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Quantitative analysis of IgG antinuclear antibody in chronic periodontitis patients

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Abstract

Background: Periodontitis is a bacterial infection of tooth-supporting tissues; the immunopathologic mechanismsinclude inflammatory cells and chemical mediators, which persist inflammation and develop a local autoimmune.The presence of autoantibodies against extracellular matrix components, anti-neutrophil cytoplasmic antibodies(ANCA) and anti-DNA was detected. This study aimed to provide evidence of altered humoral immune response inchronic periodontitis, as well as to determine the presence of auto-antibodies in this disease.Subjects and Methods: Blood samples were collected from 35 patients with chronic periodontitis (20 with severperiodontitis and 15 with moderate periodontitis) and from 30 healthy age and sex matched individuals served ascontrols. Clinical periodontal parameters used in this study were plaque index, gingival index, probing pocket depth,clinical attachment level and bleeding on probing. The levels of serum IgG-antinuclear antibody were determinedusing enzyme-linked immunosorbent assays, whereas serum immunoglobulin (IgG, IgM and IgA) were estimated bysingle radial immune diffusion method.Results: Serum levels of IgG-antinuclear antibody and IgG were significantly higher in sever chronic periodontitis thanin moderate chronic periodontitis and healthy controls (p<0.05). On the other hand, the serum levels of IgM and IgAshowed no significant differences among three studied groups (p>0.05). Concerning the correlation between serumIgG-antinuclear antibody and clinical periodontal parameters, the level of this autoantibody did not show anycorrelation with clinical parameters of periodontitis (p>0.05).Conclusion: The production of antibodies against self structures could be involved in the pathogenic mechanism ofchronic periodontitis


Article
Evaluation of Serum Immunoglobulins and Complement Components Level in Children with Atopic Dermatitis in Al-Hilla City

Authors: Hanan Selman Hessan --- Nebras Nesserllah Kiether --- Ahmed Mohammed Abbas
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2014 Volume: 22 Issue: 9 Pages: 2436-2432
Publisher: Babylon University جامعة بابل

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Abstract

Immune status was examined in 30 children with atopic dermatitis, their ages ranged between 1-10 years, were clinically diagnosed in dermatology consultation at Merjan teaching hospital and 15 apparently healthy children were included as a control in the study which lasted from September to December 2012.Immunological parameters test were done by taking venous blood from the patients and healthy children to determine the level of immunoglobulins of IgM, IgG, IgA and complement proteins C3 ,C4 level in their serum .It was shown that positive changes in an immunological assays that were significant increases in IgM, IgG ,IgA , C3 and C4 levels in serum of patients in comparison to healthy children .

تم فحص الحالة المناعية لدى 30 طفلا" مصابا" بالتهاب الجلد الاستشرائي تراوحت أعمارهم بين 1-10 سنوات والذين شخصوا سريريا"في الاستشارية الجلدية في مستشفى مرجان التعليمي و15 من أطفال الاصحاء كعينة ضابطة للدراسة التي امتدت للفترة من ايلول الى كانون الاول 2012 .اختبار المعايير المناعية قد أجريت وذلك بسحب الدم الوريدي من المرضى والأطفال الأصحاء لتحديد مستوى الكلوبيولينات المناعية IgMو IgG و IgA وبروتينات المتممة C3 و C4. وقد أظهرت الفحوصات المناعية تغيرات ايجابية إذ كانت هناك زيادة معنوية في مستوى IgM و IgGو IgA وبروتينات المتممة C3 و C4 في مصل المرضى مقارنة بالأطفال الأصحاء.

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