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Article
DermatologicalSide Effects of Sildenafil among a group of Iraqi Males

Author: Nadheer A.Matloob
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 4 Pages: 398-401
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:Sildenafil is a drugthat is used to treat erectile dysfunctions, itacts byinhibiting CGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis.The most common adverse effects of sildenafil are headache, dyspepsia, nasal congestion and impaired vision which includesphotophobia and blurred vision. Many dermatological side effects are present like flushing, urticaria, sweating and many others.
Patients and Methods: Fifty six males were included in this study, with ages between 37 – 60 years and a mean age of50.1 ± 7.1years. The study was conducted from November 2004 till May 2009 in the Department of Dermatology of Al-KadhymiaTeaching Hospital in Baghdad; allpatientsexperienced dermatological side effects every time they use the drug. Full history and full examination including dermatological examination were done for all patients.
Results:The commonest dermatological side effect was flushing of the face which was seen in 44 (78.6%) patients followed by hyperhydrosis which was seen in 14 (25%) patients then urticaria which was seen in 12 (21.4%) patients.It is seemed that side effects were more with 100mg dose than with 50mg dose (78 side effect against 22 one) and this result was statistically significantConclusion:Dermatological side effects of sildenafil are fairly common and dermatologist must be aware of theseside effects especially when he searches for the cause of angioedema, urticaria,pruritis as well as erythroderma


Article
The relationship of depressive symptoms in cancer patients with treatment by chemotherapy.

Author: Ali K. Khudhair* PhD Psych. Nursing, MSN, BSN د. علي كامل خضير
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 3 Pages: 269-271
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary: Background: depressed mood and anxiety are common symptoms in hospitalized cancer patients .it is often presumed that anxiety and depression affect the occurrence and experience of physical symptoms . the researcher was aimed to assess the level of depression among cancer patients and the chemotherapy side effects and to find out the significant difference between depression level regarding these side effects.Patients and methods: A descriptive analytical study was conducted on a purposive sample of 50 cancer patients from both sexes who were admitted to Radiation and Neuclur Medicine Hospital in Baghdad for the purpose of giving chemotherapy for the period from April 4th to June 20th , 2008. A structured interview using the Self Care Diary (SCD) of Nail et al (1991) and Hospital Anxiety and Depression Scale (HADS) was implemented for data collection.Results: It was found that cancer patient has a significant level of depression and the relationship between depression and presence of chemotherapy side effects in hospitalized cancer patients is not significant.Conclusions: there is no relationship between depression and chemotherapy side effects but it may be due to the disease it self.Key words: depression, chemotherapy, side effects.


Article
A Study Medicinal and Nutritional Effects of Thyme on Hematological Changes in Male Albino Rats
دراسة التأثيرات الطبية والغذائية للزعتر على المتغيرات الدموية في ذكور الجرذان

Authors: Noori Mohammed Luaibi نوري محمد لعيبي --- Murtadha Ghafil Jasim مرتضى غافل جاسم --- Amenah Hussein Mousa آمنة حسين موسى
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2017 Volume: 58 Issue: 3A Pages: 1177-1188
Publisher: Baghdad University جامعة بغداد

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Abstract

The increase in the use of thyme in Iraq and neighboring countries, which may be result in serious side effects necessitate the demand for testing different concentrations of thyme extract (500,750,1000) mg/kg of body weight on rats to be given either by injection or feeding grinded dried thyme leaves added to pellets (50,100,150) g /kg of pellet in of different periods , (10,20,30) days for injection and feeding 2 times weekly. Thyme extracts leaves effects on RBCs, WBCs and Differential WBCs counts were measured. statistical analysis showed significance increase difference (P≤0.05) in RBCs, WBCs and Lymphocyte, Nutrophile and Monocyte counts and decrease in Eosinphil counts in rats treated with 1000 mg of thyme /kg of body weight and 150 g/kg of pellet in 10 days, in 20 days treatment group was showed highly significance increase difference (P≤0.01) compared to control group in RBCs, WBCs, Lymphocyte, Nutrophile and Monocyte counts and decrease in Eosinphil counts in rats treated with thyme extract by (750,1000) mg/kg of body weight and (100,150) g/kg of pellet and in 30 days thyme extract cause highly significance increase difference (P≤0.001) in RBCs, WBCs, Lymphocyte, Nutrophile and Monocyte counts and decrease in Eosinphil counts in rats treated with thyme by (500-750–1000) mg/kg of body weight comparing with the negative and positive controls and (50-100–150) g/kg of pellet comparing with the negative control for feeding .

