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Article
Bacterial Infections Associated withCutaneous Leishmaniasis

Authors: Ali Abdul-Latef AL-Ani --- Saleem O AL-Mawala --- Shehab A Lafi
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2007 Volume: 4 Issue: 1 Pages: 23-26
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:Oriental sore occurs mostly in the mediteranian region , North Africa ,and the Middle East . Rodents are the main reservoir for the parasite . The wet type caused by L. major is rural and the dry type caused by L. tropica is urban and humans are presumably the only reservoir. Sand fly vectors are involved in all forms.
Objectives: This study aimed to show the most important bacterial infections concomitant with cutaneous leishmaniasis .
Methods; The study was performed on 75 patients (ages 1-50 years ) from both sexes were attending Skin Diseases Department of Ramadi General Hospital during the period extended from January to June 2000. These patients were clinically diagnosed as patients with cutaneous leishmaniasis. Skin specimens were taken for bacteriological and parasitological investigations .The same thing was done for specimens from 25 intact individuals resembling the test group as negative controls.
Results: Children showed more lesions with Positive cutaneous leishmaniasis, adult females, showed more l lesions than adult males. Children showed more bacterial isolates than adults, from both positive and negative l lesions. Staphylococcal and Streptococcal isolates took the first rank of isolation in all age groups and both sexes. E. coli and fecal Streptococci were isolated from children only.
Conclusion: Bacterial invasion for the skin lesion with cutaneous leishmaniasis complicates the lesion and leads to misdiagnosis, in addition to the delay of healing of the lesion via bacterial end-products. There is a need for accurate diagnostic techniques like polymerase chain reaction (PCR) for both bacterial and parasitic agents, suitable effective antimicrobial therapy, in addition to the antileishmanial agents. Good sanitation of the lesion and community education to prevent infections.
Keywords: Bacteria and Leishmania, Bacterial skin infection, L concomitant infections.


Article
Molluscum Contagiosum in Baquba City Epidimiological Study with Identification of Mc Viruses by Polymeras Chain Reaction

Authors: Khudhair Khalf Al-Kayalli --- Raghad Ibrahim Ahmed --- Brooj Mohammad Irzuqy --- Wathek Mohammed Husain
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2015 Volume: 8 Issue: 1 Pages: 8-13
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Molluscum contagiosum is a DNA virus, which may infect the mucous membrane, it is caused by Molluscipox virus and there are four types (MCV1-4). The sites of predilection of lesions are the face and neck, both genders equally affected and most commonly seen in childhood age group. Objectives: To study the epidemiological variables of Molluscum contagiosum and to confirm the clinical diagnosis and type of Molluscum cotagiosum virus (MCV) by Polymerase chain reaction (PCR) technique. Patients and methods: The present study was conducted for the period from 1st November 2011 to 30th April 2012 in outpatient clinic of Baquba teaching hospital in Baquba city. One hundred and sixty two patients with molluscum contagiosum were examined and diagnosed clinically and the diagnosis was confirmed by Polymerase chain reaction technique .The lesions of moluscum contagiosum were seen on different sites of the body, age of patients ranged from (1-80 years) with a mean age of 35+_9years . They were 114(70.6%) males and 48(29.4%) females.Results: The results showed that 72 (44.4%) patients of age group (31-40 years), of which 50 (70%) were males and 22 (30%) females, 35 (21.6%) of age group (ten years or less). This study revealed that 56(35%) of patients were illiterate, without statistical significant difference between MC infection and educational levels. In 78% of patients the lesions located on the head and neck, 70% on the right side and in 78% of patients the number of lesions was ≤10 lesions, 70% of patients lived in the urban areas and 30% in rural areas. Eighty five percent (85%) of patients give positive results for MCV, 58.8% of them shows positive results for MCV type 1 and 2 (73.3% MCV-2 and 26.7% MCV-1), while 41.2% shows negative results . Conclusion: We concluded that Molluscum contagiosum was a disease of adult, predominantly males and on the right side of the face and 73.3% of PCR positive results were MCV-2.


Article
Histological Changes Of Mice Skin Infected by Nocardia asteroides (Bacteria Isolated From The Soil)

Author: Ramzia Hassan Abdul Rahman
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2009 Volume: 14 Issue: 1 Pages: 37-41
Publisher: Tikrit University جامعة تكريت

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Abstract

Experimental infection in laboratory Mice of (18-20) gm weight and (4-8) weeks age was made by injection bacterial solution containing Nocardia asteroides isolated from the soil in concentration of (1×107) CFU/ml, in the foot pads of these animals.The results proved the ability of these bacteria to cause infection after about 30 days of inoculation and resulted in many histological changes in the sole of the foot of these mice represented by inflammatory cells infiltration and abscess formation containing many granules can be seen by the naked eye represent the Nocardia asteroides bacteria whichare thread like, positive for gram stain and can be stain by Modified Ziehl-Neelsen.This study proved that those mice inoculated by Nocardia asteroides suspension by injection in their sole lead to infection and many histological changes in the foot skin were obvious. Bacterial clearance or disease progression is related to pathogenic or virulence factors of the bacteria in the one hand and the immune response killing ability of host in the other hand

