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Article
Early Evaluation of Serum Albumin Level in Pediatric Burned Patients

Authors: Kadhum J. A. Shaba'a --- Hasan Th. Ghanem --- Suhad R. Majeed
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2009 Volume: 2 no.8, 9 Issue: 5 Pages: 681-686
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Burn patients are unique in that not only do they reduce albuminsynthesis in response to trauma, but also they experience accelerated albuminlosses into their wound dressings and soft tissue.Methods: Serum albumin has been determined in 26 children with age rangedbetween (l-14) years and with total body surface area of burn (11-60%) during theirinitial few weeks of care. Their serum albumin levels were estimated at second day,seventh day and fourteenth day after burn. Intravenous albumin was administered byinfusion of 1-2 g/kg/d when plasma Albumin fell bellow 2 g/100ml. or bellows 2.5g/100ml in the presence of enteral feeding intolerance or pulmonary dysfunction,their further results were excluded.Results: The mean plasma Albumin was 3.062 g/100ml) at day 2 , 2.952 g/100mlat day 7 and 2.45 g/100ml at day 14 . The relationship between the surface area ofburn and albumin concentration was not significant, (r = - 0.1111406). The valueof albumin was found to be 0.752 g/dl under the normal average value (p< 0.005).Conclusion: Hypoalbuminemia is usual in pediatric burned patients especiallyafter 7 -14 day of the accident, the period of high risk of septic complications.Keywords: Serum albumin, Hypoalbuminemia, Burn


Article
Relationship between serum albumin as an antioxidant and periodontitis

Author: Dr. Hazim Mahmoud Ibrahem B.D.S., M. Sc., Ph.D. * د. حازم محمد ابراهيم
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2006 Volume: 3 Issue: 4 Pages: 371-378
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Objective: The aim of this study was to assess the plasma antioxidant status inpatients with periodontitis using serum albumin concentration as a criterionindex. .Materials and methods: This study was conducted on 20 individuals (10 healthycontrol and 10 with chronic periodontitis). Serum albumin level was detected bythe bromcresol green albumin (BCG) colorimetric method.Results: Patients with periodontitis had a significant decrease in the level of serumalbumin than that of the healthy subjects (p<0.05).Conclusion: The result of the present study demonstrated decreased level of serumalbumin in patients with periodontitis, which indicates decreased antioxidantactivity in patients with periodontitis on comparison with the healthyindividuals.


Article
Changes in Body Weight, Serum (Sodium, Potas-sium) and Serum Albumin after Intermaxillary Fixation in Traumatized and Obese Patients (Comparative Study)

Authors: Wael Sheet --- Mohmmed K. Hassouni
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2012 Volume: 12 Issue: 19 Pages: 52-56
Publisher: Mosul University جامعة الموصل

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Abstract

Aims of the study: to evaluate the effects of intermaxillary fixation (IMF) on body weight, serum electrolytes ( Na+ and K+ ) and serum Albumin in traumatized and obese patients and to compare the changes between these two groups. Materials and Methods: A non randomized prospective study was done. The anthropometric measurement included 4 sites of skin fold thickness (triceps, biceps, subsca-pular and suprailiac skin folds), upper arm circumference, body mass index and laboratory investiga-tions to assess serum(Na+ and K+) levels and serum albumin level. The patients were divided in to 2 groups, the first group included 25 traumatized patients and the second group included 7 volunteer ob-ese patients and IMF was placed for those patients as one of the treatment lines for their body weight reduction and were considered as the control group. The parameters were recorded for each patient in the 2 groups preoperatively, one week, three weeks and six weeks postoperatively. Paired and un paired T tests were used in the statistical analysis, a P value < 0.05 was considered highly significant. Results: The changes of the anthropometric measurements, body mass index, serum K+ and serum albumin were statistically highly significant in traumatized patients with body weight loss ranging be-tween (5-8) Kg in this group. The changes of the anthropometric measurements and body mass index in the obese patients group were also statistically highly significant with a loss of (5-6) Kg in body weight in this group. The changes of anthropometric measurements and body mass index were statisti-cally highly significant in traumatized patients than in obese patients, while the changes in serum (Na+ and K+ ) and serum Albumin level were statistically not significant between the two groups. Conclu-sion: IMF compromises the nutritional status of the patients leading to loss of water, fat and protein in both traumatized and obese patients but the effect more pronounced in traumatized patient due to the metabolic and hormonal response to trauma together with the limited oral intake.