نظرا لزيادة استخدام نبات الزعتر في العراق والبلدان المجاورة والتي من الممكن ان تنتج تاثيرات جانبية لذلك من الضروري اختبار تراكيز مختلفة من مستخلص الزعتر (500–750–1000) ملغم /كغم من وزن الجسم المعطاة لذكور الجرذان اما عن طريق الحقن او أوراق الزعتر المجففة المطحونة المضافة الى العليقة (50– 100–150) غم/كغم من العليقة في فترات زمنية مختلفة (10–20-30) يوم لكل من الحقن والتغذية بمعدل مرتين أسبوعيا. تم قياس تاثير مستخلص الزعتر في عدد كريات الدم الحمر والبيض والفحص التفريقي لكريات الدم البيض. أظهرت النتائج الإحصائية وجود زيادة معنوية (p ≤0.05) في عدد كريات الدم الحمر والخلايا البيض و(العدلة, اللمفاويه والوحيدة) وانخفاض في عدد خلايا الدم البيض (الحمضة) للجرذان المحقونة بمستخلص الزعتر بتركيز 1000 ملغم/كغم من وزن الجسم ولمدة 10 أيام وأيضا في الجرذان المتغذية على العليقة الحاوية على الزعتر المطحون 150 غم/كغم من العليقة مقارنة مع مجموعة السيطرة، واظهرت مجموعة المعاملة بــــ 20 يوما حصول ارتفاع معنوي عالي (p ≤0.01) في عدد كريات الدم الحمر والخلايا البيض (العدلة , اللمفاويه والوحيدة) وانخفاض في كريات الدم البيض (الحمضة) للجرذان المحقونة بمستخلص الزعتر (750–1000) ملغم/كغم من وزن الجسم وكذلك للجرذان المتغذية على العليقة المحتوية على الزعتر المطحون (100–150) غم/كغم من العليقة أما في 30 يوم فقد حصل ارتفاع معنوي عالي (p ≤0.001) مقارنة مع مجموعة السيطرة في عدد كريات الدم الحمر والخلايا البيض ( العدلة , اللمفاويه والوحيدة) وانخفاض في كريات الدم البيض (الحمضة) في الجرذان المحقونة بمستخلص الزعتر (500-750-1000) ملغم/كغم من وزن الجسم مقارنة مع مجموعة السيطرة الموجبة والسالبة والمتغذية على العليقة الحاوية على الزعتر (50-100-150) غم/كغم من العليقة مقارنة مع مجموعة السيطرة السالبة .


Article
Assessment of side effects of venesection (phlebotomy) procedure in Iraqi patients presenting with erythrocytosis: single center experience

Authors: Eaman Marouf Muhammad --- Raid Ahmed Alrubaye --- Alaa Fadhil Alwan
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2015 Volume: 4 Issue: 1 Pages: 61-66
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Venesection or phlebotomy is generally considered to be a safe method, butoccasionally adverse effects of varying severity may occur during or at the end of the procedure.Objectives: The aim of the study was to estimate the frequency and type of adverse eventsoccurring during venesection and to assess the practices which would help to minimize them.Materials and methods: This is prospective single-center study was conducted from October2011 to November 2012 at the emergency unit of the national center of hematology in Baghdad.All phlebotomies procedures made at the center were analyzed. All adverse events occurringduring or at the end of procedure were registered by using a standardized questionnaire.Results: Overall 3 adverse events were reported in relation to 960 venesections done, resulting inan overall adverse event rate of 0.3125%, that is, an incidence of 1 in every 320 venesections.One adverse effect was presyncopal symptoms of mild intensity, and the other two that observedwere extravasation at site of puncture.Conclusions: Only 0.3% of phlebotomies were complicated by adverse events which were verymild and easily managed. Our study confirms the fact that venesection procedure is a very safemethod which could be made even more event-free by following certain friendly, reassuring andcompetent practices.