تم إحداث إصابة تجريبية في فئران مختبرية بوزن (18-20) غم وبعمر (4-8) أسابيع عن طريق حقنها في القدم بالمعلق الجرثومي لأفراد النوع Nocardia asteroides المعزولة من التربة ذي التركيز (1× 710) خلية جرثومية / سم3 .بينت نتائج الدراسة المرضية النسيجية للفئران المصابة تجريبيا قدرة الجرثومة على إحداث الخمج الجلدي بعد 30 يوم من الحقن من خلال قدرتها على الاستيطان وإحداث الآفات المرضية والتغيرات العيانية والنسجية في القدم والمتمثلة بحدوث الالتهاب وظهور خراجات موضعية في منطقةالإصابةحاوية على سائل قيحي يحتوي السائل على حبيبات يمكن ملاحظتها بالعين المجردة تمثل جراثيم Nocardia asteroides التي تكون عصوية وتنتظم بشكل خيوط موجبة لصبغة كرام ويمكن صبغهابـصبغة , زيل-نلسن المحورة Modified Ziehl-Neelsen(صبغة كينون).أثبتت الدراسة الحالية إن معاملة الفئران بمعلق جرثومة Nocardia asteroides عن طريق الحقن في وسادة القدم ,قدرة الجرثومة على تحفيز الخمج الجلدي من خلال الآفات المرضية والتغيرات النسجية في جلد وسادة القدم


Article
Biological & Immunological Effect of Ozonated Water on Certain Skin Pathogenic Bacteria In vivo
التأثير الحيوي والمناعي للاوزون المذاب في الماء ضد بعض المسببات المرضية الجلدية البكتيرية داخل الجسم الحي

Authors: Nada S.Rezoqe ندى صباح رزوقي --- Khalid A.Habib خالد عبد الرزاق حبيب --- Dhuha S.Salih ضحى سعد صالح
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2009 Volume: 6 Issue: 4 Pages: 654-665
Publisher: Baghdad University جامعة بغداد

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Abstract

This in vivo study was conducted to investigate the effect of different concentrations of ozonated water on experimentally skin infection with some of bacterial isolates (Pseudomonas aeruginosa and Staphylococcus aureus ) which Showed dermal infection in experimental animals after 48 hours of exposure to these Microorganisms. Results revealed that ozone has the power to accelerated the healing process depending on the perfect concentration of ozonated water used and the severity of infection & nature of causative agent , in which the recovering period was 7 days for the infection caused by P. aeruginosa and 5 day for S.aureus by using the concentration 60 µg/ml . Results also indicated in this study the stimulated effect of Ozonated water on the immune system For the healthy mice at the concentration 20µg/ml through increasing in Phagocytic index ,Arthus and Delayed Type- Hypersensitivity reaction in addition to the inhibited effect of this material on this immunological Markers when the animals treated with Ozonated water at the concentration 60µg/ml .Different respond appear with the immune system For injured and infected mice when treated with ozonated water depending on the Kind of causing agent and the severity of infection .

اجريت هذه الدراسة بهدف التحري عن تاثير استخدام الاوزون المذاب في الماء بتراكيز مختلفة على بعض الاحياء المجهرية البكتيرية المسببة لتلوث الحروق والجروح . حيث تم ولاول مرة على المستوى المحلي اختبار فعالية الاوزون تجاه بكتيريا Staphylococcus aureus و Pseudomonas aeruginosa داخل الجسم الحي بعد استحداث الاصابة الجلدية تجريبياً بهذه المسببات المرضية في الفئران المختبرية والتي ظهرت عليها الاعراض السريرية للاصابة الجلدية بعد 48 ساعة وبعد ذلك عوملت فئران كل مجموعة بتراكيز مختلفة من غاز الاوزون المذاب في الماء نتج عنه انخفاض في الوقت اللازم للشفاء اعتماداً على التركيز الامثل من غاز الاوزون المذاب في الماء حيث وجد من خلال النتائج التي تم الحصول عليها ان التركيز الامثل من غاز الاوزون المذاب في الماء كان 60 مايكروغرام / مل لعلاج الاصابات الجلدية بكل من بكتيريا S.aureus وبكتيريا P.aeruginosa و مع اختلاف المدة الزمنية اللازمة للشفاء ( حسب طبيعة الاصابة ونوع الكائن المجهري المسبب للاصابة ) حيث كانت ( 5 ايام ) بالنسبة لبكتيريا S.aureus و ( 7 ايام ) لبكتيريا P.aeruginosa ، كما تضمنت الدراسة الحالية تسليط الضوء على بعض التاثيرات المناعية لغاز الاوزون المذاب في الماء في ذكور الفئران البيض السليمة والمصابة من خلال دراسة بعض المؤشرات المناعية لديها والتي هي : معامل البلعمة و تفاعلات آرثس وفرط الحساسية الآجل . حيث اظهرت نتائج معاملة الفئران السليمة بغاز الاوزون المذاب في الماء ان لهذه المادة تاثيرا منشطا لجميع قيم الفحوصات المناعية المذكورة اعلاه عند التركيز 20 مايكروغرام / مل في حين ادت المعاملة بتركيز 60 مايكروغرام / مل الى انخفاضها ، و اختلفت الاستجابة المناعية لدى الفئران المصابة عن السليمة بالنسبة لتاثرها بالتراكيز المختلفة من غاز الاوزون المذاب في الماء عند معاملتها به حسب نوع الكائن المسبب للاصابة وطبيعة الاصابة .

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