The study involved twenty five patients with benign prostatic hyperplasia (BPH) and thirteen patients with prostatic adenocarcinoma (PCA) attending Al-Kadhimiya teaching hospital from the period of November 2005 till july 2006.Results: The purification folds of two benign separated receptors (BI & BII) were 11.588 and 19.582 fold respectively whereas for the two malignant separated receptors (MI & MII) were 24.280 and 29.111 fold respectively.The choice of most appropriate conditions of the binding of 125I-testosterone with its receptors were also carried out.The concentrations of binding sites and the equilibrium dissociation constants for the binding between 125I-testosterone and its purified receptors have been determined using Scatchrad analysis and the specificity of the binding has been examined. The concentrations of two benign separated receptors (BI & BII) were 0.931 and 1.140 pmole/mg protein respectively whereas separated malignant receptors (MI & MII) have 1.056 and 2.163 pmole/mg protein respectively at 37ºC.Conclusions: Gel filtration technique and Scatchard analysis confirmed the presence of two types of testosterone receptors in each tumor type. The first eluted receptor (I) has a relatively higher molecular weight with a lower affinity constant for testosterone binding than the other(II).


Article
Procaspase- 3 Status in Benign Prostatic Hyperplasia and Carcinoma (A Correlative Retrospective Study)

Author: Alaa A. Qader* MBChB, MSc
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 3 Pages: 316-319
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary: Background: Benign prostatic hyperplasia and prostatic adenocarcinoma are two of the most common pathologic mass lesions. Both are encountered mainly in elderly males. The caspases family is a group of at least 15 known proteases that serve as initiator & effector molecules of the apoptosis pathway. Caspase-3, in particular, is thought to play a pathogenetic role in both prostatic hyperplasia and carcinoma. Finasteride is a medication that has routinely been given to patients with hyperplasia and carcinoma; its prostate size-reducing effect is thought to be mediated through caspases.Patients and methods: fifty patients with prostatic mass lesions were included in this study (20 with hyperplasia & 30 with adenocarcinoma); all were on finasteride treatment. The carcinoma cases were graded according to Gleason scoring system. All cases were analyzed for procaspase-3 strength of staining. Results: benign hyperplasia & well-differentiated carcinomas show high expression of procaspase-3, in contrast loss of expression of this marker was noted in moderately & poorly differentiated carcinomas. Conclusion: there is a strong statistical correlation between caspase-3 expression and the degree of tumor differentiation. This may allow the utilization of this marker as a potential prognostic factor, especially in limited biopsy samples. Key words: prostatic hyperplasia, prostatic adenocarcinoma, procaspase-3, Gleason grade


Article
Molecular Localization of Epstein Barr Virus and Rb Tumor Suppressor Gene Expression in Tissues from Prostatic Adenocarcinoma and Benign Prostatic Hyperplasia
التموضع الجزيئي للتعبير الجيني لراشح الابشتاين بار والجين الكابت السرطاني Rb في أنسجة البروستات السرطانية والحميدة

Author: Saad Hasan Mohammed Ali 1 Shakir H. Mohammed Al-Alwany 2
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2014 Volume: 13 Issue: 2-2 Pages: 161-172
Publisher: Baghdad University جامعة بغداد

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Abstract

Epstein- Barr virus (EBV) is a ubiquitous in that infecting more than 90% of adult population worldwide. Recently, EBV has been linked to the development of variety of human malignancies including prostate tissues that range from benign prostatic hyperplasia (BPH) to prostatic adenocarcinoma (PAC). Somatic point mutations in Rb gene have been detected in prostate cancer and are involved in progression steps of prostate carcinogenesis. To analyze the distribution and impact of concordant Rb expression and latent EBV infection on a group of prostate adenocarcinoma and benign prostatic hyperplasia. Seventy- two formalin-fixed, paraffin- embedded prostatic tissues were obtained in this study; 40 biopsies from prostatic carcinoma and 20 from benign prostate hyperplasia as well as 12 apparently normal prostatic autopsies control group. Detection of EBV-EBERs was done by ultra-sensitive version of in situ hybridization method where as immunohistochemistry detection system was used to demonstrate the expression of Rb gene. Detection of EBV-EBERs -ISH reactions in tissues with PAC was observed in 19 out of 40 (47.5%), while in the tissues from BPH was detected in 10% (2 out of 20). No EBV-EBERs positive – ISH reaction was detected in healthy prostate tissues in the control group. The differences between the percentages of EBERs detection in tissues PAC and each of BPH & control groups were statistically highly significant (p < 0.01). Positive Rb immune histo chemical (IHC) reactions were observed in 19 PAC cases (47.5%) and in 2 BPH cases (10%). Our results indicate that the EBV might contribute to the development of subset of prostate tumors. In addition, the significant percentage of expression of possible Rb gene as well as EBV in prostate adenocarcinoma could indicate for an important role of these molecular and viral factors in prostatic carcinogenesis.

