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HISTOPATHOLOGICAL STUDY OF R- FSH EFFECTS ON FEMALE REPRODUCTIVE SYSTEM, LIVER AND KIDNEYS IN RATTUS NORVEGICUS RATS

Authors: Noora S. Ghalib --- Batool S. Hamza --- Kassim F. Abdulkareem
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2017 Volume: 16 Issue: 2 Pages: 334-343
Publisher: Basrah University جامعة البصرة

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Abstract

The present study aims to evaluate the histopathological changes induced by recombinantfollicle stimulating hormone (follitropin alpha) on reproductive organs as well as the liver andkidneys of female rats. The experiment was done on 24 white female rats (Rattus norvegicus)sexually mature weighing 150-200 gram, divided into 4 equal groups of 6 animals: control groupwhich was given distilled water. Single dose group, double dose group and triple dose groupswhich were injected by 0.5 iu.,1 iu. and 1.5 iu of recombinant FSH respectively. The drug wasgiven subcutaneously during the pro-estrous phase for ten consecutive cycles, then animals fromeach group were sacrificed to study the histopathological changes. The histopathologicalexamination of the ovaries, uterus, liver, and kidneys revealed variable changes in differentorgans.The ovarian sections showed many Graafian follicles without ova and many corpus lutealcysts, fibrosis, and thickened granulosa cell layer, and the ovary was surrounded by excessiveadipose tissue. The uterus in single and double doses showed dilated cavity, thin endometrium,thin muscular layer and diminished endometrial glands while in triple dose showed atrophy ofendometrial lining and glands, hypertrophied muscular layer with slit like endometrial cavity andformation of multiple endometrial cyst. The liver sections showed few changes like dilatedcentral vein, congestion of sinusoids, vacuolation of hepatocytes, with moderate degree of fattydegeneration A few hepatocytes appeared necrotic but without inflammatory response. Thekidneys in single and double doses showed unremarkable changes, while in triple doseglomerular congestion, congested vessels, hemorrhage, and degeneration and necrosis ofproximal tubules were found.

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