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Article
Caries experience in relation to salivary physicochemical and immunological changes among asthmatic patients in Mosul city / Iraq

Authors: Mohammed S. Younus --- Ahlam T. Mohammed
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: 4 Pages: 86-90
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Asthma is a pulmonary disorder characterized by reversible stenosis of the peripheral bronchi. Thisdisease could affect the oral health; as a result asthmatic patients may have a higher risk of developing dentaldiseases. This study was conducted to evaluate the caries experience and salivary elements among asthmaticpatients using Ventoline inhaler.Materials and methods: The study group consisted of 30 male asthmatic patients with an age range 20-24years(under Ventoline inhaler). The control group includes 30 subjects matching with study group in age and gender.Plaque and DMFS index were used for recording caries experience. Stimulated salivary samples were collected andthen salivary flow rate, S-IgA and salivary elements concentrations (Ca, Na, K and PO4) were determined.Results: The mean value of dental caries (DMFS) and plaque index (Pl I) were found to be higher among study groupcompared to control group with statistically significant difference for Pl I (P<0.05), while not significant difference wasobserved for DMFS (P>0.05). The mean value of salivary flow rate, Ca, PO4 , Na and K ions concentrations were foundto be lower among study group compared to the control group with no statistically significant difference (P>0.05),except for Ca and K ions the differences were statistically significant (P<0.05). S-IgA in the study group was higherthan the control group and the difference was not significant (P>0.05).Conclusions: Individuals with asthma have a higher caries prevalence, worse oral cleanliness and lower salivaryelements compared to the control group, so a special preventive programs need to be designed for those patients


Article
Salivary Immunoglobulin A Assessment in Lymphoma Patients before and after Chemotherapy

Authors: Mohammed H. Abdulshaheed محمد عبد الشهيد --- Fawaz D. Al-Aswad فواز الاسود --- Haider N. Salh حيدر صالح
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 3 Pages: 65-68
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Lymphomas are group of diseases caused by malignant lymphocytes that accumulate in lymph nodesand caused the characteristics lymphadenopathy. Occasionally, they may spill over into blood or infiltrate organsoutside the lymphoid tissue. The major subdivision of lymphomas is into Hodgkin lymphoma and non–Hodgkinlymphoma and this is based on the histologic presence of Reed-Sternberg cells in Hodgkin lymphoma. Salivaryimmunoglobulin A is the prominent immunoglobulin and is considered to be the main specific defense mechanism inoral cavity. The aim of this study was to determine the level of salivary immunoglobulin A in lymphoma patientsbefore and after chemotherapy treatment.Subjects, materials and methods: The study included 25 patients (15 male and 10 female) with non–Hodgkinlymphoma(B-cell type) , 25 patients( 16 male and 9 female ) with Hodgkin lymphoma and 25 (15 male and 10female) healthy control group. Whole un-stimulated saliva was collected to determine the level of salivaryimmunoglobulin A, which measured by Enzyme Link Immunosorbent Assay.Results: The level of salivary immunoglobulin A was significantly higher in pre-treatment patients in comparison withcontrol group, and there was a significant decrease after chemotherapy treatment when compared to their baseline levels in both study groups.Conclusion: The salivary immunoglobulin A was higher in lymphoma patients than control, then its level showedobvious decrease after chemotherapy treatment.


Article
Role of SalivaryTumor Necrosis Factor-alpha and Immunoglobulin-Ain Recurrent Aphthous Stomatitis

Authors: Mustafa M. Saliah مصطفى محمد صالح --- Batool H Al-Ghurabei بتول الغرابي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2011 Volume: 53 Issue: 2 Pages: 207-210
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:Until today, the etiology of recurrent aphthous stomatitis (RAS) remains unknown, although hints of its etiologic basis lay on genetic susceptibility, infectious agents and alterations in immune mechanics.Objectives:The aim of this study was to investigate the possible alterations in salivarytumor necrosis factor-alpha (TNF-α) and Immunoglobulin-A (IgA) level in patients with RAS and its relation with clinical types of disease.
Subjects and Methods:Salivary TNF-αlevels were investigated in50 RAS patients and 25 healthy controls by enzyme-linked immunosorbent assay (ELISA). Single radial immune diffusion method was used for estimation ofIgAlevel in two studied groups.
Results:Salivary level of TNF-α was significantly higher in RAS patients than in healthy controls (p<0.001), Moreover, the level of TNF-α was significantly increased in minor type of disease than in major and herptiform types (p<0.05).On the other hand, the levelof IgA showed no significant differences between patients and healthy controls and neither among clinical types of disease(p>0.05).
Conclusion: These findings suggestthat saliva provides an ideal medium for the detection of pro-inflammatory markers of the oral cavity, moreover; salivary TNF-α may play an important role in pathogenesis of this disease and it may also have an important role in the search of new treatments for this disease. As well as these results indicated to a possible role of mucosal immune system in pathogenesis of RAS.


Article
Salivary IgA in chronic kidney disease patients undergoing hemodialysis in Missan governorate

Authors: Faris Abid Hatem فارس عبد حاتم --- Zaheda Jassim Mohammad زاهدة جاسم محمد
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 2 Pages: 54-57
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Chronic kidney disease is a worldwide health problem, with adverse outcomes of cardiovasculardisease and premature death, can be divided into five stages, depending on how severe the damage is to thekidneys, or the level of decrease in kidney function, the final stage of chronic kidney disease is called end-stagerenal disease, salivary immunoglobulin A is the main immunoglobulin found in mucous secretions, including tears,saliva, colostrum and secretions from the genitourinary tract gastrointestinal tract, prostate and respiratoryepithelium. It is also found in small amounts in blood.This study aimedto measuresalivary flow rate andsalivaryimmunoglobulin Alevels in chronic kidney disease patients on hemodialysis treatment in comparison withhealthy control subjects.Materials and Methods: Ninety (90) subjects were participated in this study; 45 Patients undergoing hemodialysis withchronic kidney diseases; 45 health control subjects. Saliva collected was measured and levels of salivaryimmunoglobulin A were measured by Enzyme Link Immunosorbent Assay (Elisa).Results:The present studyrevealed that the mean value of salivary flow rate in chronic kidney disease patients was(0.34 ± 0.19) ml/min, while for healthy control subjects was (1.02 ± 0.39) ml/min, there wasstatisticallysignificantlydecrease in salivary flow rate ofchronic kidney disease on hemodialysis patients as compared to control healthysubjects.The present study revealed that the (Mean±SD) of the immunoglobulin A in chronic kidney disease patientson hemodialysis (388.81±227.86) μg./ml, while in control group (273.98±155.89) μg./ml, the result revealed statisticallysignificant increase in chronic kidney disease patients on hemodialysis as compared to control subjects.Conclusions: Salivary immunoglobulin (IgA) reflects the functional capacity of the glands. Increased concentrationof this component is usually marker of a poor general condition

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