ايبشتاين- بار فيروس (EBV) فايروس يتواجد في كل مكان و يصيب أكثر من 90٪ من السكان البالغين في جميع أنحاء العالم. في الآونة الأخيرة تم ربط EBV في تطور مجموعة متنوعة من الأورام الخبيثة للإنسان بما في ذلك أنسجة البروستات التي تتراوح من تضخم البروستات الحميد (BPH) الى سرطان غدية البروستات الخبيث (PAC). تم الكشف عن الطفرات النقطية الجسمية في جينات الريتينوبلاستوماRB في سرطان البروستات والتي تشارك في خطوات تطور سرطان البروستات. الغرض من الدراسة عن الكشف عن علاقة ايبشتاين- بار فيروس (EBV) للإصابات الكامنة وتأثير تعبير جين الريتينوبلاستوماRB على مجموعة من مرضى سرطانات غدية البروستات وتضخم البروستات الحميد. تم الحصول على اثنين وسبعين عينة مريض لأنسجة البروستات المثبتة بالفورمالين، والتي مثلت عينات الدراسة وكالاتي: اربعون خزعه من سرطان غدية البروستات وعشرون خزعه من تضخم البروستات الحميد فيما مثلت اثنا عشر خزعه من انسجة البروستات للاشخاص السليمين كمجموعة سيطرة. تم الكشف عن ايبشتاين- بار فيروس (EBV) بوساطة طريقة التهجين الموقعي ذات الحساسية العالية. بينما تم استخدام تقنية الفحص الكيمائي المناعي النسجي للتدليل على تعبير جينات الريتينوبلاستوماRB . اظهرت نتائج الكشف عن ايبشتاين- بار فيروس (EBV) بوساطة طريقة التهجين الموقعي ذات الحساسية العالية (ISH) في انسجة سرطان غدية البروستات نسبة 47.5٪ (19 من 40 عينه)، بينما في انسجة بروستات الورم الحميد BPH)) كانت نسبة الإصابة 10٪ (2 من 20عينه). لا توجد نتائج موجبة للاصابة ب ايبشتاين- بار فيروس (EBV) في انسجة البروستات للأشخاص السليمين المستخدمين كمجموعة سيطرة. اظهر التحليل الاحصائي للفروق بين النسب المئوية للكشف عن ايبشتاين- بار فيروس (EBV) في انسجة سرطان غدية البروستات PAC وكل من وتضخم البروستات الحميد BPH ومجموعة السيطرة فرقا معنويا عاليا عند (0.01< P). كانت نتائج الفحص الكيمائي المناعي النسجي لسرطان غدية البروستات إيجابية بنسبة 47.5% (19من 40 عينه) وفي تضخم البروستات الحميد بنسبة10٪ (2 من 20 عينه) بينما في مجموعة السيطرة كانت النتائج سلبية.نتائج الدراسة الحالية تشير إلى أن EBV قد تسهم في تطوير فرعية من أورام البروستات. وبالإضافة إلى ذلك، يمكن للنسبة الكبيرة من التعبير الجيني لـ RB لهما دوران مهمان كعوامل فايروسية وجزيئية في تسرطن البروستات.


Article
Expression of Transforming Growth Factor β Type I and II Receptor in Prostate Cancer
تعبير مستقبلات عامل تحويل النمو (TGF-β) النوع الاول والثاني في سرطان البروستات

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Abstract

This study was carried out to establish the correlation between expression of Transforming growth factor beta receptor one (TGF-βRI) and Transforming growth factor beta receptor two (TGF-βRII) and prostate cancer progression, and to establish the role of prostate cancer development. Immunohistochemistry (IHC) technique was used to detect the level of expression of TGF-βRI and TGF-βRII protein in tissues of patients and healthy control groups. TGF-βR1 protein was expressed in 3 (18.7%) and 14 (56%) of poorly and moderately differentiated malignancy respectively. There was significant difference in mean level of TGF-βRI protein expression among all studied groups. TGF-βRII protein was expressed in 6 (37.5%) and 22 (88%) of poorly and moderately differentiated malignancy respectively, There was significant difference in mean level of TGF-βRII protein expression among all studied groups. We concluded that there was statistically significant association between the loss of expression of TGF-β1 signaling receptors, especially TGF-βRI, and increasing grades of malignancy in prostate cancer, leading to a more malignant phenotype.