Article
Direct Determination of Tetracycline Hydrochloride and the Interaction with Bovine Serum Albumin by UV Spectra in Water
التقدير المباشر لتتراسايكلين هيدروكلورايد وتداخله مع مصل الالبومين ألبقري بواسطة الأشعة فوق البنفسجية

Authors: Isam J. Al-Nuri عصام جمال الدين النوري --- Banan A. Akrawi بنان احمد عقراوي --- Sana A. Hussin سناء علي حسين
Journal: Rafidain journal of science مجلة علوم الرافدين ISSN: 16089391 Year: 2017 Volume: 26 Issue: 1E Pages: 77-91
Publisher: Mosul University جامعة الموصل

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Abstract

The UV fourth order derivative spectra were selected as the more reliable technique for the direct quantification of pure Tetracycline Hydrochloride in water, after the measurement of the zero, first, second, third and fourth order spectra, within the concentration range at (0.2885-144.27)µg/ml with R2 =0.9998 and RSD=0.215 %. Bovine serum albumin was directly quantified by the fourth order UV derivative technique within the concentration range (6.7-2680) µg/ml with R2 = 0.9998 and RSD=0.324 %. Appreciable interaction between Tetracycline hydrochloride and Bovine serum Albumin was found in accordance with the fraction coefficient and the apparent binding constant. The UV–fourth order derivative technique appears to be in a good accuracy and precise method for the direct quantification of Tetracycline Hydrochloride and Bovine Serum Albumin (BSA) in water.

يتضمن البحث تطبيق طريقة المشتقة الرابعة للأشعة فوق البنفسجية للتقدير الكمي المباشر، للتتراسايكلين هيدروكلورايد في الماء وبعد أن تم قياس مشتقات الأطياف الأخرى الأولى، الثانية، الثالثة والرابعة وجد إن انسب طريقة وأكثرها حساسية هي طريقة المشتقة الرابعة وتم استخدامها في التقدير المباشر لمصل الالبومين ألبقري وجد أن هناك تداخلا" بنسبة جيدة بين عقار التتراسايكلين هيدروكلورايد ومصل الالبومين ألبقري من خلال حساب قيمة نسبة التوزيع الجزئي وثابت الترابط الظاهري العالية. وتعد طريقة المشتقة الرابعة استنادا" إلى النتائج المستحصلة طريقة ذات دقة وتوافقية جديدتين بالإضافة إلى سهولة القياس.


Article
Estimation of Ionized Calcium Concentration in Critically Ill Patients

Author: Ali Sh. Saadoon*, Faez A. Mahdi**, Samad M. Ahmad*
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2016 Volume: 15 Issue: 2 Pages: 247-250
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Hypocalcaemia is a commonly encountered problem in critically ill patients, and it has been shown to correlate with increased ICU stay and mortality. OBJECTIVE:This study is to estimate serum ionized calcium level and to evaluate whether calcium adjusted for albumin accurately predicts ionized calcium concentrations. PATIENT AND METHOD: Cross sectional study conducted to 47 randomly selected adult patients admitted in Baghdad teaching hospital/ ICU from June 2014-october 2014. Ionized Ca level was determined using ion-specific electrode methodology, on heparinised plasma. The total Ca concentration was adjusted for serum Albumin. RESULTS: From total 47 patients, 40 patients were showed low serum calcium level (mean 6.79 mg/dl), and 28 were showed low corrected s.calcium (mean 7.77 mg/dl).Low serum albumin was independently associated with hypocalcaemia on admission. 30 patients (63.83%) reported low total S. alb. mean s. albumin where 2.8mmol. .


Article
Measurementof Serum AlbuminbyThree Different Methods
قياس مستوى الالبومين في الدم باستخدام ثلاث طرق مختلفة

Author: Taghreed,AbdulHameed
Journal: karbala journal of pharmaceutical sciences مجلة كربلاء للعلوم الصيدلانية ISSN: 70272221 Year: 2013 Issue: 4 Pages: 111-118
Publisher: Kerbala University جامعة كربلاء

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Abstract

In this study ,serum albumin level was determined in 61 blood samples using three different methods ,cellulose acetate electrophoresis (CAE), salt fractionation and bromocresolgreen(BCG) . The values of serum albumin (mean (95% confidence interval)) measured in gm/L by the above methods were 38.95 (1.64) , 38.13 (1.76) and 38.11 (1.8) respectively .There were no significant differences in the level of serum albumin determined by these methods (P≥0.05). Also, these methods showed statistically significant differences in the level of serum albumin determined by these methods (P≤ 0.001) ,As the BCG method give a relatively inaccurate albumin levels in abnormal sera therefore ,it is recommended that the BCG is to be used only as a screening method for serum albumin measurement for its simplicity and rapidity

في هذه الدراسة ,تم قياسمستوى الالبومين في الدم في 61 نموذج با ستخدام ثلاث طرق مختلفة الترحيل الكهربائي , الترسيب التجزيئي , وطريقة البروموكريسول كرين (BCG),وكانت قيمالالبومين]( 95%CL) X-[مقاسا ب غم/لترللطرق الثلاثة هي38.95(1.64),38.13(1.76))38.11(1.8) على التوالي .لم يكن هناك ةاختلاف احصائي مهم في مستوى الالبومين مقاسا بالطرق الثلاثة (0.05p≥). أظهرت الدراسة وجود ترابط موجب مهم احصائيا بين الطرق الثلاثة( 0.001P ≤) ونتيجة لكون طريقة(BCG) تعطي نتائج البومين غير دقيقة نسبيا في النماذج غيرالطبيعية, لذلك نوصي باستعمالها فقط كطريقة مسح لقياس مستوى الالبومين وذلك لبساطتها وسرعتها.