Article
Insight on the Side Effects of Lipid Lowering Agents (Statin) in Iraqi Patients with Ischemic Heart Diseases

Author: Basil N. Saeed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 3 Pages: 266-269
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:3-hydroxy-3methyl glutaryl co enzyme inhibitor (MMG-COA) (statin) is a very common drug used in many medical conditions regardless of the presence or absence of dyslipidemia. One of these conditions is the cardiac disorders.OBJECTIVE:Throwing a light on the prevalence of their side effects in Iraqi patients.PATIENTS AND METHODS:Two hundred seventy patients with ischemic heart disease from the period of November 2006-November 2007 referred to Baghdad teaching hospital (the medical city). Those cases were using statin and grouped into two groups.Group A: patients admitted with acute coronary syndrome (myocardial infarction and unstable angina) (230 patients 77%).Group B: patients with associated risk factors (Hypertension, diabetes mellitus, smoking and secondary lipidemia) 40 cases 23%, have history of ischemic heart disease on treatment they use the drug in range of (10-40) daily with review monthly for the side effects. All 270 cases were free from other organic disorders (i.e. renal, thyroid, malignancy, or any longstanding disease). All patients went through a questionnaire which includes: age, gender, risk factors (Hypertension, diabetes mellitus, smoking, and lipidemia), routine blood tests, lipid profile, liver function tests, C-reactive proteins, thyroid function tests, chest X-ray, electrocardiography and echocardiography done for all patients, all patients used to take drugs in the range of 10-40mg daily for at least one year.RESULT:The side effects noticed in this study were gastric, musculoskeletal, elevated liver enzymes (40%, 28.9%, and 1% respectively from the total number of patients). Other side effects in other systems like skin, respiratory, and cardiac were not encountered.CONCLUSION:This study showed that the side effects of statin were not involving all the body systems.


Article
Dexaject dosage for carriage horses: side effects & fixing
جرعات الديكساجكت المعطاة لخيول الأحمال: اثارها الجانبية ومدى الشفاء

Authors: Abdul-Samad Uleiwi Hassan --- Ali Hussein Aldujaily --- Shatha Atta Abeed
Journal: Kufa Journal For Veterinary Medical Sciences مجلة الكوفة للعلوم الطبية البيطرية ISSN: 20779798 Year: 2018 Volume: 9 Issue: 1 Pages: 59-67
Publisher: University of Kufa جامعة الكوفة

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Abstract

The instant study clarify excellent treatment response of dexaject with a dose 3.5/2 mg-mlin fixing musculoskeletal injuries imaged by x-rays to get a statistical probability less than 0.001(P<0.001) put it in progress for uses without serious side effects mentioned or noticed in carriagehorse models

بيّنت الدراسة الراهنة ان افضل استجابة علاجية للعقار الديكساجكت كانت بجرعة 3.5وهذا ما )p<0.001( الاصابات العضلية-الهيكلية المشخّصة بواسطة أشعة أكس وبمستوى معنوية إحتمالي اقل من 0.001سنّمه عملية الإستخدام لعدم إظهاره آثاراً عرضية خطيرة تذكر او تلاحظ في عينات خيول الأحمال المعالجة.


Article
Psychiatric Squele of Sodium Valproate VersusCarbamazipine in Patients with Primary Generalized Epilepsy

Authors: Hassan Aziz حسان عزيز --- Abdul R Al Yasiri عبد الياسري --- Zaki N. Hasan زكي نوح حسن
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2009 Volume: 5 Issue: 1 Pages: 19-24
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: psychiatric and behavioral side effects are common in patients with epilepsy and it may represent an intrinsic feature of the disease itself or a side effect of the antiepileptic use. Our aim in the present study is to assess the psychiatric side effects of Sodium Valproate and Carbamazipine .as these drugs are the most commonly used antiepileptic drugs in Iraq.Methods: 80 patients with primary generalized epilepsy on Carbamazipine and 50 patients on Sodium Valproate were enrolled in the present study; all the patients were assessed for any psychological disturbances using semi-structural interview based on the tenth edition of the international classification of the diseases(ICD 10) adopted by WHO.Results: thirty percent of patients taking Sodium Valproate and (9%) of patients taking Carbamazipine were found to have depression while (16%) of patients taking Sodium Valproate and (20%) of patients taking Carbamazipine were found to have anxiety. There were no reported psychosis, suicidal attempts, cognitive deficit and mania in both groups of patients in the present study.Discussion: Carbamazipine is associated with lower rates of psychological side effects than Sodium Valproate; this result may be related to mood stabilization effects of Carbamazipine.Conclusion: Carbamazipine is preferred to Sodium Valproate when the efficacy of both drugs is comparable.


