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Article
Short Term Effects of Antiepileptic Drugs on the Heart Using Electrocardiograph as an Assessment Tool of Investigation: A Pilot case Finding Study

Author: Sura A. Al-Mahdawi *, Marwan S.M. Al-Nimer**,Namir M.T. Bdullah ***
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2015 Volume: 14 Issue: 4 Pages: 492-498
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Antiepileptic drugs can induce changes in the electrocardiograph (ECG) records including prolongation of QT interval but there is no evidence to link this effect with the sudden death that reported in epilepsy. The new generations of antiepileptic drugs showed variable effect on the heart. Lamotrigine did not prolonged the QT interval in healthy subjects while levetiracetam prolonged the QT interval in patients cardiac channelopathy presented with congenital long QT syndrome.OBJECTIVE:This study aimed to investigate effects of antiepileptic drugs that prescribed in a therapeutic regimen to new cases of epilepsy as a part of management on the ECG records at the end of the 1st three months of treatment.PATIENTS AND METHODS: A total number of 25 patients, presented for the first time with epilepsy, were recruited from Al-Yarmouk Teaching hospital. Each patient was assessed clinically by consultant neurology prior to enrollment in the study. An electrocardiogram (ECG) was obtained at the time of entry into the study prior to the admission of the study and after three months of treatment with antiepileptic drugs. In addition to the measurements of heart rate and different ECG intervals, a QT-nomogram and cardiac restitution were used in analysis.RESULTS:At the time of entry, three patients had a significant short corrected QT interval (QTcB); four patients had a borderline QTcB interval; and one patient had prolonged QTcB interval. QT-nomogram revealed that many patients have abnormal interval and antiepileptic drugs significantly reduced the relaxation phase of cardiac cycle and prolonged the ventricular repolarization.CONCLUSION:Antiepileptic drugs carried a harmful effect on the heart and their assessment should be not restricted in the measurement of QT interval before and after treatment or to study their effects on the healthy subject as epilepsy is commonly associated with mutation of sodium and/or potassium channels. Case finding of significant prolonged QT interval in respect to gender and age, assessment of QT nomogram and cardiac restitution are useful tools to identify the patients who are at risk of arrhythmias.

Keywords

KEY WORDS: epilepsy --- ECG --- QTcB --- restitution.


Article
Restitution to cancel the disciplinary in iraq
ردّ الاعتبار في إلغاء العقوبة الانضباطيّة في العراق (دراسة مقارنة)

Author: saeb mohammed صائب محمد ناظم الموسوي
Journal: Risalat al-huquq Journal مجلة رسالة الحقوق ISSN: 20752032 Year: 2016 Volume: 8 Issue: 1 Pages: 268-279
Publisher: Kerbala University جامعة كربلاء

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Abstract

Standing theoretical and practical research topic restitution to cancel the disciplinary sanctions with a view to writing off the sanctions fully for the past and the future and raise the administrative orders issued under or appear to remove its implications for the future only, by request by the employee Punisher or under certain administrative actions taken by the administration on its own If what specific conditions include the elimination service functional real satisfying for a certain period in the job in order not to commit disciplinary infractions and encouragement to move toward job performance optimization to achieve the public interest available .

تبدو المكانة النظريّة والعمليّة لموضوع البحث ردّ الاعتبار في إلغاء العقوبة الانضباطيّة بقصد شطب العقوبة بشكل كامل بالنسبة للماضي والمستقبل ورفع الاوامر الادارية التي صدرت بموجبها أو إزالة آثارها بالنسبة للمستقبل فقط ، وذلك بواسطة طلب من قبل الموظف المعاقب او بموجب إجراءات ادارية معينة تتخذها الادارة من تلقاء نفسها إذا ما توافرت شروط محددة تتضمن قضاء خدمة وظيفيّة فعليّة مُرضيّة لمدة معينة في وظيفته بهدف عدم ارتكاب المخالفات الانضباطيّة والتشجيع للتوجه نحو الاداء الوظيفي الامثل لتحقيق المصلحة العامة .

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