Article
Studies on Preparation and Characterization of Blend Polymers for Hydrogels Synthesis and Use for Protein Release
دراسة حول تحضير وتشخيص هيدروجيلات من توليف البوليمرات واستخدامها في إطلاق البروتين

Authors: Fawzi H. Jabrail فوزي حبيب جبرائيل --- Roua'a K. Al-Ojar رؤى قاسم الاُجار
Journal: Rafidain journal of science مجلة علوم الرافدين ISSN: 16089391 Year: 2019 Volume: 28 Issue: 2E: Chem. Pages: 211-227
Publisher: Mosul University جامعة الموصل

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Abstract

Carboxy methyl cellulose, pectin, chitosan or acrylic acid– poly (vinyl alcohol) blend hydrogels were prepared using Glutaraldehyde (GLU) as chemical or sodium hexameta phosphate (SHMP) as physical cross-linking agent. The prepared hydrogels have carried the advantage properties of both blend materials and can be used for loading and releasing of BSA protein. The degree of swelling of the prepared hydrogels was measured due to their different functional groups in different pHs of (pH4, pH7 and pH9) in addition to the electrolyte solution of 0.1 N NaCl. The blend hydrogels are characterized for their chemical structure using FT-IR. The XRD analysis was investigated for determination of the hydrogels crystallographic structure. The differential thermal analysis DTA and scanning electron microscope SEM were depended to study the thermal stability and surface morphology of the hydrogel respectively. The hydrogels were loaded with BSA protein model, and time of loading at (1.5, 3.0, 4.5 and 6.0) hrs were measured, beside the pH of the loading solution of ph4, pH6 and pH8 were considered and the BSA concentrations of (0.5, 1.0, 1.5 and 2.0) g/L have been investigated for maximum loading percentages %Lmax of BSA on the hydrogels. Finally the loaded BSA was released under different release conditions in 0.9% w/vNaCl solution and pH4, pH6 and pH8 were depended and the BSA was tested to release at 15, 25 and 40oC releasing medium temperatures.

تم تحضير هيدروجيلات من توليف البوليمرات الطبيعية )الكاربوكسي مثيل سليلوزCMC والبكتين PE والكايتوسان(CS أَو من المونمر الصناعي حامض الأكريليكِ AA مع البولي (فينايل الكحول) PVA وباستخدام عامل التشابك الكيميائي الكلوتارالديهايد GLU او عامل التشابك الفيزيائي الهكساميتا فوسفات الصوديوم SHMP. وكانت الهيدروجيلات المحضرة تحمل الخواص المميزة للمواد المولفة وأظهرت قابليتها في تحميل أو إطلاق البروتينِ BSA. درجة انتفاخ الهيدروجيلات المحضرة تم قياسها بالاعتماد على مجاميعها الوظيفيةِ المختلفةِ في أوساط حامضية مختلفة ( pH7, pH4 وpH9) إضافة إلى المحلول الملحي الالكتروليتي 0.1NNaCl. إن الهيدروجيلات المولفة قد تم تشخيص تراكيبها الكيميائية بالاعتماد على مطياف الأشعة تحت الحمراء FTIR، كما وتم دراسة تحليلXRD لتقدير التراكيب البلورية للهيدروجيل. وقد اعتمد جهاز التحليل الحراري التفاضليDTA وجهاز المسح المجهري الألكترونِي SEMلدِراسَة الإستقراريةِ الحراريِة وبنية السطح (المورفولوجيا) للهيدروجيل على التوالي. لدراسة تحميل الهيدروجيل تم اعتماد بروتينِBSA كموديل للتحميل، قياس زمن التحميل بالاعتماد على الأوقات الآتية(1.5, 3.0, 4.5 and 6.0) hrs ، واعتماد الأس الهيدروجيني pH4) و pH6 و (pH8 لمحلول التحميل وكذلك تراكيز محلول BSA عند (0.5, 1.0, 1.5 and 2.0) g/L، وذلك للحصول على نسب التحميل المئويةِ القصوى %Lmax مِنْ BSA على الهيدروجيل. وأخيراً؛ تم إطلاق BSAالمحمّل تحت ظروف إطلاقِ مختلفةِ حيث اعتمد محلول NaCl0.9% w/vكوسط للإطلاق فيpH4 و pH6 وpH8 وعند درجات حرارة إطلاق في (15, 25 and 40)oC.

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