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Article
Salivary gland tumors: A review of 171 cases, with particular reference to histological types, site, age and gender distribution

Author: Faris I. Al-Khiro
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2014 Volume: 26 Issue: 1 Pages: 88-91
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Salivary tumors are uncommon, being of low incidence worldwide. This study aimed to assess casescollected in this series of salivary gland tumors in regard to histopathological typing, in relation to age, siteand gender.Materials and methods: This is a retrospective study; cases were collected from public and private laboratories. Atotal number of 171 cases were collected. The slides were reviewed and reclassified for histopathological typingaccording to WHO classification 2005.Results: Benign tumors were more common than malignant tumors. The most common histological type was benignmixed tumor, followed by Warthin’s tumor. The most common malignant tumor was adenoid cystic carcinoma. Onehundred twenty three cases out of 171 cases developed in the parotid, the most common site for salivary tumors,with a low risk for malignancy, while minor salivary glands show higher risk for malignancy. Salivary tumors developedin females more than males with a ration 1.4:1, the peak incidence in the sixth and seventh decades for both benignand malignant tumors. There was no significant difference between right and left tumors, bilateral tumors wereuncommon.Conclusions: The results of this study reveal similarity to the findings of other studies on salivary tumors done in Iraq andthe neighboring countries


Article
Immunohistochemical Expression of P53 in Benign Pleomorphic Adenomas of Salivary Glands: A clinicopathological Study

Authors: Layla Horamy Fatah --- Ameera Kamal Khaleel
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 3 Pages: 642-652
Publisher: Babylon University جامعة بابل

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Abstract

Pleomorphic adenoma (PA) is the most common benign neoplasm of the salivary gland and shows remarkable morphological diversity. It, malignant transformation is not very rare. Mutation in the tumor suppressor gene (p53) may lead to the progression of this tumor. The purpose of this study was to analyze the immunohistochemical expression of p53 in salivary glands PAs in relation to sex, age, primary anatomical site, the duration, size and histopathological subtype of the tumor. The materials used in this study consist of (45) paraffin-embedded salivary gland biopsy specimens of benign pleomorphic adenoma of salivary gland. The p53 immunoreactivity was semi-quantitatively evaluated in 1000 cells examined under the microscope at x40 magnification and recorded as percentage of p53 positive tumor cells over the total number of cells examined in the area. PAs showed negative expression of p53 in 60% of cases. The p53 labeling index was ranging between 6% to 70%. Statistical analysis showed no significant relation of the mean labeling indices with the sex, age, duration of the tumor, size, and histopathological subtype (p>0.05), but it showed significant relation with the gland site (p<0.05).


Article
Immunohistochemical Expression of P53 and bcl-2 in benign and malignant salivary glands tumors

Authors: Dr. Husam Omer Mohammed M.Sc ** د. حسام عمر --- Dr. Jamal N. Ahmed M.Sc* د. جمال احمد --- Dr. Natheer H. AL-Rawi M.Sc, Ph.D * د.نذير الراوي
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2007 Volume: 4 Issue: 1 Pages: 13-21
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Objectives: Salivary glands tumors are relatively uncommon neoplasm with widely variable histopathologic and biologic characteristics. Alteration in some proto-oncogenes and tumor suppressor genes may lead to the development and progression of these tumors. The purpose of the present study was to analyze the immunohistochemical expression of P53 and bcl-2 in some salivary gland tumors in relation to tumor size, histological grade and extent of invasion.Study Design: The series consisted of 22 formalin-fixed paraffin embedded blocks of salivary glands tumors collected from the files of Oral pathology Department./College of Dentistry/ Baghdad University. The specimens consisted of (10) benign salivary gland tumors ( Pleomorphic Adenomas) and (12) malignant salivary gland tumors [ (2) Carcinoma ex Pleomorphic Adenoma, (3) Muco-Epidermoid Carcinoma, (2) Adenocarcinoma (5) Adenoid cystic carcinoma]. These were analyzed for immunohistochemical detection of P53 and bcl-2 in their cell types.Results: Pleomorphic Adenoma showed negative expression of P53 and bcl-2 in 70% of cases, whereas all malignant salivary glands tumors were positive for P53 and bcl-2. P53 and bcl-2 immune-reactivity were associated with larger tumor size, higher tumor grade and greater extent of invasion without reaching statistical significance level.Conclusion: P53 expression could be used as a useful tumor marker for malignant transformation of Pleomorphic adenoma and bcl-2 expression could be used as a useful monitor for measuring the aggressiveness of these neoplasms.


Article
Diagnostic Value of Fine Needle Aspiration Cytology (FNAC) in Salivary Gland Tumors

Authors: Atheer Talib Jiboon --- Najwa Jamil AbdulRazzak --- Sabah Abdulaziz
Journal: Journal of Oral and Dental Research مجلة طب الفم والاسنان ISSN: 23106417 Year: 2017 Volume: 4 Issue: 2 Pages: 130-139
Publisher: Iraqi Association for Oral Research الجمعية العراقية لبحوث طب الفم

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Abstract

Introduction Salivary gland tumors represent the most complex and diverse group of tumors encountered in the head and neck region. The diagnosis of these tumors is challenging and the histological examination in the form of incisional biopsy is the standard preoperative diagnostic method, but for major salivary glands this technique harbors the potential for facial scar, facial nerve injury, development of fstula and tumor cells spillage. This is why it is restricted to the minor gland pathology It is restricted to the minor gland pathology. Fine-needle aspiration cytology (FNAC), on the other hand, does not have such complications and therefore it is more accepted and preferable as a preoperative diagnostic method. Aim Assessment of diagnostic value of fne needle aspiration cytology (FNAC) in salivary gland tumors. Patients and Methods Twenty patients were involved; FNAC was performed. The study was conducted in the Department of Oral and Maxillofacial Surgery in Alshaheed Ghazi Alhareery for Specialized Surgeries Hospital at Medical City_ Baghdad, in the period from November 2015 to November 2016. FNAC was performed as preoperative diagnostic toolResults There was no signifcant difference between benign and malignant salivary gland tumors in terms of patients’ age and gender. The majority of tumors were in the parotid and minor salivary glands in the palate respectively. The malignant tumors showed higher prevalence, Mucoepidermoid Carcinoma followed by Adenoid Cystic Carcinoma were the most common malignant tumors while Pleomorphic Adenoma was the most common benign tumor. The values of FNAC Accuracy, Sensitivity, Specifcity, Positive predictive value (PPV) and Negative predictive value (NPV) were: 85%, 84.62%, 85.71%, 91.7% and 75% respectively. Conclusions FNAC has a reasonable reliability in differentiating benign and malignant salivary gland tumors with accepted level of accuracy, sensitivity, specifcity, positive predictive value and negative predictive value. The high positive predictive value of FNAC in this study indicates the good reliability to confrm the malignancy.

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