Article
Psychiatric Squele of Sodium Valproate Versus CarbamazipineIn Patients with Primary Generalized Epilepsy

Authors: Hassan Aziz Hassan حسان عزيز حسان --- Abdul-Rasul Al Yasiri عبد الرسول الياسري --- Zeki Noah Hasan زكي نوح حسن
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2008 Volume: 4 Issue: 2 Pages: 77-82
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: psychiatric and behavioral side effects are common in patients with epilepsy and it may represent an intrinsic feature of the disease itself or a side effect of the antiepileptic use. Our aim in the present study is to assess the psychiatric side effects of Sodium Valproate and Carbamazipine .as these drugs are the most commonly used antiepileptic drugs in Iraq.Methods: 80 patients with primary generalized epilepsy on Carbamazipine and 50 patients on Sodium Valproate were enrolled in the present study; all the patients were assessed for any psychological disturbances using semi-structural interview based on the tenth edition of the international classification of the diseases(ICD 10) adopted by WHO.Results: thirty percent of patients taking Sodium Valproate and (9%) of patients taking Carbamazipine were found to have depression while (16%) of patients taking Sodium Valproate and (20%) of patients taking Carbamazipine were found to have anxiety. There were no reported psychosis, suicidal attempts, cognitive deficit and mania in both groups of patients in the present study.Discussion: Carbamazipine is associated with lower rates of psychological side effects than Sodium Valproate; this result may be related to mood stabilization effects of Carbamazipine.Conclusion: Carbamazipine is preferred to Sodium Valproate when the efficacy of both drugs is comparable.


Article
The Effect of Atenolol on CK-MB Levels in Hypertensive Patients

Author: Inaam A. Amin انعام احمد امين
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2009 Volume: 18 Issue: 1 Pages: 61-64
Publisher: Baghdad University جامعة بغداد

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Abstract

Atenolol is one of beta-adrenergic receptor blocking agent. It is widely used for the treatment of hypertension as a selective antihypertensive drug. But long term usage of atenolol may cause one of the cardiovascular diseases like myocardial infarction. To prove the relationship between atenolol and cardiovascular disease, measurement of creatinekinase-MB as a diagnostic indicator in early and long term usage of this drug by hypertensive patients is recommended. A comparative study was conducted in Al-Yarmouk Teaching Hospital–Emergency Department- on 30 hypertensive patients using atenolol. They were divided into (2) groups A and B according to the duration of the drug usage. Group A- (15) patients with a mean age (56+6) years. They used atenolol for a period of (1-5) years. Group B- also (15) patients with mean age (60+6) years. They used atenolol for (6-20) years. Both groups were with nearly the same number of males and females. All subjects of the study groups were screened to exclude evidence of hyper or hypothyroidism, diabetes and chronic renal failure. Venous blood samples were taken in first 8 hours after onset symptoms of cardiac attack from each patients and the levels of creatine kinase-MB were estimated and compared between the (2) groups. There is a significant correlation between levels of serum creatine kinase-MB of group A and group B (P<0.05). Atenolol causes increased level of serum CK-MB and this increase was directly proportional to the duration of the drug usage. CK-MB is one of cardiac markers that released from heart muscle when it is damaged as a result of myocardial infraction. So, atenolol has a significant correlation with development of myocardial diseases.