سرطان البروستات هو الورم الخبيث الاكثر شيوعا والسبب الرئيسي الثاني لوفيات السرطان ذات الصلة بين الذكور. سرطان البروستات ينشأ في البروستات, الغدة التي تقع تحت المثانة وفقط امام المستقيم . الالتهاب هوعملية فسيولوجية جوهرية والتي يمكن ان تنشأ في أي نسيج استجابة الى ضرر الصدمات وضرر الاصابات والضرر المتسبب بواسطة المناعة الذاتية . عامل تحويل النمو بيتا 1(TGF-β1) هو المنظم المحتمل لنمو الخلايا السرطانية في البروستات والذي يبعث إشارات من خلال معقد متباين مؤلف من النوع 1 والنوع 2 من المستقبلات .أجريت هذه الدراسة لتحديد العلاقة بين التعبير عن عامل تحويل النمو بيتا 1(TGF-β1) ,المستقبل الاول لعامل تحويل النمو بيتا (TGF-βR1),المستقبل الثاني لعامل تحويل النمو بيتا (TGF-βR2) و تطور سرطان البروستات. وكذلك لتحديد دور الانترلوكين17 في تطور سرطان البروستات. تم استخدام تقنية التعبير المناعي النسيجي الكيميائي (IHC) في الكشف عن مستوى التعبير عن عامل تحويل النمو بيتا 1(TGF-β1) , المستقبل الاول لعامل تحويل النمو بيتا (TGF-βR1), المستقبل الثاني لعامل تحويل النمو بيتا (TGF-βR2) بروتين في انسجة مرضى سرطان البروستات ومجموعة السيطرة. تم استخدام تقنية التعبير المناعي النسيجي الكيميائي (IHC) ايضا لدراسة تعبير المستقبل الاول لعامل تحويل النمو بيتا (TGF-βR1) في نسيج البروستات . أظهرت النتائج بأن هذا البروتين تم تعبيره في 3 (18.7%) و 14 (56%) من الورم الخبيث ضعيف و متوسط التمايز على التعاقب, مع تفاعل ضعيف للصبغة المناعية هي النتيجة الاكثر شيوعا. كان هنالك اختلاف واضح بمعدل مستوى تعبير بروتين المستقبل الاول لعامل تحويل النمو بيتا بين كل المجاميع المدروسة. المستقبل الثاني لعامل تحويل النمو بيتا (TGF-βR2) هو بروتين تم تعبيره في 6 (37.5%) و 22 (88%) من الورم الخبيث ضعيف و متوسط التمايز على التعاقب, مع تفاعل ضعيف للصبغة المناعية هي النتيجة الاكثر شيوعا. كان هنالك اختلاف واضح بمعدل مستوى تعبير بروتين المستقبل الثاني لعامل تحويل النمو بيتا (TGF-βR2) بين كل المجاميع المدروسة.


Article
THE EFFECT OF BODY MASS INDEX AND WAIST CIRCUMFERENCE ON PROSTATE SPECIFIC ANTIGEN IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA (BPH)

Author: Saad D. Farhan سعد داخل فرحان
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2011 Volume: 9 Issue: 1 Pages: 34-40
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Obesity may be associated with lower prostate specific antigen(PSA) values, If true, this would result in fewer obese men having an elevated PSA, fewer biopsies performed, and fewer cancers detected , consequently cancers may be missed or not detected until at a more advanced stage.Objective: We examined the influences of age, body mass index (BMI) and waist circumference (WC) on PSA before and after adjusting for prostate volume. We also examined associations among age, body mass index, waist circumference and prostate volume (PV).Methods: We analyzed 125 Iraqi men aged 40 to 84 years old who attained the urological outpatient clinic for BPH evaluation during 2009. Curent health status information including prostate related problems, medical interview, basic physical examination and anthropometric measurements including height, weight, BMI and waist circumference were taken for all patients. Blood tests including PSA concentration were performed after overnight fast. A radiologist performed transrectal prostate ultrasound. PSA measurements preceded routine digital examination and transrectal prostate ultrasound.Results: The median serum PSA was significantly lower among obese subjects compared to normal BMI subjects. BMI showed a statistically significant moderately strong negative linear correlation (r = -0.5) with serum PSA. Waist circumference showed a similar pattern with a statistically significant linear correlation with serum PSA (r = -0.43); the median serum PSA was significantly lower among subjects with highest waist circumference compared to subjects in the lowest quartile of waist circumference. The median PSA was significantly higher among subjects with large prostate size compared to those with lowest quartile prostate size. The anthropometric measures were tested for association with PSA density, to adjust for the effect of prostate size on serum PSA.Conclusion: The current data suggest that the PSA cut-points used to recommend biopsy need to be adjusted for the degree of obesity.Keywords: body mass index, waist circumference, prostate specific antigen.

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