التينورمين هو واحد من مجموعة الأدوية التي تعمل على غلق مستقبلات بيتا، وهو يستخدم بشكل واسع في معالجة ارتفاع ضغط الدم ولهذا فإن هذا العقار قد يصنف كدواء اختياري لتقليل ارتفاع ضغط الدم ولكن استخدام هذا العقار على مدى طويل قد يسبب حدوث واحد من امراض الجهاز القلبي الوعائي. ولإثبات العلاقة بين عقار التينورمين وأمراض الجهاز القلبي الوعائي بواسطة قياس أنزيم الكرياتين كاينيس م ب ككاشف تحليلي على المدى القصير والبعيد لاستخدام هذا العقار لدى مرضى ارتفاع ضغط الدم، ولهذا أجريت دراسة مقارنة حالات في مستشفى اليرموك التعليمي- قسم الطوارئ- على (٣٠) مريضاً يعانون من ارتفاع ضغط الدم ويستعملون تينورمين كعلاج وتم تقسيم هؤلاء المرضى إلى مجموعتين (أ وب) وفقاً إلى طول فترة استعمالهم لعقار التينورمين. المجموعة (أ) وتتألف من (١٥) مريضاً، معدل أعمارهم (٥٦+٦) سنة واستعملوا التينورمين لفترة زمنية تراوحت بين (١-٥) سنة والمجموعة (ب) وتتألف أيضاً من (١٥) مريضاً، معدل أعمارهم (٦٠+٦) سنة استعملوا التينورمين لمدة تراوحت بين (٦-٢٠) سنة. كلا المجموعتين تقريباً تضم نفس العدد من كلا الجنسين، وكل المرضى المشمولين بهذه الدراسة غير مصابين بأمراض الغدة الدرقية ولا بداء السكري أو عجز الكلية المزمن. تم أخذ عينات من دم كل مريض خلال الساعات الثمانية الأولى بعد ظهور أعراض الأزمة القلبية لقياس مستوى أنزيم الكرياتين كاينيس م ب وتمت مقارنة النتائج بين المجموعتين. كان معدل الأنزيم كرياتين كاينيس م ب في مصول دم المجموعة (ب) مقارنةً بالمجموعة (أ) عالية وبمعنوية واضحة ٠٫٠٥ P< . ومن خلال النتائج التي تم الحصول عليها تبين أن عقار التينورمين يؤدي إلى ارتفاع وزيادة مستوى الأنزيم كرياتين كاينيس م ب وهذه الزيادة تتناسب طردياً مع طول الفترة الزمنية لاستعمال التينورمين وبما أن هذا الأنزيم مؤشر حيوي خاص لأمراض الجهاز القلبي الوعائي، لذا فإن عقار التينورمين له علاقة معنوية بحدوث أمراض الجهاز القلبي الوعائي وخصوصاً احتشاء العضلة القلبية.


Article
Effect of Peganum Harmala Methanol Extract on Liver and Kidney of Mice Administered MTX Drug

Author: Saddam Yahya Diwan
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2013 Volume: 16 Issue: 4 Pages: 161-166
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

This research was designed to evaluate the role of Peganum harmala methanol seed extract in amelioration the biochemical side effect of liver and kidney in mice administered MTX drug. The biochemical detections for both kidney functions (urea and creatinine) and liver enzymes (GOT, GPT and ALP) were investigated. This detection was carried on 30 mice through two stages. In stage Ι, two doses (75 and 100) mg/kg of P. harmala seed extract and a single dose of MTX 50 mg/kg were used. The tested materials were dosed as a single dose (0.1 ml) per a day for 6 days, and then mice were sacrificed on day 7 for subsequent assesments. In stage ІІ, interaction between MTX drug and two doses of extract were carried out. Mice were given MTX dose on day one, while the extract was given in day two till day 6, then mice were sacrificed on day 7 for laboratory evaluation. Results revealed that mice treated MTX showed a significant increase in liver enzymes and kidney function; in contrast, biochemical parameters demonstrated the amelioration effect of extract through decreasing these parameters.

صممت الدراسة الحالية لتقييم دور المستخلص الميثانولي لبذور نبات الحرمل في تحسين التأثيرات الجانبية على كبد وكلية الفئران المعالجة بعقارMTX المضاد للأورام، حيث أجريت بعض الفحوصات الكيموحيوية على وظائف الكلية (اليوريا والكرياتنين) وأنزيمات الكبد (GOT, GPT, و ALP). أجريت الدراسة على 30 فأرة بيضاء من خلال مرحلتين: شملت المرحلة الأولى دراسة تأثير جرعتين من مستخلص النبات (75 و 100) ملغم/ كغم وجرعة 50 ملغم/كغم من عقار MTX. جرعت الفئران بالمستخلص لمدة ستة أيام وفي اليوم السابع ضحي بالحيوانات لغرض أجراء التقييمات المختبرية. في المرحلة الثانية أجري تداخل بين عقارMTX والمستخلص النباتي، وفي هذا التداخل جرعت الحيوانات في اليوم الأول بجرعة واحدة من عقار MTX، أما في اليوم الثاني وحتى اليوم السادس فقد أعطيت الحيوانات جرعات من المستخلص. أظهرت النتائج أن معاملة الحيوانات بعقار MTX قد تسبب في زيادة معنوية في أنزيمات الكبد ووظائف الكلية، وعلى العكس، اظهرت المعاملة بالمستخلص النباتي دوراً في تحسين المعاملات الكيميائية للكبد والكلية من خلال فحص مستويات هذه المعاملات.

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